Abstract:
BACKGROUND:Posttransplantation bone disease is a well-described phenomenon; among its etiology is immunosuppressant-induced bone disease. Mycophenolate mofetil (MMF) has emerged as a promising new immunosuppressant. Our study was designed to investigate the effect of MMF on in vivo bone mineral metabolism. METHODS:Twenty-four 6-month-old male Sprague-Dawley rats were randomized into two groups to receive either MMF vehicle daily for 28 days or 30 mg/kg MMF daily for 28 days. The serum was assayed for osteocalcin and 1,25-dihydroxy vitamin D3. Subsequent to double-labeling, the right tibiae were removed on day 28 for histomorphometry. RESULTS:MMF suppressed bone gla protein (osteocalcin) levels on days 14 and 28 (P < 0.05). Except for percentage osteoid perimeter, there was no difference in bone histomorphometry between the two groups. CONCLUSION:In this relatively short-term study, MMF did not cause osteopenia in the rat model, but the suppressed bone gla protein merits further study.
journal_name
Transplantationjournal_title
Transplantationauthors
Dissanayake IR,Goodman GR,Bowman AR,Ma Y,Pun S,Jee WS,Epstein Sdoi
10.1097/00007890-199801270-00025subject
Has Abstractpub_date
1998-01-27 00:00:00pages
275-8issue
2eissn
0041-1337issn
1534-6080journal_volume
65pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::Tolerance induction by CD45RB monoclonal antibody (mAb) in murine allograft models is associated with an alteration in the CD45RBlo/CD45RBhi T-cell ratio in favor of CD45RBlo T cells, which can function as regulatory cells and promote tolerance. It has been proposed that inversion of the CD45RBhi/CD45RBlo normal T-cel...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000072373.77323.D4
更新日期:2003-07-27 00:00:00
abstract::There is substantial evidence that increased cellular calcium may activate processes that lead to cellular injury and death, and calcium entry blockers (CEB) have been shown to protect against renal ischemic injury. This approach has been used experimentally to enhance kidney preservation during both warm and cold isc...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198802000-00012
更新日期:1988-02-01 00:00:00
abstract::In a prospective randomized double-blind placebo-controlled trial, the effect of rh-SOD, given in a dose of 200 mg intravenously during surgery to cyclosporine-treated recipients of cadaveric renal allografts, on both acute and chronic rejection events as well as patient and graft survival was investigated by analyzin...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007890-199401001-00010
更新日期:1994-01-01 00:00:00
abstract::SLT presents an interesting concept to alleviate the organ shortage for children with end-stage liver disease. The procedure has, however, not gained wide acceptance. This is not only related to the complexity of the procedure, but also to the poorer results and the complications reported on the right side graft. We r...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1995-04-27 00:00:00
abstract:BACKGROUND:We have previously shown that phosphorothioate intercellular adhesion molecule (ICAM)-1 antisense oligodeoxynucleotide (oligo) IP-9125 blocks the expression of rat ICAM-1 mRNA in rat L2 cells. A single ex situ perfusion of grafts with unformulated IP-9125, suspended in Euro-Collins solution, prolonged the su...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199909270-00022
更新日期:1999-09-27 00:00:00
abstract::Hepatic artery thrombosis is a dreadful complication of orthotopic liver transplantation. It should be suspected in cases of fulminant liver failure, delayed bile leak, or intermittent sepsis of unknown cause after liver transplantation. Accurate diagnosis is assisted by ultrasound and computerized tomography scans, b...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198512000-00019
更新日期:1985-12-01 00:00:00
abstract::Increased QT dispersion (QTd), predicting patients with risk of malignant arrhythmia, have recently been reported in hemodialysis patients (HDp). In this prospective study, we aimed to investigate changes in QTd and signal averaged-ECG (SAECG) in HDp after transplantation. Twenty-seven HDp (M/F:18/9, mean age 30+/-8 y...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-200111150-00009
更新日期:2001-11-15 00:00:00
abstract:BACKGROUND:This study examined the relationship between transplant vascular sclerosis (TVS) and tissue fibrosis, features of chronic rejection that can develop rapidly in accepted heterotopic murine cardiac allografts. METHODS:The rate of development of interstitial fibrosis or TVS development was determined by comput...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199710270-00020
更新日期:1997-10-27 00:00:00
abstract:BACKGROUND:Early and late complications related to the pancreas after simultaneous kidney-pancreas transplantation (SKPT) frequently result in graft loss. The authors describe a surgical rescue technique that allows salvage of the pancreatic graft when surgical complications appear after the transplant. METHODS:Of 158...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000041784.27763.A9
更新日期:2003-01-27 00:00:00
abstract:BACKGROUND:The shortage of livers for transplantation has prompted transplant centers to seek alternatives to conventional cadaveric liver transplantation. Left lateral segmentectomy from living donors has proven to be a safe operation for the donor with excellent results in the pediatric population. Left lobectomy, co...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199909270-00012
更新日期:1999-09-27 00:00:00
abstract::Currently it is not feasible to isolate sufficient numbers of islets from a single pancreas for clinical transplantation. We examined whether small numbers of islets obtained from multiple donors could be used for transplantation. Islets were isolated from four inbred strains of mice (DBA/2, DBA/1, C3H, and A.SW) by a...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1988-06-01 00:00:00
abstract::We report the management of a patient with the late onset of chronic graft-versus-host disease (GVHD) after orthotopic liver transplantation. GVHD is a rare complication of solid organ transplants that usually presents early after transplantation and is fatal in the majority of cases. Our patient differs from the typi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200105270-00022
更新日期:2001-05-27 00:00:00
abstract::Glutathione is important in cellular defense against oxidative stress. We postulated that administration of N-acetylcysteine (NAC), a glutathione precursor, might help maintain or replenish hepatic glutathione stores, thereby reducing reperfusion injury in liver grafts after warm ischemia. Eighteen pigs were subjected...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199501150-00002
更新日期:1995-01-15 00:00:00
abstract:BACKGROUND:Combined lung and liver transplantation (Lu-LTx) is a therapeutic option for selected patients with coexisting lung and liver disease. For several reasons, Lu-LTx is performed in few centers and information about the technical issues, posttransplant management and long-term outcomes associated with this proc...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181636f3f
更新日期:2008-02-27 00:00:00
abstract::Endothelial damage has been implicated in the pathogenesis of chronic rejection. Conversely, expression of protective genes [including A20, A1, bcl-xl, and hemoxygenase-1 (HO-1)] in the endothelium has been associated with long-term graft survival. Overexpression of protective genes in cultured endothelial cells confe...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200102150-00020
更新日期:2001-02-15 00:00:00
abstract::Organ shortage in liver transplantation has led the transplant community to expand the donor organ pool and reduce waiting list mortality by using so-called marginal donor or extended criteria donor (ECD) livers. The exact impact of these criteria on graft function and recipient survival are still under investigation....
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318186ad7a
更新日期:2008-10-15 00:00:00
abstract::Although solid organ transplant results have improved significantly in recent decades, a pivotal cause of impaired long-term outcome is the development of antibody-mediated rejection (AMR), a condition characterized by the presence of donor specific antibodies to human leukocyte antigen (HLA) or non-HLA antigens. High...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003551
更新日期:2020-11-17 00:00:00
abstract::Organ donation after circulatory death (DCD) has been endorsed by the World Health Organization and is practiced worldwide. This overview examines current DCD practices, identifies problems and challenges, and suggests clinical strategies for possible improvement. Although there is uniform agreement on DCD donor candi...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.TP.0000437178.48174.db
更新日期:2014-02-15 00:00:00
abstract::With advances in microsurgery and molecular biology, the mouse model for organ transplantation has become increasingly popular. However, knowledge about these models is limited, as only a small number of centers have experience with murine models. In this study, we compared the rejection pattern after liver, kidney, h...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199611150-00016
更新日期:1996-11-15 00:00:00
abstract::Two hundred twenty-eight patients from a total of 466 (49%) receiving renal allografts under cyclosporine/prednisone (CsA/Pred) immunosuppression experienced at least one episode of posttransplant hepatotoxicity. All patients were documented to have normal serum bilirubin, serum glutamic oxaloacetic transaminase (SGOT...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198701000-00009
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:To identify factors related with successful pregnancy in renal transplant recipients and the effect of pregnancy on long-term graft outcome. METHODS:The study group consisted of 48 women who conceived after undergoing renal transplantation (total pregnancies 74). The control group consisted of 187 nonpregna...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318170f8ed
更新日期:2008-05-27 00:00:00
abstract:BACKGROUND:Frequencies of alloreactive T cells determined by limiting dilution assays (LDA) may not adequately reflect the donor-reactive immune status in transplant recipients. To reevaluate LDA frequencies, we developed a flow cytometry test for direct determination of alloreactive T-cell frequencies and compared the...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200208270-00023
更新日期:2002-08-27 00:00:00
abstract::The recipients of combined kidney-pancreas transplants (SPK) are unique because they routinely receive two allografts from the same donor. In a previous study, we found that the long-term graft survival of the two allografts was different, with better graft survival seen in the pancreas allograft. In an attempt to und...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199408270-00006
更新日期:1994-08-27 00:00:00
abstract:BACKGROUND:Scientific Registry of Transplant Recipients report cards of US organ transplant center performance are publicly available and used for quality oversight. Low center performance (LP) evaluations are associated with changes in practice including reduced transplant rates and increased waitlist removals. In 201...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001373
更新日期:2017-06-01 00:00:00
abstract::There is increasing evidence that various maturational stages of B-cells infiltrate various solid organ transplants undergoing acute rejection. The presence of immature CD20 and mature CD138 plasma cells associate with more aggressive and steroid-recalcitrant graft rejection and portend poor graft outcomes. Though ass...
journal_title:Transplantation
pub_type: 社论,评审
doi:10.1097/TP.0b013e318177793e
更新日期:2008-06-27 00:00:00
abstract::Renal function was observed retrospectively in a population of 228 adults who underwent a cardiac allograft at the University of Pittsburgh from June 1980 through June 1987, survived a minimum of one year, and received cyclosporine. Renal function was determined by serial measurement of serum creatinine concentration....
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199010000-00012
更新日期:1990-10-01 00:00:00
abstract::Mixed lymphocyte culture--lymphocyte-mediated cytotoxicity (MLC-LMC) reactions by recipient spleen cells were strongly and specifically increased shortly after primarily vascularized heart grafts were placed in mice. Subsequently, in strain combinations in which eventual long-term graft survival occurred, the MLC-LMC ...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1987-04-01 00:00:00
abstract:BACKGROUND:Immunosuppressive drugs that target T cells are useful for prolonging allograft survival. The anti-CD3 immunotoxin FN18-CRM9 has been shown to effectively prolong renal allograft survival in a rhesus monkey model of transplantation. However, immunotoxin-treated monkeys showed increased levels of inflammatory...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199909150-00016
更新日期:1999-09-15 00:00:00
abstract::We report two cases of Kaposi's sarcoma (KS) after orthotopic liver transplantation for cirrhosis of the liver related to hepatitis C virus. Both cases were Saudi-born Arabs who were negative for human immunodeficiency virus; one patient was receiving FK506 plus prednisolone, and the other patient was receiving FK506....
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199705270-00025
更新日期:1997-05-27 00:00:00
abstract:BACKGROUND:Long-term acceptance of semi-identical orthotopic liver transplants (OLTs) in inbred swine is induced by a 12-day course of FK506. To study whether acceptance is attributable to central or peripheral immune mechanisms, the effect of complete thymectomy was determined. METHODS:Total thymectomy was performed ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000121762.47432.15
更新日期:2004-04-27 00:00:00