Everolimus with reduced cyclosporine versus MMF with standard cyclosporine in de novo heart transplant recipients.

abstract：BACKGROUND:Significant disparity exists in the United Kingdom between the need for organ transplant and supply of deceased donor organs. In the recent years, efforts to increase donation has improved the rate of mainly deceased donors after circulatory death and from older donors. The rate of donation from pediatric po...

journal_title：Transplantation

authors： Dave RV,Hakeem AR,Dawrant MJ,Ecuyer CL,Lewington AJ,Attia MS,Hostert L,Finlay E,Ahmad N

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Low-molecular-weight heparin (LMWH) has been shown to prolong survival of rat cardiac allografts independently from immunosuppressive treatment. Furthermore, long-term treatment reduces the development of chronic graft vascular disease after experimental heart transplantation. The aim of the present study wa...

journal_title：Transplantation

authors： Braun C,Schultz M,Fang L,Schaub M,Back WE,Herr D,Laux V,Rohmeiss P,Schnuelle P,van der Woude FJ

更新日期：2001-07-27 00:00:00

abstract：:A study was designed to determine if cold preservation induces an increase in lymphocyte adherence to liver sinusoids on reperfusion. Rat livers were stored at 1 degree C in University of Wisconsin solution for 45 min, 8 hr, or 30 hr, and then reperfused for 90 min at 37 degrees C in an isolated perfused rat liver app...

journal_title：Transplantation

authors： Clavien PA,Morgan GR,Sanabria JR,Petrunka C,Levy GA,Robert P,Harvey C,Strasberg SM

更新日期：1991-09-01 00:00:00

abstract：:Genetic manipulation of pancreatic islets before transplantation has the potential to alter cellular immunity as well as islet function. The purpose of this study was to examine the feasibility of gene transfer to islets, using replication-defective adenoviral vectors. Newborn mouse islets were infected with AdHCMVsp1...

journal_title：Transplantation

authors： Csete ME,Benhamou PY,Drazan KE,Wu L,McIntee DF,Afra R,Mullen Y,Busuttil RW,Shaked A

更新日期：1995-01-27 00:00:00

abstract：BACKGROUND:The detection of acute rejection in heart transplantation remains an important feature of transplant management, especially in the early phase. Frequent surveillance with endomyocardial biopsy is necessary, even though it is an invasive procedure and carries a certain risk. Hence, noninvasive biomarkers able...

journal_title：Transplantation

authors： Crescioli C,Buonamano A,Scolletta S,Sottili M,Francalanci M,Giomarelli P,Biagioli B,Lisi G,Pradella F,Serio M,Romagnani P,Maccherini M

更新日期：2009-01-27 00:00:00

abstract：BACKGROUND:Bioluminescence imaging (BLI) modalities are being developed to monitor islet transplant mass and function in vivo. The aim of this study was to use the BLI system to determine how the change in functional islet mass correlated to metabolic abnormalities during the course of alloimmune rejection in a murine ...

journal_title：Transplantation

authors： Chen X,Zhang X,Larson CS,Baker MS,Kaufman DB

更新日期：2006-05-27 00:00:00

abstract：BACKGROUND:Membrane CD30 is an important costimulatory molecule for activated T lymphocytes, and serum level of soluble CD30 (sCD30) is considered a marker for predicting outcome in kidney transplantation. METHODS:We investigated the kinetics of CD30 expression on CD4 and CD8 T-cell populations and the source of sCD30...

journal_title：Transplantation

authors： Velásquez SY,García LF,Opelz G,Alvarez CM,Süsal C

更新日期：2013-07-27 00:00:00

abstract：:We retrospectively compared the clinical and financial impact of a final cross-match by T cell flow cytometry (FXM) versus conventional complement-dependent cytotoxicity (CXM) in consecutive primary cadaveric kidney (K) and primary simultaneous cadaveric pancreas-kidney (SPK) transplant recipients. Mean follow-up was ...

journal_title：Transplantation

authors： Pelletier RP,Orosz CG,Adams PW,Bumgardner GL,Davies EA,Elkhammas EA,Henry ML,Ferguson RM

更新日期：1997-06-15 00:00:00

abstract：:Cyclosporine (CsA) administration and nitric oxide (NO) blockade promote similar chronic renal hemodynamic alterations in rats. We evaluated various clinical CsA doses under conditions of NO blockade using L-NAME (N-nitro L-arginine methyl ester). Groups of Sprague-Dawley rats kept on a normal salt (+NaCl) or low-salt...

journal_title：Transplantation

authors： Gardner MP,Houghton DC,Andoh TF,Lindsley J,Bennett WM

更新日期：1996-05-27 00:00:00

abstract：:We have previously observed that transplant recipient sera with endothelial antibodies are bound to epidermal cells, as shown by immunofluorescence on sections of skin. It was also reported that early kidney failures that occurred despite negative T cell crossmatches were associated with, and could have been predicted...

journal_title：Transplantation

authors： Moraes JR,Moraes ME,Luo YM,Stastny P

更新日期：1991-02-01 00:00:00

abstract：:Nonmajor histocompatibility complex (non-MHC) antigens are important targets of graft rejection and graft-versus-host disease in clinical transplantation. Little is known regarding immunity to non-MHC antigens. To study this problem we evaluated the effect of antihuman thymocyte globulin (ATG) on reactivity in autolog...

journal_title：Transplantation

authors： Harada M,Gale RP

更新日期：1981-02-01 00:00:00

abstract：BACKGROUND:Organ donors are frequently trauma victims, but the impact of donor hemorrhagic shock and resuscitation (HSR) on pulmonary graft function has not been assessed. L-arginine treatment during reperfusion increases the production of endothelial nitric oxide and thus ameliorates ischemia-reperfusion injury. Objec...

journal_title：Transplantation

authors： Preissler G,Löhe F,Ebersberger U,Huff I,Bittmann I,Messmer K,Jauch KW,Angele MK

更新日期：2009-06-15 00:00:00

abstract：:Cyclosporine, but not its nonimmunosuppressive analog cyclosporine H (CsH), caused in a variety of hematopoietic cell types a growth arrest in the G0/G1 phase of the cell cycle. This arrest was associated with a significant reduction in the c-myc mRNA levels, which could be observed already 1 hr following CsA treatmen...

journal_title：Transplantation

authors： Yonish-Rouach E,Kimchi A,Rubinstein M

更新日期：1991-06-01 00:00:00

abstract：:T cell surface proteins involved in transmembrane signalling resulting in the activation of T cells were investigated utilizing as probes monoclonal antibodies directed at T cell surface antigens. Here we report that mAbs that react with a framework determinant of alpha/beta heterodimer of T cell receptor for antigen,...

journal_title：Transplantation

authors： Suthanthiran M

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND:Spontaneous tolerance to liver allograft has been reported previously in outbred pig models, but the lack of genetic background did not allow to analyze the impact of the major histocompatibility complex (MHC) on tolerance induction. A model of semi-identical liver allograft was therefore developed in inbred...

journal_title：Transplantation

authors： Oike F,Talpe S,Otsuka M,Dehoux JP,Lerut J,Otte JB,Gianello P

更新日期：2000-06-15 00:00:00

abstract：:Thymectomy of mice aged 6-8 weeks causes a disproportion of splenic T cell sets, the Ly123 set being relatively decreased and the Ly23 set relatively increased (Ly123 decrease: Ly23 increase). A similar disproportion of splenic T cell sets was found to occur spontaneously with advancing age (12-18 months). By PA-SRBC ...

journal_title：Transplantation

authors： Newcomb EW,Goldberg EH,de Sousa M,Goldstein G,Boyse EA,Scheid MP

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND:Brain death (BD) affects the viability of lungs for transplantation. A correlation exists between high lung inflammation after BD and the decrease in female sex hormones, especially estradiol. Therefore, we investigated the effects of 17β-estradiol (E2) treatment on the lungs of female brain dead rats. METH...

journal_title：Transplantation

authors： Ricardo-da-Silva FY,Armstrong R Jr,Vidal-Dos-Santos M,Correia CJ,Coutinho E Silva RDS,da Anunciação LF,Moreira LFP,Leuvenink HGD,Breithaupt-Faloppa AC

更新日期：2020-10-07 00:00:00

abstract：:CD4+ cells from CsA-treated DA rats with long-surviving PVG heart allografts specifically suppress the capacity of naive CD4+ cells to restore allograft rejection in irradiated DA rats, but have normal donor-specific alloreactivity in MLC. CD4+ suppressor cells from CsA-treated DA rats cultured for 3 days against eith...

journal_title：Transplantation

authors： Pearce NW,Spinelli A,Gurley KE,Hall BM

更新日期：1993-02-01 00:00:00

abstract：:: Hepatitis C virus (HCV) infection is common in solid organ allograft recipients and is a significant cause of morbidity and mortality after transplantation, so effective management will improve outcomes. In this review, we discuss the extent of the problem associated with HCV infection in donors and kidney, heart, a...

journal_title：Transplantation

authors： Carbone M,Mutimer D,Neuberger J

更新日期：2013-03-27 00:00:00

abstract：:We studied the reactivity of cardiac graft-infiltrating cells, cultured from endomyocardial biopsy specimens, toward heart endothelial cells (Hec). In two cases, Hec derived from the specific donor heart or Hec compatible with the donor were lysed, but not the syngeneic B cell line. A vessel-derived endothelial cell l...

journal_title：Transplantation

authors： Jutte NH,Knoop CJ,Heijse P,Balk AH,Mochtar B,Claas FH,Weimar W

更新日期：1996-08-15 00:00:00

abstract：BACKGROUND:Acute liver failure (ALF) carries a high mortality unless urgent orthotopic liver transplantation (OLT) is performed on time. Live donors are utilized to treat this irreversible condition first in pediatric cases and then in adults. Herein, we aimed to report our experience with live donors for ALF in a coun...

journal_title：Transplantation

authors： Kilic M,Aydin U,Noyan A,Arikan C,Aydogdu S,Akyildiz M,Karasu Z,Zeytunlu M,Alper M,Batur Y

更新日期：2007-08-27 00:00:00

abstract：:Graft and patient survival rates after transplantation of ABO-incompatible liver allografts have been poor. We used plasmapheresis and a potent immunosuppressive regimen to control hemagglutinin levels and prevent early rejection. Ten patients who had a United Network for Organ Sharing status of 4 received ABO-incompa...

journal_title：Transplantation

authors： Mor E,Skerrett D,Manzarbeitia C,Sheiner PA,Schwartz ME,Emre S,Thung SN,Miller CM

更新日期：1995-04-15 00:00:00

abstract：BACKGROUND:Few studies have examined the effectiveness of a risk-stratified approach to screening kidney transplantation candidates for ischemic heart disease (IHD). METHODS:We retrospectively reviewed records from all adult patients (n = 514) placed on the deceased donor kidney transplantation waiting list at a singl...

journal_title：Transplantation

authors： Kasiske BL,Malik MA,Herzog CA

更新日期：2005-09-27 00:00:00

abstract：BACKGROUND:Cardiac allograft vasculopathy (CAV) is a major limitation in long-term graft survival after heart transplantation (HTx). Its prediction and detection at an early stage is a challenge because an accurate, minimally invasive blood test is lacking. The aim of this study was to analyze the relationship of Tact ...

journal_title：Transplantation

authors： Roldán C,Mirabet S,Cecilia C,Brossa V,Roig E,Martín C,Gelpí C

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Live kidney donation is safe for healthy donors and an effective treatment for patients with end-stage renal disease. Many potential donors are referred for live kidney donation, but only a small percentage donate. This study aims to determine reasons for nondonation and establish if racial differences exist...

journal_title：Transplantation

authors： Lunsford SL,Simpson KS,Chavin KD,Menching KJ,Miles LG,Shilling LM,Smalls GR,Baliga PK

更新日期：2006-10-15 00:00:00

abstract：:The mode of action of glucocorticosteroids as immunosuppressive and antiinflammatory agents is not fully understood. Glucocorticosteroids block synthesis of interleukin 1 by interfering with the transcription of the IL-1 beta gene. Glucocorticosteroids may also induce rapid degradation of IL-1 mRNA. In the presence of...

journal_title：Transplantation

authors： Zanker B,Walz G,Wieder KJ,Strom TB

更新日期：1990-01-01 00:00:00

abstract：:Spodoptera frugiperda (Sf9) insect cells secreted a class I MHC RT1.Aa heavy chain protein when infected with baculovirus that bore a construct that contained a honeybee melittin secretion (ms) signal attached to RT1.Aa cDNA. The RT1.Aa heavy chain protein in the culture supernatant and cell lysate immunoprecipitated ...

journal_title：Transplantation

authors： Wang M,Stepkowski SM,Wang ME,Tian L,Qu X,Tu Y,He G,Kahan BD

更新日期：1996-02-15 00:00:00

abstract：:We retrospectively investigated the impact of pancreas transplantation on cardiovascular disease risk factors in patients with type 1 diabetic end-stage renal disease (ESRD). Two cohorts of patients, 44 simultaneous pancreas and kidney transplant patients (SPK) and 30 kidney transplant-alone patients (KTA), were inclu...

journal_title：Transplantation

authors： Luan FL,Miles CD,Cibrik DM,Ojo AO

更新日期：2007-08-27 00:00:00

abstract：:Following liver transplantation bile formation may be influenced by hepatic denervation and cyclosporine therapy. To better establish any effect of liver transplantation on bile secretion, 6 mongrel dogs were studied: 3 underwent liver denervation by a modified autotransplantation procedure and insertion of a Thomas c...

journal_title：Transplantation

authors： Sutherland FR,Preshaw RM,Shaffer EA

更新日期：1993-02-01 00:00:00

abstract：:This is a short review of tolerance from the point of view of the clinician. Various examples of tolerance occurring in patients and animal models that relate to the clinical experience are described. There may be different mechanisms by which tolerance is achieved, but from the patient's point of view operational tol...

journal_title：Transplantation

authors： Calne RY

更新日期：2004-03-27 00:00:00