Transforming growth factor-β1-gene polymorphism in the development of kidney disease after liver transplantation.

abstract：:Class I molecules of the MHC affect target cell sensitivity to NK cell repertoire. In the mouse, absence of MHC class I molecules on target cells is associated with an increased susceptibility to NK cell-mediated lysis, while syngeneic class I molecules confer protection. In contrast to the protective role of syngenei...

journal_title：Transplantation

authors： Salcedo M,Höglund P,Ljunggren HG

更新日期：1995-08-15 00:00:00

abstract：BACKGROUND:One of the main concerns after living donor liver transplantation is the risk of morbidity and/or mortality that it imposes on the donors. Respiratory postoperative complications in living liver donors have already been reported but their frequency seems to be underestimated. We designed a prospective study ...

journal_title：Transplantation

authors： Dondero F,Taillé C,Mal H,Sommacale D,Sauvanet A,Farges O,Francoz C,Durand F,Delefosse D,Denninger MH,Vilgrain V,Marrash-Chahla R,Fournier M,Belghiti J

更新日期：2006-01-27 00:00:00

abstract：:The histopathological changes and the course of graft-versus-host (GVH) disease were studied in the rat model of small-bowel transplantation using the Lewis----LBN-F1 strain combination. Allograft-induced GVH disease led to the recipients' death from enteritis, dermatitis and emaciation after 14.4 +/- 2.9 days (hetero...

journal_title：Transplantation

authors： Schraut WH,Lee KK,Dawson PJ,Hurst RD

更新日期：1986-03-01 00:00:00

abstract：:The ability of concanavalin-A (Con-A) to activate lymphocytes to secrete human lymphotoxin (LT) was tested in the presence of agents known to modify the intracellular levels of cyclic nucleotides (cAMP and cGMP). Lymphocytes were treated with these agents at different stages of activation: (1) during the first encount...

journal_title：Transplantation

authors： Prieur AM,Granger GA

更新日期：1975-10-01 00:00:00

abstract：:We examined the cytokine profiles associated with tolerance and rejection using the mouse model of neonatal tolerance. BALB/c mice primed with CAF1 splenocytes during the neonatal stage showed increased A/J skin graft survival of > 60 days and failed to develop anti-A/J cytotoxic responses, but rejected third-party C5...

journal_title：Transplantation

authors： Chen N,Field EH

更新日期：1995-04-15 00:00:00

abstract：:To formulate a model predicting survival after liver retransplantation, we analyzed in detail the last 150 cases of hepatic retransplantation at UCLA. Cox proportional hazards regression analysis identified five variables that demonstrated independent simultaneous prognostic value in estimating patient survival after ...

journal_title：Transplantation

authors： Markmann JF,Gornbein J,Markowitz JS,Levy MF,Klintmalm GB,Yersiz H,Morrisey M,Drazan K,Farmer DG,Ghobrial RM,Goss J,Seu P,Martin P,Goldstein LI,Busuttil RW

更新日期：1999-02-15 00:00:00

abstract：BACKGROUND:Small bowel transplantation in children weighing less than 10 kg is hindered by the lack of size-matched donors. The ability to create reduced size small bowel grafts from adult cadaveric donors suitable for use in young children has been studied. METHODS:Volumetric assessment of computed tomography scans w...

journal_title：Transplantation

authors： Delrivière L,Muiesan P,Marshall M,Davenport M,Dhawan A,Kane P,Karani J,Rela M,Heaton N

更新日期：2000-04-15 00:00:00

abstract：BACKGROUND:Vaccine-preventable viral infections are associated with increased risk of morbidity and mortality in immunocompromised patients. Current guidelines recommend routine screening and vaccination of all patients before solid organ transplantation. We studied rates of immunity against vaccine-preventable viruses...

journal_title：Transplantation

authors： Gardiner A,Liu K,Bonnichsen M,Joshi V,Davis RJ,Strasser SI

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:CTLA4 immunoglobulin (Ig)G that binds to B7 effectively inhibits the signaling of CD28/CTLA4-B7 pathway and induces antigen specific T cell unresponsiveness in vitro and in vivo. Using CTLA4IgG, we examined induction of long-term graft survival and the mechanism of maintenance of tolerance in rat allogeneic ...

journal_title：Transplantation

authors： Tarumi K,Murakami M,Yagihashi A,Nakagawa I,Hirata K,Uede T

更新日期：1999-02-27 00:00:00

abstract：BACKGROUND:Renal transplant patients have an increased incidence of skin cancers, predominantly on sun-exposed surfaces. Clinical observation identified some patients with an increased number of viral warts, keratoses, and skin malignancies on the side of the arteriovenous fistula. METHODS:In a population of 980 patie...

journal_title：Transplantation

authors： Bordea C,Cortina-Borja M,Wojnarowska F,Morris PJ

更新日期：2001-01-15 00:00:00

abstract：:Hepatitis C virus (HCV) remains the leading indication for liver transplant in much of the world and has traditionally been associated with diminished posttransplant survival due to recurrent HCV-related liver disease. This field has been dramatically changed by the advent of safe and effective direct-acting antiviral...

journal_title：Transplantation

authors： Verna EC,Brown RS Jr

更新日期：2017-05-01 00:00:00

abstract：:Late deaths (after more than 1 year) after liver transplantation were analyzed in a series of 464 consecutive patients who received liver grafts between 1982 and 1993. Recipients who survived the first posttransplant year (n = 365) had actuarial 5- and 10-year survival rates of 92% and 84%, respectively. Thirty-five p...

journal_title：Transplantation

authors： Asfar S,Metrakos P,Fryer J,Verran D,Ghent C,Grant D,Bloch M,Burns P,Wall W

更新日期：1996-05-15 00:00:00

abstract：BACKGROUND:The induction of tolerance to pig antigens in primates may facilitate the development of successful clinical xenotransplantation protocols. The infusion of mobilized porcine peripheral blood leukocytes (PBPCs, comprised of approximately 2% peripheral blood progenitor cells) into splenectomized preconditioned...

journal_title：Transplantation

authors： Appel JZ 3rd,Alwayn IP,Correa LE,Cooper DK,Robson SC

更新日期：2001-10-15 00:00:00

abstract：BACKGROUND:Recent evidence suggests that living kidney donors are at an increased risk of end-stage renal disease. However, predicting which donors will have renal dysfunction remains challenging, particularly among those with no clinical evidence of disease at the time of donation. Although renal biopsies are not rout...

journal_title：Transplantation

authors： Fahmy LM,Massie AB,Muzaale AD,Bagnasco SM,Orandi BJ,Alejo JL,Boyarsky BJ,Anjum SK,Montgomery RA,Dagher NN,Segev DL

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Recently, TT virus (TTV) was discovered as a potential causative agent for non-A-E hepatitis. Little is known about the prevalence of TTV infection in renal transplant recipients. METHODS:One hundred and seventeen Brazilian renal transplant recipients and 100 normal subjects were examined to determine the p...

journal_title：Transplantation

authors： Yokosuka O,Ikeuchi T,Kanda T,Kawai S,Imazeki F,Saisho H,Mazzalli M,Filho GA,Nishimura NF,Soares EC

更新日期：2000-10-27 00:00:00

abstract：BACKGROUND:Monoclonal antibody induced tolerance to high doses of multiple lymphocyte stimulating (MLS)+minor mismatched bone marrow has recently been associated with clonal deletion, as reported in fully allogeneic models of bone marrow transplantation. FasL-induced apoptosis has been shown to mediate antigen-specific...

journal_title：Transplantation

authors： Honey K,Bemelman F,Cobbold SP,Waldmann H

更新日期：2000-04-27 00:00:00

abstract：:Adhesion of leukocytes to vascular endothelium is a necessary step leading to the migration of cells into underlying tissues. Vascular adhesion molecules regulate this process and may play an important role in graft rejection. Immunocytochemical studies have been used to investigate the expression of vascular adhesion...

journal_title：Transplantation

authors： Taylor PM,Rose ML,Yacoub MH,Pigott R

更新日期：1992-09-01 00:00:00

abstract：:The pig has been considered unsuitable for experimental pancreatic transplantation. In order to develop a model for segmental transplantation, the vascular anatomy was studied in 41 pigs. No variation in venous drainage of the pancrease was found. In contrast, 3 variations of arterial supply were noted. In 29 of the p...

journal_title：Transplantation

authors： Shokouh-Amiri MH,Rahimi-Saber S,Andersen HO

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Machine perfusion (MP) has evolved as a promising approach for the ex situ preservation in organ transplantation. However, the literature on the use of MP in human vascularized composite allografts is scarce. The aim of this study was to evaluate the effects of hypothermic MP with an acellular perfusate in h...

journal_title：Transplantation

authors： Haug V,Kollar B,Tasigiorgos S,Endo Y,Kauke M,Safi AF,Veeramani A,Abdulrazzak O,Bausk B,Walt D,Pomahac B

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Recent insights suggest that endothelial cell (EC) activation plays a major role in renal ischemia-reperfusion (I/R) injury. Interactions between ECs and pericytes via signaling molecules, including angiopoietins, are involved in maintenance of the vascular integrity. Experimental data have shown that enhanc...

journal_title：Transplantation

authors： de Vries DK,Khairoun M,Lindeman JH,Bajema IM,de Heer E,Roest M,van Zonneveld AJ,van Kooten C,Rabelink TJ,Schaapherder AF,Reinders ME

更新日期：2013-08-15 00:00:00

abstract：BACKGROUND:Increasing long-term allograft survival is the main challenge in organ transplantation, and allograft loss due to chronic rejection has been found to correlate with episodes of early acute rejection. It is important to understand the mechanisms that maintain the donor-specific hyporesponsive state. This stud...

journal_title：Transplantation

authors： Mittal SK,Sharma RK,Gupta A,Naik S

更新日期：2009-08-15 00:00:00

abstract：:This study describes VG01, a monoclonal antibody to a novel lymphocyte activation antigen. The cells reacting with VG01 were first characterized by indirect immunofluorescence and fluorescence-activated cell sorter analysis. The antigen defined by VG01 was expressed on circulating T lymphocytes (23.8 +/- 9.0) and on t...

journal_title：Transplantation

authors： Denegri JF,Gilks CB,Altin M,Peterson J,Lafleur L

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND:Long-term follow-up and management of donors was undertaken in a specialist kidney transplant unit in Pakistan to identify risk and prevent adverse outcomes in living related kidney donors. METHODS:In an observation cohort study between 1985 and 2012, 3748 donors were offered free medical follow-up and trea...

journal_title：Transplantation

authors： Rizvi SA,Zafar MN,Jawad F,Aziz T,Hussain Z,Hashmi A,Hussain M,Akhtar F,Ahmed E,Naqvi R,Naqvi SA

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:The majority of chronic hepatitis is ascribable to hepatitis C virus (HCV) infection, whereas the clinical impact has not been understood in kidney transplant recipients. Our current study was carried out to assess the impact of HCV infection on kidney recipients over the long-term, and to investigate the ef...

journal_title：Transplantation

authors： Hanafusa T,Ichikawa Y,Kishikawa H,Kyo M,Fukunishi T,Kokado Y,Okuyama A,Shinji Y,Nagano S

更新日期：1998-08-27 00:00:00

abstract：:Acute rejection (AR) remains the biggest challenge during the first year after heart transplantation despite advances in immunosuppressive therapy. The early detection and curbing of AR are crucial to the survival of transplant recipients. However, as the criterion standard for AR, endomyocardial biopsy has several li...

journal_title：Transplantation

authors： Chen Y,Zhang L,Liu J,Zhang P,Chen X,Xie M

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Immunosuppression in renal transplantation, although manageable in the short-term, is a major hurdle for long-term graft survival. Recently, increased frequencies of CD4CD25 regulatory T cells (Tregs) have been described as an additional mechanism that induces alloimmune tolerance. METHODS:We assessed 64 re...

journal_title：Transplantation

authors： Segundo DS,Ruiz JC,Izquierdo M,Fernández-Fresnedo G,Gómez-Alamillo C,Merino R,Benito MJ,Cacho E,Rodrigo E,Palomar R,López-Hoyos M,Arias M

更新日期：2006-08-27 00:00:00

abstract：:Temperature is a key parameter in organ preservation that has been consistently linked to primary nonfunction (PNF). In this communication, and for the first time anywhere, continued and direct measurements of human liver intraparenchymal temperatures are reported in six clinical cases of orthotopic liver transplantat...

journal_title：Transplantation

authors： Villa R,Fondevila C,Erill I,Guimerà A,Bombuy E,Gómez-Suárez C,Sacristán JC,García-Valdecasas JC

更新日期：2006-02-15 00:00:00

abstract：BACKGROUND:A new supercooling system using a variable magnetic field has been recently developed. Subzero nonfreezing preservation has been believed to be a beneficial method because of the lower metabolic rate. The purpose of this study was to evaluate the hemodynamic and metabolic effects of rat heart preservation in...

journal_title：Transplantation

authors： Kato H,Tomita S,Yamaguchi S,Ohtake H,Watanabe G

更新日期：2012-09-15 00:00:00

abstract：:Neonatal tolerance to alloantigens and autoantigens in mice is mediated by T helper (Th)2 immunity. If a strong and pure Th2 response could be engaged to alloantigens in adult mice, it might result in allograft tolerance. In an attempt to induce Th2 immunity in adults, we studied the T-cell response to peptide I-A bet...

journal_title：Transplantation

authors： Lehmann PV,Matesic D,Benichou G,Heeger PS

更新日期：1997-07-27 00:00:00

abstract：BACKGROUND:The long-term outcome of simultaneous kidney pancreas transplant recipients is not well established. METHODS:We retrospectively reviewed all patients who underwent simultaneous kidney-pancreas transplantation with bladder drainage at our center between January 1989 and December 1991. A total of 57 patients ...

journal_title：Transplantation

authors： Sudan D,Sudan R,Stratta R

更新日期：2000-02-27 00:00:00