Human herpesvirus-6 meningoencephalitis in a recipient of an unrelated allogeneic bone marrow transplantation.


BACKGROUND:Human herpesvirus-6 (HHV-6) has been implicated in bone marrow suppression, interstitial pneumonitis, and fatal meningoencephalitis in bone marrow transplant (BMT) recipients. METHODS:We describe the case of a woman with acute myeloid leukemia in second remission who developed febrile meningoencephalitis 8 months after a second unrelated BMT. RESULTS:Computed tomography and magnetic resonance images of the brain were nonspecific. Analysis of cerebrospinal fluid (CSF) revealed lymphocytosis and an increased protein level. Using polymerase chain reaction methods, HHV-6 was the only pathogen detected in CSF, peripheral blood mononuclear cells, and bone marrow. The patient was treated with ganciclovir and foscarnet for 3 months. All clinical manifestations resolved and HHV-6 polymerase chain reaction analysis of CSF became negative 40 days after the beginning of antiviral treatment. CONCLUSIONS:This observation strongly suggests that HHV-6 should be sought in BMT patients with neurological complications and that HHV-6 meningoencephalitis may respond to ganciclovir and foscarnet therapy.






Rieux C,Gautheret-Dejean A,Challine-Lehmann D,Kirch C,Agut H,Vernant JP




Has Abstract


1998-05-27 00:00:00












  • Increased incidence of acute myeloid leukemia after liver transplantation? Description of three new cases and review of the literature.

    abstract:BACKGROUND:Acute myeloid leukemia (AML) after solid organ transplantation is rare, with only six AML cases after liver transplantation (LT) being reported. METHODS:Characteristics of three AML cases observed among 799 recipients of LT in the authors' institution and estimation of the standardized incidence ratio (SIR)...


    pub_type: 杂志文章,评审


    authors: Camós M,Esteve J,Rimola A,Grande L,Rozman M,Colomer D,Villamor N,Costa D,Montserrat E

    更新日期:2004-01-27 00:00:00

  • Complement-mediated pulmonary xenograft injury: studies in swine-to-primate orthotopic single lung transplant models.

    abstract:BACKGROUND:The pathogenesis of acute pulmonary xenograft injury has not yet been determined. The present study evaluates the role of complement in mediating pulmonary xenograft dysfunction by using cobra venom factor (CVF) to deplete recipient complement and transgenic swine, which express human regulators of complemen...


    pub_type: 杂志文章


    authors: Yeatman M,Daggett CW,Parker W,Byrne GW,Logan JS,Platt JL,Davis RD

    更新日期:1998-04-27 00:00:00

  • Is a clinical application of hybrid liver support systems limited by an initial disorder in cellular amino acid and alpha-keto acid metabolism, rather than by later gradual loss of primary hepatocyte function?

    abstract::The in-vitro amino acid (AA) and alpha-keto acid (KA) metabolism of bioreactors initially seeded with 2.5 x 10(9) pig hepatocytes was investigated with a perfusion technique. Considerable changes in the culture medium concentrations of AA and KA were measured during the first days in culture. This is indicative of dyn...


    pub_type: 杂志文章


    authors: Gerlach JC,Fuchs M,Smith MD,Bornemann R,Encke J,Neuhaus P,Riedel E

    更新日期:1996-07-27 00:00:00

  • A comparison of discharge immunosuppressive drug regimens in primary cadaveric kidney transplantation.

    abstract:BACKGROUND:Finding the best combination of immunosuppression is an important challenge in kidney transplantation. Current short-term (1- and 3-year) allograft survival is quite good, making it difficult to determine differences in therapeutic regimens without large sample sizes. Using data from the United Network for O...


    pub_type: 杂志文章


    authors: Cherikh WS,Myron Kauffman H,Maghirang J,Bleyer AJ,Johnson CP

    更新日期:2003-08-15 00:00:00

  • The importance of the effect of underlying disease on rejection outcomes following orthotopic liver transplantation.

    abstract::Despite major advances in immunopharmacology, virtually all patients receive the same center-specific immunosuppressive regimen following orthotopic liver transplantation (OLT). The present analysis was performed on the hypothesis that the original disease representing the indication for OLT leads to a different initi...


    pub_type: 杂志文章


    authors: Berlakovich GA,Imhof M,Karner-Hanusch J,Gotzinger P,Gollackner B,Gnant M,Hanelt S,Laufer G,Muhlbacher F,Steininger R

    更新日期:1996-02-27 00:00:00

  • A Phase I/II Trial of the Interleukin-6 Receptor-Specific Humanized Monoclonal (Tocilizumab) + Intravenous Immunoglobulin in Difficult to Desensitize Patients.

    abstract:BACKGROUND:Current desensitization (DES) methods are not always effective. Thus, novel, more effective approaches are desirable. Interleukin (IL)-6 is an attractive target as it promotes B-cell differentiation to plasma cells, is important for immunoglobulin production, and induces Th17 cells. Here, we undertook a phas...


    pub_type: 杂志文章


    authors: Vo AA,Choi J,Kim I,Louie S,Cisneros K,Kahwaji J,Toyoda M,Ge S,Haas M,Puliyanda D,Reinsmoen N,Peng A,Villicana R,Jordan SC

    更新日期:2015-11-01 00:00:00

  • The effect of acute rejection and cyclosporin A-treatment on induction of platelet-derived growth factor and its receptors during the development of chronic rat renal allograft rejection.

    abstract:BACKGROUND:In the development of chronic kidney allograft rejection acute rejection (AR) is the single most important risk factor. Although Cyclosporin A (CsA) medication has decreased the incidence of AR, chronic rejection (CR) is still the major reason for late allograft loss. Platelet-derived growth factor (PDGF) is...


    pub_type: 杂志文章


    authors: Savikko J,Kallio EA,Taskinen E,von Willebrand E

    更新日期:2002-02-27 00:00:00

  • Cytokine pattern during rejection and infection after liver transplantation--improvements in postoperative monitoring?

    abstract::Despite improvements in immunosuppression, rejection occurs in 50% of liver transplant patients and may cause significant morbidity. The most frequent cause of death after liver transplantation is severe infection. Determination of the cytokine network may lead to earlier detection of patients at risk for severe rejec...


    pub_type: 杂志文章


    authors: Platz KP,Mueller AR,Rossaint R,Steinmüller T,Lemmens HP,Lobeck H,Neuhaus P

    更新日期:1996-11-27 00:00:00

  • The extent and predictors of waiting time geographic disparity in kidney transplantation in the United States.

    abstract:BACKGROUND:Waiting time to deceased donor kidney transplant varies greatly across the United States. This variation violates the final rule, a federal mandate, which demands geographic equity in organ allocation for transplantation. METHODS:Retrospective analysis of the United States Renal Data System and United Netwo...


    pub_type: 杂志文章,多中心研究


    authors: Davis AE,Mehrotra S,McElroy LM,Friedewald JJ,Skaro AI,Lapin B,Kang R,Holl JL,Abecassis MM,Ladner DP

    更新日期:2014-05-27 00:00:00

  • Successful Treatment of Chronic Hepatitis C Virus Infection With Sofosbuvir and Ledipasvir in Renal Transplant Recipients.

    abstract:BACKGROUND:Treatment of chronic hepatitis C virus (HCV) infection after renal allograft transplantation has been an obstacle because of contraindications associated with IFN-based therapies. Direct-acting antiviral agents are highly efficient treatment options that do not require IFN and may not require ribavirin. Ther...


    pub_type: 杂志文章


    authors: Eisenberger U,Guberina H,Willuweit K,Bienholz A,Kribben A,Gerken G,Witzke O,Herzer K

    更新日期:2017-05-01 00:00:00

  • Pulmonary hemorrhage as a cause of death in allogeneic bone marrow recipients with severe acute graft-versus-host disease.

    abstract::Acute graft-versus-host disease (GVHD) has recently been associated with endothelial cell injury. The potential clinical significance was explored here in an autopsy review. Thirty-seven allogeneic bone marrow recipients were identified in the autopsy files at The Johns Hopkins Hospital with no evidence of systemic in...


    pub_type: 杂志文章


    authors: Wojno KJ,Vogelsang GB,Beschorner WE,Santos GW

    更新日期:1994-01-01 00:00:00

  • Prevention of acute allograft rejection in nonhuman primate lung transplant recipients: induction with chimeric anti-interleukin-2 receptor monoclonal antibody improves the tolerability and potentiates the immunosuppressive activity of a regimen using low

    abstract:BACKGROUND:In previous studies of cynomolgus monkey lung allograft recipients, we demonstrated significant immunosuppressive efficacy but reduced tolerability after combined treatment with high doses of microemulsion cyclosporine (CsA) and SDZ RAD (40-O-(2-hydroxyethyl)-rapamycin). The current study was designed to com...


    pub_type: 杂志文章


    authors: Hausen B,Gummert J,Berry GJ,Christians U,Serkova N,Ikonen T,Hook L,Legay F,Schuler W,Schreier MH,Morris RE

    更新日期:2000-02-27 00:00:00

  • Antilymphocytic antibodies and bone marrow transplantation. XI. Evidence that reduced Thy-1 expression in Thy-1.1 mice prevents suppression of graft-versus-host disease with anti-Thy-1 monoclonal antibodies.

    abstract::Considerable variations in the suppression of graft-versus-host disease with monoclonal anti-Thy-1 antibodies were found to relate to substantial differences noted in the expression of mouse Thy-1 marker on lymph node and spleen cells of Thy-1.1 (AKR/J, C57BL/6.Thy-1.1) and Thy 1.2 (AKR/Cu, C57BL/6) mice. Thy-1.1 mice...


    pub_type: 杂志文章


    authors: Mysliwietz J,Thierfelder S,Hoffmann-Fezer G,Kummer U

    更新日期:1990-04-01 00:00:00

  • Anti-inflammatory effect of transforming growth factor-beta1 in myoblast transplantation.

    abstract:BACKGROUND:The inflammatory reaction that occurs during the 5 days after transplantation led at 3 days to the death of 70% of injected myoblasts. Use of anti-inflammatory agents appeared to be a possible way to increase myoblast survival. The application of gene transfer techniques to cell transplantation offers the po...


    pub_type: 杂志文章


    authors: Merly F,Huard C,Asselin I,Robbins PD,Tremblay JP

    更新日期:1998-03-27 00:00:00

  • Neighborhood Poverty and Sex Differences in Live Donor Kidney Transplant Outcomes in the United States.

    abstract:BACKGROUND:Neighborhood poverty has been associated with worse outcomes after live donor kidney transplantation (LDKT), and prior work suggests that women with kidney disease may be more susceptible to the negative influence of poverty than men. As such, our goal was to examine whether poverty differentially affects wo...


    pub_type: 杂志文章


    authors: Purnell TS,Luo X,Crews DC,Bae S,Ruck JM,Cooper LA,Grams ME,Henderson ML,Waldram MM,Johnson M,Segev DL

    更新日期:2019-10-01 00:00:00

  • Successful renal transplantation after endovascular bifurcated stent graft repair of an abdominal aortic aneurysm.

    abstract::Renal transplantation after repair of aortoiliac aneurysms with traditional prosthetic vascular grafts has been shown to be effective. Vascular surgery continues to rapidly evolve, most notably with the advancement of endovascular repair of abdominal aortic aneurysms. Controlled trials continue to support the trend to...


    pub_type: 杂志文章


    authors: George P,Tan HP,Beebe H,Ratner LE

    更新日期:2001-08-15 00:00:00

  • Deficient T cell granulocyte-macrophage colony stimulating factor production in allogeneic bone marrow transplant recipients.

    abstract::The proliferation and differentiation of donor hematopoietic progenitor cells in bone marrow transplantation (BMT) recipients is influenced by hematopoietic growth factors, which could derive from either T cells or adherent stromal bone marrow cells, or both. In this study of 20 BMT recipients, we asked whether T lymp...


    pub_type: 杂志文章


    authors: Thomas S,Clark SC,Rappeport JM,Nathan DG,Emerson SG

    更新日期:1990-04-01 00:00:00

  • Mechanisms of acquired thymic unresponsiveness to renal allografts. Thymic recognition of immunodominant allo-MHC peptides induces peripheral T cell anergy.

    abstract::We have recently shown that a single intrathymic injection of synthetic 25mer peptides, representing full sequences of the hypervariable domain of RT1.BuB (4 peptides) and RT1.Du beta (4 peptides) WF class II MHC molecules, 48 hr before transplantation induces donor-specific unresponsiveness to WF rat renal allografts...


    pub_type: 杂志文章


    authors: Sayegh MH,Perico N,Gallon L,Imberti O,Hancock WW,Remuzzi G,Carpenter CB

    更新日期:1994-07-27 00:00:00

  • Inability of isolated soluble interleukin-2 receptor levels to predict biopsy rejection scores after heart transplantation.

    abstract::Successful cardiac transplantation requires suppression of rejection, and endomyocardial biopsy is generally used to quantify this and guide immunotherapy. Biopsy, however, is an invasive, costly, cardiac catheterization with repetition limited. Since rejection requires lymphocyte activation, an alternative method of ...


    pub_type: 杂志文章


    authors: Young JB,Windsor NT,Smart FW,Kleiman NS,Weilbaecher DG,Noon GP,Nelson DL,Lawrence EC

    更新日期:1991-03-01 00:00:00

  • Intact pig pancreatic islet function in the presence of human xenoreactive natural antibody binding and complement activation.

    abstract:BACKGROUND:The expression of xenogeneic epitopes and the activation of human complement by adult pig islets after prolonged culture have hitherto not been described. MATERIALS AND METHODS:Freshly isolated and cultured islets were analyzed by fluorescence-activated cell sorter analysis, fluorescence microscopy, and imm...


    pub_type: 杂志文章


    authors: Mirenda V,Le Mauff B,Cassard A,Huvelin JM,Boeffard F,Faivre A,Soulillou JP,Anegon I

    更新日期:1997-05-27 00:00:00

  • Respiratory tract viral infections in bone marrow transplant patients.

    abstract:BACKGROUND:Community respiratory viruses such as respiratory syncytial virus (RSV), adenovirus, influenza A, influenza B, and the parainfluenza group are frequent causes of respiratory disease in bone marrow transplant (BMT) patients. MATERIAL AND METHODS:During the period from March 1993 to August 1999, 810 samples o...


    pub_type: 杂志文章


    authors: Raboni SM,Nogueira MB,Tsuchiya LR,Takahashi GA,Pereira LA,Pasquini R,Siqueira MM

    更新日期:2003-07-15 00:00:00

  • In vivo bioluminescence imaging of transplanted islets and early detection of graft rejection.

    abstract:BACKGROUND:Bioluminescence imaging (BLI) modalities are being developed to monitor islet transplant mass and function in vivo. The aim of this study was to use the BLI system to determine how the change in functional islet mass correlated to metabolic abnormalities during the course of alloimmune rejection in a murine ...


    pub_type: 杂志文章


    authors: Chen X,Zhang X,Larson CS,Baker MS,Kaufman DB

    更新日期:2006-05-27 00:00:00

  • Induction of hyperacute rejection of skin allografts by CD8+ lymphocytes.

    abstract:BACKGROUND:Second-set rejection is generally regarded as a phenomenon mainly mediated by humoral cytotoxic antibodies, although a few discordant data have been presented. In the reported experiments, we have taken advantage of the absence of production of specific cytotoxic alloantibodies contrasting with the normal de...


    pub_type: 杂志文章


    authors: Yoshimura R,Chargui J,Aitouche A,Veyron P,Touraine JL

    更新日期:2000-04-15 00:00:00

  • Antigen-specific immunosuppression induced by liver transplantation in the rat.

    abstract::We have demonstrated that DA hearts grafted into PVG rats were completely protected from rejection by simultaneous liver transplantation from the same donor. In subsequent experiments PVG animals were given DA hearts followed 5 or 6 days later by livers from the same donor strain. Instead of the expected rapid rejecti...


    pub_type: 杂志文章


    authors: Kamada N,Wight DG

    更新日期:1984-09-01 00:00:00

  • Monitoring for HHV-6 infection after renal transplantation: evaluation of risk factors for sustained viral replication.

    abstract:BACKGROUND:Human herpesvirus-6 (HHV-6) is known to reactivate after renal transplantation and has been associated with several clinical manifestations. Risk factors for sustained viral replication, however, remain unclear. METHODS:Thirty consecutive kidney transplant patients were prospectively followed for HHV-6 repl...


    pub_type: 杂志文章


    authors: Luiz CR,Machado CM,Canto CL,Christ SC,Pestana JO,Kotton CN,Camargo LF

    更新日期:2013-03-27 00:00:00

  • Monitoring the patient off immunosuppression. Conceptual framework for a proposed tolerance assay study in liver transplant recipients.

    abstract::The mission of the recently established Immune Tolerance Network includes the development of protocols for the induction of transplant tolerance in organ allograft recipients and the development of assays that correlate with and may be predictive of the tolerant state. The state of clinical organ transplant tolerance ...


    pub_type: 杂志文章,评审


    authors: Thomson AW,Mazariegos GV,Reyes J,Donnenberg VS,Donnenberg AD,Bentlejewski C,Zahorchak AF,O'Connell PJ,Fung JJ,Jankowska-Gan E,Burlingham WJ,Heeger PS,Zeevi A

    更新日期:2001-10-27 00:00:00

  • Early Outcomes of the New UK Deceased Donor Kidney Fast-Track Offering Scheme.

    abstract:BACKGROUND:The UK Kidney Fast-Track Scheme (KFTS) was introduced in 2012 to identify kidneys at high risk of discard and to rapidly facilitate transplantation. A retrospective analysis of kidneys transplanted through the KFTS was undertaken. METHODS:UK Transplant Registry data were collected on deceased donor kidneys ...


    pub_type: 杂志文章


    authors: Callaghan CJ,Mumford L,Pankhurst L,Baker RJ,Bradley JA,Watson CJE

    更新日期:2017-12-01 00:00:00

  • Mediators involved in the immunomodulatory effects of apoptotic cells.

    abstract::Immunomodulatory properties are attributed to apoptotic cells. These properties have been used to modulate allogeneic immune responses in experimental transplantation settings. In independent studies, apoptotic cell infusion has been shown to favor hematopoietic cell engraftment, to increase heart graft survival, and ...


    pub_type: 杂志文章,评审


    authors: Saas P,Bonnefoy F,Kury-Paulin S,Kleinclauss F,Perruche S

    更新日期:2007-07-15 00:00:00

  • Natural killer cell interaction with murine allogeneic MHC class I molecules.

    abstract::Class I molecules of the MHC affect target cell sensitivity to NK cell repertoire. In the mouse, absence of MHC class I molecules on target cells is associated with an increased susceptibility to NK cell-mediated lysis, while syngeneic class I molecules confer protection. In contrast to the protective role of syngenei...


    pub_type: 杂志文章


    authors: Salcedo M,Höglund P,Ljunggren HG

    更新日期:1995-08-15 00:00:00

  • Plasminogen activator inhibitor-1 polymorphism is associated with progressive renal dysfunction after acute rejection in renal transplant recipients.

    abstract:BACKGROUND:Plasma level of plasminogen activator inhibitor (PAI)-1 is genetically determined by a polymorphism in the promoter region, involving two alleles, 4G and 5G. Plasma PAI-1 concentrations are higher in subjects homozygous for the 4G allele than other genotypes (5G/5G and 4G/5G). Such genetic variation in fibri...


    pub_type: 杂志文章


    authors: Chow KM,Szeto CC,Szeto CY,Poon P,Lai FM,Li PK

    更新日期:2002-12-27 00:00:00