Alterations in rat pulmonary macrophage function by the immunosuppressive agents cyclosporine, azathioprine, and prednisolone.

abstract：BACKGROUND:Donor-derived cell-free DNA (dd-cfDNA) is a potential noninvasive molecular marker of graft rejection after kidney transplant, whose diagnostic accuracy remains controversial. METHODS:We performed a systematic review and meta-analysis to evaluate the diagnostic accuracy of dd-cfDNA. Relevant literature was ...

journal_title：Transplantation

authors： Xiao H,Gao F,Pang Q,Xia Q,Zeng X,Peng J,Fan L,Liu J,Wang Z,Li H

更新日期：2020-09-02 00:00:00

abstract：:We are reporting the first known case of sequential combined living donor liver/small bowel transplantation (LDL/SBT). A 2-year-old boy born with gastroschisis and intestinal malrotation lost his entire small bowel and colon shortly after birth. He underwent a living donor small bowel transplant at 1 year of age that ...

journal_title：Transplantation

authors： Testa G,Holterman M,John E,Kecskes S,Abcarian H,Benedetti E

更新日期：2005-05-27 00:00:00

abstract：:Cold-storage preservation of the canine pancreas prior to islet isolation has previously been noted to reduce the intrasplenic islet autograft success rate; but the mechanism of this deleterious effect has not been determined. We undertook a study in both outbred dogs and Lewis (RT1-1) rats to determine the influence ...

journal_title：Transplantation

authors： Munn SR,Kaufman DB,Field MJ,Viste AB,Sutherland DE

更新日期：1989-01-01 00:00:00

abstract：:The results of OKT3 use for steroid-resistant rejection rescue in adult liver transplantation were analyzed retrospectively from a single transplant center. Comparison was made with concurrent patients who had no rejection (NR) or steroid-responsive rejections (SR). The records of 290 patients who underwent 323 liver ...

journal_title：Transplantation

authors： Solomon H,Gonwa TA,Mor E,Holman MJ,Gibbs J,Watemberg I,Netto G,Goldstein RM,Husberg BS,Klintmalm GB

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:The risk associated with transplantation of renal allografts from hepatitis B virus core antibody-positive (HBcAb(+)), hepatitis B virus surface antigen-negative (HBsAg(-)) donors is not well defined. METHODS:Over 4 years, we performed 45 kidney transplants from IgG HBcAb(+), IgM HBcAb(-), HBsAg(-) donors i...

journal_title：Transplantation

authors： Madayag RM,Johnson LB,Bartlett ST,Schweitzer EJ,Constantine NT,McCarter RJ Jr,Kuo PC,Keay S,Oldach DW

更新日期：1997-12-27 00:00:00

abstract：:A cadaveric renal transplant was performed on a 63-year-old woman. The donor renal artery and vein were anastomosed to the recipient external iliac vessels using the vascular clipping system. These vascular anastomoses were performed with four stay sutures and several clips for each anastomosis, without a continuous v...

journal_title：Transplantation

authors： Mital D,Foster PF,Jensik SC,del Rio JV,Sankary HN,McChesney LP,Williams JW

更新日期：1996-10-27 00:00:00

abstract：BACKGROUND:Leflunomide is a novel immunosuppressive agent with promising activity for xenotransplantation. It is not clear yet which mechanisms of action of leflunomide are responsible for that. METHODS:In a hamster-to-C57BL/6 nude mouse heart transplantation model, a 2-week course of leflunomide was used after transp...

journal_title：Transplantation

authors： Yan Y,Verbeken E,Yu L,Rutgeerts O,Goebels J,Segers C,Lin Y,Waer M

更新日期：2005-01-27 00:00:00

abstract：BACKGROUND:Pregnancy after heart transplantation (HTx) may expose the recipient to hemodynamic and immunologic risks and the newborn to toxic effects of immunosuppressive therapy. Adequate preconception counseling is crucial to identify optimal timing and to modify immunosuppressive therapy to minimize risks for both t...

journal_title：Transplantation

authors： Macera F,Occhi L,Masciocco G,Varrenti M,Frigerio M

更新日期：2018-09-01 00:00:00

abstract：:The potential usefulness of verapamil, a calcium channel blocker to renal allograft preservation, was investigated using the isolated perfused rat kidney. Two models of ischemic injury were used. In the first model, rat kidneys were exposed to 40 min of 37 degrees C ischemia on the perfusion circuit. Addition of verap...

journal_title：Transplantation

authors： Shapiro JI,Cheung C,Itabashi A,Chan L,Schrier RW

更新日期：1985-12-01 00:00:00

abstract：BACKGROUND:Tacrolimus (Tac) and mycophenolate mofetil (MMF) are newly approved immunosuppressive agents. However, the safety and efficacy of the combination of MMF and Tac in primary liver transplantation has not been determined. METHODS:An Institutional Review Board-approved, open-label prospective randomized protoco...

journal_title：Transplantation

authors： Jain AB,Hamad I,Rakela J,Dodson F,Kramer D,Demetris J,McMichael J,Starzl TE,Fung JJ

更新日期：1998-11-27 00:00:00

abstract：BACKGROUND:Existing data indicate that non-human leukocyte antigen (HLA) immunogenetic polymorphisms influence the risk of complications after allogeneic hemopoietic stem-cell transplantation. However, prior studies have been limited by small sample size and limited genotyping. METHODS:We examined 22 polymorphisms in ...

journal_title：Transplantation

authors： Mullighan C,Heatley S,Doherty K,Szabo F,Grigg A,Hughes T,Schwarer A,Szer J,Tait B,To B,Bardy P

更新日期：2004-02-27 00:00:00

abstract：:The absorption of oral cyclosporine (CsA) was studied in a canine small intestinal transplantation model. Absorption of CsA was almost absent in bowel-resected dogs. Autotransplanted dogs showed a persisting malabsorption of CsA (mean peak of 687 +/- 348 ng/ml vs. 1683 +/- 154 ng/ml in control dogs). Allotransplanted ...

journal_title：Transplantation

authors： Wassef R,Cohen Z,Nordgren S,Langer B

更新日期：1985-05-01 00:00:00

abstract：:Whole-body irradiation has been extensively used to ablate immune responsiveness in rodent recipients in adoptive allograft assays. This study was undertaken to determine the relative radioresistance and the tempo of regeneration, following whole-body irradiation, of cells involved in the allograft response. Six disti...

journal_title：Transplantation

authors： Farnsworth A,Wotherspoon JS,Dorsch SE

更新日期：1988-09-01 00:00:00

abstract：:The formation of free radicals after orthotopic liver transplantation in the rat correlates with graft failure. Fatty livers from alcoholics transplant poorly, so these studies were designed to examine the effect of alcohol on free radical formation in a rearterialized rat liver transplantation model. Treatment of rat...

journal_title：Transplantation

authors： Gao W,Connor HD,Lemasters JJ,Mason RP,Thurman RG

更新日期：1995-03-15 00:00:00

abstract：BACKGROUND:Bone marrow stromal cells (BMSC) transplantation offers promise in the treatment of chronic paraplegia in rodents. Here, we report the effect of this cell therapy in adult pigs suffering chronic paraplegia. METHODS:Three months after spinal cord injury, autologous BMSC in autologous plasma was injected into...

journal_title：Transplantation

authors： Zurita M,Vaquero J,Bonilla C,Santos M,De Haro J,Oya S,Aguayo C

更新日期：2008-09-27 00:00:00

abstract：BACKGROUND:The role of combined liver-kidney transplantation (CLKT) for cirrhotic patients with renal failure (RF) is controversial. Since the model for end-stage liver disease era, there has been a rise in the number of CLKT. Using the Organ Procurement Transplant Network/United Network for Organ Sharing database, thi...

journal_title：Transplantation

authors： Fong TL,Khemichian S,Shah T,Hutchinson IV,Cho YW

更新日期：2012-08-27 00:00:00

abstract：BACKGROUND:Diarrhea is a frequent complication of solid organ transplantation. Cryptosporidiosis is classically reported in patients with acquired immunodeficiency syndrome and emerged as a cause of persistent diarrhea in solid organ transplant patients. METHODS:Through the ANOFEL Cryptosporidium National Network and ...

journal_title：Transplantation

authors： Lanternier F,Amazzough K,Favennec L,Mamzer-Bruneel MF,Abdoul H,Tourret J,Decramer S,Zuber J,Scemla A,Legendre C,Lortholary O,Bougnoux ME,ANOFEL Cryptosporidium National Network and Transplant Cryptosporidium Study Group.

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:The organ shortage has led many transplant centers to accept kidneys from old, suboptimal deceased donors, and make increasing use of old-for-old allocation systems. We report the experience of an Italian transplant center in the utilization of "ultra-old" (>75 years old) donors. METHODS:Sixty grafts from d...

journal_title：Transplantation

authors： Collini A,Kalmar P,Dhamo A,Ruggieri G,Carmellini M

更新日期：2009-06-27 00:00:00

abstract：:Heterologous anti-immunoglobulin (AI) is a potent immunosuppressive agent which compares favorably to anti-thymocyte serum (ATS) in inhibiting E and EAC-rosette formation and diminishing the secondary antibody response to sheep erythrocytes and E. coli lipopolysaccharide. AI prolongs H-2 incompatible skin allograft su...

journal_title：Transplantation

authors： Constantian MB,Couser WG,French PJ,Davis RC

更新日期：1976-09-01 00:00:00

abstract：:Antibodies against B lymphocytes were found in the serum of the majority of 59 kidney transplant recipients and of 22 eluates obtained from kidney allografts undergoing rejection. To characterize these B cell lymphocytotoxins we have used a mouse monoclonal anti-DR antibody (L227) that inhibits cytotoxicity of antibod...

journal_title：Transplantation

authors： Nunez G,McPhaul JJ Jr,Stastny P

更新日期：1983-05-01 00:00:00

abstract：:Glucocorticoids (GC) inhibit IL-2 gene transcription by interfering with the binding of the nuclear factor activator protein-1 on the IL-2 promoter. Calcineurin, a Ca2+/calmodulin-dependent protein phosphatase, is an essential component of the T cell antigen receptor signal transduction pathway leading to IL-2 gene tr...

journal_title：Transplantation

authors： Paliogianni F,Boumpas DT

更新日期：1995-05-15 00:00:00

abstract：BACKGROUND:Current histological methods cannot accurately determine the survival rate of human pancreatic islets following portal vein infusion. This is due, in part, to the low number of infused islets relative to the whole liver. In this study, we assessed the ability of confocal laser scanning microscopy (CLSM) to t...

journal_title：Transplantation

authors： Sui F,Tang W,Karunananthan J,Qi C,Li J,He N,Kandeel F,Li J

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:We recently described a new approach that enables the generation of human/mouse chimera by adoptive transfer of human peripheral blood mononuclear cells into lethally irradiated normal strains of mice or rats, radioprotected with bone marrow from donors with severe combined immune deficiency. In such human/m...

journal_title：Transplantation

authors： Burakova T,Marcus H,Canaan A,Dekel B,Shezen E,David M,Lubin I,Segal H,Yair R

更新日期：1997-04-27 00:00:00

abstract：:Cyclosporine (CsA) is an immunosuppressive drug requiring dose individualization and regular control due to its highly variable pharmacokinetics. Since gastroparesis may influence the absorption of CsA, a randomized cross-over study was performed to assess the pharmacokinetics and tolerability of a novel microemulsion...

journal_title：Transplantation

authors： van der Pijl JW,Srivastava N,Denouël J,Burggraaf J,Schoemaker RC,van der Woude FJ,Cohen AF

更新日期：1996-08-27 00:00:00

abstract：BACKGROUND:The hepatic arteries (HAs) in a hepatic graft are usually reconstructed using the recipient's left or right HAs in living donor liver transplantation (LDLT). There have been no apparent selection criteria concerning which of the recipient's HAs should be used. This study retrospectively investigated whether ...

journal_title：Transplantation

authors： Uchiyama H,Ikegami T,Soejima Y,Ninomiya M,Kayashima H,Taketomi A,Shirabe K,Maehara Y

更新日期：2010-04-27 00:00:00

abstract：:A murine monoclonal antihuman T cell antibody is described that is pan-T in that it reacts with all T cells, including those from thymus, but not with B cells or other cells, except for a small subpopulation of null cells. Biochemical analysis demonstrated that the antigen detected is a glycoprotein, Mr 50,000 daltons...

journal_title：Transplantation

authors： Thurlow PJ,Lovering E,d'Apice AJ,McKenzie IF

更新日期：1983-09-01 00:00:00

abstract：BACKGROUND:There are few prospective studies of prednisone-free immunosuppression (IS) in pediatric kidney transplant (KTx) recipients. We studied the outcomes of a protocol using rapid discontinuation of prednisone (RDP, <1 week) and thymoglobulin induction. METHODS:Twenty-one RDP recipients (mean age 14+/-3 years) r...

journal_title：Transplantation

authors： Chavers BM,Chang YC,Gillingham KJ,Matas A

更新日期：2009-07-27 00:00:00

abstract：BACKGROUND:The influence of the graft composition on the clinical outcome after allogeneic peripheral blood stem cell (PBSC) transplantation is not well established. METHODS:The cellular composition of the apheretic products obtained from 63 human leukocyte antigen-identical siblings was prospectively correlated with ...

journal_title：Transplantation

authors： Iori AP,Torelli GF,De Propris MS,Milano F,Pupella S,Gozzer M,Mancini F,Milani ML,Intoppa S,Cerretti R,Lucarelli B,Valle V,Malandruccolo L,Iannella E,Arleo E,Guarini A,Foà R

更新日期：2008-02-15 00:00:00

abstract：BACKGROUND:Globalization and migration patterns have increased the number of donors from countries with high incidence rates of tuberculosis (TB) in low incidence countries, with the subsequent increase in risk of TB transmission to the recipients. METHODS:Retrospective cohort study, including all actual deceased dono...

journal_title：Transplantation

authors： Coll E,Torre-Cisneros J,Calvo R,Garrido G,Matesanz R

更新日期：2013-07-27 00:00:00

abstract：BACKGROUND:Several single nucleotide polymorphisms (SNPs) in the multidrug resistance (MDR1) gene may play a role in the interindividual variation of cyclosporine A (CsA) absorption in renal transplant patients. METHODS:An analysis of CsA absorption measured by the dose- and weight-adjusted 4 hr area under the time-co...

journal_title：Transplantation

authors： Foote CJ,Greer W,Kiberd B,Fraser A,Lawen J,Nashan B,Belitsky P

更新日期：2007-05-27 00:00:00