Abstract:
:HLA "matched" unrelated donor bone marrow transplants are associated with an increased incidence and severity of graft-versus-host disease in comparison with HLA-identical sibling transplants. This is presumably due to HLA and non-HLA histocompatibility differences between donor and recipient. Using a limiting dilution assay, we have previously demonstrated a relationship between cytotoxic T lymphocyte precursor frequency and HLA disparity. In this study we have compared CTL-p frequencies with clinical GVHD, and demonstrate for the first time a significant correlation (P less than 0.005) between high CTL precursor frequency prior to BMT and severity of acute GVHD after HLA A, B, DR "matched" unrelated donor transplants using T cell depleted marrow. This assay system may be of value in the final selection of HLA "matched" unrelated donors for BMT.
journal_name
Transplantationjournal_title
Transplantationauthors
Kaminski E,Hows J,Man S,Brookes P,Mackinnon S,Hughes T,Avakian O,Goldman JM,Batchelor JRsubject
Has Abstractpub_date
1989-10-01 00:00:00pages
608-13issue
4eissn
0041-1337issn
1534-6080journal_volume
48pub_type
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