Glucocorticoids regulate calcineurin-dependent trans-activating pathways for interleukin-2 gene transcription in human T lymphocytes.

abstract：:Numerous studies have reported successful allotransplantation of hepatocytes. However, none have shown long-term correction of a liver-related metabolic defect. In this study, we used a method of regional hepatocyte transplantation and subsequent induction of transplanted cell proliferation by regeneration response in...

journal_title：Transplantation

authors： Eguchi S,Rozga J,Lebow LT,Chen SC,Wang CC,Rosenthal R,Fogli L,Hewitt WR,Middleton Y,Demetriou AA

更新日期：1996-09-15 00:00:00

abstract：:A murine monoclonal antihuman T cell antibody is described that is pan-T in that it reacts with all T cells, including those from thymus, but not with B cells or other cells, except for a small subpopulation of null cells. Biochemical analysis demonstrated that the antigen detected is a glycoprotein, Mr 50,000 daltons...

journal_title：Transplantation

authors： Thurlow PJ,Lovering E,d'Apice AJ,McKenzie IF

更新日期：1983-09-01 00:00:00

abstract：BACKGROUND:One of the alternative options to simultaneous pancreas-kidney transplantation (SPKT) for type I diabetics with renal failure is sequential transplant of a living donor kidney followed by a deceased donor pancreas transplant (pancreas after living donor kidney transplant [PALK]). We retrospectively compared ...

journal_title：Transplantation

authors： Poommipanit N,Sampaio MS,Cho Y,Young B,Shah T,Pham PT,Wilkinson A,Danovitch G,Bunnapradist S

更新日期：2010-06-27 00:00:00

abstract：BACKGROUND:The development of kidney dysfunction is one of the most important after liver transplantation (LT). Genetic variants of pathogenetically relevant cytokines may influence the development and course of the disease. The aim of our study was to evaluate the role of transforming growth factor-β1 (TGF-β1) polymor...

journal_title：Transplantation

authors： Eurich D,Neumann UP,Boas-Knoop S,Neuhaus R,Bahra M,Neuhaus P,Schmitz V

更新日期：2012-03-15 00:00:00

abstract：BACKGROUND:The emergence of a ganciclovir (GCV)-resistant human cytomegalovirus (HCMV) strain in a heart transplant recipient (HTR) coinfected by multiple HCMV strains was investigated. METHODS:A HTR with primary HCMV infection was treated with three induction courses of intravenous GCV followed by a 2-month maintenan...

journal_title：Transplantation

authors： Baldanti F,Simoncini L,Sarasini A,Zavattoni M,Grossi P,Revello MG,Gerna G

更新日期：1998-08-15 00:00:00

abstract：BACKGROUND:Although antibody mechanisms play a pathogenetic role in liver allograft rejection, no data exist on B lymphocytes, plasma cells, complement, and chemokines in rejected liver tissue. METHODS:Liver biopsy specimens from 25 patients with acute allograft rejection (AR) (rejection activity index, RAI score: 1-9...

journal_title：Transplantation

authors： Krukemeyer MG,Moeller J,Morawietz L,Rudolph B,Neumann U,Theruvath T,Neuhaus P,Krenn V

更新日期：2004-07-15 00:00:00

abstract：BACKGROUND:Recent insights suggest that endothelial cell (EC) activation plays a major role in renal ischemia-reperfusion (I/R) injury. Interactions between ECs and pericytes via signaling molecules, including angiopoietins, are involved in maintenance of the vascular integrity. Experimental data have shown that enhanc...

journal_title：Transplantation

authors： de Vries DK,Khairoun M,Lindeman JH,Bajema IM,de Heer E,Roest M,van Zonneveld AJ,van Kooten C,Rabelink TJ,Schaapherder AF,Reinders ME

更新日期：2013-08-15 00:00:00

abstract：BACKGROUND:Status 1A patients are prioritized over liver disease patients regardless of Model for End-stage Liver Disease (MELD) score. We aimed to identify groups with high waitlist mortality in Status 1A and MELD ≥40 patients to determine who would most benefit from transplantation. METHODS:Data on patients listed a...

journal_title：Transplantation

authors： Safwan M,Nwagu U,Collins K,Abouljoud M,Nagai S

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:The cascade of immunological effects brought about by donor bone marrow cell (DBMC) infusions in human organ transplantation, especially in the context of continuous pharmacologic immunosuppression, is not fully understood. Yet, in inbred rodents and even primates, administration of specific bone marrow cell...

journal_title：Transplantation

authors： Mathew JM,Carreno M,Zucker K,Fuller L,Kenyon N,Esquenazi V,Ricordi C,Tzakis AG,Miller J

更新日期：1998-04-15 00:00:00

abstract：:Patient entry is now complete in a prospective trial of anti-Tac, a murine IgG2a monoclonal antibody directed against the p55 chain of the human IL-2 receptor, for the prevention of renal allograft rejection. Recipients of primary cadaver allografts were randomized to receive either anti-Tac (20 mg q.d. x 10 days begi...

journal_title：Transplantation

authors： Kirkman RL,Shapiro ME,Carpenter CB,McKay DB,Milford EL,Ramos EL,Tilney NL,Waldmann TA,Zimmerman CE,Strom TB

更新日期：1991-01-01 00:00:00

abstract：:We have demonstrated that DA hearts grafted into PVG rats were completely protected from rejection by simultaneous liver transplantation from the same donor. In subsequent experiments PVG animals were given DA hearts followed 5 or 6 days later by livers from the same donor strain. Instead of the expected rapid rejecti...

journal_title：Transplantation

authors： Kamada N,Wight DG

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND:Posttransplant lymphoproliferative disease (PTLD) is a major complication after bone marrow and solid organ transplantation. The disease encompasses a spectrum of abnormal, Epstein-Barr virus (EBV)-associated B-cell proliferations. We have previously shown that EBV-infected, spontaneous lymphoblastoid cell l...

journal_title：Transplantation

authors： Nepomuceno RR,Snow AL,Robert Beatty P,Krams SM,Martinez OM

更新日期：2002-08-15 00:00:00

abstract：:Weight gain following renal transplantation occurs frequently but has not been investigated quantitatively. A retrospective chart review of 115 adult renal transplant recipients was used to describe patterns of weight gain during the first 5 years after transplantation. Only 23 subjects (21%) were overweight before th...

journal_title：Transplantation

authors： Johnson CP,Gallagher-Lepak S,Zhu YR,Porth C,Kelber S,Roza AM,Adams MB

更新日期：1993-10-01 00:00:00

abstract：:Graft pancreatitis and allograft rejection were both accompanied by increased serum levels of immunoreactive anionic trypsin (irAT) in a porcine pancreatic allograft transplantation model. Characterization of this immunoreactivity by gel filtration revealed different elution profiles in these conditions that can be he...

journal_title：Transplantation

authors： Källén R,Borgström A

更新日期：1992-01-01 00:00:00

abstract：:Two patients with Fanconi's anemia treated for 5 years with oxymetholone developed hepatic function abnormalities in association with hepatic tumors demonstrated by isotope liver-spleen scan or abdominal echogram. The lesions resolved over a period of 26 months after allogeneic marrow transplantation, and the patients...

journal_title：Transplantation

authors： Schmidt E,Deeg HJ,Storb R

更新日期：1984-05-01 00:00:00

abstract：:Between December 1983 and August 1985, 110 cadaver transplants were performed at our institution. All were started on cyclosporine (CsA) and prednisone (P) for immunosuppressive therapy. Of the 110 patients, 46 were converted from CsA to azathioprine (AZA) for a variety of reasons (cost, toxicity, patient preference, ...

journal_title：Transplantation

authors： Gonwa TA,Nghiem DD,Schulak JA,Corry RJ

更新日期：1987-02-01 00:00:00

abstract：:One of the most powerful influences on cadaveric renal graft survival is the enhancing effect of blood transfusions from unrelated individuals (1, 2). However, the optimum number of transfusions required to achieve this effect remains controversial. Enhanced graft survival following only one or two transfusions has be...

journal_title：Transplantation

authors： Martin S,Dyer PA,Harris R,Manos J,Mallick NP,Gokal R,Johnson RW

更新日期：1985-03-01 00:00:00

abstract：:Treatment of BN recipients with soluble WAG/Rij histocompatibility antigens (HCA) did not produce prolongation of (WAG/Rij X BN) F1 heart allografts but resulted in specific sensitization of the recipients in most cases. Three different anti-WAG/Rij sera (ADS) were tested, either alone or complexed in equivalence to 0...

journal_title：Transplantation

authors： Marquet RL,Heystek GA,Tank B,van ES AA

更新日期：1976-06-01 00:00:00

abstract：INTRODUCTION:The purpose of the current study was to investigate the capacity of CD4+, CD8+, or non-T cells to independently initiate acute rejection of allogeneic hepatocytes using reconstituted SCID, CD4 or CD8 knockout (KO) recipient mice. METHODS:Allogeneic hepatocytes (FVB/N, H-2q) were transplanted into C57BL/6....

journal_title：Transplantation

authors： Bumgardner GL,Gao D,Li J,Baskin JH,Heininger M,Orosz CG

更新日期：2000-12-27 00:00:00

abstract：:The role of TNF in the expression of GVHD and GVHD-related immunodeficiency was studied in a well-established murine GVHD model of bone marrow transplantation across minor histocompatibility barriers (B10.BR-->GBA/J) both in vitro and in vivo. Splenocytes from animals with GVHD profoundly inhibited the proliferation o...

journal_title：Transplantation

authors： Wall DA,Sheehan KC

更新日期：1994-01-01 00:00:00

abstract：:The optimal timing of administration of free radical scavengers in lung preservation has yet to be determined. In previous studies, the oxygen free radical scavenger dimethylthiourea (DMTU) has improved pulmonary function when added to Eurocollins flush solution at the time of lung harvest and infused at the time of l...

journal_title：Transplantation

authors： Lambert CJ Jr,Egan TM

更新日期：1992-08-01 00:00:00

abstract：:The interactions of steroid hormones and human peripheral blood lymphocytes (PBLs) have been investigated following glass-wool column separation of PBLs and incubation in a serum-free medium in the presence of phytohemagglutinin (PHA). Addition of hydrocortisone or progesterone above physiological concentrations resul...

journal_title：Transplantation

authors： Neifeld JP,Tormey DC

更新日期：1979-05-01 00:00:00

abstract：:In a cross-sectional survey of the quality of life of 45 liver transplant recipients, physical and psychological status, physical complaints, capability to participate in daily life, social support, and global quality of life were assessed. The average time of follow-up was 9 months after transplantation. Nine patient...

journal_title：Transplantation

authors： Leyendecker B,Bartholomew U,Neuhaus R,Hörhold M,Blumhardt G,Neuhaus P,Klapp BF

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:Human leukocyte antigen (HLA) antibodies produced after transplantation are frequently measured in transplant recipients, because they are strongly associated with humoral rejection and graft loss. However, antibodies can be induced by posttransplant blood transfusions rather than by the graft, casting doubt...

journal_title：Transplantation

authors： Scornik JC,Schold JD,Bucci M,Meier-Kriesche HU

更新日期：2009-05-15 00:00:00

abstract：BACKGROUND:It is unclear whether ischemic preconditioning (IPC) of solid organs induces remote IPC (RIPC) in donors after brain death (DBD). METHODS:Outcomes in kidney recipients from 163 DBD in two randomized trials of liver IPC (5 min=62 and 10 min=101) were obtained retrospectively from the Scientific Registry of T...

journal_title：Transplantation

authors： Desai KK,Mora-Esteves C,Holland BK,Dikdan G,Fisher A,Wilson DJ,Koneru B

更新日期：2014-02-15 00:00:00

abstract：BACKGROUND:We explored the efficacy of the Oxford classification for assessing native immunoglobulin A nephropathy (IgAN) in posttransplantation patients compared with the glomerular injury score and Haas classification. METHODS:A total of 125 renal allograft biopsies obtained from 114 patients diagnosed with IgAN reg...

journal_title：Transplantation

authors： Lim BJ,Joo DJ,Kim MS,Kim YS,Kim SI,Kim Y,Huh KH,Koh MJ,Jeong HJ

更新日期：2013-06-27 00:00:00

abstract：BACKGROUND:In organ transplantation, several immunosuppressants are currently used to control graft rejection. Clinically, no single immunosuppressive agent can completely prevent posttransplantation immunoreaction; thus, combination therapy is usually performed. Novel agents with more powerful immunosuppressive activi...

journal_title：Transplantation

authors： Yamamoto S,Okuda T,Yamasaki K,Tanaka H,Kubo S,Takemura S,Ikeda K,Minamiyama Y,Hirohashi K,Suehiro S

更新日期：2004-12-15 00:00:00

abstract：BACKGROUND:Diagnosing acute rejection (AR) in kidney transplant recipients typically requires an invasive kidney biopsy. A previous study has suggested that expression of five genes in peripheral blood can indicate the presence of AR in American pediatric kidney transplant recipients. This study aims to validate if the...

journal_title：Transplantation

authors： Lee A,Jeong JC,Choi YW,Seok HY,Kim YG,Jeong KH,Moon JY,Lee TW,Ihm CG,Jeon HJ,Koo TY,Ahn C,Lim SJ,Yang J,Lee SH

更新日期：2014-10-15 00:00:00

abstract：:Forty-three human liver allograft biopsies and normal liver were directly analyzed for inflammatory and immunoregulatory cytokine gene expression by polymerase chain reaction (PCR). IL-5 gene expression was predominantly present in biopsies from liver allografts with histopathological evidence of acute rejection. IL-2...

journal_title：Transplantation

authors： Martinez OM,Krams SM,Sterneck M,Villanueva JC,Falco DA,Ferrell LD,Lake J,Roberts JP,Ascher NL

更新日期：1992-02-01 00:00:00

abstract：:We have recently shown that a single intrathymic injection of synthetic 25mer peptides, representing full sequences of the hypervariable domain of RT1.BuB (4 peptides) and RT1.Du beta (4 peptides) WF class II MHC molecules, 48 hr before transplantation induces donor-specific unresponsiveness to WF rat renal allografts...

journal_title：Transplantation

authors： Sayegh MH,Perico N,Gallon L,Imberti O,Hancock WW,Remuzzi G,Carpenter CB

更新日期：1994-07-27 00:00:00