Alteration in CD45RBhi/CD45RBlo T-cell ratio following CD45RB monoclonal-antibody therapy occurs by selective deletion of CD45RBhi effector cells.

abstract：BACKGROUND:Donor hepatectomy and liver implantation time reduce long-term graft and patient survival after liver transplantation. It is not known whether these surgical times influence early outcomes after liver transplantation. METHODS:This single-center study evaluated the effect of donor hepatectomy and implantatio...

journal_title：Transplantation

authors： Gilbo N,Fieuws S,Meurisse N,Nevens F,van der Merwe S,Laleman W,Verslype C,Cassiman D,van Malenstein H,Roskams T,Sainz-Barriga M,Pirenne J,Jochmans I,Monbaliu D

更新日期：2020-05-28 00:00:00

abstract：:Data from 60 consecutive ABO-incompatible kidney transplantations performed in Stockholm, Sweden; Freiburg, Germany; and Uppsala, Sweden, revealed significant variation in preoperative A/B antibody levels, with median titers of 1:32, 1:128, and 1:8, respectively. We wanted to investigate whether these differences were...

journal_title：Transplantation

authors： Kumlien G,Wilpert J,Säfwenberg J,Tydén G

更新日期：2007-12-27 00:00:00

abstract：:Cell surface markers of isolated graft-infiltrating cells (GIC) were studied, and functional in vitro assays performed in 8 cases of acute irreversible rejection of human renal allografts. The GIC were mostly activated T cells (OKT11+, OKT3+, Ia+), with predominance of the cytotoxic/suppressor T cell phenotype (OKT8+)...

journal_title：Transplantation

authors： Charpentier BM,Bach MA,Lang P,Martin B,Fries D

更新日期：1987-07-01 00:00:00

abstract：:The interactions of rapamycin (Rapa), CsA, and donor-specific transfusion (DST) were examined in an ACI to Lewis rat heterotopic cardiac allograft model. Survival data were truncated at 175 days for the purpose of statistical comparisons. Vehicle (Veh)-treated animals rejected at a mean of 7.3 +/- 0.2 days. Treatment ...

journal_title：Transplantation

authors： Davies CB,Madden RL,Alexander JW,Cofer BR,Fisher RA,Anderson P

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:Few studies have examined the effectiveness of a risk-stratified approach to screening kidney transplantation candidates for ischemic heart disease (IHD). METHODS:We retrospectively reviewed records from all adult patients (n = 514) placed on the deceased donor kidney transplantation waiting list at a singl...

journal_title：Transplantation

authors： Kasiske BL,Malik MA,Herzog CA

更新日期：2005-09-27 00:00:00

abstract：:Until recently, islet allotransplantation for type 1 diabetic patients has been largely unsuccessful. Previous pharmacologic studies of single drugs have suggested that one factor contributing to this poor success is toxicity of immunosuppressive drugs on transplanted islets. However, no comprehensive study of agents ...

journal_title：Transplantation

authors： Paty BW,Harmon JS,Marsh CL,Robertson RP

更新日期：2002-02-15 00:00:00

abstract：BACKGROUND:Suppressive dendritic cells (DCs) are a promising tool for tolerance induction in transplantation. A human DCs subpopulation, which constitutively expresses indoleamine-2,3-dioxygenase (IDO), a molecule shown to prevent the rejection of fetus during pregnancy, has recently been described. This subset, charac...

journal_title：Transplantation

authors： Löb S,Ebner S,Wagner S,Weinreich J,Schäfer R,Königsrainer A

更新日期：2007-02-27 00:00:00

abstract：:Most alloreactive T cells specifically recognize peptides bound to donor MHC molecules. In addition to peptides, solvent accessible MHC residues also may stimulate alloreactive T cells. We studied T cell receptor (TCR) usage by 16 independent anti-HLA-B7 alloreactive cytolytic T lymphocyte (CTL) clones. Most or all of...

journal_title：Transplantation

authors： Li YY,Smith KD,Shi Y,Lutz CT

更新日期：1996-10-15 00:00:00

abstract：BACKGROUND:There is a lack of information about survival after dropout from the liver transplant waiting list. Therefore, we aimed to assess the overall survival, and risk factors for death, after waiting list dropout due to hepatocellular carcinoma (HCC) progression. METHODS:We assessed patients who dropped out of th...

journal_title：Transplantation

authors： Gorgen A,Rosales R,Sadler E,Beecroft R,Knox J,Dawson LA,Ghanekar A,Grant D,Greig PD,Sapisochin G

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Organ transplantation has been successfully practiced for decades, but the outcome of cell transplantation remains disappointing. This is the case in animal models; liver allografts in mice are spontaneously accepted without requirement of immunosuppression, whereas hepatocyte transplants in the same combina...

journal_title：Transplantation

authors： Jiang G,Yang HR,Wang L,Wildey GM,Fung J,Qian S,Lu L

更新日期：2008-12-15 00:00:00

abstract：:CD4+ cells from CsA-treated DA rats with long-surviving PVG heart allografts specifically suppress the capacity of naive CD4+ cells to restore allograft rejection in irradiated DA rats, but have normal donor-specific alloreactivity in MLC. CD4+ suppressor cells from CsA-treated DA rats cultured for 3 days against eith...

journal_title：Transplantation

authors： Pearce NW,Spinelli A,Gurley KE,Hall BM

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:Primary hyperoxaluria is a rare autosomal recessive metabolic disease that often progresses to end-stage renal disease (ESRD). Liver transplantation is curative for patients with the alanine: glyoxylate aminotransferase deficiency. For oxalosis patients with minor enzyme deficiencies, renal transplantation m...

journal_title：Transplantation

authors： Cibrik DM,Kaplan B,Arndorfer JA,Meier-Kriesche HU

更新日期：2002-09-15 00:00:00

abstract：:There is increasing evidence that various maturational stages of B-cells infiltrate various solid organ transplants undergoing acute rejection. The presence of immature CD20 and mature CD138 plasma cells associate with more aggressive and steroid-recalcitrant graft rejection and portend poor graft outcomes. Though ass...

journal_title：Transplantation

authors： Zarkhin V,Li L,Sarwal M

更新日期：2008-06-27 00:00:00

abstract：:If ABO antigens/antibodies play any role in the pathogenesis of acute graft-versus-host disease (GVHD), one would expect the highest incidence of GVHD in recipients of minor ABO-mismatched grafts, followed by ABO-matched grafts, and the lowest incidence in major ABO-mismatched transplants. To test this hypothesis 174 ...

journal_title：Transplantation

authors： Bacigalupo A,Van Lint MT,Occhini D,Margiocco M,Ferrari G,Pittaluga PA,Frassoni F,Peralvo J,Lercari G,Carubia F

更新日期：1988-06-01 00:00:00

abstract：:We examined the cytokine profiles associated with tolerance and rejection using the mouse model of neonatal tolerance. BALB/c mice primed with CAF1 splenocytes during the neonatal stage showed increased A/J skin graft survival of > 60 days and failed to develop anti-A/J cytotoxic responses, but rejected third-party C5...

journal_title：Transplantation

authors： Chen N,Field EH

更新日期：1995-04-15 00:00:00

abstract：BACKGROUND:Endothelial dysfunction (ED) has a major role in the cardiovascular outcome of patients with chronic kidney disease (CKD). The aim of this study was to investigate the relation between fetuin A levels and ED in kidney transplant recipients. METHODS:Forty-two living donor kidney transplant recipients, 21 (11...

journal_title：Transplantation

authors： Caglar K,Yilmaz MI,Saglam M,Cakir E,Kilic S,Eyileten T,Sonmez A,Oguz Y,Oner K,Ors F,Vural A,Yenicesu M

更新日期：2007-02-27 00:00:00

abstract：BACKGROUND:More than 30% of potential kidney transplant recipients have pre-existing anti-human leukocyte antigen antibodies. This subgroup has significantly lower transplant rates and increased mortality. Desensitization has become an important tool to overcome this immunological barrier. However, limited data is avai...

journal_title：Transplantation

authors： Riella LV,Safa K,Yagan J,Lee B,Azzi J,Najafian N,Abdi R,Milford E,Mah H,Gabardi S,Malek S,Tullius SG,Magee C,Chandraker A

更新日期：2014-06-27 00:00:00

abstract：:In this report we describe a modified, sensitive MLR test that appears to detect fine antigenic disparities between HLA-identical siblings confirmed as such by serology and the standard MLR test. In a group of 40 consecutive allogeneic bone marrow transplants, reactivity detected by the modified MLR test correlated wi...

journal_title：Transplantation

authors： Bishara A,Brautbar C,Nagler A,Slavin S,Leshem B,Cohen I,Kedar E

更新日期：1994-05-27 00:00:00

abstract：:A panel of ethicists, organ procurement organization executives, physicians, and surgeons was convened by the sponsorship of the American Society of Transplant Surgeons to determine whether an ethically acceptable pilot trial could be proposed to provide a financial incentive for a family to consent to the donation of...

journal_title：Transplantation

authors： Arnold R,Bartlett S,Bernat J,Colonna J,Dafoe D,Dubler N,Gruber S,Kahn J,Luskin R,Nathan H,Orloff S,Prottas J,Shapiro R,Ricordi C,Youngner S,Delmonico FL

更新日期：2002-04-27 00:00:00

abstract：:The cytotoxicity of tumour-bearer serum against a transplanted aminoazodye-induced rat hepatoma was revealed using normal rat serum as the source of complement as assessed using a short-term 51Cr release test. The tumour-bearing rat was not deficient in a functional complement system and direct cytolysis against hepat...

journal_title：Transplantation

authors： Price MR,Höffken K,Baldwin RW

更新日期：1979-08-01 00:00:00

abstract：BACKGROUND:The influence of recipient body mass index (BMI) on pediatric-donor kidney transplant outcomes is unclear. We aimed to determine graft survival and functional outcomes of pediatric-donor kidneys compared with adult kidneys stratified by recipient BMI group. METHODS:Scientific Registry of Transplant Recipien...

journal_title：Transplantation

authors： Kayler LK,Zendejas I,Gregg A,Wen X

更新日期：2012-02-27 00:00:00

abstract：BACKGROUND:The purpose of this study is to examine the effects of the coronavirus disease 2019 (COVID-19) pandemic on adult lung transplants and report practice changes in the United States. METHODS:A retrospective analysis of a public dataset from the United Network for Organ Sharing was performed regarding adult lun...

journal_title：Transplantation

authors： Chan EG,Chan PG,Harano T,Ryan JP,Morrell MR,Sanchez PG

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Bronchiolitis obliterans syndrome (BOS) is the leading cause of late mortality after lung transplantation. METHODS:We added azithromycin (AZI) (250 mg/day for 5 days, followed by 250 mg every other day) to the current immunosuppressive therapy in eight lung transplant recipients (mean age 36 years) with est...

journal_title：Transplantation

authors： Verleden GM,Dupont LJ

更新日期：2004-05-15 00:00:00

abstract：BACKGROUND:Liver transplant recipients suffer many postoperative complications. Few studies evaluated the effects of fluid management on these complications. We conducted an observational cohort study to evaluate the association between intraoperative fluid balance and postoperative acute kidney injury (AKI) and other ...

journal_title：Transplantation

authors： Carrier FM,Chassé M,Sylvestre MP,Girard M,Legendre-Courville L,Massicotte L,Bilodeau M

更新日期：2020-07-01 00:00:00

abstract：:The combination of pharmacokinetic and pharmacodynamic (measurement of the biological effect) monitoring of immunosuppressive drugs provides a method for the optimization of drug dosing. We chose to investigate this using mycophenolic acid (MPA), an immunosuppressive drug that mediates its effect by the inhibition of ...

journal_title：Transplantation

authors： Langman LJ,Shapiro AM,Lakey JR,LeGatt DF,Kneteman NM,Yatscoff RW

更新日期：1996-01-15 00:00:00

abstract：:Loss of bile ducts is a characteristic feature of chronic rejection in the liver allograft (also known as irreversible rejection and vanishing bile-duct syndrome). Typically, this occurs as a progressive lesion resulting in irreversible damage and graft failure requiring retransplantation. In this study, we describe 6...

journal_title：Transplantation

authors： Hubscher SG,Buckels JA,Elias E,McMaster P,Neuberger J

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:This study addresses the question of the mechanism for maintaining tolerance to donor alloantigen in the absence of antigen and the role of secondary lymphoid tissues. METHODS:Depleting anti-CD4 antibody administration in conjunction with allogeneic heart transplantation generates donor-specific operational...

journal_title：Transplantation

authors： Chosa E,Hara M,Watanabe A,Matsuzaki Y,Nakamura K,Hamano K,Wood KJ,Onitsuka T

更新日期：2007-05-15 00:00:00

abstract：BACKGROUND:The use of calcineurin inhibitors is associated with chronic nephrotoxicity and lower glomerular filtration rate (GFR). As a result, one strategy of transplant immunosuppression is calcineurin inhibitor elimination. METHODS:The aim of this study was to determine the outcome of a prospective randomized trial...

journal_title：Transplantation

authors： Heilman RL,Younan K,Wadei HM,Mai ML,Reddy KS,Chakkera HA,Gonwa TA

更新日期：2011-10-15 00:00:00

abstract：OBJECTIVE:The purpose of this study was to identify pretransplantation and posttransplantation indicators for the development of diabetes mellitus in the first 2 months after renal transplantation and to examine the influence of a cyclosporine A (CsA)-based versus a tacrolimus-based immunosuppressive regimen on these r...

journal_title：Transplantation

authors： Sato T,Inagaki A,Uchida K,Ueki T,Goto N,Matsuoka S,Katayama A,Haba T,Tominaga Y,Okajima Y,Ohta K,Suga H,Taguchi S,Kakiya S,Itatsu T,Kobayashi T,Nakao A

更新日期：2003-11-15 00:00:00

abstract：BACKGROUND:To better understand how different histologic patterns of allograft inflammation found on biopsies of human cardiac allografts progress to high-grade rejection, we undertook a statistical analysis of our institutional database to detect statistical patterns among different types of myocardial allograft infla...

journal_title：Transplantation

authors： Smith RN,Chang Y,Houser S,Dec GW,Grazette L

更新日期：2002-06-27 00:00:00