Abstract:
:There is increasing evidence that various maturational stages of B-cells infiltrate various solid organ transplants undergoing acute rejection. The presence of immature CD20 and mature CD138 plasma cells associate with more aggressive and steroid-recalcitrant graft rejection and portend poor graft outcomes. Though associative, the causal role of B-cells in graft rejection remains to be better understood. This review discusses the possible roles of B-cells in graft rejection, whether involved as antigen presenting, as indirect effector, or antibody producing cells.
journal_name
Transplantationjournal_title
Transplantationauthors
Zarkhin V,Li L,Sarwal Mdoi
10.1097/TP.0b013e318177793esubject
Has Abstractpub_date
2008-06-27 00:00:00pages
1705-14issue
12eissn
0041-1337issn
1534-6080pii
00007890-200806270-00005journal_volume
85pub_type
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