Adherence to Lamivudine after an early withdrawal of hepatitis B immune globulin plays an important role in the long-term prevention of hepatitis B virus recurrence.

Abstract:

:Lamivudine combined with hepatitis B immune globulin (HBIg) is the standard of care for preventing the recurrence hepatitis B virus after liver transplant. To determine the risk of hepatitis B virus (HBV) recurrence after early withdrawal of HBIg in patients receiving lamivudine maintenance therapy, 20 patients receiving a course of HBIg and lamivudine after transplantation and long-term maintenance therapy with lamivudine and 9 patients receiving HBIg and lamivudine indefinitely were analyzed. The survival rate was 90% after a mean follow-up of 83 months. The HBV recurrence rate was 14% with a mean period of 91 months free from HBV recurrence. Both groups had similar HBV recurrence rates, 15% for the combination and 11% for lamivudine alone. Four patients, 3 of whom were noncompliant with therapy, experienced posttransplant HBV recurrence. Patients who adhere to long-term prophylaxis with lamivudine after early withdrawal of HBIg have a low risk of HBV recurrence, similar to those who receive combination prophylaxis.

journal_name

Transplantation

journal_title

Transplantation

authors

Buti M,Mas A,Prieto M,Casafont F,González A,Miras M,Herrero JI,Jardi R,Esteban R

doi

10.1097/01.tp.0000277289.23677.0a

subject

Has Abstract

pub_date

2007-09-15 00:00:00

pages

650-4

issue

5

eissn

0041-1337

issn

1534-6080

pii

00007890-200709150-00014

journal_volume

84

pub_type

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