Respiratory complications: a major concern after right hepatectomy in living liver donors.

Abstract:

BACKGROUND:One of the main concerns after living donor liver transplantation is the risk of morbidity and/or mortality that it imposes on the donors. Respiratory postoperative complications in living liver donors have already been reported but their frequency seems to be underestimated. We designed a prospective study to evaluate the rate and the nature of postoperative pulmonary complications in 112 consecutive donors. METHODS:The medical records of the 112 living liver donors operated on at our center from 1998 to 2003 were reviewed and all the cases of respiratory complications were retrieved. Moreover, since 2000, all patients had a computed tomography angiography of the thorax at day 7 on a prospective basis. RESULTS:In all, 112 hepatectomies (44 right and 68 left) for adult-to-adult or adult-to-child liver donation were performed in our center. No postoperative mortality was recorded. Fourteen major respiratory complications developed in of 11 of 112 donors (9.8%), in all cases after right hepatectomy, and included nonsevere pulmonary embolism (n=7), right pleural empyema (n=3), and bacterial pneumonia (n=3). Minor respiratory complications (7.1% of the donors) included iatrogenic pneumothorax (n=3) and pleural effusion requiring thoracocentesis (n=5). Abdominal complications (mainly biliary leak) developed in 10 donors (8.9%), who in the vast majority remained free of pulmonary complications. CONCLUSIONS:In our series, pulmonary complications are frequent in living liver donors. These complications are mainly observed after right hepatectomy. The particular prevalence of pulmonary embolism should lead to focus on its early diagnosis and prevention.

journal_name

Transplantation

journal_title

Transplantation

authors

Dondero F,Taillé C,Mal H,Sommacale D,Sauvanet A,Farges O,Francoz C,Durand F,Delefosse D,Denninger MH,Vilgrain V,Marrash-Chahla R,Fournier M,Belghiti J

doi

10.1097/01.tp.0000191624.70135.35

subject

Has Abstract

pub_date

2006-01-27 00:00:00

pages

181-6

issue

2

eissn

0041-1337

issn

1534-6080

pii

00007890-200601270-00007

journal_volume

81

pub_type

杂志文章
  • Novel Therapeutic Approaches to Allosensitization and Antibody-mediated Rejection.

    abstract::Modification of pathogenic antibodies for autoimmune diseases illuminated the biologic relevance of B cells, plasma cells, and pathogenic antibodies in autoimmunity. They have also rejuvenated interest in how B cells mediate multiple effector functions that include antibody production, antigen presentation to T cells,...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/TP.0000000000002462

    authors: Jordan SC,Ammerman N,Choi J,Huang E,Peng A,Sethi S,Najjar R,Toyoda M,Lim K,Louie S,Vo A

    更新日期:2019-02-01 00:00:00

  • Hypersensitivity reactions in the small intestine. 6. Pathogenesis of the graft-versus-host reaction in the small intestinal mucosa of the mouse.

    abstract::The intestinal phase of the graft-versus-host reaction (GVHR) has been investigated in adult F1 mice bearing grafts of fetal gut using an H-2-incompatible and an H-2-compatible, Mls-incompatible combination. The results indicate that the mitotic activity of the intestinal crypts and the number of intraepithelial lymph...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198109000-00011

    authors: Mowat AM,Ferguson A

    更新日期:1981-09-01 00:00:00

  • Atrial anastomotic thrombus causes neurologic deficits in a lung transplant recipient.

    abstract::Pulmonary thrombus formation in the region of atrial anastomosis following lung transplantation has been reported by several authors. Such patients typically present immediately after surgery with significant hemodynamic compromise causing pulmonary edema and hypoxemia. We describe a patient who presented with bilater...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199609150-00028

    authors: Stang MR,Hinderliter AL,Gott KK,Paradowski LJ,Aris RM

    更新日期:1996-09-15 00:00:00

  • Monocytotoxic antibodies after bone marrow transplantation in aplastic anemia.

    abstract::Pre- and post transplant sera from 51 cases of bone marrow transplants performed for severe aplastic anemia were tested on monocytes (M) and corresponding B cells (B) from a panel of unrelated donors. One-third of the sera were cytotoxic for B and M either from different or from the same individuals, while 45% reacted...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198206000-00006

    authors: Gluckman JC,Gluckman E,Azogui O,Guillet J,Baldwin WM,Devergie A,Chapuis F,Brisson E,Andersen E,Dausset J

    更新日期:1982-06-01 00:00:00

  • Effects of Intraoperative Fluid Balance During Liver Transplantation on Postoperative Acute Kidney Injury: An Observational Cohort Study.

    abstract:BACKGROUND:Liver transplant recipients suffer many postoperative complications. Few studies evaluated the effects of fluid management on these complications. We conducted an observational cohort study to evaluate the association between intraoperative fluid balance and postoperative acute kidney injury (AKI) and other ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000002998

    authors: Carrier FM,Chassé M,Sylvestre MP,Girard M,Legendre-Courville L,Massicotte L,Bilodeau M

    更新日期:2020-07-01 00:00:00

  • Tacrolimus in cardiac transplantation: efficacy and safety of a novel dosing protocol.

    abstract:BACKGROUND:Although used for more than 20 years, optimal dosing strategies of most immunosuppressants have never been determined. Tacrolimus, one of the newer agents used in solid-organ transplantation, is gaining increasing popularity because of its ability to reverse refractory rejection in cyclosporine-treated patie...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1097/00007890-200210270-00014

    authors: Baran DA,Galin I,Sandler D,Segura L,Cheng J,Courtney MC,Correa R,Chan M,Fallon JT,Spielvogel D,Lansman SL,Gass AL

    更新日期:2002-10-27 00:00:00

  • Atypical mixed lymphocyte culture. Identity between mother and child in leukemia and aplastic anemia.

    abstract::The mixed lymphocyte culture tests between one patient with acute lymphocytic leukemia and her mother and between another patient with aplastic anemia and his mother were found nonreactive, despite a one-haplotype difference for HL-A. Two crossovers in each family at the MLC locus or a specific defect in lymphocyte r...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-197501000-00008

    authors: Opelz G

    更新日期:1975-01-01 00:00:00

  • Temperature-dependent phospholipid degradation in the rat liver during preservation for transplantation. A comparison between different preservation solutions.

    abstract::For the development of liver injury during preservation for transplantation, phospholipid degradation may be of importance. We therefore measured the degradation of [3H]-arachidonic acid (20:4)- and [14C]-linoleic acid (18:2)-labeled phospholipids during cold and warm preservation of rat livers in Eurocollins, Univers...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199404270-00003

    authors: Ar'Rajab A,Ahrén B,Nilsson A

    更新日期:1994-04-27 00:00:00

  • A new micromethod for the detection of HL-A antigens on cultured human tumor cells.

    abstract::A rapid microcytotoxicity assay for the detection of HL-A antigens on tissue culture cells derived from human solid tumors is described. Tumor cells were prelabeled with 125Iododeoxyuridine. Isotopically labeled tumor cells were reacted with up to 37 highly selected HL-A antisera and diluted rabbit complement. Results...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-197509000-00005

    authors: Fritze D,Kern DH,Drogemuller CR,Pilch YH

    更新日期:1975-09-01 00:00:00

  • Urinary matrix metalloproteinases and their endogenous inhibitors predict hepatic regeneration after murine partial hepatectomy.

    abstract:BACKGROUND:Matrix metalloproteinases (MMPs) play a key role in extracellular matrix remodeling events associated with hepatic regeneration after partial hepatectomy. We therefore hypothesized that urinary MMPs and their endogenous tissue inhibitors of matrix metalloproteinases (TIMPs) might also provide important infor...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000137935.81103.a2

    authors: Greene AK,Puder M,Roy R,Kilroy S,Louis G,Folkman J,Moses MA

    更新日期:2004-10-27 00:00:00

  • Hypothermic Ex Situ Perfusion of Human Limbs With Acellular Solution for 24 Hours.

    abstract:BACKGROUND:Machine perfusion (MP) has evolved as a promising approach for the ex situ preservation in organ transplantation. However, the literature on the use of MP in human vascularized composite allografts is scarce. The aim of this study was to evaluate the effects of hypothermic MP with an acellular perfusate in h...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000003221

    authors: Haug V,Kollar B,Tasigiorgos S,Endo Y,Kauke M,Safi AF,Veeramani A,Abdulrazzak O,Bausk B,Walt D,Pomahac B

    更新日期:2020-09-01 00:00:00

  • Impact of renal posttransplantation amputation on allograft outcomes: a study of United States renal data system.

    abstract:BACKGROUND:The prevalence of renal posttransplantation amputation and its impact on allograft and patient survival have not been widely reported. METHODS:We used an incident cohort of patients who underwent renal transplantation between June 2004 and September 2009. Amputation data were obtained using Medicare institu...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31828e72b4

    authors: Brar A,Jindal RM,Sumrani N,John D,Mondal Z,Tedla F,Salifu MO

    更新日期:2013-05-27 00:00:00

  • Donation after circulatory death: current practices, ongoing challenges, and potential improvements.

    abstract::Organ donation after circulatory death (DCD) has been endorsed by the World Health Organization and is practiced worldwide. This overview examines current DCD practices, identifies problems and challenges, and suggests clinical strategies for possible improvement. Although there is uniform agreement on DCD donor candi...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/01.TP.0000437178.48174.db

    authors: Morrissey PE,Monaco AP

    更新日期:2014-02-15 00:00:00

  • Safety of belatacept bridging immunosuppression in hepatitis C-positive liver transplant recipients with renal dysfunction.

    abstract:BACKGROUND:Perioperative renal dysfunction in liver transplant recipients complicates maintenance immunosuppressive therapy, particularly in patients with hepatitis C. Calcineurin inhibitors exacerbate renal dysfunction and mammalian target-of-rapamycin inhibitors are generally avoided because of perceived perioperativ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000438635.44461.2e

    authors: LaMattina JC,Jason MP,Hanish SI,Ottmann SE,Klassen DK,Potosky D,Hutson WR,Barth RN

    更新日期:2014-01-27 00:00:00

  • Rapamycin: immunosuppression, hyporesponsiveness, and side effects in a porcine renal allograft model.

    abstract::Rapamycin prolongs allograft survival and induces donor-specific tolerance in some small animal transplant models. Large animal studies, however, are limited. We studied rapamycin in a porcine renal allograft model. Donor-recipient combinations were chosen based on high response in pretransplant MLCs. Allografts were ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Almond PS,Moss A,Nakhleh RE,Melin M,Chen S,Salazar A,Shirabe K,Matas AJ

    更新日期:1993-08-01 00:00:00

  • Peripheral monitoring of direct and indirect alloantigen presentation pathways in clinical heart transplant recipients.

    abstract::It has been reported that the response to alloantigens presented by the direct and indirect pathway may be of differential relevance after human kidney transplantation. Accordingly, we monitored these routes in peripheral blood mononuclear cells (PBMC) of heart transplant patients from before transplantation and up to...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199601150-00033

    authors: van Besouw NM,Vaessen LM,Daane CR,Jutte NH,Balk AH,Claas FH,Weimar W

    更新日期:1996-01-15 00:00:00

  • Major histocompatibility complex control of NK-related allogeneic lymphocyte cytotoxicity in rats. The contributions of strong and medial transplantation antigens.

    abstract::Allogeneic lymphocyte cytotoxicity (ALC) describes the elimination of allogeneic lymphocytes in vivo by an NK-related activity. There is evidence that ALC is demonstrable between donor and recipient when these are incompatible at MHC gene loci alone. Since ALC is a property of T cell-deficient nude rats, the role of t...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198811000-00025

    authors: Ager A,Fajumi J,Sparshott SM,Ford WL,Butcher GW

    更新日期:1988-11-01 00:00:00

  • Population pharmacokinetics of tacrolimus in children who receive cut-down or full liver transplants.

    abstract:BACKGROUND:The aim of this study was to investigate the population pharmacokinetics of tacrolimus in pediatric liver transplant recipients and to identify factors that may explain pharmacokinetic variability. METHODS:Data were collected retrospectively from 35 children who received oral immunosuppressant therapy with ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200109270-00013

    authors: Staatz CE,Taylor PJ,Lynch SV,Willis C,Charles BG,Tett SE

    更新日期:2001-09-27 00:00:00

  • The effect of limited courses of cyclosporine on survival and immunocompetence of allogeneic bone marrow chimeras.

    abstract::Isolator-maintained CBH/Ola (Rtlc) rats were lethally irradiated and reconstituted with spleen and bone marrow cells from fully allogeneic WAG or Wistar (Rtlu) donors. Hematopoietically reconstituted rats were treated with cyclosporine (CsA)4 as prophylaxis for graft-versus-host disease (GVHD) for periods ranging from...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198511000-00002

    authors: Denham S,Attridge SR,Barfoot RK

    更新日期:1985-11-01 00:00:00

  • Long-term survival of hamster-to-rat cardiac xenografts in the absence of a Th2 shift.

    abstract:BACKGROUND:In hamster-to-rat cardiac xenografts, long-term survival (LTS) is obtained in 60% of recipients if vascular rejection is overcome by cobra venom factor and cyclosporine (CsA). It has been suggested that this accommodation state could be due to the Th2 response. METHODS:We examined the infiltrate by using im...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199806270-00004

    authors: Brouard S,Blancho G,Moreau A,Heslan JM,Cuturi MC,Soulillou JP

    更新日期:1998-06-27 00:00:00

  • 31P nuclear magnetic resonance spectroscopic evaluation of liver preservation solutions.

    abstract::The individual effects of verapamil and 2 antioxidants on perfused rat liver nucleoside triphosphate (NTP) recovery following cold storage in University of Wisconsin (UW) solution was assessed using 31P nuclear magnetic resonance spectroscopy. The pharmacological agents were added to UW solution and were present only ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Bowers JL,Neymark E,Cook CU,Clouse ME

    更新日期:1994-06-15 00:00:00

  • Effects of combination cyclosporine/mizoribine immunosuppression on canine renal allograft recipients.

    abstract::Heterotopic renal allografts following bilateral nephrectomies were placed in 21 healthy mongrel dogs. One group of 11 dogs received cyclosporine (5 mg/kg/24 hr, orally), and 1 group of 10 dogs received cyclosporine and mizoribine (5 mg/kg and 3 mg/kg/24 hr, orally). Body weights, blood cell counts, serum chemistry pr...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198805000-00003

    authors: Gregory CR,Gourley IM,Cain GR,Broaddus TW,Cowgill LD,Willits NH,Patz JD,Ishizaki G

    更新日期:1988-05-01 00:00:00

  • Improvement of donor myocardial function after treatment of autonomic storm during brain death.

    abstract:BACKGROUND:In experimental brain death models, autonomic storm (AS) triggers severe myocardial dysfunction, which can be attenuated by pharmacologic treatment. The aim of this study was to determine the incidence of AS in a cohort of human organ donors and to evaluate the potential interest of AS treatment on myocardia...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000235825.97538.d5

    authors: Audibert G,Charpentier C,Seguin-Devaux C,Charretier PA,Grégoire H,Devaux Y,Perrier JF,Longrois D,Mertes PM

    更新日期:2006-10-27 00:00:00

  • Utilization of donors who have suffered cardiopulmonary arrest and resuscitation in intestinal transplantation.

    abstract:BACKGROUND:Cardiopulmonary resuscitation (CPR) of a person destined to become an organ donor has been associated with overall poor donor quality, especially for the intestinal donor, as splanchnic vasoconstriction that is intended to preserve coronary and cerebral blood flow may result in clinically relevant intestinal...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3181852f9a

    authors: Matsumoto CS,Kaufman SS,Girlanda R,Little CM,Rekhtman Y,Raofi V,Laurin JM,Shetty K,Fennelly EM,Johnson LB,Fishbein TM

    更新日期:2008-10-15 00:00:00

  • Transplantation of pediatric en bloc cadaver kidneys into adult recipients.

    abstract:BACKGROUND:To maximize the renal donor pool, cadaveric pediatric en bloc kidneys have been transplanted as a dual unit by some transplant centers. We compared the short- and long-term outcomes of adult recipients of cadaveric pediatric en bloc renal transplants versus those of matched recipients of cadaveric adult kidn...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199812270-00020

    authors: Hobart MG,Modlin CS,Kapoor A,Boparai N,Mastroianni B,Papajcik D,Flechner SM,Goldfarb DA,Fischer R,O'Malley KJ,Novick AC

    更新日期:1998-12-27 00:00:00

  • Membranous glomerulopathy following kidney transplantation. Association with renal vein thrombosis in two of nine cases.

    abstract::The association of renal vein thrombosis and membranous glomerulopathy in native kidneys has been well documented. However, this association has only occasionally been described following renal transplantation. A review of 693 renal transplant recipients revealed 77 (11%) in whom persistent, heavy proteinuria (greater...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: First MR,Mendoza N,Maryniak RK,Weiss MA

    更新日期:1984-12-01 00:00:00

  • Plasma polymerase chain reaction for cytomegalovirus DNA after allogeneic marrow transplantation: comparison with polymerase chain reaction using peripheral blood leukocytes, pp65 antigenemia, and viral culture.

    abstract::In a prospective longitudinal study, detection of cytomegalovirus (CMV) DNA in plasma (plasma polymerase chain reaction [PCR]) was compared with PCR of CMV DNA in peripheral blood leukocytes (PBL PCR), the CMV pp65 antigenemia assay, and viral cultures from blood, urine, and throat of 29 patients, 14 of whom received ...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00007890-199707150-00020

    authors: Boeckh M,Gallez-Hawkins GM,Myerson D,Zaia JA,Bowden RA

    更新日期:1997-07-15 00:00:00

  • Topical use of cidofovir induced acute renal failure.

    abstract:BACKGROUND:Cidofovir has antiviral activity against a wide spectrum of DNA viruses. Several small studies have focused on the efficacy of topical cidofovir in various viral-induced diseases. We report a systemic complication of such therapy. CASE REPORT:A bone marrow transplant recipient with chronic renal failure dev...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200202270-00033

    authors: Bienvenu B,Martinez F,Devergie A,Rybojad M,Rivet J,Bellenger P,Morel P,Gluckman E,Lebbé C

    更新日期:2002-02-27 00:00:00

  • Monitoring the patient off immunosuppression. Conceptual framework for a proposed tolerance assay study in liver transplant recipients.

    abstract::The mission of the recently established Immune Tolerance Network includes the development of protocols for the induction of transplant tolerance in organ allograft recipients and the development of assays that correlate with and may be predictive of the tolerant state. The state of clinical organ transplant tolerance ...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:

    authors: Thomson AW,Mazariegos GV,Reyes J,Donnenberg VS,Donnenberg AD,Bentlejewski C,Zahorchak AF,O'Connell PJ,Fung JJ,Jankowska-Gan E,Burlingham WJ,Heeger PS,Zeevi A

    更新日期:2001-10-27 00:00:00

  • Detection of Ia alloantigens on phytohemagglutinin-stimulated T blast cells.

    abstract::The expression of Ia antigens on leukoagglutinin-induced blast cells was studied using a sensitive protein A-rosetting technique and quantitative absorption with conventional and monoclonal Ia antibodies. By direct testing, 40 to 60% of CBA (Iak) blast cells were shown to be Ia+ (Iak+, Ia.17+, and Ias-), expressing bo...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198105010-00005

    authors: Michaelides M,McKenzie IF

    更新日期:1981-05-01 00:00:00