Abstract:
BACKGROUND:The objectives of this study are to investigate the impact of cytomegalovirus (CMV) donor (D)/recipient (R) serostatus on kidney transplant outcomes in recipients who received CMV prophylaxis and to investigate the association of individual antiviral agents (acyclovir, ganciclovir, and valganciclovir) with outcomes in high-risk recipients (D+/R-). METHODS:By using the Organ Procurement and Transplant Network/United Network for Organ Sharing database, 25,058 deceased donor kidney recipients (≥ 18 years, 2004-2008) who received CMV prophylaxis were stratified into four groups: D+/R+ (11,875), D-/R+ (6046), D+/R- (4555), and D-/R- (2582). The impact of CMV D/R serostatus on acute rejection (6 months and 1 year posttransplant) and long-term outcomes of death-censored graft failure and mortality were compared. The impact of the individual antiviral agent on long-term outcome was further evaluated in the high-risk group (D+/R-). RESULTS:In multivariate analysis, CMV D/R status was not associated with acute rejection. Compared with D-/R-, D+/R- was associated with an increased risk for death-censored graft failure (hazard ratio=1.28, P=0.01), all-cause mortality(hazard ratio=1.36, P=0.003), and mortality because of viral infection (hazard ratio=8.36, P=0.04). In the D+/R- group, valganciclovir usage was associated with a decreased risk for death-censored graft failure (hazard ratio=0.65, P=0.007) and mortality because of viral infection (hazard ratio=0.22, P=0.03) compared with ganciclovir usage. CONCLUSIONS:CMV mismatch (D+/R-) was no longer a risk factor for acute rejection in kidney recipients who received antiviral prophylaxis but was still an independent risk factor for death-censored graft failure, all-cause mortality, and viral infection-related mortality.
journal_name
Transplantationjournal_title
Transplantationauthors
Kuo HT,Ye X,Sampaio MS,Reddy P,Bunnapradist Sdoi
10.1097/TP.0b013e3181f7c053subject
Has Abstractpub_date
2010-11-27 00:00:00pages
1091-8issue
10eissn
0041-1337issn
1534-6080journal_volume
90pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:Gene targeting in large animals has the potential to be useful in medicine as well as in agriculture. Previously, we reported the first successful targeting of the bovine alpha1,3-galactosyltransferase (alpha1,3GT) gene and establishment of a heterozygous knockout cell line. In this report, we generated both...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000190422.66657.f1
更新日期:2006-03-15 00:00:00
abstract:BACKGROUND:Since 1995, dual-kidney transplantation using organs from marginal donors has been used at our center to expand the organ donor pool and decrease the waiting time for deceased donor kidney transplantation. This approach has allowed for a shorter waiting period without compromising outcome in the early posttr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000130452.01521.b1
更新日期:2004-09-15 00:00:00
abstract:BACKGROUND:Conversion from tacrolimus to cyclosporin has not previously been reported as routine clinical practice, but only as indicated by rejection or adverse effects. METHODS:The safety and metabolic outcome of elective conversion from tacrolimus to cyclosporin was examined in 19 recipients of cadaver renal transp...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:2000-07-15 00:00:00
abstract:BACKGROUND:We evaluated liver transplantation waitlist and posttransplantation outcomes in those aged 18 to 24 years compared with both younger (0-17 years) and older (25-34 years) registrants and recipients. METHODS:Using national data from the United Network for Organ Sharing, competing risk, Cox regression and Kapl...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001689
更新日期:2017-07-01 00:00:00
abstract::The effects of FK506 on exocrine function of the pancreas in Sprague-Dawley rats were examined and compared with those of cyclosporine. FK506 did not affect the levels of amylase and lipase in the pancreas of rats given the drug orally in a daily dose of 1 or 5 mg/kg for 2 weeks. Furthermore, the pancreas of the rats ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199211000-00023
更新日期:1992-11-01 00:00:00
abstract::We have tested the predictive model for risk of sensitization by donor-specific transfusions developed at the University of California, San Francisco for its applicability to the DST experience at UW/Madison. Patient sample sizes between the two groups were similar (n = 249 for UW/Madison, n = 261 for UCSF) and the tw...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198901000-00031
更新日期:1989-01-01 00:00:00
abstract::SLT presents an interesting concept to alleviate the organ shortage for children with end-stage liver disease. The procedure has, however, not gained wide acceptance. This is not only related to the complexity of the procedure, but also to the poorer results and the complications reported on the right side graft. We r...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1995-04-27 00:00:00
abstract::When normal mice are exposed for short periods to ultraviolet light (UV), they support the progressive growth of transplanted syngeneic UV-induced tumors. Normal nonirradiated mice almost always reject these tumor implants. The UV-mediated suppression of the antitumor response can be adoptively transferred to normal s...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197708000-00005
更新日期:1977-08-01 00:00:00
abstract::The major role of anti-alphaGal antibodies in the hyperacute rejection of pig organs by humans and baboons has been clearly demonstrated. Spacered alpha-galactose disaccharide (Gal(alpha1)-3Gal) hapten was produced by chemical synthesis and covalently attached to a flexible, hydrophilic polymer (PAA), which in turn wa...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199611270-00001
更新日期:1996-11-27 00:00:00
abstract:BACKGROUND:The beneficial effects of glycemic control on both survival and function of transplanted kidneys in patients with type 1 diabetes mellitus (T1DM) and end-stage renal disease (ESRD) have been recognized. METHODS:Herein, we present the clinical outcome of a single-center pilot trial of islet after kidney (IAK...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318166a27b
更新日期:2008-03-27 00:00:00
abstract:BACKGROUND:Acute graft dysfunction caused by ischemia-reperfusion injury is recognized as a major source of morbidity and mortality following adult heart transplantation. The aim of this study was to determine whether treating the donor and recipient with cariporide, an inhibitor of the sodium-hydrogen exchanger, could...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000054619.13962.30
更新日期:2003-03-15 00:00:00
abstract::We present a case report of a pediatric orthotopic liver transplant recipient who developed lymphoma with hypercalcemia on cyclosporine and prednisone immunosuppression. This is the first reported posttransplant lymphoproliferative disorder complicated by hypercalcemia, with a finding of an elevated 1,25 dihydroxyl vi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198912000-00022
更新日期:1989-12-01 00:00:00
abstract::Patients who require cystectomy are usually treated with an ileal conduit or intestinal neobladder for urinary control. In some of them, however, the bowel segment cannot be used because of previous abdominal surgery or radiation treatment. Bladder transplantation from cadavers may be beneficial to these patients, if ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199704150-00002
更新日期:1997-04-15 00:00:00
abstract:BACKGROUND:The role of CD20+ B cells in renal allograft rejection has been reappreciated. Importantly, recent studies suggest a relation between CD20+ B cell aggregates and poorer clinical outcome. In the present study, we attempted to confirm these early reports in a tightly controlled patient population and to differ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181860a74
更新日期:2008-09-27 00:00:00
abstract::Hepatocyte allotransplantation has been performed successfully in several small animal models for the amelioration of inborn metabolic errors. Before a human clinical trial of hepatocyte allotransplantation can be attempted, preliminary experience in a large animal model is needed. We transplanted isolated mongrel hep...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199705150-00003
更新日期:1997-05-15 00:00:00
abstract::HLA "matched" unrelated donor bone marrow transplants are associated with an increased incidence and severity of graft-versus-host disease in comparison with HLA-identical sibling transplants. This is presumably due to HLA and non-HLA histocompatibility differences between donor and recipient. Using a limiting dilutio...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1989-10-01 00:00:00
abstract:BACKGROUND:Modification of the aminoacid sequence of peptides derived from the HLA class I heavy chain in combination with computer rational design resulted in the development of a peptide, RDP1258, with enhanced immunosuppressive activity. METHODS:We evaluated the activity of this peptide, analyzing infiltrate by imm...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199906270-00017
更新日期:1999-06-27 00:00:00
abstract:BACKGROUND:Cyclosporine A (CsA)-induced chronic nephrotoxicity is characterized by renal dysfunction and interstitial fibrosis. Early and progressive renal macrophage influx, correlating with latter interstitial fibrotic areas, has been associated with CsA treatment. This study investigated the role of macrophages, the...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/tp.0b013e3181da0587
更新日期:2010-06-15 00:00:00
abstract::Methods are described for preparing large amounts of horse anti-human thymocyte globulin (ATG, ATGAM; The Upjohn Company) for clinical use. These methods have been used since 1968 to provide material for clinical trials. Characteristics of 40 lots of ATG are summarized. ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197910000-00007
更新日期:1979-10-01 00:00:00
abstract:BACKGROUND:Diagnosing acute rejection (AR) in kidney transplant recipients typically requires an invasive kidney biopsy. A previous study has suggested that expression of five genes in peripheral blood can indicate the presence of AR in American pediatric kidney transplant recipients. This study aims to validate if the...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000138
更新日期:2014-10-15 00:00:00
abstract:BACKGROUND:Graft arterial disease (GAD) is a major cause of late graft loss after organ transplantation. Alloimmune responses and vascular remodeling eventually cause the transplant organ to develop GAD. In this study, we aimed to limit the development of GAD by inhibiting alloimmune responses and vascular smooth muscl...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000576
更新日期:2015-05-01 00:00:00
abstract::Of 213 renal allgraft recipients suspected to have had pulmonary tuberculosis, 132 had sputum examinations and 14 showed acid-fast bacilli. Of the remaining 118 patients, 25 had gastric aspirations, 18 had bronchoalveolar lavage, and 75 did not require further investigation because of spontaneous improvement or confir...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199603270-00023
更新日期:1996-03-27 00:00:00
abstract:INTRODUCTION:Factors contributing to kidney transplant fibrosis remain incompletely understood, particularly in the absence of acute complications. METHODS:Baseline and 1-year surveillance biopsies from 15 uncomplicated living donor kidney transplants were subjected to microarray and quantitative reverse transcription...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000265501.33362.d3
更新日期:2007-06-15 00:00:00
abstract:BACKGROUND:Human herpesvirus-6 (HHV-6) has been implicated in bone marrow suppression, interstitial pneumonitis, and fatal meningoencephalitis in bone marrow transplant (BMT) recipients. METHODS:We describe the case of a woman with acute myeloid leukemia in second remission who developed febrile meningoencephalitis 8 ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199805270-00024
更新日期:1998-05-27 00:00:00
abstract:BACKGROUND:We herein investigate critical ischemia times and the effect of novel preservation solutions such as new histidine-tryptophan-ketoglutarate (HTK-N) and TiProtec on the individual tissues of a rat limb isograft. METHODS:Orthotopic hind-limb transplantations were performed in male Lewis rats after 2 hours, 6 ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001845
更新日期:2017-09-01 00:00:00
abstract::Orthotopic liver transplantation is frequently associated with a complex coagulation disorder, influencing the outcome of the procedure. In this respect, disseminated intravascular coagulation (DIC) had been suggested to be of causative importance for bleeding complications after reperfusion of the liver graft. In 10 ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199109000-00018
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:Deoxyspergualin (DSG), a potent immunosuppressive drug, has been clinically used as a rescue therapy for acute graft rejection. However, DSG has severe adverse effects that limits its use. Here, we examined the optimized therapeutic protocol for DSG using chronopharmacological profiles of it. METHODS:First,...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199905150-00012
更新日期:1999-05-15 00:00:00
abstract:BACKGROUND:Although longer pretransplant dialysis has been associated with poor kidney transplant outcome, no data about this association exist from the current era or from Europe. We studied the association of pretransplant dialysis duration on outcomes after kidney transplantation across two different time periods. ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000085
更新日期:2014-08-27 00:00:00
abstract:BACKGROUND:The inflammation response is modulated by the elaborated chemokine-chemokine receptor system, which also plays an important role in the development of acute rejection (AR). In this study, we hypothesized that functional genetic variants of some of these modulatory proteins might influence the outcome of AR. ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000178378.53616.ca
更新日期:2005-11-15 00:00:00
abstract::Pregraft transfusion combined with immunosuppression at the time of grafting improves the survival of clinical and experimental allografts. The mechanisms responsible for this effect were investigated in the murine model of cardiac transplantation, combining transfusions 7 to 30 days prior to transplantation with cycl...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199012000-00026
更新日期:1990-12-01 00:00:00