Effect of HLA matching on organ distribution among whites and African-Americans.

abstract：BACKGROUND:Rat lung allograft rejection is mediated by collagen type V (col(V)) specific T-helper-cell 17 (Th17) cells. Adoptive transfer of these cells is sufficient to induce rejection pathology in isografts, whereas tolerance to col(V) suppresses allograft rejection. Therefore, we tested whether regulatory T cells f...

journal_title：Transplantation

authors： Braun RK,Molitor-Dart M,Wigfield C,Xiang Z,Fain SB,Jankowska-Gan E,Seroogy CM,Burlingham WJ,Wilkes DS,Brand DD,Torrealba J,Love RB

更新日期：2009-12-27 00:00:00

abstract：BACKGROUND:Remote ischemic preconditioning (RIPC) protects against liver ischemia reperfusion (IR) injury. An essential circulating mediator of this protection is nitric oxide (NO) induced by lower limb RIPC. One of the mechanisms through which NO generally acts is the soluble guanylyl cyclase-cyclic GMP (sGC-cGMP) pat...

journal_title：Transplantation

authors： Abu-Amara M,Yang SY,Quaglia A,Rowley P,Tapuria N,Fuller B,Davidson B,Seifalian A

更新日期：2012-05-15 00:00:00

abstract：BACKGROUND:Liver transplant recipients for hepatitis C virus (HCV)-related cirrhosis usually remain anti-HCV-seropositive after transplantation. The aim of this study was to characterize, longitudinally, the profile of HCV-specific antibodies and cryoglobulins in liver transplant recipients with recurrent HCV infection...

journal_title：Transplantation

authors： Gane EJ,Maertens G,Ducatteeuw A,Qian KP,Lau JY,Jones H,Davies E,Naoumov NV,Williams R

更新日期：1999-01-15 00:00:00

abstract：BACKGROUND:Currently, many transplantation centers do not follow former living kidney donors on a long-term basis. Several potential barriers have been identified to provide this follow-up of former living kidney donors, including concerns that donor insurance will not reimburse transplantation centers or primary care ...

journal_title：Transplantation

authors： Kher A,Rodrigue J,Ajaimy M,Wasilewski M,Ladin K,Mandelbrot D

更新日期：2012-11-27 00:00:00

abstract：:In order to study further whether a relationship exists between the extent of ischemia-preservation-reperfusion injury (IPRI) and acute rejection (AR) events in liver allografts, we retrospectively reviewed 213 consecutive cyclosporine-treated patients who received their first liver allograft between 1/1/93 and 12/31/...

journal_title：Transplantation

authors： Shackleton CR,Martin P,Melinek J,Stothers L,Millis JM,Olthoff KM,Imagawa DK,Kinkhabwala M,Rudich S,Seu P

更新日期：1995-09-27 00:00:00

abstract：BACKGROUND:In live donor liver transplantation portal flush only of the graft is done on the bench. There are no data on antegrade arterial flush along with portal flush of the graft. METHODS:Consecutive patients undergoing elective right lobe live donor liver transplantation were block-randomized to receive either po...

journal_title：Transplantation

authors： Pamecha V,Sandhyav R,Sinha PK,Bharathy KGS,Sasturkar S

更新日期：2018-04-01 00:00:00

abstract：:Apoptotic cells are endowed with immunomodulatory properties. The authors propose infusing apoptotic cells as a cell-based therapy product to facilitate allogeneic hematopoietic engraftment after a nonmyeloablative conditioning regimen. Such an approach may be used to obtain macrochimerism in combined hematopoietic ce...

journal_title：Transplantation

authors： Kleinclauss F,Perruche S,Cahn JY,Tiberghien P,Saas P

更新日期：2003-05-15 00:00:00

abstract：BACKGROUND:Extended partial hepatectomy (PH) in patients is leading to portal hyperperfusion but reduced hepatic arterial perfusion (HAP), and is invariably causing focal hepatic venous outflow obstruction (FHVOO). We observed in a rat model that PH in combination with right median hepatic vein ligation (RMHV-L) caused...

journal_title：Transplantation

authors： Huang H,Deng M,Jin H,Liu A,Dahmen U,Dirsch O

更新日期：2014-05-27 00:00:00

abstract：:Hepatocyte transplantation (HT) has been performed in patients with liver-based metabolic disease and acute liver failure as a potential alternative to liver transplantation. The results are encouraging in genetic liver conditions where HT can replace the missing enzyme or protein. However, there are limitations to th...

journal_title：Transplantation

authors： Hughes RD,Mitry RR,Dhawan A

更新日期：2012-02-27 00:00:00

abstract：:In an attempt to investigate the nonspecificity of the effect of administration of donor splenocytes treated with mitomycin C (MMC) 7 days before transplantation in inducing immunological unresponsiveness, the survival rates of liver, heart, small bowel, and skin allografts were compared in the RT1-incompatible ACI(RT...

journal_title：Transplantation

authors： Yamaguchi Y,Harland R,Wyble C,Mori K,Bollinger RR

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND:Mycophenolate mofetil (MMF), compared to azathioprine (AZA), reduces acute rejection and treatment failure in cyclosporine (CsA) and steroid regimens, but its effect on graft survival is unproven from prospective studies and prolonged use is costly. This study evaluated the efficacy and tolerability of repla...

journal_title：Transplantation

authors： Sadek S,Medina J,Arias M,Sennesael J,Squifflet JP,Vogt B,Neo Int-05 Study group.

更新日期：2002-08-27 00:00:00

abstract：BACKGROUND:Posttransplant diabetes mellitus (PTDM) is a frequent complication in renal-transplant recipients (RTRs). We conducted a prospective study to assess the potential role of PTDM in the development of atherosclerotic events (AE) in RTRs. METHODS:Three hundred fifty-seven consecutive RTRs were enrolled in this ...

journal_title：Transplantation

authors： Ducloux D,Kazory A,Chalopin JM

更新日期：2005-02-27 00:00:00

abstract：:Children who experience acute liver failure following liver transplantation will have multiple organ failure and a high rate of mortality unless emergency retransplantation can be performed. Transplant hepatectomy with portocaval shunting has been described as a bridge to transplantation in the most severe cases, as w...

journal_title：Transplantation

authors： Hammer GB,So SK,Al-Uzri A,Conley SB,Concepcion W,Cox KL,Berquist WE,Esquivel CO

更新日期：1996-07-15 00:00:00

abstract：BACKGROUND:Immunosuppressive regimens for kidney transplantation which reduce the long-term burden of immunosuppression are attractive, but little data are available to judge the safety and efficacy of the different strategies used. We tested the hypothesis that the simple, cheap, regimen of alemtuzumab induction combi...

journal_title：Transplantation

authors： Chan K,Taube D,Roufosse C,Cook T,Brookes P,Goodall D,Galliford J,Cairns T,Dorling A,Duncan N,Hakim N,Palmer A,Papalois V,Warrens AN,Willicombe M,McLean AG

更新日期：2011-10-15 00:00:00

abstract：:The following findings were noted among 45 bone marrow transplant recipients. The patients without cytomegalovirus (CMV) infection or chronic graft-versus-host disease (GVHD) showed normal lymphocyte stimulation in vitro by concanavalin A (Con A) more than 3 months after transplantation, and normal stimulation by phyt...

journal_title：Transplantation

authors： Paulin T,Ringdén O,Lönnqvist B

更新日期：1985-04-01 00:00:00

abstract：BACKGROUND:We previously reported that no cytotoxic T-lymphocyte precursor frequencies (CTLpf) were found in 60% of patients on azathioprine or mycophenolate mofetil+Pred long after kidney transplantation. We questioned whether the absence of donor-specific CTLpf was associated with low levels of stimulatory Th1 (tumor...

journal_title：Transplantation

authors： van Besouw NM,de Kuiper R,van der Mast BJ,van de Wetering J,Baan CC,Weimar W

更新日期：2009-05-27 00:00:00

abstract：BACKGROUND:Antigen sensitization alters the use of genes encoding the variable and constant regions of immunoglobulin, changing avidity, and function. Alterations in variable region genes induced by carbohydrate antigens have been studied extensively in animals but are incompletely characterized in humans. We asked how...

journal_title：Transplantation

authors： Yu PB,Parker W,Nayak JV,Platt JL

更新日期：2005-07-15 00:00:00

abstract：BACKGROUND:Dysregulation of the coagulation system due to inflammatory responses and cross-species molecular incompatibilities represents a major obstacle to successful xenotransplantation. We hypothesized that complement inhibition mediated by transgenic expression of human CD46 in pigs might also regulate the coagula...

journal_title：Transplantation

authors： Bongoni AK,Kiermeir D,Schnider J,Jenni H,Garimella P,Bähr A,Klymiuk N,Wolf E,Ayares D,Voegelin E,Constantinescu MA,Seebach JD,Rieben R

更新日期：2015-10-01 00:00:00

abstract：:The value of percutaneous core needle biopsy in the immunohistological evaluation of renal allograft dysfunction was studied in 72 consecutive biopsies performed in 42 patients. The phenotypes of infiltrating cells mediating graft destruction were identified with monoclonal antibodies and immunoperoxidase staining tec...

journal_title：Transplantation

authors： Waltzer WC,Miller F,Arnold A,Anaise D,Rapaport FT

更新日期：1987-01-01 00:00:00

abstract：:High levels of tumor necrosis factor-alpha, interleukin-2, and gamma-interferon appeared in the circulation of kidney transplant recipients after the first injection of the monoclonal antibody OKT3. This initial injection was systematically followed by fever. The three cytokines were released in all patients (n = 9), ...

journal_title：Transplantation

authors： Abramowicz D,Schandene L,Goldman M,Crusiaux A,Vereerstraeten P,De Pauw L,Wybran J,Kinnaert P,Dupont E,Toussaint C

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:The deleterious effect of steatosis on transplanted livers is mainly related to a microcirculation impairment. We investigated the effect of preservation duration on the recovery of isolated perfused rat steatotic livers and tested the effect of pentoxifylline (PTX), known to have a beneficial effect on hepa...

journal_title：Transplantation

authors： Arnault I,Bao YM,Sebagh M,Anjo A,Dimicoli JL,Lemoine A,Delvart V,Adam R

更新日期：2003-07-15 00:00:00

abstract：BACKGROUND:The clinical impact of chronic transplant glomerulopathy (CTG) on the outcome of kidney allograft receiving calcineurin inhibitors (CNIs) remains uncertain. A retrospective study of renal transplant recipients at Ospedale Maggiore of Milan was undertaken to evaluate the clinical outcome of patients with CTG....

journal_title：Transplantation

authors： Banfi G,Villa M,Cresseri D,Ponticelli C

更新日期：2005-11-27 00:00:00

abstract：BACKGROUND:Both chemokines and adhesion molecules mediate allograft rejection by recruiting leukocytes into the allograft. We investigated the association of six single nucleotide polymorphisms (SNPs) located in interleukin (IL)-8, CXCR1, CXCR2, and selectin with kidney allograft outcomes. METHODS:The promoter regions...

journal_title：Transplantation

authors： Ro H,Hwang YH,Kim H,Jeong JC,Lee H,Doh YS,Park HC,Oh KH,Park MH,Ha J,Yang J,Ahn C

更新日期：2011-01-15 00:00:00

abstract：BACKGROUND:An increase in serum alpha-glutathione S-transferase concentration (GST) has been shown to be a more sensitive and specific marker of hepatocellular damage than equivalent increases in transaminase activities. A randomized clinical trial of 60 liver transplants in 49 patients was carried out to assess the cl...

journal_title：Transplantation

authors： Hughes VF,Trull AK,Gimson A,Friend PJ,Jamieson N,Duncan A,Wight DG,Prevost AT,Alexander GJ

更新日期：1997-11-27 00:00:00

abstract：BACKGROUND:Preexisting IgG antibodies to donor human leukocyte antigens (HLA) are a risk factor for rapid allograft rejection. However, non-HLA antibodies, of the IgM class, also called autoreactive antibodies, are not believed to affect graft survival. The aim of this study was to determine the incidence and clinical ...

journal_title：Transplantation

authors： Smith JD,Hamour IM,Burke MM,Mahesh B,Stanford RE,Haj-Yahia S,Robinson DR,Kaul P,Yacoub MH,Banner NR,Rose ML

更新日期：2009-03-27 00:00:00

abstract：BACKGROUND:The impact of nutritional status on outcome of allogeneic stem cell transplantation (alloSCT) is controversial. This study investigates the influence of pretransplant weight loss and serologic indicators of nutritional homeostasis on relapse and death of acute myeloid leukemia (AML) after alloSCT. METHODS:P...

journal_title：Transplantation

authors： Dietrich S,Radujkovic A,Stölzel F,Falk CS,Benner A,Schaich M,Bornhäuser M,Ehninger G,Krämer A,Hegenbart U,Ho AD,Dreger P,Luft T

更新日期：2015-05-01 00:00:00

abstract：:Moderate hyperhomocysteinemia, an independent cardiovascular risk factor, has been reported in renal transplant recipients. In the present study, plasma concentrations of total homocysteine were significantly increased in 120 renal transplant recipients as compared with 60 healthy controls (19.0 +/- 6.9 vs. 11.6 +/- 2...

journal_title：Transplantation

authors： Arnadottir M,Hultberg B,Vladov V,Nilsson-Ehle P,Thysell H

更新日期：1996-02-15 00:00:00

abstract：BACKGROUND:Living-related (LR) human leukocyte antigen (HLA)-identical renal transplant (RTx) recipients often receive standard immunosuppression, despite the absence of mismatched major HLA-antigens and the known complications of long-term use of immunosuppression. No data are available on the need for immunosuppressi...

journal_title：Transplantation

authors： van de Wetering J,Gerrits JH,van Besouw NM,Ijzermans JN,Weimar W

更新日期：2009-03-15 00:00:00

abstract：:We recently reported that reconstitution of lethally irradiated B10 mouse recipients with 40 x 10(6) untreated WF rat bone marrow cells resulted in stable fully xenogeneic chimerism (WF rat----B10 mouse). In these animals, the tolerance induced for skin xenografts was highly MHC specific in that donor-specific WF rat ...

journal_title：Transplantation

authors： Zeng YJ,Ricordi C,Tzakis A,Rilo HL,Carroll PB,Starzl TE,Ildstad ST

更新日期：1992-02-01 00:00:00

abstract：:Frozen sections of lymph nodes from normal mice were examined by immunofluorescence with anti-T lymphocyte and anti-Ig reagents and by autoradiography following [3H]TdR administration. The scattered T lymphocytes present among B lymphocytes of primary follicles were found to be mostly nonproliferating; the few prolife...

journal_title：Transplantation

authors： Berman MA,Rafiei S,Gutman GA

更新日期：1981-11-01 00:00:00