"Striped" pattern of medullary ray fibrosis in allograft biopsies from kidney transplant recipients maintained on tacrolimus.

Abstract:

BACKGROUND:A striped pattern of fibrosis has been described in the kidneys of patients undergoing long-term cyclosporine or tacrolimus therapy. This lesion is frequently misconstrued as being specific for drug toxicity. METHODS:We performed clinicopathologic correlation on 18 patients with striped fibrosis identified by reviewing 61 biopsies from kidney transplant recipients maintained with tacrolimus. RESULTS:Acute rejection was identified in 14 of 18 patients, chronic rejection in 9 of 18 patients, potential diabetic microvascular injury in 8 of 18, and pre-existing donor disease in 2 of 18. In only one patient could striped fibrosis be ascribed primarily to tacrolimus. Striped fibrosis could also be demonstrated in 6 of 10 late allograft biopsy specimens from patients maintained with only azathioprine, and 8 of 10 native biopsies from patients with advanced diabetes mellitus. CONCLUSION:Multiple insults contribute to the pathogenesis of striped fibrosis in the kidney. This lesion can be attributed entirely to chronic drug toxicity in only a minority of allografts.

journal_name

Transplantation

journal_title

Transplantation

authors

Dell'Antonio G,Randhawa PS

doi

10.1097/00007890-199902150-00025

subject

Has Abstract

pub_date

1999-02-15 00:00:00

pages

484-6

issue

3

eissn

0041-1337

issn

1534-6080

journal_volume

67

pub_type

杂志文章
  • Race, Risk, and Willingness of End-Stage Renal Disease Patients Without Hepatitis C Virus to Accept an HCV-Infected Kidney Transplant.

    abstract:BACKGROUND:Despite effective antiviral treatment, hundreds of kidneys from deceased donors with hepatitis C virus (HCV) are discarded annually. Little is known about the determinants of willingness to accept HCV-infected kidneys among HCV-negative patients. METHODS:At 2 centers, 189 patients undergoing initial or reev...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000002099

    authors: McCauley M,Mussell A,Goldberg D,Sawinski D,Molina RN,Tomlin R,Doshi SD,Abt P,Bloom R,Blumberg E,Kulkarni S,Esnaola G,Shults J,Thiessen C,Reese PP

    更新日期:2018-04-01 00:00:00

  • Defining a Willingness-to-transplant Threshold in an Era of Organ Scarcity: Simultaneous Liver-kidney Transplant as a Case Example.

    abstract:BACKGROUND:Organ scarcity continues in solid organ transplantation, such that the availability of organs limits the number of people able to benefit from transplantation. Medical advancements in managing end-stage organ disease have led to an increasing demand for multiorgan transplant, wherein a patient with multiorga...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000002788

    authors: Cheng XS,Goldhaber-Fiebert J,Tan JC,Chertow GM,Kim WR,Wall AE

    更新日期:2020-02-01 00:00:00

  • Glomerular sclerosis in a renal isograft and identical twin donor. A family study.

    abstract::Loss of renal mass has been associated with the development of glomerular sclerosis in animals and human beings. The pathophysiology of this renal injury is unknown, but glomerular sclerosis in animals can be aggravated or accelerated following exposure to nephrotoxic antibodies, puromycin aminoglycoside or renal irra...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198410000-00006

    authors: Parfrey PS,Hollomby DJ,Gilmore NJ,Knaack J,Schur PH,Guttmann RD

    更新日期:1984-10-01 00:00:00

  • Multiple donor allotransplantation. A new approach to pancreatic islet transplantation.

    abstract::Currently it is not feasible to isolate sufficient numbers of islets from a single pancreas for clinical transplantation. We examined whether small numbers of islets obtained from multiple donors could be used for transplantation. Islets were isolated from four inbred strains of mice (DBA/2, DBA/1, C3H, and A.SW) by a...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Gotoh M,Porter J,Kanai T,Monaco AP,Maki T

    更新日期:1988-06-01 00:00:00

  • Factors influencing T-lymphopoiesis after allogeneic hematopoietic cell transplantation.

    abstract::In adult recipients of allogeneic hematopoietic cell transplants (HCT) studied at 1 year after grafting, there was a significant correlation between the counts of T cell receptor excision circle (TREC)-containing CD4 T cells (presumed recent thymic emigrants) and the counts of total T cells (r=0.65, P<0.001). Thus, th...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200204150-00026

    authors: Storek J,Joseph A,Dawson MA,Douek DC,Storer B,Maloney DG

    更新日期:2002-04-15 00:00:00

  • The clinical impact of chronic transplant glomerulopathy in cyclosporine era.

    abstract:BACKGROUND:The clinical impact of chronic transplant glomerulopathy (CTG) on the outcome of kidney allograft receiving calcineurin inhibitors (CNIs) remains uncertain. A retrospective study of renal transplant recipients at Ospedale Maggiore of Milan was undertaken to evaluate the clinical outcome of patients with CTG....

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000181167.88133.d2

    authors: Banfi G,Villa M,Cresseri D,Ponticelli C

    更新日期:2005-11-27 00:00:00

  • Living-related donor renal transplantation in HIV+ recipients using alemtuzumab preconditioning and steroid-free tacrolimus monotherapy: a single center preliminary experience.

    abstract:BACKGROUND:End-stage renal disease (ESRD) is an increasing problem in patients infected with the human immunodeficiency virus (HIV). The use of highly active antiretroviral therapy (HAART) has decreased the morbidity associated with HIV and has prompted renewed interest in renal transplantation. METHODS:We performed f...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000145880.38548.0d

    authors: Tan HP,Kaczorowski DJ,Basu A,Khan A,McCauley J,Marcos A,Fung JJ,Starzl TE,Shapiro R

    更新日期:2004-12-15 00:00:00

  • CORM-401 Reduces Ischemia Reperfusion Injury in an Ex Vivo Renal Porcine Model of the Donation After Circulatory Death.

    abstract:BACKGROUND:Carbon monoxide (CO) inhalation protects organ by reducing inflammation and cell death during transplantation processes in animal model. However, using CO in clinical transplantation is difficult due to its delivery in a controlled manner. A manganese-containing CO releasing molecules (CORM)-401 has recently...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000002201

    authors: Bhattacharjee RN,Richard-Mohamed M,Sun Q,Haig A,Aboalsamh G,Barrett P,Mayer R,Alhasan I,Pineda-Solis K,Jiang L,Alharbi H,Saha M,Patterson E,Sener A,Cepinskas G,Jevnikar AM,Luke PPW

    更新日期:2018-07-01 00:00:00

  • Outcome, incidence, and timing of infectious complications in small bowel and multivisceral organ transplantation patients.

    abstract:BACKGROUND:Infectious complications still represent a major cause of morbidity and mortality in patients with organ transplantation. In particular, small bowel or multivisceral transplantation is complicated to a greater extent than other grafts as a consequence of infectious complications including sepsis. METHODS:Th...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000185622.91708.57

    authors: Guaraldi G,Cocchi S,Codeluppi M,Di Benedetto F,De Ruvo N,Masetti M,Venturelli C,Pecorari M,Pinna AD,Esposito R

    更新日期:2005-12-27 00:00:00

  • OKT3 rescue for steroid-resistant rejection in adult liver transplantation.

    abstract::The results of OKT3 use for steroid-resistant rejection rescue in adult liver transplantation were analyzed retrospectively from a single transplant center. Comparison was made with concurrent patients who had no rejection (NR) or steroid-responsive rejections (SR). The records of 290 patients who underwent 323 liver ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199301000-00017

    authors: Solomon H,Gonwa TA,Mor E,Holman MJ,Gibbs J,Watemberg I,Netto G,Goldstein RM,Husberg BS,Klintmalm GB

    更新日期:1993-01-01 00:00:00

  • Prolongation of allograft survival by combination therapy with anti-thymocyte serum and anti-immunoglobulin.

    abstract::Heterologous anti-immunoglobulin (AI) is a potent immunosuppressive agent which compares favorably to anti-thymocyte serum (ATS) in inhibiting E and EAC-rosette formation and diminishing the secondary antibody response to sheep erythrocytes and E. coli lipopolysaccharide. AI prolongs H-2 incompatible skin allograft su...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-197609000-00003

    authors: Constantian MB,Couser WG,French PJ,Davis RC

    更新日期:1976-09-01 00:00:00

  • The Outcomes of Portal Vein Reconstruction With Vein Graft Interposition in Pediatric Liver Transplantation for Small Children With Biliary Atresia.

    abstract:BACKGROUND:Several technical modifications in portal vein (PV) reconstruction have shown excellent outcomes in pediatric liver transplantation (LT); however, which procedure is the best for PV reconstruction of the hypoplastic PV in pediatric LT remains unclear. METHODS:One hundred sixteen pediatric patients aged 1 or...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000002793

    authors: Sakamoto S,Uchida H,Kitajima T,Shimizu S,Yoshimura S,Takeda M,Hirata Y,Fukuda A,Kasahara M

    更新日期:2020-01-01 00:00:00

  • Predictors of graft survival in pediatric living-related kidney transplant recipients.

    abstract:BACKGROUND:A successful kidney transplant from a living-related donor (LRD) remains the most effective renal replacement therapy for children with end-stage renal failure. The use of LRD kidneys results in decreased time on dialysis, increased graft survival, and better function compared with kidneys transplanted from ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200007270-00008

    authors: Ishitani M,Isaacs R,Norwood V,Nock S,Lobo P

    更新日期:2000-07-27 00:00:00

  • Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells.

    abstract::Beta cell replacement has the potential to restore euglycemia in patients with insulin-dependent diabetes. Although great progress has been made in establishing allogeneic islet transplantation from deceased donors as the standard of care for those with the most labile diabetes, it is also clear that the deceased dono...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/TP.0000000000002217

    authors: Odorico J,Markmann J,Melton D,Greenstein J,Hwa A,Nostro C,Rezania A,Oberholzer J,Pipeleers D,Yang L,Cowan C,Huangfu D,Egli D,Ben-David U,Vallier L,Grey ST,Tang Q,Roep B,Ricordi C,Naji A,Orlando G,Anderson DG,P

    更新日期:2018-08-01 00:00:00

  • Psychiatric care of patients undergoing organ transplantation.

    abstract::Transplantation provides life-saving therapy to critically ill patients with end-stage organ failure. We found that the specialized knowledge of mental health clinicians and physicians, committed to the evaluation and management of transplant recipients, is essential for the optimal care of these patients who require ...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/TP.0b013e3181a754d4

    authors: Surman OS,Cosimi AB,DiMartini A

    更新日期:2009-06-27 00:00:00

  • Use of donor beta 2-microglobulin-deficient transgenic mouse liver cells for isografts, allografts, and xenografts.

    abstract::Donor graft major histocompatibility complex class I antigens are targets for both allogeneic and xenogeneic rejection. Mice homozygous for beta 2-microglobulin gene disruption express reduced amounts of surface MHC class I antigens. Liver cells from such mutant mice were transplanted into isogeneic, allogeneic, and x...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199304000-00046

    authors: Li X,Faustman D

    更新日期:1993-04-01 00:00:00

  • Post hoc analyses: after the facts.

    abstract::Prospective clinical trials are constructed with high levels of internal validity. Sample size and power considerations usually address primary endpoints. Primary endpoints have traditionally included events that are becoming increasingly less common and thus have led to growing use of composite endpoints and noninfer...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/TP.0000000000000581

    authors: Srinivas TR,Ho B,Kang J,Kaplan B

    更新日期:2015-01-01 00:00:00

  • Malignant disease in renal transplant patients.

    abstract::The incidence of malignant disease (renal cancer and skin cancer excluded) was analyzed in 934 renal transplant patients from one center, transplanted between 1965 and 1981, and followed through 1983. National Cancer Registry data were used for statistical comparison. Cancers of the lip, vulva, and anus and malignant ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Blohmé I,Brynger H

    更新日期:1985-01-01 00:00:00

  • Hyperexpression of Foxp3 and IDO during acute rejection of islet allografts.

    abstract:BACKGROUND:We investigated the hypothesis that Foxp3+ cells are an integral component of antiallograft immunity but are dominated by pathogenic effectors. METHODS:Wild-type H-2b C57BL/6 (B6) mice or B6 mice with a targeted disruption of c-Rel gene (c-Rel-/-) were used as recipients of islet grafts from allogeneic DBA/...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000263991.74052.46

    authors: Yang H,Ding R,Sharma VK,Hilaire FS,Lagman M,Li B,Thomas DA,Luo X,Song P,Stauffer C,August P,Suthanthiran M

    更新日期:2007-06-27 00:00:00

  • Regulatory T cells: potential in organ transplantation.

    abstract::Active regulation or suppression of donor reactive cells is emerging as a key mechanism for inducing and maintaining unresponsiveness to donor alloantigens. Accumulating evidence suggests that a balance between immunoregulation and deletion of donor alloantigen reactive T cells can provide effective control of immune ...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/01.TP.0000106477.70852.29

    authors: Wood KJ,Luo S,Akl A

    更新日期:2004-01-15 00:00:00

  • Optimal Outcomes in Young Class 3 Patients With Thalassemia Undergoing HLA-Identical Sibling Bone Marrow Transplantation.

    abstract:BACKGROUND:Bone marrow transplantation (BMT) for class 3 patients with thalassemia is challenging due to high rates of graft rejection and transplant-related mortality. Since the first studies of BMT in the late 1980s, a number of conditioning regimens have been designed to improve outcomes, but with suboptimal results...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000000928

    authors: Gaziev J,Isgrò A,Sodani P,Marziali M,Paciaroni K,Gallucci C,De Angelis G,Andreani M,Testi M,Alfieri C,Ribersani M,Galluccio T,Battarra MR,Morrone A,Lucarelli G

    更新日期:2016-04-01 00:00:00

  • Clinicopathologic features of graft rejection of the first human hand allograft.

    abstract:BACKGROUND:The first human hand allograft, performed in Lyon, France, on September 23, 1998, was removed during month 29 posttransplantation as the result of rejection because the patient did not comply with the immunosuppressive treatment. METHODS:The patient was regularly examined from the day of transplantation to ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000079458.81970.9A

    authors: Kanitakis J,Jullien D,Petruzzo P,Hakim N,Claudy A,Revillard JP,Owen E,Dubernard JM

    更新日期:2003-08-27 00:00:00

  • Risk factors for liver transplantation across the ABO barrier.

    abstract::A retrospective study was performed to identify risk factors affecting the fate of liver allografts transplanted across the ABO barrier. Over a 5-year period, 30 patients received 31 emergency OLTs with ABO-incompatible allografts. One-year graft and patient survival rates were 37.1% and 48.4%, respectively. This grou...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199409150-00003

    authors: Lo CM,Shaked A,Busuttil RW

    更新日期:1994-09-15 00:00:00

  • Comparison of pulsatile perfusion and cold storage for paired kidney allografts.

    abstract::Use of pulsatile perfusion to optimize outcomes in deceased donor kidney transplantation remains controversial. This study is a retrospective analysis of all cadaveric renal allografts procured locally by our center over a 3-year period. Kidney pairs were identified in which one kidney underwent pulsatile perfusion an...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e318187b978

    authors: Shah AP,Milgrom DP,Mangus RS,Powelson JA,Goggins WC,Milgrom ML

    更新日期:2008-10-15 00:00:00

  • Basic anatomical and physiological differences between species should be considered when choosing combinations for use in models of hepatic xenotransplantation: an investigation of the guinea pig-to-rat combination.

    abstract::Published data on the guinea pig-to-rat hepatic xenotransplant model describe problems concerning poor graft reperfusion. To further investigate this phenomenon, orthotopic liver xenotransplantation between weight-matched guinea pigs and rats were performed using Kamada's technique. On reperfusion, all cases had porta...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199807150-00017

    authors: Delriviere LD,Havaux X,Gibbs P,Gianello PR

    更新日期:1998-07-15 00:00:00

  • Parenchymal liver injury in orthotopic liver transplantation.

    abstract:BACKGROUND:A 35-year period of clinical development resulted in orthotopic liver transplantation (OLT) becoming a standardized surgical procedure. Despite this progress, the rate of technical complications is still high. Although the main problem in most analyses is vascular or bile duct failure, we observed a remarkab...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200005270-00018

    authors: Soliman T,Langer F,Puhalla H,Pokorny H,Grunberger T,Berlakovich GA,Langle F,Muhlbacher F,Steininger R

    更新日期:2000-05-27 00:00:00

  • Alterations in chemokine receptor CCR5 expression on blood dendritic cells correlate with acute graft-versus-host disease.

    abstract:BACKGROUND:Dendritic cells (DC) are important in the development of acute graft-versus-host disease (GVHD) after allogeneic hemopoietic cell transplantation (alloHCT). The trafficking of immature DC from blood to GVHD target organs is likely to be regulated by chemokine receptors. METHODS:We performed flow cytometry t...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31829e6d5b

    authors: Shahin K,Sartor M,Hart DN,Bradstock KF

    更新日期:2013-10-27 00:00:00

  • Accept or Decline? An Analytics-Based Decision Tool for Kidney Offer Evaluation.

    abstract:BACKGROUND:When a deceased-donor kidney is offered to a waitlisted candidate, the decision to accept or decline the organ relies primarily upon a practitioner's experience and intuition. Such decisions must achieve a delicate balance between estimating the immediate benefit of transplantation and the potential for futu...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000001824

    authors: Bertsimas D,Kung J,Trichakis N,Wojciechowski D,Vagefi PA

    更新日期:2017-12-01 00:00:00

  • Continuous venovenous hemofiltration with dialysis in combination with total hepatectomy and portocaval shunting. Bridge to liver transplantation.

    abstract::Children who experience acute liver failure following liver transplantation will have multiple organ failure and a high rate of mortality unless emergency retransplantation can be performed. Transplant hepatectomy with portocaval shunting has been described as a bridge to transplantation in the most severe cases, as w...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199607150-00026

    authors: Hammer GB,So SK,Al-Uzri A,Conley SB,Concepcion W,Cox KL,Berquist WE,Esquivel CO

    更新日期:1996-07-15 00:00:00

  • Results of a prospective randomized trial of sirolimus conversion in kidney transplant recipients on early corticosteroid withdrawal.

    abstract:BACKGROUND:The use of calcineurin inhibitors is associated with chronic nephrotoxicity and lower glomerular filtration rate (GFR). As a result, one strategy of transplant immunosuppression is calcineurin inhibitor elimination. METHODS:The aim of this study was to determine the outcome of a prospective randomized trial...

    journal_title:Transplantation

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/TP.0b013e31822805d7

    authors: Heilman RL,Younan K,Wadei HM,Mai ML,Reddy KS,Chakkera HA,Gonwa TA

    更新日期:2011-10-15 00:00:00