Clinical relevance of anti-HLA donor-specific antibodies detected by Luminex assay in the development of rejection after renal transplantation.

abstract：BACKGROUND:African American kidney transplant recipients generally exhibit poor long-term graft survival compared with other ethnic groups. The combination of sirolimus, tacrolimus, and corticosteroids has proven to be effective in reducing rejection episodes in high-risk organ and islet cell transplant recipients but ...

journal_title：Transplantation

authors： Hricik DE,Anton HA,Knauss TC,Rodriguez V,Seaman D,Siegel C,Valente J,Schulak JA

更新日期：2002-07-27 00:00:00

abstract：BACKGROUND:Pregnancy after heart transplantation (HTx) may expose the recipient to hemodynamic and immunologic risks and the newborn to toxic effects of immunosuppressive therapy. Adequate preconception counseling is crucial to identify optimal timing and to modify immunosuppressive therapy to minimize risks for both t...

journal_title：Transplantation

authors： Macera F,Occhi L,Masciocco G,Varrenti M,Frigerio M

更新日期：2018-09-01 00:00:00

abstract：:Since calcium channel blocking agents and CsA exert an antiproliferative effect upon T cell mitogenesis, we have compared and characterized their immunosuppressive properties at the level of gene activation. Verapamil (greater than or equal to 30 microM), which blocks T cell mitogenesis and a rise in cytosolic calcium...

journal_title：Transplantation

authors： Walz G,Zanker B,Wieder K,Hadro E,Moscovitch-Lopatin M,Smith BR,Strom TB

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND:The influence of recipient body mass index (BMI) on pediatric-donor kidney transplant outcomes is unclear. We aimed to determine graft survival and functional outcomes of pediatric-donor kidneys compared with adult kidneys stratified by recipient BMI group. METHODS:Scientific Registry of Transplant Recipien...

journal_title：Transplantation

authors： Kayler LK,Zendejas I,Gregg A,Wen X

更新日期：2012-02-27 00:00:00

abstract：:This study describes VG01, a monoclonal antibody to a novel lymphocyte activation antigen. The cells reacting with VG01 were first characterized by indirect immunofluorescence and fluorescence-activated cell sorter analysis. The antigen defined by VG01 was expressed on circulating T lymphocytes (23.8 +/- 9.0) and on t...

journal_title：Transplantation

authors： Denegri JF,Gilks CB,Altin M,Peterson J,Lafleur L

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND:Alcoholic liver disease has emerged as a leading indication for hepatic transplantation, although it is a controversial use of resources. We aimed to examine all aspects of liver transplantation associated with alcohol abuse. METHODS:Retrospective cohort analysis of 123 alcoholic patients with a median of 7...

journal_title：Transplantation

authors： Bellamy CO,DiMartini AM,Ruppert K,Jain A,Dodson F,Torbenson M,Starzl TE,Fung JJ,Demetris AJ

更新日期：2001-08-27 00:00:00

abstract：:Natural anti-carbohydrate antibodies are central to hyperacute rejection in ABO-incompatible allotransplantation and in discordant xenotransplantation. ABO-incompatible rejection has been inhibited successfully using intravenous soluble carbohydrates as antibody inhibitors. The approach has been less successful previo...

journal_title：Transplantation

authors： Cairns T,Lee J,Goldberg L,Cook T,Simpson P,Spackman D,Palmer A,Taube D

更新日期：1995-12-15 00:00:00

abstract：BACKGROUND:Early calcineurin inhibitor (CNI) withdrawal with mycophenolate mofetil (MMF) has not become routine practice, due to concerns about excess acute rejection. Therapeutic drug monitoring may be advantageous when the CNI or MMF is withdrawn. METHODS:This prospective, randomized, concentration-controlled withdr...

journal_title：Transplantation

authors： Mourer JS,Hartigh Jd,van Zwet EW,Mallat MJ,Dubbeld J,de Fijter JW

更新日期：2012-05-15 00:00:00

abstract：BACKGROUND:Interleukin- (IL) 10 may be a potent regulator for controlling of allograft rejection. A single administration of IL-10 is not effective for controlling graft rejection. Gene transfer is an attractive vehicle for prolonging the expression of short-lived proteins. METHODS:Donor or recipient livers were trans...

journal_title：Transplantation

authors： Tashiro H,Shinozaki K,Yahata H,Hayamizu K,Okimoto T,Tanji H,Fudaba Y,Yamamoto H,Fan X,Ito H,Asahara T

更新日期：2000-07-27 00:00:00

abstract：BACKGROUND:The subclass of IgG antibodies contributes to their capability to activate complement. It is currently unknown whether the pretransplant IgG subclass composition allows distinguishing harmful from presumably irrelevant donor-specific human leukocyte antigen (HLA) antibodies (HLA-DSA) detected by single-antig...

journal_title：Transplantation

authors： Hönger G,Hopfer H,Arnold ML,Spriewald BM,Schaub S,Amico P

更新日期：2011-07-15 00:00:00

abstract：:Cyclosporine (CsA) administration and nitric oxide (NO) blockade promote similar chronic renal hemodynamic alterations in rats. We evaluated various clinical CsA doses under conditions of NO blockade using L-NAME (N-nitro L-arginine methyl ester). Groups of Sprague-Dawley rats kept on a normal salt (+NaCl) or low-salt...

journal_title：Transplantation

authors： Gardner MP,Houghton DC,Andoh TF,Lindsley J,Bennett WM

更新日期：1996-05-27 00:00:00

abstract：BACKGROUND:Renal transplant patients have an increased incidence of skin cancers, predominantly on sun-exposed surfaces. Clinical observation identified some patients with an increased number of viral warts, keratoses, and skin malignancies on the side of the arteriovenous fistula. METHODS:In a population of 980 patie...

journal_title：Transplantation

authors： Bordea C,Cortina-Borja M,Wojnarowska F,Morris PJ

更新日期：2001-01-15 00:00:00

abstract：:We developed and applied a quantitative competitive polymerase chain reaction method to study the expression of various cytokine genes in Con A-stimulated murine splenocytes. This method relies on the use of competitive templates that differ from the target cytokine cDNA templates only by the introduction of a unique ...

journal_title：Transplantation

authors： Zheng XX,Strom TB,Steele AW

更新日期：1994-07-15 00:00:00

abstract：BACKGROUND:Intestinal transplantation is known to be associated with a high risk of early complications and mortality. METHODS:We analyzed prospective data of 51 primary small bowel transplantations from December 1999 to August 2009 and identified perioperative factors that impact on early mortality (≤6 months after t...

journal_title：Transplantation

authors： Dopazo C,Gupte GL,Sharif K,Perera MT,Hartley J,Muiesan P,Mayer DA,Bromley P,Bennett J,Kelly DA,van Mourik I,McKiernan P,Beath SV,Mirza DF

更新日期：2012-10-27 00:00:00

abstract：:In recent years there have been major advances in the technology for the detection and definition of human leukocyte antigen antibodies. In this overview we describe the evolution in laboratory technology, the techniques currently available and consider their application in antibody specificity definition and in under...

journal_title：Transplantation

authors： Fuggle SV,Martin S

更新日期：2008-08-15 00:00:00

abstract：:Healthy rat islets were encapsulated in alginate-polylysine-alginate capsules measuring 0.25-0.35 mm in diameter using a modified encapsulation technique. The encapsulated islets were transplanted intraperitoneally in nonimmunosuppressed streptozotocin-induced diabetic BALB/c mice. The diabetic condition of the experi...

journal_title：Transplantation

authors： Lum ZP,Krestow M,Tai IT,Vacek I,Sun AM

更新日期：1992-06-01 00:00:00

abstract：:Deposition of the C4d complement degradation product has been shown to be a marker of antibody-mediated rejection of solid organ allografts, including kidney, heart, liver, and lung. We investigated whether C4d deposition also would be useful in monitoring rejection in human composite tissue allografts. A total of 60 ...

journal_title：Transplantation

authors： Kanitakis J,McGregor B,Badet L,Petruzzo P,Morelon E,Devauchelle B,Dubernard JM

更新日期：2007-07-27 00:00:00

abstract：BACKGROUND:Only four centers have reported their results with renal transplantation in human immunodeficiency virus (HIV)+ recipients on highly active antiretroviral therapy, and acute rejection (AR) rates have consistently ranged from 43% to 67%. METHODS:We examined the outcomes of eight adult HIV+ primary renal allo...

journal_title：Transplantation

authors： Gruber SA,Doshi MD,Cincotta E,Brown KL,Singh A,Morawski K,Alangaden G,Chandrasekar P,Losanoff JE,West MS,El-Amm JM

更新日期：2008-07-27 00:00:00

abstract：:Although bisphosponates are proposed as first-line treatment for posttransplant bone disease they are not optimal in all situations. A kidney transplant recipient developed hypercalcemia from mobilization of extraskeletal calcium. He had low serum parathyroid hormone and vitamin D; high calcium excretion; and normal c...

journal_title：Transplantation

authors： Dhingra RK,Sprague SM,Ojo AO,Leavey SF

更新日期：2001-06-27 00:00:00

abstract：:We investigated the preventive effect of the immunosuppressive agent FK506 on autoimmune insulitis in nonobese diabetic mice. The mice were given FK506 in a dose of 1.0 mg/kg, every other day, from age 2 to 12, 2 to 6, and 4 to 12 weeks, respectively; after which, the incidence of insulitis and overt diabetes was moni...

journal_title：Transplantation

authors： Kai N,Motojima K,Tsunoda T,Kanematsu T

更新日期：1993-04-01 00:00:00

abstract：:Recent reports document the efficacy of transjugular intrahepatic portocaval shunts (TIPS) for the prevention of portal hypertensive bleeding and have advocated its use as a bridge to liver transplantation. There are no reports, however, analyzing liver transplant results for patients with indwelling TIPS. We reviewed...

journal_title：Transplantation

authors： Freeman RB Jr,FitzMaurice SE,Greenfield AE,Halin N,Haug CE,Rohrer RJ

更新日期：1994-08-15 00:00:00

abstract：:Cyclosporine prevents the development of diabetes in spontaneously diabetic BB rats and NOD mice. However, islet transplants have been shown to be subject to immunologic destruction in hosts treated with CsA and anti-CD4 antibody or those rendered tolerant to donor antigens. This study determines whether the minimum d...

journal_title：Transplantation

authors： Dugoni WE Jr,Bartlett ST

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND:The beneficial effects of glycemic control on both survival and function of transplanted kidneys in patients with type 1 diabetes mellitus (T1DM) and end-stage renal disease (ESRD) have been recognized. METHODS:Herein, we present the clinical outcome of a single-center pilot trial of islet after kidney (IAK...

journal_title：Transplantation

authors： Cure P,Pileggi A,Froud T,Messinger S,Faradji RN,Baidal DA,Cardani R,Curry A,Poggioli R,Pugliese A,Betancourt A,Esquenazi V,Ciancio G,Selvaggi G,Burke GW 3rd,Ricordi C,Alejandro R

更新日期：2008-03-27 00:00:00

abstract：BACKGROUND:Recently, TT virus (TTV) was discovered as a potential causative agent for non-A-E hepatitis. Little is known about the prevalence of TTV infection in renal transplant recipients. METHODS:One hundred and seventeen Brazilian renal transplant recipients and 100 normal subjects were examined to determine the p...

journal_title：Transplantation

authors： Yokosuka O,Ikeuchi T,Kanda T,Kawai S,Imazeki F,Saisho H,Mazzalli M,Filho GA,Nishimura NF,Soares EC

更新日期：2000-10-27 00:00:00

abstract：BACKGROUND:Previous studies have indicated that patients on maintenance hemodialysis have worse survival compared with kidney transplant (KTx) recipients. However, none of these studies have compared mortality of the US patients using alternative dialysis modalities such as home hemodialysis (HHD) with KTx recipients. ...

journal_title：Transplantation

authors： Molnar MZ,Ravel V,Streja E,Kovesdy CP,Mehrotra R,Kalantar-Zadeh K

更新日期：2016-10-01 00:00:00

abstract：:A total of 159 patients received renal cadaveric grafts under 2 different allocation systems. System 1, a local variance (i.e., a point system different from that of United Network for Organ Sharing [UNOS]), and system 2, the current UNOS point system, differed in the relative emphasis on waiting time and HLA match. T...

journal_title：Transplantation

authors： Zachary AA,Braun WE,Hayes JM,McElroy JB,Novick AC,Schulak JA,Sharp WV

更新日期：1994-04-15 00:00:00

abstract：BACKGROUND:Suppressive dendritic cells (DCs) are a promising tool for tolerance induction in transplantation. A human DCs subpopulation, which constitutively expresses indoleamine-2,3-dioxygenase (IDO), a molecule shown to prevent the rejection of fetus during pregnancy, has recently been described. This subset, charac...

journal_title：Transplantation

authors： Löb S,Ebner S,Wagner S,Weinreich J,Schäfer R,Königsrainer A

更新日期：2007-02-27 00:00:00

abstract：:Infection remains one of the major complications of nonspecific immunosuppression in renal transplant patients and accounts for significant morbidity and mortality. The incidence of infectious complications has been shown to be related to the degree of immunosuppression and correlated with the total steroid dosage, us...

journal_title：Transplantation

authors： Salama AD,Rogers T,Lord GM,Lechler RI,Mason PD

更新日期：1997-01-15 00:00:00

abstract：:Hepatic grafts from non-heartbeating donors may alleviate the organ shortage, but they inherently suffer from warm ischemia. In the present study, we tested our hypothesis that augmentation of endogenous adenosine by inhibition of nucleoside transport with R75231 attenuates ischemic liver injury. Adult female beagle d...

journal_title：Transplantation

authors： Todo S,Zhu Y,Zhang S,Jin MB,Ishizaki N,Tanaka H,Subbotin V,Starzl TE

更新日期：1997-01-27 00:00:00

abstract：BACKGROUND:Induction therapy is associated with excellent short-term kidney graft outcome. The aim of this study was to evaluate differences in the intragraft transcriptome after successful induction therapy using two rabbit antithymocyte globulins. METHODS:The expression of 376 target genes involved in tolerance, inf...

journal_title：Transplantation

authors： Urbanova M,Brabcova I,Girmanova E,Zelezny F,Viklicky O

更新日期：2012-03-27 00:00:00