Vitamin D deficiency in lung transplant patients: is it important?

abstract：BACKGROUND:Posttransplantation bone disease is a well-described phenomenon; among its etiology is immunosuppressant-induced bone disease. Mycophenolate mofetil (MMF) has emerged as a promising new immunosuppressant. Our study was designed to investigate the effect of MMF on in vivo bone mineral metabolism. METHODS:Twe...

journal_title：Transplantation

authors： Dissanayake IR,Goodman GR,Bowman AR,Ma Y,Pun S,Jee WS,Epstein S

更新日期：1998-01-27 00:00:00

abstract：:Suspensions of viable lymph node cells (LNCs), both unlabeled and 3H-uridine labeled, from adult Fischer (FI) rats were inoculated into the lumens of established, surgically isolated segments of ileum in adult (FI x DA)F1 hybrid hosts. Vascular, lymphatic, and nerve supplies of the isolated segment were preserved. It ...

journal_title：Transplantation

authors： Seelig LL Jr,Billingham RE

更新日期：1981-10-01 00:00:00

abstract：BACKGROUND:The role of natural killer (NK) cells and macrophages (Møs) in the absence of T cell immunity in discordant xenograft (xg) rejection was investigated. METHODS:Guinea pig hearts were transplanted into athymic nude rats receiving no treatment or antixenoantibody (xAb), anticomplement (C), antinatural killer (...

journal_title：Transplantation

authors： Xia G,Ji P,Rutgeerts O,Waer M

更新日期：2000-07-15 00:00:00

abstract：BACKGROUND:Previous reports have established the feasibility of using livers from controlled, non-heart-beating donors (CNHBD) with good immediate graft function. This has been largely borne out of necessity because of the donor shortage. METHODS:Retrospective database review for the last 7 years (1995-2002), encompas...

journal_title：Transplantation

authors： Manzarbeitia CY,Ortiz JA,Jeon H,Rothstein KD,Martinez O,Araya VR,Munoz SJ,Reich DJ

更新日期：2004-07-27 00:00:00

abstract：:To improve long-term outcome after renal transplantation, attention should be placed on the tailored use of immunosuppressive regimens that have a more favorable impact on the immunological and nonimmunological risk profiles of an individual recipient. Tacrolimus is widely used for maintenance and rejection immunosupp...

journal_title：Transplantation

authors： First MR

更新日期：2001-09-27 00:00:00

abstract：:Acute graft-versus-host disease (GVHD) has recently been associated with endothelial cell injury. The potential clinical significance was explored here in an autopsy review. Thirty-seven allogeneic bone marrow recipients were identified in the autopsy files at The Johns Hopkins Hospital with no evidence of systemic in...

journal_title：Transplantation

authors： Wojno KJ,Vogelsang GB,Beschorner WE,Santos GW

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Mycophenolic acid (MPA) is an inhibitor of lymphocyte proliferation and is well established as an immunosuppressive agent in solid organ transplantation. The initial formulation of the drug was a prodrug formulation, mycophenolate mofetil (MMF, Cellcept), which is well absorbed and rapidly converted to mycop...

journal_title：Transplantation

authors： Johnston A,He X,Holt DW

更新日期：2006-12-15 00:00:00

abstract：BACKGROUND:In Th (T helper) 1/Th2 balance in response to signals given during donor antigen presentation, induction of allograft prolongation is more often related to Th2-type than with Th1-type immunity. Here, we examined the effect of interleukin (IL)-33, a novel member of the IL-1 family, on cardiac allograft surviv...

journal_title：Transplantation

authors： Yin H,Li XY,Jin XB,Zhang BB,Gong Q,Yang H,Zheng F,Gong FL,Zhu JY

更新日期：2010-05-27 00:00:00

abstract：BACKGROUND:Injection of neonatal BALB/c mice with semi-allogeneic splenocytes leads to antigen-specific tolerance lasting into adulthood. Tolerant mice accept A/J skin grafts and fail to generate CD8 cytotoxic T lymphocyte (CTL) activity against A/J targets. Anergic CD8 T cells are present in tolerant mice, and CD4 reg...

journal_title：Transplantation

authors： Gao Q,Rouse TM,Kazmerzak K,Field EH

更新日期：1999-12-27 00:00:00

abstract：BACKGROUND:Successful kidney transplantation normalizes elevated proatrial natriuretic peptide (proANP) plasma concentrations of renal failure patients in the early posttransplant period. We evaluated plasma and urinary proANP fragments in the late posttransplant period. METHODS:Immunoreactive proANP(1-30) and proANP(...

journal_title：Transplantation

authors： Franz M,Woloszczuk W,Hörl WH

更新日期：2001-07-15 00:00:00

abstract：:Over the last decade there have been major advances in all aspects of liver transplantation with the consequence that the number of patients who could benefit from the procedure is increasing. As a result, the number of patients listed for liver transplantation is growing while the donor pool is remaining constant or ...

journal_title：Transplantation

authors： Neuberger J,Ubel PA

更新日期：2000-11-27 00:00:00

abstract：BACKGROUND:Primary hyperoxaluria is a rare autosomal recessive metabolic disease that often progresses to end-stage renal disease (ESRD). Liver transplantation is curative for patients with the alanine: glyoxylate aminotransferase deficiency. For oxalosis patients with minor enzyme deficiencies, renal transplantation m...

journal_title：Transplantation

authors： Cibrik DM,Kaplan B,Arndorfer JA,Meier-Kriesche HU

更新日期：2002-09-15 00:00:00

abstract：:The potent immunosuppressive action of rabbit antithymocyte globulin (RATG) in allotransplant recipients has been recognized for many years. Some of the antibody specificities and immunoregulatory effects of RATG have been described, but a comprehensive definition of RATG components has not been reported previously. I...

journal_title：Transplantation

authors： Rebellato LM,Gross U,Verbanac KM,Thomas JM

更新日期：1994-03-15 00:00:00

abstract：BACKGROUND:Two patients underwent cadaver transplantation with kidneys from a donor with a history of World Health Organization Class IV/V lupus nephritis, and we report their clinical and pathological outcome. METHODS:The donor had a diagnosis of lupus nephritis made by renal biopsy 5 years before donation. At the ti...

journal_title：Transplantation

authors： Lipkowitz GS,Madden RL,Kurbanov A,Mulhern JG,O'Shea MH,Germain MJ,Freeman J,Braden GL

更新日期：2000-03-27 00:00:00

abstract：BACKGROUND:The aging of liver transplant (LT) recipients, the weighting of the model for end-stage liver disease score, and the increased prevalence of nonalcoholic steatohepatitis has led to an increased number of older LT recipients with pre-LT chronic kidney disease (CKD). There are limited data on the impact of inc...

journal_title：Transplantation

authors： Goldberg DS,Vianna RM,Martin EF,Martin P,Arosemena Benitez LR,O'Brien CB,Bhamidimarri KR

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Allograft rejection is mediated by cytokines. As polymorphism in cytokine genes can result in interindividual differences in cytokine production, we hypothesize that some patients may have an increased risk of rejection. METHODS:We have related polymorphisms that influence cytokine production in the tumor n...

journal_title：Transplantation

authors： Turner D,Grant SC,Yonan N,Sheldon S,Dyer PA,Sinnott PJ,Hutchinson IV

更新日期：1997-09-15 00:00:00

abstract：:Data from 60 consecutive ABO-incompatible kidney transplantations performed in Stockholm, Sweden; Freiburg, Germany; and Uppsala, Sweden, revealed significant variation in preoperative A/B antibody levels, with median titers of 1:32, 1:128, and 1:8, respectively. We wanted to investigate whether these differences were...

journal_title：Transplantation

authors： Kumlien G,Wilpert J,Säfwenberg J,Tydén G

更新日期：2007-12-27 00:00:00

abstract：:Pre-existing alloantibodies against the mismatched HLA-A and HLA-B antigens of the donor, when present in current sera, are believed to be detrimental to kidney graft survival. When these antibodies are present only in historical sera, their immunoglobulin class has reported to be important with respect to the expecte...

journal_title：Transplantation

authors： Roelen DL,van Bree J,Witvliet MD,Habraken I,van Beelen E,van't Sant PH,de Waal LP,van Rood JJ,Claas FH

更新日期：1994-05-15 00:00:00

abstract：BACKGROUND:BK virus-associated nephropathy (BKVN) is associated with an increased risk of graft failure. METHODS:Levels of mRNAs encoding proteins implicated in inflammation and fibrosis were measured in urine collected at the time of biopsy diagnosis of BKVN in 29 kidney graft recipients and analyzed for prognosticat...

journal_title：Transplantation

authors： Dadhania D,Snopkowski C,Muthukumar T,Lee J,Ding R,Sharma VK,Christos P,Bang H,Kapur S,Seshan SV,Suthanthiran M

更新日期：2013-07-27 00:00:00

abstract：BACKGROUND:We have previously shown that phosphorothioate intercellular adhesion molecule (ICAM)-1 antisense oligodeoxynucleotide (oligo) IP-9125 blocks the expression of rat ICAM-1 mRNA in rat L2 cells. A single ex situ perfusion of grafts with unformulated IP-9125, suspended in Euro-Collins solution, prolonged the su...

journal_title：Transplantation

authors： Chen W,Bennett CF,Wang ME,Dragun D,Tian L,Stecker K,Clark JH,Kahan BD,Stepkowski SM

更新日期：1999-09-27 00:00:00

abstract：BACKGROUND:Umbilical cord blood transplantation (UCBT) is increasingly used and produces similar results to matched unrelated donor transplantation. METHODS:We performed a retrospective single-center analysis of 50 umbilical cord blood transplantations UCBTs performed from 2001 to 2010, including 37 single and 13 doub...

journal_title：Transplantation

authors： Berglund S,Le Blanc K,Remberger M,Gertow J,Uzunel M,Svenberg P,Winiarski J,Ljungman P,Ringdén O,Uhlin M,Mattsson J

更新日期：2012-11-27 00:00:00

abstract：:We have previously demonstrated that streptozotocin-induced diabetic rats have decreased guanylate cyclase (EC 4.6.1.2) activity in liver and other tissues which was returned to normal by the administration of exogenous insulin. Since successful pancreatic islet transplants have been shown to lower basal hepatic gluco...

journal_title：Transplantation

authors： Vesely DL,Selawry H,Levey GS

更新日期：1979-06-01 00:00:00

abstract：:Tolerance induction by CD45RB monoclonal antibody (mAb) in murine allograft models is associated with an alteration in the CD45RBlo/CD45RBhi T-cell ratio in favor of CD45RBlo T cells, which can function as regulatory cells and promote tolerance. It has been proposed that inversion of the CD45RBhi/CD45RBlo normal T-cel...

journal_title：Transplantation

authors： Luke PP,Deng JP,O'Brien CA,Everest M,Hall AV,Chakrabarti S,O'Connell PJ,Zhong R,Jevnikar AM

更新日期：2003-07-27 00:00:00

abstract：BACKGROUND:At the time of transplantation, a recipient's serum is tested against the prospective donor's lymphocytes to identify specific reactivity and to look for a donor-specific crossmatch (CXM). Here, we investigated the relationship between the pretransplantation lymphocytotoxic CXM results and the long-term outc...

journal_title：Transplantation

authors： Shin M,Moon HH,Kim JM,Park JB,Kwon CH,Kim SJ,Lee SK,Joh JW

更新日期：2013-06-15 00:00:00

abstract：BACKGROUND:Overexposure to cyclosporine is a risk factor for chronic allograft nephropathy (CAN) and dose reduction has been advocated. The purpose of this study was to determine the impact of adding the non-nephrotoxic immunosuppressant, rapamycin, after cyclosporine dose reduction in renal-allograft recipients with C...

journal_title：Transplantation

authors： Saunders RN,Bicknell GR,Nicholson ML

更新日期：2003-03-27 00:00:00

abstract：:Sixty-two adults who underwent orthotopic liver transplantations between February 1981 and June 1983 were followed for a mean of 170 days after the operation. Twenty-six patients developed 30 episodes of significant fungal infection. Candida species and Torulopsis glabrata were responsible for 22 episodes and Aspergil...

journal_title：Transplantation

authors： Wajszczuk CP,Dummer JS,Ho M,Van Thiel DH,Starzl TE,Iwatsuki S,Shaw B Jr

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:Mixed lymphohematopoietic chimerism can provide an effective means of inducing longterm immunological tolerance and has been documented in a monkey allograft model. A conditioning regimen including nonmyeloablative or myeloablative irradiation and splenectomy has been used to induce chimerism in a pig-to-pri...

journal_title：Transplantation

authors： Kozlowski T,Monroy R,Xu Y,Glaser R,Awwad M,Cooper DK,Sachs DH

更新日期：1998-07-27 00:00:00

abstract：:A single posttransplant test for human leukocyte antigen (HLA) antibodies in heart and lung graft patients was examined for its predictive value for graft survival as part of the 13th and 14th international histocompatibility workshops. We included patients with HLA antibodies who were tested 6 or more months after tr...

journal_title：Transplantation

authors： Morales-Buenrostro LE,Castro R,Terasaki PI

更新日期：2008-02-15 00:00:00

abstract：OBJECTIVES:To determine whether humoral autoimmune responses associated with dilated cardiomyopathy (DCM) influence the postoperative clinical course following cardiac transplantation. METHODS:ELISA levels of preformed cardiac myosin (CM) autoantibodies (Abs) in patients with a pretransplant diagnosis of dilated cardi...

journal_title：Transplantation

authors： Warraich RS,Pomerance A,Stanley A,Banner NR,Dunn MJ,Yacoub MH

更新日期：2000-04-27 00:00:00

abstract：:A controlled trial was carried out to assess the value of intensive plasma exchange in 27 renal transplant recipients with clinical and histological evidence of acute vascular rejection. In addition to standard immunosuppression, 13 patients received plasma exchange on six consecutive days at a mean exchange volume of...

journal_title：Transplantation

authors： Allen NH,Dyer P,Geoghegan T,Harris K,Lee HA,Slapak M

更新日期：1983-05-01 00:00:00