Mitotic behaviour and proliferative metabolism in allogenic rat kidney transplants in the first 6 days after recirculation.

Abstract:

:Comparative experiments were performed on 41 allogenic rat kidney transplants to determine the mitotic behaviour and proliferative metabolism (application of 3H-thymidine) in the first 6 days after recirculation. Three days after transplantation, DNA synthesis in the tubular epithelial cells of the cortex and the medulla reached its peak. After this time the 3H-thymidine labelling index for these cell nuclei dropped. On the 6th day, the value was equal to that of the first day. The following points are signs of rapid transplant rejection. It was predicted that the DNA synthesis in the epithelial cell nuclei would decline, and also that the lymphocytes would proliferate in the interstitial tissue of the transplant's cortex and medulla. From the 4th day on, these changes were observed. The changes in the proliferative metabolism of the tubular epithelial cell nuclei preceded the mitotic changes by a few hr. The transplant changes caused by ischemia followed by tissue rejection can be made comprehensible by the determination of the average cell density of 3H-thymidine-labelled cortical, medullar, and tubular epithelial cells.

journal_name

Transplantation

journal_title

Transplantation

authors

Lauschke H

doi

10.1097/00007890-197807010-00003

subject

Has Abstract

pub_date

1978-07-01 00:00:00

pages

4-9

issue

1

eissn

0041-1337

issn

1534-6080

journal_volume

26

pub_type

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    更新日期:1990-03-01 00:00:00

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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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    authors: Ooi BS,Rubin SC,Pesce AJ,Pollak VE

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    doi:10.1097/00007890-198911000-00008

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    更新日期:1989-11-01 00:00:00

  • Rat xenograft survival in mice treated with donor-specific transfusion and anti-CD154 antibody is enhanced by elimination of host CD4+ cells.

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    更新日期:2001-01-27 00:00:00

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    更新日期:1998-04-15 00:00:00

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    更新日期:2001-09-27 00:00:00

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    更新日期:1998-08-27 00:00:00

  • The effect of verapamil on renal function after warm and cold ischemia in the isolated perfused rat kidney.

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    pub_type: 杂志文章

    doi:10.1097/00007890-198512000-00004

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    更新日期:1985-12-01 00:00:00

  • Apollon/RNF41 myocardial messenger RNA diagnoses cardiac allograft apoptosis in rejection.

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    doi:10.1097/TP.0b013e3181c3c690

    authors: Aharinejad S,Andrukhova O,Gmeiner M,Thomas A,Krenn K,Zuckermann A,Grimm M

    更新日期:2010-01-27 00:00:00

  • Randomized trial of mycophenolate mofetil versus enteric-coated mycophenolate sodium in primary renal transplant recipients given tacrolimus and daclizumab/thymoglobulin: one year follow-up.

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    pub_type: 杂志文章,随机对照试验

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    authors: Ciancio G,Burke GW,Gaynor JJ,Roth D,Sageshima J,Kupin W,Tueros L,Hanson L,Rosen A,Ruiz P,Miller J

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  • Further characterization of immunological unresponsiveness induced in mice by ultraviolet radiation. Growth and induction of nonultraviolet-induced tumors in ultraviolet-irradiated mice.

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    更新日期:2004-04-27 00:00:00

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    doi:10.1097/00007890-199201000-00016

    authors: Legendre C,Kreis H,Bach JF,Chatenoud L

    更新日期:1992-01-01 00:00:00

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  • Antibodies to hepatitis C virus envelope proteins correlate with hepatitis C viraemia after liver transplantation.

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    pub_type: 杂志文章

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    authors: Gane EJ,Maertens G,Ducatteeuw A,Qian KP,Lau JY,Jones H,Davies E,Naoumov NV,Williams R

    更新日期:1999-01-15 00:00:00