Abstract:
BACKGROUND:Liver transplant recipients suffer many postoperative complications. Few studies evaluated the effects of fluid management on these complications. We conducted an observational cohort study to evaluate the association between intraoperative fluid balance and postoperative acute kidney injury (AKI) and other postoperative complications. METHODS:We included consecutive adult liver transplant recipients who had their surgery between July 2008 and December 2017. Our exposure was intraoperative fluid balance, and our primary outcome was the grade of AKI at 48 hours after surgery. Our secondary outcomes were the grade of AKI at 7 days, the need for postoperative renal replacement therapy, postoperative red blood cell transfusions, time to first extubation, time to discharge from the intensive care unit (ICU), and 1-year survival. Every analysis was adjusted for potential confounders. RESULTS:We included 532 transplantations in 492 patients. We observed no effect of fluid balance on either 48-hour AKI, 7-day AKI, or on the need for postoperative renal replacement therapy after adjustments for confounders. A higher fluid balance increased the time to ICU discharge, and increased the risk of dying (hazard ratio = 1.21 [1.04,1.40]). CONCLUSIONS:We observed no association between intraoperative fluid balance and postoperative AKI. Fluid balance was associated with longer time to ICU discharge and lower survival. This study provides insight that might inform the design of a clinical trial on fluid management strategies in this population.
journal_name
Transplantationjournal_title
Transplantationauthors
Carrier FM,Chassé M,Sylvestre MP,Girard M,Legendre-Courville L,Massicotte L,Bilodeau Mdoi
10.1097/TP.0000000000002998subject
Has Abstractpub_date
2020-07-01 00:00:00pages
1419-1428issue
7eissn
0041-1337issn
1534-6080pii
00007890-202007000-00021journal_volume
104pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:The chemokine receptor CCR7 plays a pivotal role in the homing of naïve T cells and regulatory T cells to secondary lymphoid organs and the migration of dendritic cells into afferent lymphatic vessels. Antigen presentation, T cell recruitment, and expansion of regulatory cells are crucial events in establish...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181826a97
更新日期:2008-08-27 00:00:00
abstract:BACKGROUND:The administration of systemic immunosuppressive agents to recipients of solid organ or bone marrow transplants results in an immunocompromised status. As the number of organ recipients and their life span increase with recent progress in organ transplantation, ocular complications tend to become more divers...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000259386.59375.8a
更新日期:2007-03-27 00:00:00
abstract:BACKGROUND:Chronic red cell aplasia can develop in immunocompromised patients including transplant recipients infected with parvovirus B19 (PV B19). Renal involvement with PV B19 infection is not well-recognized. METHODS:We diagnosed erythroid hypoplasia associated with PV B19 infection in three renal transplant recip...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199712270-00037
更新日期:1997-12-27 00:00:00
abstract::The frequencies of circulating donor-reactive cytotoxic lymphocyte precursors (CLP) and Il-2-producing helper lymphocyte precursors (HLP) were determined by limiting dilution analysis in 19 kidney allograft recipients before and at various intervals (up to 2 years) after transplantation. A significant, selective, and ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199309000-00025
更新日期:1993-09-01 00:00:00
abstract::The effect of cyclosporine and metabolite 17 (M17) as well as other CsA-related compounds (CsG, dihydro-CsC, dihydro-CsD, CsH, B5.49, and H7.94) was tested on T lymphocyte clone proliferation. In these experiments, antigen and interleukin 2 (IL-2) dependent long-term T lymphocyte clones derived from a rejected human k...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198712000-00019
更新日期:1987-12-01 00:00:00
abstract::Focal segmental glomerulosclerosis (FSGS) is the primary renal disease in approximately one-tenth of pediatric patients receiving a renal allograft. Recurrence of proteinuria after renal transplantation is observed in approximately 30% of patients and negatively impacts graft survival. Risk factors for recurrence are ...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000187110.25512.82
更新日期:2005-09-27 00:00:00
abstract::Pseudoaneurysms of the hepatic artery are a rare complication of liver transplantation. Early diagnosis and treatment are essential to avoid life-threatening hemorrhage. Conventional treatment consists of surgical resection and vascular reconstruction or transarterial coil embolization. More recently, percutaneous thr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000063936.94587.10
更新日期:2003-05-27 00:00:00
abstract::T cells must be activated before they can elicit damage to allografts, through interaction of their T cell receptor (TCR) with peptide-MHC complex and through accessory molecules. Signaling through accessory molecules or costimulatory molecules is a critical way for the immune system to fine tune T cell activation. An...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0b013e31826d4672
更新日期:2013-02-27 00:00:00
abstract:BACKGROUND:Immunotherapy given post-autologous stem cell transplantation may eliminate residual tumor cells escaping the conditioning protocol. METHODS:Five children suffering from stage IV neuroblastoma were treated by recombinant interleukin-2 (IL-2) post-autologous peripheral blood stem cell transplantation. The pa...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200010150-00019
更新日期:2000-10-15 00:00:00
abstract:BACKGROUND:Detection of markers predicting allograft rejection is important for risk assessment before kidney transplantation, as well as to minimize posttransplantation immunosuppression. METHODS:We studied the expression of CD25, HLA-DR, CD134, CD62L, and CD44 by flow cytometry in CD4, CD8, and CD3 cells, from pretr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182283c58
更新日期:2011-09-15 00:00:00
abstract::The nephrotoxic effects of cyclosporine (CsA) seem to be augmented by co-existing renal injury. A high rate of prolonged delayed function (acute tubular necrosis [ATN]) and non-function (NF) has been associated with the use of CsA prior to and following renal transplantation. Cyclosporine has also been associated with...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198701000-00019
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:In December 2018, United Network for Organ Sharing approved an allocation scheme based on recipients' geographic distance from a deceased donor (acuity circles [ACs]). Previous analyses suggested that ACs would reduce waitlist mortality overall, but their impact on pediatric subgroups was not considered. ME...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003079
更新日期:2020-08-01 00:00:00
abstract::The interaction of T cell costimulatory molecules with their ligands is required for optimal T cell activation. Interference with such interactions can induce antigen unresponsiveness and delay xeno- and allograft rejection. We have previously shown that LFA3TIP, a soluble human lymphocyte function-associated antigen ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199602150-00004
更新日期:1996-02-15 00:00:00
abstract:BACKGROUND:Our objective was to evaluate graft equilibration with high viscosity (University of Wisconsin solution [UW]) or low viscosity (Bretschneider's histidine-tryptophan-ketoglutarate [HTK]) during liver procurement from non-heart beating donors (NHBD) and the potential impact of a preceding fibrinolysis with str...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200106270-00015
更新日期:2001-06-27 00:00:00
abstract:BACKGROUND AND METHODS:To investigate the frequency of apoptosis and the expression of Fas/Fas ligand (FasL) in liver allografts, we examined 97 biopsy specimens from 62 patients after orthotopic liver transplantation. The results of the biopsies were as follows: acute allograft rejection (n=32); hepatitis C virus (HCV...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199904150-00027
更新日期:1999-04-15 00:00:00
abstract:BACKGROUND:Knowledge on the reinnervation of transplanted organs is scarce, and the aim of the study was therefore to evaluate to what degree syngeneic pancreas grafts were reinnervated in rats. METHODS:Syngeneic pancreatico-duodenal transplantations were performed in normoglycemic Wistar-Furth rats. Native and transp...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200101150-00002
更新日期:2001-01-15 00:00:00
abstract:BACKGROUND:We recently demonstrated that inhibition of inducible nitric oxide synthase (iNOS) ameliorated severe acute lung allograft rejection. This study used a rat lung transplant model to determine (1) the time course and cellular localization of iNOS expression during the histological progression of unmodified acu...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199704270-00008
更新日期:1997-04-27 00:00:00
abstract::A new method of thymus transplantation is introduced, in which the graft is directly connected with the recipient's vascular system. This procedure was used both in euthymic rats and congenitally athymic nude rats. At all tested intervals after transplantation thymus grafts hardly differed from the recipient's own thy...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199010000-00028
更新日期:1990-10-01 00:00:00
abstract:BACKGROUND:Blockade of the inducible costimulator (ICOS) pathway has been shown to prolong allograft survival; however, its utility in xenotransplantation is unknown. We hypothesize that local expression of ICOS-Ig by the xenograft will suppress the T-cell response resulting in significant prolonged graft survival. ME...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31821774e0
更新日期:2011-05-27 00:00:00
abstract:BACKGROUND:Both chemokines and adhesion molecules mediate allograft rejection by recruiting leukocytes into the allograft. We investigated the association of six single nucleotide polymorphisms (SNPs) located in interleukin (IL)-8, CXCR1, CXCR2, and selectin with kidney allograft outcomes. METHODS:The promoter regions...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/tp.0b013e3181fd0195
更新日期:2011-01-15 00:00:00
abstract::Several approaches have been attempted to manage renal allograft dysfunction in cyclosporine-prednisone (CsA-Pred)-treated patients. Conversion to conventional therapy and perioperative triple drug have been associated with high rates of acute rejection episodes, infections, or neoplasms. We report our experience in d...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-199108000-00017
更新日期:1991-08-01 00:00:00
abstract:BACKGROUND:Randomized controlled trials and U.S. Registry data have demonstrated that mycophenolate mofetil (MMF) reduces acute rejection rates and improves graft survival. We undertook the first paired kidney analysis comparing the effects of MMF and azathioprine on graft outcome in the United Kingdom. METHODS:In all...
journal_title:Transplantation
pub_type: 杂志文章,meta分析
doi:10.1097/01.tp.0000250713.65004.35
更新日期:2006-12-27 00:00:00
abstract:BACKGROUND:The aim of this study was to compare the pharmacokinetic profile, tolerability, and safety of a novel once-daily extended-release formulation of tacrolimus (LCPT) with that of once-daily prolonged-release tacrolimus (ODT) in stable adult lung transplant (LT) recipients. METHODS:Phase II, open-label, single-...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002348
更新日期:2018-10-01 00:00:00
abstract::A new case of anti-factor V inhibitor is described in a 46-year-old man, who received a liver transplantation for hepatocellular carcinoma, without exposure to bovine thrombin or fibrin glue during the operative course. The inhibition occurred on the 14th postoperative day, while the patient was being treated with oxa...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199910150-00026
更新日期:1999-10-15 00:00:00
abstract:BACKGROUND:Low-molecular-weight heparin (LMWH) has been shown to prolong survival of rat cardiac allografts independently from immunosuppressive treatment. Furthermore, long-term treatment reduces the development of chronic graft vascular disease after experimental heart transplantation. The aim of the present study wa...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200107270-00007
更新日期:2001-07-27 00:00:00
abstract:BACKGROUND:Kidney transplantation (KT) of human immunodeficiency virus (HIV)-positive patients has transformed the management of end-stage kidney disease in this population. Although favourable outcomes have been reported, patients experience high rates of acute allograft rejection (AR). We examined factors associated ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000879
更新日期:2016-04-01 00:00:00
abstract::Cyclosporine treatment of BALB/c mice (at a dose of 20 mg/kg every other day for 3 weeks) caused a remarkable reduction in the PNA-, L3T4+Lyt-2- subset of thymocytes. A significant reduction of the L3T4+Lyt-2-subset was also observed in both the lymph node and spleen cells of CsA-treated mice, though the degree of the...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198903000-00020
更新日期:1989-03-01 00:00:00
abstract:BACKGROUND:Avascular osteonecrosis (AVN) is a serious complication of allogeneic stem cell transplantation (SCT). Graft-versus-host disease and its treatment with steroids are the main risk factors; underlying diagnosis, age and gender are further risk factors. It has been speculated that low baseline bone mineral dens...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/01.tp.0000164353.86447.db
更新日期:2005-06-27 00:00:00
abstract::Although extrinsic denervation is inevitable after intestinal transplantation and leads to poor intestinal function, little is known about the occurrence of extrinsic reinnervation. In this study, extrinsic sympathetic reinnervation was investigated morphologically following syngeneic intestinal transplantation perfor...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1995-02-15 00:00:00
abstract::Previously, we demonstrated that the dose-normalized tacrolimus blood concentration after renal transplantation was associated with a single nucleotide polymorphism (SNP) in the CYP3AP1 gene, probably through linkage with an SNP in the CYP3A5 gene. Individuals with at least one CYP3A5*1 allele synthesize CYP3A5 and CY...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000151766.73249.12
更新日期:2005-02-27 00:00:00