Abstract:
:The effects of FK506 on exocrine function of the pancreas in Sprague-Dawley rats were examined and compared with those of cyclosporine. FK506 did not affect the levels of amylase and lipase in the pancreas of rats given the drug orally in a daily dose of 1 or 5 mg/kg for 2 weeks. Furthermore, the pancreas of the rats showed good exocrine secretion of enzymes such as amylase and lipase on stimulation with carbachol in vitro. Cyclosporine 50 mg/kg given in the same way as FK506 also was free of effect on enzyme levels in the rat pancreas, but the exocrine secretion of the enzyme from the pancreatic lobules on stimulation with carbachol was impaired. It is concluded that FK506 does not affect pancreatic exocrine function in rats.
journal_name
Transplantationjournal_title
Transplantationauthors
Hirano Y,Hisatomi A,Ohara K,Noguchi Hdoi
10.1097/00007890-199211000-00023subject
Has Abstractpub_date
1992-11-01 00:00:00pages
883-7issue
5eissn
0041-1337issn
1534-6080journal_volume
54pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:We herein investigate critical ischemia times and the effect of novel preservation solutions such as new histidine-tryptophan-ketoglutarate (HTK-N) and TiProtec on the individual tissues of a rat limb isograft. METHODS:Orthotopic hind-limb transplantations were performed in male Lewis rats after 2 hours, 6 ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001845
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Graft thrombosis immediately after surgery remains a problem for successful pancreas transplantation. The present study evaluated the efficacy of computed tomography (CT) angiography for monitoring of graft patency in the immediate postoperative period. METHODS:The study involved 119 patients who underwent ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182692b4d
更新日期:2012-11-15 00:00:00
abstract::The calcineurin inhibitors (CNIs) have been the cornerstone of immunosuppressive therapy in recent years, though their association with dose-related nephrotoxicity is a major factor in the development of chronic allograft nephropathy in kidney transplant recipients. The novel proliferation signal inhibitor everolimus ...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000162434.62591.f3
更新日期:2005-05-15 00:00:00
abstract:BACKGROUND:Liver transplant (LT) for nonalcoholic steatohepatitis (NASH) related hepatocellular carcinoma (HCC) is not well characterized in the literature. The aim of the study was to examine characteristics and outcomes of patients who had LT for NASH-HCC (NASH) versus HCC from other liver diseases (non-NASH). METHO...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/TP.0000000000002043
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Hepatic artery thrombosis (HAT) is a significant cause of morbidity after liver transplantation. The aims of this study are to identify and compare risk factors that might contribute to HAT. METHODS:A total of 424 liver transplants performed at the University of Virginia were reviewed. HAT was defined as co...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200103270-00014
更新日期:2001-03-27 00:00:00
abstract:BACKGROUND:Recurrent hepatitis C virus (HCV) after liver transplantation (OLT) is a major cause of graft loss in HCV-positive patients. In this study, we evaluated the efficacy and safety of pegylated interferon alfa-2b (peginterferon) and ribavirin treatment for recurrent HCV after OLT and analyzed the influence of an...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/01.tp.0000225827.18034.be
更新日期:2006-07-15 00:00:00
abstract::Antibody-mediated rejection (AMR) is an important cause of graft loss and continues to present a formidable obstacle to successful transplantation. Unresolved problems continue to be the absence of effective strategies to ablate the donor-specific antibody (DSA) response as well as to attenuate the antibody-mediated g...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003298
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Histologic evaluation of small bowel allograft biopsies is important for the diagnosis of acute rejection. However, a standard histologic schema to grade the severity of intestinal acute rejection is not currently available. The primary goal of this study was to develop a histologic grading system for the di...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000062840.49159.2F
更新日期:2003-04-27 00:00:00
abstract::Hepatic artery thrombosis (HAT) after liver transplantation (LTx) usually mandates retransplantation. Prolonged preservation with Eurocollins solution has been associated with HAT. We reviewed our experience with 359 LTx patients to identify risk factors for HAT. All grafts were preserved in University of Wisconsin so...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199312000-00024
更新日期:1993-12-01 00:00:00
abstract::Mus caroli blastocysts transferred to pseudopregnant Mus musculus implant but die about midgestation. Death of the M caroli embryos is associated with infiltration of the fetoplacental units by M musculus lymphocytes, including functional cytotoxic T lymphocytes (CTL). To determine if specific maternal antifetal immun...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198806000-00021
更新日期:1988-06-01 00:00:00
abstract:BACKGROUND:Bone marrow transplantation (BMT) is effective treatment for many hematologic disease, but performed in a population with a high endemic hepatitis B virus carrier rate, the incidence of liver function impairment and fulminant hepatitis (FH) is expected to be raised. METHODS:Forty-three hepatitis B virus car...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199906150-00006
更新日期:1999-06-15 00:00:00
abstract::We retrospectively compared the clinical and financial impact of a final cross-match by T cell flow cytometry (FXM) versus conventional complement-dependent cytotoxicity (CXM) in consecutive primary cadaveric kidney (K) and primary simultaneous cadaveric pancreas-kidney (SPK) transplant recipients. Mean follow-up was ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199706150-00018
更新日期:1997-06-15 00:00:00
abstract:BACKGROUND:Islet transplantation studies with diabetic rodents frequently use treatment with diabetogens such as alloxan or streptozotocin to render hosts hyperglycemic. These chemicals produce unwanted toxic side effects, which complicate interpretations of damage produced by hyperglycemia versus direct toxin-induced ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200204270-00024
更新日期:2002-04-27 00:00:00
abstract::Seven murine anti-H-2 and three nonimmune mouse sera were tested for cytotoxicity toward B and T lymphocytes from a panel of human donors. One group of sera, including two anti-H-2.33 sera, exhibited cytotoxicity directed exclusively toward human B but not T cells from all donors. Absorption studies on human lymphobla...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197908000-00007
更新日期:1979-08-01 00:00:00
abstract::In light of the transplant community's efforts to increase living donation, preserving donor autonomy is essential. Understanding how often and the reasons why potential living kidney donors opt out of the donor evaluation process for nonmedical reasons is important for assessing donor voluntariness. The experiences o...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000001408
更新日期:2016-12-01 00:00:00
abstract::In the present study the functional and morphologic effects of two pulmoplegic solutions are evaluated. Single left-lung allotransplantation with ligation of the right pulmonary artery was performed in 15 piglets (13-20 kg). The lungs were preserved after donor prostaglandin E-1 treatment with single pulmonary artery ...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1990-06-01 00:00:00
abstract:BACKGROUND:Although the value of duodenal histology as a means to diagnose acute rejection in pancreaticoduodenal allografts has been validated, it is not known how the duodenum responds to antirejection treatment in comparison with the pancreas. METHODS:Diabetic Lewis rats received a pancreaticoduodenal allograft. Cy...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200201270-00008
更新日期:2002-01-27 00:00:00
abstract::Idarubicin was conjugated to anti-Ly-2.1 and anti-L3T4 monoclonal antibodies. These conjugates were used to investigate their effects on skin graft survival in mice. Several donor and recipient combinations were used so that the effect of individual or mixtures of conjugates on class I and class II antigenic differenc...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198907000-00018
更新日期:1989-07-01 00:00:00
abstract::Increased QT dispersion (QTd), predicting patients with risk of malignant arrhythmia, have recently been reported in hemodialysis patients (HDp). In this prospective study, we aimed to investigate changes in QTd and signal averaged-ECG (SAECG) in HDp after transplantation. Twenty-seven HDp (M/F:18/9, mean age 30+/-8 y...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-200111150-00009
更新日期:2001-11-15 00:00:00
abstract:BACKGROUND:Pediatric liver transplant recipients have traditionally been grouped according to age. Age-based classification schemes are useful in identifying clinical problems in selected age groups and also for developing solutions to these problems. Although infants in the first 3 months of life have not traditionall...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199809150-00010
更新日期:1998-09-15 00:00:00
abstract:OBJECTIVES:En bloc pediatric kidney transplants (EBPKT) are still a subject of controversy. The aim of this study was to determine whether acceptable long-term graft survival and function can be achieved in EBPKT compared with the transplant of single, cadaveric, adult donor kidneys. METHODS:A retrospective review was...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000090395.98045.09
更新日期:2003-10-27 00:00:00
abstract:BACKGROUND:Cytomegalovirus (CMV) replication has been associated with more risk for solid organ graft rejection. We wondered whether this association still holds when patients at risk receive prophylactic treatment for CMV. METHODS:We correlated CMV infection, biopsy-proven graft rejection, and graft loss in 1,414 pat...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/TP.0000000000000160
更新日期:2014-11-15 00:00:00
abstract:BACKGROUND:Although antibody mechanisms play a pathogenetic role in liver allograft rejection, no data exist on B lymphocytes, plasma cells, complement, and chemokines in rejected liver tissue. METHODS:Liver biopsy specimens from 25 patients with acute allograft rejection (AR) (rejection activity index, RAI score: 1-9...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000132324.14207.8b
更新日期:2004-07-15 00:00:00
abstract::Cyclosporine CsA nephrotoxicity was examined in male Sprague-Dawley rats with or without prior uninephrectomy, injected daily with 12.5 mg/kg CsA, and fed a salt-depleted or normal diet for 3-10 weeks. Control rats received the CsA vehicle. CsA induced a fall in creatinine clearance in salt-depleted rats, from 1.3 +/-...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199002000-00041
更新日期:1990-02-01 00:00:00
abstract:BACKGROUND:A pancreas transplant alone (PTA) in a nonuremic patient with brittle diabetes mellitus remains a rare procedure because the tradeoff for insulin independence is lifelong immunosuppression. METHODS:Herein we report our results at the University of Minnesota of 513 PTAs from December 17, 1966, through Decemb...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000296820.46978.3f
更新日期:2008-01-15 00:00:00
abstract::To investigate the clinical manifestations of Aspergillus infections in lung transplant recipients, we reviewed the mycology and autopsy reports of all double (DLT=93) and single (SLT=48) lung transplant recipients from November 1983 to May 1993. Positive Aspergillus cultures were identified in 22% of the recipients (...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199603270-00013
更新日期:1996-03-27 00:00:00
abstract::Lamivudine combined with hepatitis B immune globulin (HBIg) is the standard of care for preventing the recurrence hepatitis B virus after liver transplant. To determine the risk of hepatitis B virus (HBV) recurrence after early withdrawal of HBIg in patients receiving lamivudine maintenance therapy, 20 patients receiv...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/01.tp.0000277289.23677.0a
更新日期:2007-09-15 00:00:00
abstract::MHC expression on endothelial cells after cytomegalovirus infection was investigated using double antibody radioimmunoassays and immunofluorescence flow cytometry. After CMV infection there was an increase in class I and beta 2 microglobulin expression. This increase corresponds to the percentage of cells that are inf...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198909000-00024
更新日期:1989-09-01 00:00:00
abstract::Anti-CD3 monoclonal antibody (mAb) OKT3 is immunosuppressive, but causes severe adverse effects during the first administration ("first-dose reaction"). These adverse effects are presumably caused by cytokine release that results from T-cell activation. In vitro, T-cell activation by anti-CD3 mAb requires interaction ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199701150-00020
更新日期:1997-01-15 00:00:00
abstract:BACKGROUND:In this report, we compare the long-term outcome of pediatric liver transplantation (LTx) patients maintained with tacrolimus-based and with cyclosporine (CsA)-based immunosuppressive therapy. We examine long-term patient and graft survival, the incidence of rejection, and immunosuppression-related complicat...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200008270-00015
更新日期:2000-08-27 00:00:00