Chronic cyclosporine-induced nephropathy in the rat. A medullary ray and inner stripe injury.

Abstract:

:Cyclosporine CsA nephrotoxicity was examined in male Sprague-Dawley rats with or without prior uninephrectomy, injected daily with 12.5 mg/kg CsA, and fed a salt-depleted or normal diet for 3-10 weeks. Control rats received the CsA vehicle. CsA induced a fall in creatinine clearance in salt-depleted rats, from 1.3 +/- 0.1 to 0.8 +/- 0.1 ml/min (P less than 0.001), and in normally fed rats from 1.8 +/- 0.2 to 1.0 +/- 0.2 ml/min (P less than 0.02). Vehicle treatment had no effect. The most striking morphologic changes were those of thick ascending limb cell atrophy with concomitant fibroblastic proliferation and collagen formation; these alterations were present in the inner stripe of the outer medulla and the medullary ray. The medullary-ray findings included S2-S3 degenerative changes as well and apparently correspond to the striped fibrosis described in human CsA nephropathy. The alterations were specific to the CsA group, progressive, and most severe in the salt-depleted, CsA-injected rats (on a scale of 0-4: 1.7 +/- 0.2 for medullary rays, and 2.0 +/- 0.2 for inner stripe, P less than 0.001). Morphologic changes predicted renal failure (r = 0.3, P less than 0.01 for cortical alterations, and r = 0.5, P less than 0.001 for medullary alterations). Prior uninephrectomy did not enhance these changes. Thus, chronic CsA administration impaired kidney function and induced morphologic alterations found in regions characterized by, and in nephron segments particularly vulnerable to, limited O2 availability. Salt depletion appears to accelerate the development of chronic CsA renal injury in the rat.

journal_name

Transplantation

journal_title

Transplantation

authors

Rosen S,Greenfeld Z,Brezis M

doi

10.1097/00007890-199002000-00041

subject

Has Abstract

pub_date

1990-02-01 00:00:00

pages

445-52

issue

2

eissn

0041-1337

issn

1534-6080

journal_volume

49

pub_type

杂志文章
  • Higher frequency of high-grade rejections in cardiac allograft patients after Quilty B lesions or grade 2/4 rejections.

    abstract:BACKGROUND:To better understand how different histologic patterns of allograft inflammation found on biopsies of human cardiac allografts progress to high-grade rejection, we undertook a statistical analysis of our institutional database to detect statistical patterns among different types of myocardial allograft infla...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200206270-00014

    authors: Smith RN,Chang Y,Houser S,Dec GW,Grazette L

    更新日期:2002-06-27 00:00:00

  • Acute tubular necrosis after renal transplantation.

    abstract::We evaluated the influence of dialysis requiring acute tubular necrosis on patient survival, and kidney survival and function in all 182 patients who needed dialysis immediately after transplantation at the University of Minnesota Hospitals. When compared to matched control patients not requiring dialysis, there was n...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198003000-00016

    authors: Brophy D,Najarian JS,Kjellstrand CM

    更新日期:1980-03-01 00:00:00

  • Ethnically diverse populations and their participation in living kidney donation programs.

    abstract:BACKGROUND:The number of living donor kidney transplantations increases steeply in Europeans, whereas the non-Europeans are dependent on deceased donor transplantations. We wondered whether a low attendance or a high decline of potential non-European donors could explain this difference. METHODS:This retrospective stu...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3181d84ca7

    authors: Roodnat JI,van de Wetering J,Zuidema W,van Noord MA,Kal-van Gestel JA,Ijzermans JN,Weimar W

    更新日期:2010-05-27 00:00:00

  • Abolition of the effect of cyclosporine on rat cardiac allograft rejection by the new immunomodulator LS-2616 (Linomide).

    abstract::The effect of the quinoline-3-carboxamide LS-2616 (Linomide), given alone or together with cyclosporine, was studied in the first set cardiac allograft transplantation model in the rat. PVG rat hearts were transplanted heterotopically to Wistar/Kyoto rat recipients on day 0. The recipients were given LS-2616 orally on...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198902000-00003

    authors: Wanders A,Larsson E,Gerdin B,Tufveson G

    更新日期:1989-02-01 00:00:00

  • Pancreas after living donor kidney versus simultaneous pancreas-kidney transplant: an analysis of the organ procurement transplant network/united network of organ sharing database.

    abstract:BACKGROUND:One of the alternative options to simultaneous pancreas-kidney transplantation (SPKT) for type I diabetics with renal failure is sequential transplant of a living donor kidney followed by a deceased donor pancreas transplant (pancreas after living donor kidney transplant [PALK]). We retrospectively compared ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3181dd3587

    authors: Poommipanit N,Sampaio MS,Cho Y,Young B,Shah T,Pham PT,Wilkinson A,Danovitch G,Bunnapradist S

    更新日期:2010-06-27 00:00:00

  • The association of IgA deficiency but not IgG or IgM deficiency with a reduced patient and graft survival following liver transplantation.

    abstract::Recipients of solid organ allografts require lifelong immunosuppression in order to prevent graft rejection and to maintain graft function. In general, such immunosuppression greatly impairs the cellular immune system, as this level of the immune system is principally responsible for self and non-self recognition. The...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199208000-00015

    authors: Van Thiel DH,Finkel R,Friedlander L,Gavaler JS,Wright HI,Gordon R

    更新日期:1992-08-01 00:00:00

  • Bone marrow transplantation following total lymphoid irradiation. I. Correlation with field size and suppressor cell induction.

    abstract::Total lymphoid irradiation (TLI) induces a unique state of immunosuppression. Although permanent bone marrow chimerism has been obtained in rodents prepared by TLI, uniform marrow engraftment has been more difficult to obtain in larger mammals. Accordingly, studies were performed to assess the immunologic perturbation...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198307000-00004

    authors: Lowry RP,Carpenter CB,Gurley KE,Merrill JP

    更新日期:1983-07-01 00:00:00

  • Pregnancy after donor nephrectomy.

    abstract::Potential female donors frequently ask whether unilateral nephrectomy will impair future childbearing capabilities. To address this question, we surveyed 220 women who underwent donor nephrectomy between 1985 and 1992. Of the 144 women who responded, 33 became pregnant after donation for a total of 45 pregnancies. Sev...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199612270-00044

    authors: Wrenshall LE,McHugh L,Felton P,Dunn DL,Matas AJ

    更新日期:1996-12-27 00:00:00

  • Activation of the purine salvage pathway in mononuclear cells of cardiac recipients treated with mycophenolate mofetil.

    abstract:BACKGROUND:The objective of this study was to investigate purine nucleotide metabolism in peripheral blood mononuclear cells (PBMC) of cardiac transplant recipients switched from azathioprine to mycophenolate mofetil (MMF). METHODS:Concentrations of guanosine 5'triphosphate (GTP) and adenosine 5'triphosphate (ATP), th...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1097/01.tp.0000225759.54343.23

    authors: Devyatko E,Zuckermann A,Bohdjalian A,Roedler S,Dunkler D,Grimm M,Weigel G

    更新日期:2006-07-15 00:00:00

  • The vascular endothelial cell antigen system.

    abstract::Vascular endothelial cells (VEC) are clearly immunogenic and express antigens unique to vascular endothelial cells. The observation that peripheral blood monocytes also express this VEC antigen system made prospective testing feasible. Preformed antibody to the VEC/monocyte antigen system of the donor usually leads to...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198503000-00016

    authors: Cerilli J,Brasile L,Galouzis T,Lempert N,Clarke J

    更新日期:1985-03-01 00:00:00

  • Diltiazem in renal allograft recipients receiving cyclosporine.

    abstract::Of 113 cyclosporine-treated primary renal allograft recipients, 60 were randomized to receive standard therapy without diltiazem (ND) and 53 received standard therapy plus diltiazem (D). There was no difference in CsA blood levels between ND and D at all intervals between 3 and 24 months follow-up, yet the D group req...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00007890-199302000-00014

    authors: Chrysostomou A,Walker RG,Russ GR,d'Apice AJ,Kincaid-Smith P,Mathew TH

    更新日期:1993-02-01 00:00:00

  • In vivo treatment with antiporcine T cell antibodies.

    abstract::The effects of in vivo administration of monoclonal antibodies directed against the two major mature T cell subsets of miniature swine have been examined. Antibody 76-2-11, specific for the porcine CD8 cell-surface antigen, caused elimination of CD8+ T cells from the peripheral lymphocyte pool by 4-6 days following a ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199007000-00014

    authors: Suzuki T,Sundt TM 3rd,Mixon A,Sachs DH

    更新日期:1990-07-01 00:00:00

  • Early indices of warm ischemic damage in autotransplanted canine kidneys preserved by simple hypothermic storage.

    abstract::After measurement of normal renal function, dog kidneys (n = 52) were subjected to 3, 15, or 30 min of normothermic warm ischemia (WI). After 24 hr of preservation by simple hypothermic storage (SHS) in a modified Collins solution, autotransplant was done and renal function was again measured beginning at 1 hr. Compar...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198611000-00003

    authors: Gregg CM,Lai MK,Mandour WA,Linke CA

    更新日期:1986-11-01 00:00:00

  • Characterization of antiidiotypic antibodies to donor HLA that develop after liver transplantation.

    abstract::Several studies have reported the development of antiidiotypic antibodies to anti-HLA alloantibodies in renal allograft transplant recipients, postulating their potential beneficial role in allograft survival. In order to evaluate the role of anti-HLA antiidiotypic antibodies in human liver transplant recipients and t...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199308000-00037

    authors: Chauhan B,Phelan DL,Marsh JW,Mohanakumar T

    更新日期:1993-08-01 00:00:00

  • Transmembrane signalling via the T cell antigen receptor heterodimer and the CD2 antigen. A synergistic pathway for activation of T cells.

    abstract::T cell surface proteins involved in transmembrane signalling resulting in the activation of T cells were investigated utilizing as probes monoclonal antibodies directed at T cell surface antigens. Here we report that mAbs that react with a framework determinant of alpha/beta heterodimer of T cell receptor for antigen,...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198902000-00033

    authors: Suthanthiran M

    更新日期:1989-02-01 00:00:00

  • 3-[(dodecylthiocarbonyl)methyl]-glutarimide attenuates graft arterial disease by suppressing alloimmune responses and vascular smooth muscle cell proliferation.

    abstract:BACKGROUND:Graft arterial disease (GAD) is a major cause of late graft loss after organ transplantation. Alloimmune responses and vascular remodeling eventually cause the transplant organ to develop GAD. In this study, we aimed to limit the development of GAD by inhibiting alloimmune responses and vascular smooth muscl...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000000576

    authors: Zaitsu M,Yamashita K,Shibasaki S,Tsunetoshi Y,Fukai M,Ogura M,Yoshida T,Igarashi R,Kobayashi N,Umezawa K,Todo S

    更新日期:2015-05-01 00:00:00

  • Intact pig pancreatic islet function in the presence of human xenoreactive natural antibody binding and complement activation.

    abstract:BACKGROUND:The expression of xenogeneic epitopes and the activation of human complement by adult pig islets after prolonged culture have hitherto not been described. MATERIALS AND METHODS:Freshly isolated and cultured islets were analyzed by fluorescence-activated cell sorter analysis, fluorescence microscopy, and imm...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199705270-00015

    authors: Mirenda V,Le Mauff B,Cassard A,Huvelin JM,Boeffard F,Faivre A,Soulillou JP,Anegon I

    更新日期:1997-05-27 00:00:00

  • Glyoxalase II and glutathione levels in rat liver mitochondria during cold storage in Euro-Collins and University of Wisconsin solutions.

    abstract::Glutathione and glyoxalase II levels were evaluated in cytosolic and mitochondrial compartments of rat liver after 7 and 24 hr of cold storage in University of Wisconsin (UW) and Euro-Collins solutions. 1-4 A similar time-dependent depletion of cytosolic glutathione up to about 60% of control values was observed in bo...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199605150-00026

    authors: Jassem W,Ciarimboli C,Cerioni PN,Saba V,Norton SJ,Principato G

    更新日期:1996-05-15 00:00:00

  • Response to varicella immunization in pediatric liver transplant recipients.

    abstract:BACKGROUND:Individuals undergoing therapeutic immunosuppression are at risk of severe varicella-zoster virus (VZV) infection, particularly those without evidence of previous infection. METHODS:Eleven children, median age 10 months (range 5.5 months to 7 years and 9 months) received one dose of varicella vaccine (Varil...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200011150-00023

    authors: Donati M,Zuckerman M,Dhawan A,Hadzic N,Heaton N,North-Lewis P,Mieli-Vergani G

    更新日期:2000-11-15 00:00:00

  • Prevention of complement-mediated activation of xenogeneic endothelial cells in an in vitro model of xenograft hyperacute rejection by C1 inhibitor.

    abstract::The complement system plays a major role in hyperacute rejection of discordant xenografts. In an immediately vascularized xenograft of a porcine organ to a primate, natural antibodies bind to the vascular endothelium of the graft, triggering activation of complement via the classical pathway. One consequence of antibo...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199311000-00024

    authors: Dalmasso AP,Platt JL

    更新日期:1993-11-01 00:00:00

  • Treatment with humanized monoclonal antibodies against CD80 and CD86 combined with sirolimus prolongs renal allograft survival in cynomolgus monkeys.

    abstract:BACKGROUND:Co-stimulatory blockade has been shown to prolong allograft survival in different transplant models. We investigated the effect of combining humanized anti-CD80 and anti-CD86 monoclonal antibodies (mAb) with sirolimus in cynomolgus monkey renal transplant recipients. METHODS:After renal transplantation, gro...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000066806.10029.7A

    authors: Bîrsan T,Hausen B,Higgins JP,Hubble RW,Klupp J,Stalder M,Celniker A,Friedrich S,O'Hara RM,Morris RE

    更新日期:2003-06-27 00:00:00

  • Outcomes of kidney transplant tourism and risk factors for de novo urothelial carcinoma.

    abstract:BACKGROUND:To date, the outcomes of transplant tourism have not been reported extensively. In addition, data about the accuracy of urine cytology for the detection and the role of the BK virus (BKV) in the carcinogenesis of urothelial carcinoma (UC) after renal transplantation are lacking. METHODS:Three hundred seven ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000000023

    authors: Tsai HL,Chang JW,Wu TH,King KL,Yang LY,Chan YJ,Yang AH,Chang FP,Pan CC,Yang WC,Loong CC

    更新日期:2014-07-15 00:00:00

  • Major histocompatibility complex control of NK-related allogeneic lymphocyte cytotoxicity in rats. The contributions of strong and medial transplantation antigens.

    abstract::Allogeneic lymphocyte cytotoxicity (ALC) describes the elimination of allogeneic lymphocytes in vivo by an NK-related activity. There is evidence that ALC is demonstrable between donor and recipient when these are incompatible at MHC gene loci alone. Since ALC is a property of T cell-deficient nude rats, the role of t...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198811000-00025

    authors: Ager A,Fajumi J,Sparshott SM,Ford WL,Butcher GW

    更新日期:1988-11-01 00:00:00

  • The protective effects of the thromboxane synthetase inhibitor Dazmegrel on nephrotoxicity in cyclosporine-treated rats.

    abstract::Renal vasoconstriction has been implicated as a major contributing factor for the nephrotoxic effects of cyclosporine. In an attempt to assess the relative contribution of thromboxane (Tx), the effects of coadministering CsA with the selective Tx synthetase inhibitor, Dazmegrel (DAZ) (Pfizer, Inc.), were determined. R...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199111000-00016

    authors: Gladue RP,Newborg MF

    更新日期:1991-11-01 00:00:00

  • Islets in alginate macrobeads reverse diabetes despite minimal acute insulin secretory responses.

    abstract:BACKGROUND:Encapsulation of islets has been widely investigated as a treatment for diabetes. The characteristics and dynamics of insulin secretion by encapsulated islets in response to glucose and other secretagogues are not well understood. METHODS:In our study, macroencapsulated syngeneic islets at 3-4 wk after tran...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200101270-00006

    authors: Trivedi N,Keegan M,Steil GM,Hollister-Lock J,Hasenkamp WM,Colton CK,Bonner-Weir S,Weir GC

    更新日期:2001-01-27 00:00:00

  • International Liver Transplant Society Practice Guidelines: Diagnosis and Management of Hepatopulmonary Syndrome and Portopulmonary Hypertension.

    abstract::Two distinct pulmonary vascular disorders, hepatopulmonary syndrome (HPS) and portopulmonary hypertension (POPH) may occur as a consequence of hepatic parenchymal or vascular abnormalities. HPS and POPH have major clinical implications for liver transplantation. A European Respiratory Society Task Force on Pulmonary-H...

    journal_title:Transplantation

    pub_type: 杂志文章,实务指引

    doi:10.1097/TP.0000000000001229

    authors: Krowka MJ,Fallon MB,Kawut SM,Fuhrmann V,Heimbach JK,Ramsay MA,Sitbon O,Sokol RJ

    更新日期:2016-07-01 00:00:00

  • IgG antibodies against an HLA antigen are associated with activated cytotoxic T cells against this antigen, IgM are not.

    abstract::Pre-existing alloantibodies against the mismatched HLA-A and HLA-B antigens of the donor, when present in current sera, are believed to be detrimental to kidney graft survival. When these antibodies are present only in historical sera, their immunoglobulin class has reported to be important with respect to the expecte...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199405150-00018

    authors: Roelen DL,van Bree J,Witvliet MD,Habraken I,van Beelen E,van't Sant PH,de Waal LP,van Rood JJ,Claas FH

    更新日期:1994-05-15 00:00:00

  • Effect of renal allograft dysfunction upon cyclosporine trough levels in host blood.

    abstract::Cyclosporine (CsA) dose adjustment after renal transplantation is generally based on serum, plasma, or whole-blood trough level values. In the face of increased levels, the dosage is reduced in order to prevent CsA-induced nephrotoxicity. There is a paucity of data, however, on the kinetics of CsA in association with ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198512000-00006

    authors: Arnold AN,Waltzer WC,Anaise D,Weinstein SW,Rapaport FT

    更新日期:1985-12-01 00:00:00

  • Computer-assisted quantification of fibrosis in chronic allograft nephropaty by picosirius red-staining: a new tool for predicting long-term graft function.

    abstract:BACKGROUND:Chronic allograft nephropathy (CAN) has become the predominant limiting factor for long-term transplant survival. A cardinal histomorphologic correlate for CAN is interstitial fibrosis. Currently, no method has been established in routine use that reliably quantifies the extent of interstitial fibrosis in re...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000078899.62040.E5

    authors: Pape L,Henne T,Offner G,Strehlau J,Ehrich JH,Mengel M,Grimm PC

    更新日期:2003-09-27 00:00:00

  • CD4+CD25+ cells regulate CD8 cell anergy in neonatal tolerant mice.

    abstract:BACKGROUND:Injection of neonatal BALB/c mice with semi-allogeneic splenocytes leads to antigen-specific tolerance lasting into adulthood. Tolerant mice accept A/J skin grafts and fail to generate CD8 cytotoxic T lymphocyte (CTL) activity against A/J targets. Anergic CD8 T cells are present in tolerant mice, and CD4 reg...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199912270-00013

    authors: Gao Q,Rouse TM,Kazmerzak K,Field EH

    更新日期:1999-12-27 00:00:00