Liver transplantation for alcoholic cirrhosis: long term follow-up and impact of disease recurrence.

abstract：BACKGROUND:Abrupt temperature shift from hypothermia to normothermia incurred on reperfusion of organ grafts has been delineated as a genuine factor contributing to reperfusion injury and graft dysfunction after transplantation. METHODS:In a first clinical series of 6 patients, cold-stored livers, all allocated by the...

journal_title：Transplantation

authors： Hoyer DP,Mathé Z,Gallinat A,Canbay AC,Treckmann JW,Rauen U,Paul A,Minor T

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The vast majority of polyomavirus nephropathy (PVN) are due to BK virus, but rare cases result from JC virus reactivation. To date, only a handful of biopsy-proven JC-PVN cases have been reported. Here, we describe the clinical and pathologic findings in 7 patients with biopsy-proven JC-PVN. METHODS:Search ...

journal_title：Transplantation

authors： Wiegley N,Walavalkar V,Aujla H,Chen LX,Huang Y,Lee BK,Jen KY

更新日期：2020-06-17 00:00:00

abstract：BACKGROUND:Finding the best combination of immunosuppression is an important challenge in kidney transplantation. Current short-term (1- and 3-year) allograft survival is quite good, making it difficult to determine differences in therapeutic regimens without large sample sizes. Using data from the United Network for O...

journal_title：Transplantation

authors： Cherikh WS,Myron Kauffman H,Maghirang J,Bleyer AJ,Johnson CP

更新日期：2003-08-15 00:00:00

abstract：BACKGROUND:Apoptosis has been identified after ischemia-reperfusion (IR) injury to the brain, heart, kidney, retina, and the adrenals. Intestinal IR injury causes villous and crypt damage, which has so far been attributed to cellular necrosis. This study was undertaken to investigate the possible role of apoptosis afte...

journal_title：Transplantation

authors： Shah KA,Shurey S,Green CJ

更新日期：1997-11-27 00:00:00

abstract：:Thirteen renal allograft recipients (6 patients on cyclosporine/7 patients on azathioprine) participated in a short-term oral protein-loading study to determine the effect of cyclosporine on an allograft's functional reserve. The baseline glomerular filtration rate of the two groups were similar (52 +/- 18 ml/min/1.73...

journal_title：Transplantation

authors： Nunley JR,King A,Comstock T,Posner M,Marshall C,Sica DA

更新日期：1991-01-01 00:00:00

abstract：:T cells play an important role in protective immunity against tuberculosis. As patients are not reimmunized with BCG after BMT, the question arises as to whether PPD-specific memory T cells are transferred from the marrow donor to the recipient and persist in the long-term. We studied long-term survivors of non-T cell...

journal_title：Transplantation

authors： Rouleau M,Senik A,Leroy E,Vernant JP

更新日期：1993-01-01 00:00:00

abstract：:To determine the extent to which pretransplant immunity resulting from natural infection protects against cytomegalovirus (CMV) disease, we analyzed CMV serology on 153 kidney donor and recipient pairs and followed transplant patients to determine incidence and severity of CMV disease. The overall incidence of CMV dis...

journal_title：Transplantation

authors： Smiley ML,Wlodaver CG,Grossman RA,Barker CF,Perloff LJ,Tustin NB,Starr SE,Plotkin SA,Friedman HM

更新日期：1985-08-01 00:00:00

abstract：:Infectious complications in patients with recurrent hepatitis C virus (HCV) hepatitis after liver transplantation were prospectively assessed and compared with those of all other liver transplant recipients without HCV hepatitis operated on during the same period. Major infections occurred in 64% (14/22) of the patien...

journal_title：Transplantation

authors： Singh N,Gayowski T,Wagener MM,Marino IR

更新日期：1996-02-15 00:00:00

abstract：:Sera were obtained from 48 gravida II prenatal and 211 multiparous nonpregnant females and examined for leukocyte antibodies comparing a standard lymphocytotoxicity (CY) test with capillary agglutination (CA). Antibody was detected in 41% of the samples in both groups but only CA tests were positive with approximately...

journal_title：Transplantation

authors： Thompson JS,Jackson D,Greazel NA,Parmely MJ,Severson CD

更新日期：1976-02-01 00:00:00

abstract：BACKGROUND:It has been postulated that chimerism after transplantation might promote graft acceptance. In the present study, we prospectively assessed blood chimerism in 10 lung transplant recipients during the first posttransplant year and investigated whether chimerism was associated with an immunologically stable si...

journal_title：Transplantation

authors： Knoop C,Andrien M,Defleur V,Antoine M,de Francquen P,Goldman M,Estenne M

更新日期：1997-07-15 00:00:00

abstract：BACKGROUND:After cold ischemia, electrons transferred in the electron transport chain may leak out of the mitochondria in proportion to the deterioration of mitochondrial oxidative phosphorylation. This seems to be one major cause of the lipid peroxidation that occurs mainly in the hepatocytes at reperfusion in liver t...

journal_title：Transplantation

authors： Ohkohchi N,Endoh T,Oikawa K,Seya K,Satomi S

更新日期：1999-04-27 00:00:00

abstract：:Survival times of allogeneic fetal pancreases were determined across various immunogenetic barriers using several inbred rat strains. Pancreases from 17-day-old embryos transplanted beneath the kidney capsule of normal, nonimmunosuppressed recipients were richly vascularized within a short period regardless of histoin...

journal_title：Transplantation

authors： Mullen Y,Shintaku IP

更新日期：1980-01-01 00:00:00

abstract：:To determine the importance of static lung inflation during storage, graft performance was evaluated at different levels of intratracheal pressure and varying ischemic intervals. Lewis rat lungs were perfused with low-potassium Euro-Collins and stored for 4 or 8 hr either in atelectasis (4 hr: group I; 8 hr: group IV,...

journal_title：Transplantation

authors： Hausen B,Ramsamooj R,Hewitt CW,Schroder F,Beuke M,Poets CF,Schafers HJ

更新日期：1996-12-27 00:00:00

abstract：:Ninety-eight renal transplant recipients who had been followed for 1-6.5 years (median 3.2 years) were reviewed to determine the effect of donor and recipient hepatitis B surface antigen status on the incidence of hepatitis and on patient survival. The cumulative risk of developing hepatitis posttransplant was signifi...

journal_title：Transplantation

authors： Chan PC,Lok AS,Cheng IK,Chan MK

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:During the isolation process, pancreatic islets are exposed to an environment of sterile inflammation resulting in an upregulated inflammatory state before transplantation. Toll-like receptor 4 (TLR4) has been identified as a major mediator of sterile inflammation. Therefore, we sought to determine whether e...

journal_title：Transplantation

authors： Chang CA,Murphy K,Kane RR,Lawrence MC,Naziruddin B

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Recurrent hepatitis C virus (HCV) after liver transplantation (OLT) is a major cause of graft loss in HCV-positive patients. In this study, we evaluated the efficacy and safety of pegylated interferon alfa-2b (peginterferon) and ribavirin treatment for recurrent HCV after OLT and analyzed the influence of an...

journal_title：Transplantation

authors： Neumann U,Puhl G,Bahra M,Berg T,Langrehr JM,Neuhaus R,Neuhaus P

更新日期：2006-07-15 00:00:00

abstract：:The development of allospecific cellular immunity during acute rat renal allograft rejection parallels alterations occurring in arachidonic acid metabolism, including increased production of the vasoconstrictor eicosanoid thromboxane A2 (TxA2). We have previously demonstrated that chronic inhibition of thromboxane syn...

journal_title：Transplantation

authors： Ruiz P,Coffman TM,Klotman PE,Sanfilippo F

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND:Although graft local infusion (GLI) treatment via the portal vein or the hepatic artery has been the pivotal strategy in ABO incompatible (ABOi) living donor liver transplantation (LDLT) in Japan, the procedure is associated with a high rate of catheter-associated complications. METHODS:A new ABOi-LDLT prot...

journal_title：Transplantation

authors： Ikegami T,Taketomi A,Soejima Y,Yoshizumi T,Uchiyama H,Harada N,Iguchi T,Hashimoto N,Maehara Y

更新日期：2009-08-15 00:00:00

abstract：BACKGROUND:Hyperacute rejection (HAR) of pig-to-primate discordant xenografts is caused by the deposition of preexisting natural antibodies that recognize Galalpha1-3Gal (alphaGal)-terminating oligosaccharides on glycoproteins and glycolipids, followed by complement-mediated lysis of the graft's endothelium. In vitro, ...

journal_title：Transplantation

authors： Simon PM,Neethling FA,Taniguchi S,Goode PL,Zopf D,Hancock WW,Cooper DK

更新日期：1998-02-15 00:00:00

abstract：:When normal mice are exposed for short periods to ultraviolet light (UV), they support the progressive growth of transplanted syngeneic UV-induced tumors. Normal nonirradiated mice almost always reject these tumor implants. The UV-mediated suppression of the antitumor response can be adoptively transferred to normal s...

journal_title：Transplantation

authors： Spellman CW,Daynes RA

更新日期：1977-08-01 00:00:00

abstract：:Since chemotaxis is an important mechanism by which leukocytes are recruited to allografts during rejection, the effect of immunosuppressant agents on in vitro chemotactic responses of neutrophils, monocytes, and lymphocytes was studied. Cyclosporine caused profound inhibition of lymphocyte chemotaxis to three differe...

journal_title：Transplantation

authors： Adams DH,Wang LF,Neuberger JM,Elias E

更新日期：1990-11-01 00:00:00

abstract：:Biliary tract problems remain an important cause of complication following orthotopic hepatic transplantation. We describe 12 liver transplantation patients who developed bile peritonitis secondary to a biliary leak after T tube removal. Each of these patients underwent an urgent ERCP that exhibited leakage outside th...

journal_title：Transplantation

authors： Ostroff JW,Roberts JP,Gordon RL,Ring EJ,Ascher NL

更新日期：1990-05-01 00:00:00

abstract：:A prospective study of intentional stopping of steroids 6 months after transplantation was done with 29 pediatric renal transplant recipients with a mean age of 10.4 +/- 3.4 years. Immunosuppression consisted of cyclosporine and methylprednisolone. We stopped giving MP to 24 children: to twenty after six months, four ...

journal_title：Transplantation

authors： Ghio L,Tarantino A,Edefonti A,Mocciaro A,Giani M,Guerra L,Berardinelli L,Vegeto A

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Graft vascular disease, a major cause of late graft failure in cardiac transplant patients, is associated with the presence of class II major histocompatibility complex molecules on the endothelium. 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors, e.g., simvastatin, have been shown to reduce the in...

journal_title：Transplantation

authors： Sadeghi MM,Tiglio A,Sadigh K,O'Donnell L,Collinge M,Pardi R,Bender JR

更新日期：2001-05-15 00:00:00

abstract：:In a three-year period between January 1980 and December 1982, 242 consecutive cadaver transplant recipients in one center were tested before transplantation by cytotoxicity against a random panel of T and B lymphocytes at 5 degrees C and 37 degrees C incubation. They were also tested for HLA-A, B, and DR antigens. Ki...

journal_title：Transplantation

authors： Mendez R,Chatterjee SN,Mendez R,Bogaard T

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND:The full potential of pancreatic islet transplantation (PIT) has not been realized because of the difficulties associated with islet isolation, particularly when associated with a remote islet isolation center. Herein, we describe the principles of pancreatic procurement for PIT, which have allowed us to ach...

journal_title：Transplantation

authors： Lee TC,Barshes NR,Brunicardi FC,Alejandro R,Ricordi C,Nguyen L,Goss JA

更新日期：2004-08-15 00:00:00

abstract：:Endothelial cells serve an important role in augmenting immune responses through enhanced expression of MHC class II antigens. Immune-mediated vascular injury associated with rejection requires reendothelialization to restore vascular integrity. The origin of the reparative endothelial cells can be determined when ABO...

journal_title：Transplantation

authors： O'Connell JB,Renlund DG,Bristow MR,Hammond EH

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND:The role of CD20+ B cells in renal allograft rejection has been reappreciated. Importantly, recent studies suggest a relation between CD20+ B cell aggregates and poorer clinical outcome. In the present study, we attempted to confirm these early reports in a tightly controlled patient population and to differ...

journal_title：Transplantation

authors： Scheepstra C,Bemelman FJ,van der Loos C,Rowshani AT,van Donselaar-Van der Pant KA,Idu MM,ten Berge IJ,Florquin S

更新日期：2008-09-27 00:00:00

abstract：:Tolerogen-specific alloreactivity, in the form of mixed lymphocyte responses and cell mediated lympholysis, was measured in vitro using lymphocytes from mice that received neonatal inoculations of H-2 semiallogeneic hematopoietic cells. It was found that depletion of specific alloreactivity, as detected by these assay...

journal_title：Transplantation

authors： Streilein JW,Strome P,Wood PJ

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND:The role of anti-human leukocyte antigen (HLA) donor-specific antibodies (DSA) detected by Luminex in the development of rejection is not fully understood. METHODS:A study including 369 patients who received transplants from deceased donors with a negative complement-dependent cytotoxicity crossmatch (XM) w...

journal_title：Transplantation

authors： Caro-Oleas JL,González-Escribano MF,Gentil-Govantes MÁ,Acevedo MJ,González-Roncero FM,Blanco GB,Núñez-Roldán A

更新日期：2012-08-27 00:00:00