Long-term graft outcome with mycophenolate mofetil and azathioprine: A paired kidney analysis.

abstract：BACKGROUND:The infiltration of epithelium by CD8+ T lymphocytes in human renal or liver allografts is a critical feature of acute rejection. CD103 expression can be acquired in vitro by CD8+ cytotoxic T lymphocytes in response to allogeneic renal epithelial cells and promotes their adhesion to epithelium and subsequent...

journal_title：Transplantation

authors： Leteurtre E,Copin MC,Labalette M,Noel C,Roumilhac D,Pruvot FR,Lecomte-Houcke M,Gosselin B,Dessaint JP

更新日期：2000-07-15 00:00:00

abstract：BACKGROUND:Donor pigs transgenic for human decay-accelerating factor (hDAF) were used in a xenogeneic ex vivo liver perfusion model to study the effect of this modification on the development of hyperacute rejection. METHODS:Three transgenic pigs were hepatectomized after hypothermic portal and transaortal gravity per...

journal_title：Transplantation

authors： Pascher A,Poehlein C,Storck M,Prestel R,Mueller-Hoecker J,White DJ,Abendroth D,Hammer C

更新日期：1997-08-15 00:00:00

abstract：:Our current knowledge of cytotoxic T lymphocytes (CTL) is largely derived from studies of effector populations generated in allogeneic mixed leukocyte cultures (MLC) and assayed for lytic activity to lymphoid cell (LC) targets. We herein report that the CTL response to allogeneic renal epithelial cell lines (REC) is d...

journal_title：Transplantation

authors： Hadley GA,Rostapshova EA,Bartlett ST

更新日期：1996-07-15 00:00:00

abstract：:Despite human leukocyte antigen (HLA) identity between donor and recipient, several patients develop acute graft-versus-host disease (aGVHD) after hematopoetic stem cell transplantation (HSCT) because of minor histocompatibility antigen (mHag) incompatibilities. The impact of multiple mHag disparities on the clinical ...

journal_title：Transplantation

authors： Heinemann FM,Ferencik S,Ottinger HD,Beelen DW,Grosse-Wilde H

更新日期：2004-04-15 00:00:00

abstract：BACKGROUND:Bone marrow stromal cells (BMSC) transplantation offers promise in the treatment of chronic paraplegia in rodents. Here, we report the effect of this cell therapy in adult pigs suffering chronic paraplegia. METHODS:Three months after spinal cord injury, autologous BMSC in autologous plasma was injected into...

journal_title：Transplantation

authors： Zurita M,Vaquero J,Bonilla C,Santos M,De Haro J,Oya S,Aguayo C

更新日期：2008-09-27 00:00:00

abstract：:Four skin graft models are created which vary in the rates of lymphatic and vascular reconstitution. Rat allografts (Brown Norway or (L times BN)F1 hybrid) transplanted to Lewis recipients by conventional (immediate lymphatic, delayed vascular), surgical anastomosis (immediate lymphatic, immediate vascular) or isolate...

journal_title：Transplantation

authors： Wustrack KO,Gruber RP,Lucas ZJ

更新日期：1975-02-01 00:00:00

abstract：:Cyclosporine extends kidney allograft survival in the chacma baboon, and this study explores various administration protocols to generate optimal serum concentrations of the drug, assessed by radioimmunoassay and by inhibition of lymphocyte transformation by phytohemagglutinin and allogeneic lymphocytes in culture. Se...

journal_title：Transplantation

authors： Smit JA,Drielsma RF,Myburgh JA,Laupacis A,Stiller CR

更新日期：1983-08-01 00:00:00

abstract：BACKGROUND:To define whether immunosuppressive agents that block the interleukin (IL)-2 pathway could prevent activation-induced cell death of activated T cells in the graft, we measured expression of IL-2, IL-2 receptor alpha chain (CD25), IL-15, Fas, and Fas ligand by real time reverse transcription-polymerase chain ...

journal_title：Transplantation

authors： Baan CC,Balk AH,van Riemsdijk IC,Vantrimpont PJ,Maat AP,Niesters HG,Zondervan PE,van Gelder T,Weimar W

更新日期：2003-05-27 00:00:00

abstract：BACKGROUND:The full potential of pancreatic islet transplantation (PIT) has not been realized because of the difficulties associated with islet isolation, particularly when associated with a remote islet isolation center. Herein, we describe the principles of pancreatic procurement for PIT, which have allowed us to ach...

journal_title：Transplantation

authors： Lee TC,Barshes NR,Brunicardi FC,Alejandro R,Ricordi C,Nguyen L,Goss JA

更新日期：2004-08-15 00:00:00

abstract：:Eradicating transplant tourism depends on complex solutions that include efforts to progress towards self-sufficiency in transplantation. Meanwhile, professionals and authorities are faced with medical, legal, and ethical problems raised by patients who return home after receiving an organ transplant abroad, particula...

journal_title：Transplantation

authors： Domínguez-Gil B,Danovitch G,Martin DE,López-Fraga M,Van Assche K,Morris ML,Lavee J,Erlich G,Fadhil R,Busic M,Rankin G,Al-Rukhaimi M,OʼConnell P,Chin J,Norman T,Massari P,Kamel R,Delmonico FL,Declaration of Istanbul Cu

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Targeting 2-hr postdose cyclosporine (C2) levels to 1,000 to 1,700 mg/dL during the first 6 months after renal transplantation is recommended for triple immunosuppressive regimens. This trial determines whether lower C2 levels could be targeted safely in de novo kidney transplant recipients under a quadruple...

journal_title：Transplantation

authors： Hardinger KL,Schnitzler MA,Koch MJ,Enkvetchakul D,Desai N,Jendrisak M,Lowell JA,Miller B,Shenoy S,Brennan DC

更新日期：2004-10-27 00:00:00

abstract：BACKGROUND:Skin-autofluorescence (skin-AF) noninvasively measures the tissue accumulation of advanced glycation end products (AGEs). AGEs are nephrotoxic and potential effectors of cardiovascular mortality. We investigated whether skin-AF predicted graft loss after kidney transplantation. METHODS:A total of 302 renal ...

journal_title：Transplantation

authors： Hartog JW,Gross S,Oterdoom LH,van Ree RM,de Vries AP,Smit AJ,Schouten JP,Nawroth PP,Gans RO,van Son WJ,Bierhaus A,Bakker SJ

更新日期：2009-04-15 00:00:00

abstract：:Two infants born to mothers who had been given a renal transplant and who were receiving azathioprine and prednisone have been followed up for over 2 years. Initially both had lower than normal lymphocyte counts and cortisol levels. Chromosomal aberrations similar to those found in the lymphocytes of the mothers were ...

journal_title：Transplantation

authors： Price HV,Salaman JR,Laurence KM,Langmaid H

更新日期：1976-04-01 00:00:00

abstract：:Donor graft major histocompatibility complex class I antigens are targets for both allogeneic and xenogeneic rejection. Mice homozygous for beta 2-microglobulin gene disruption express reduced amounts of surface MHC class I antigens. Liver cells from such mutant mice were transplanted into isogeneic, allogeneic, and x...

journal_title：Transplantation

authors： Li X,Faustman D

更新日期：1993-04-01 00:00:00

abstract：:Liver transplantation is the most effective treatment for selected patients with hepatocellular carcinoma. However, cancer recurrence, posttransplantation, remains to be the critical issue that affects the long-term outcome of hepatocellular carcinoma recipients. In addition to tumor biology itself, increasing evidenc...

journal_title：Transplantation

authors： Li CX,Man K,Lo CM

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Successful pancreatic islet transplantation (PIT) has resulted in several transplant centers wanting to start PIT programs. PIT remains experimental and must be performed safely for its continued use. We describe the radiographic techniques used at our center and their results. METHODS:Between January 17, 2...

journal_title：Transplantation

authors： Goss JA,Soltes G,Goodpastor SE,Barth M,Lam R,Brunicardi FC,Froud T,Alejandro R,Ricordi C

更新日期：2003-07-15 00:00:00

abstract：BACKGROUND:Mycophenolate mofetil (MMF) based immunosuppression after renal transplantation has proven to be safe and beneficial for children and adolescents. However, long-term analysis, in particular of pediatric patients, is scarce. PATIENTS:Data of 140 patients receiving MMF versus azathioprine (AZA) in combination...

journal_title：Transplantation

authors： Jungraithmayr TC,Wiesmayr S,Staskewitz A,Kirste G,Bulla M,Fehrenbach H,Dippell J,Greiner C,Griebel M,Helmchen U,Klaus G,Leichter HE,Mihatsch MJ,Michalk DV,Misselwitz J,Plank C,Tönshoff B,Weber LT,Zimmerhackl LB,Germ

更新日期：2007-04-15 00:00:00

abstract：:Ranolazine is a new drug with a novel mode of action as a metabolic modulator and membrane stabilizer. In this prospective randomized double-blind trial, a porcine model of renal autotransplantation was used to assess the effects of this drug during preservation and reperfusion of kidneys cold-stored for 24 hr in phos...

journal_title：Transplantation

authors： Lodge JP,Lam FT,Perry SL,Giles GR

更新日期：1990-11-01 00:00:00

abstract：INTRODUCTION:Cytomegalovirus infection after heart transplantation is considered as risk factor for the development of transplant arteriosclerosis. Therefore, the aim of this study was to investigate the effect of murine cytomegalovirus (MCMV) as a single risk factor on transplant arteriosclerosis in an experimental ao...

journal_title：Transplantation

authors： Heim C,Abele-Ohl S,Eckl S,Ramsperger-Gleixner M,Mahmoudian S,Weyand M,Stamminger T,Ensminger SM

更新日期：2010-08-27 00:00:00

abstract：:The early detection of allograft rejection remains elusive after solitary pancreas transplantation (PTX). We have previously described a modified technique of cystoscopic transduodenal PTX biopsy using the Biopty gun under ultrasound guidance. During the last 2 years, we performed 24 solitary PTXs with prospective pro...

journal_title：Transplantation

authors： Stratta RJ,Taylor RJ,Grune MT,Sindhi R,Sudan D,Castaldo P,Cushing KA,Radio SJ,Wisecarver JL,Matamoros A

更新日期：1995-12-27 00:00:00

abstract：:The aim of this study was to assess the feasibility of detecting anti-HLA antibodies in eluates from needle core biopsies of renal transplants with chronic allograft nephropathy. Two methods of screening, the enzyme-linked immunosorbent assay (ELISA) and flow cytometry (FlowPRA) were compared. Twenty renal transplants...

journal_title：Transplantation

authors： Martin L,Guignier F,Bocrie O,D'Athis P,Rageot D,Rifle G,Justrabo E,Mousson C

更新日期：2005-05-27 00:00:00

abstract：:The requirement for effective, minimally toxic immunosuppression remains a major obstacle to performing human composite tissue allotransplantation. The skin component of composite tissue (e.g., limb) allografts is especially antigenic, necessitating toxic immunosuppressant doses to prevent or reverse acute rejection. ...

journal_title：Transplantation

authors： van den Helder TB,Benhaim P,Anthony JP,McCalmont TH,Mathes SJ

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:Galbeta1-4GlcNAcalpha2-6 sialyltransferase (ST6GalI) is an acute phase reactant whose release from cells can be induced by proinflammatory cytokines. Because patients with chronic renal failure have high circulating levels of proinflammatory cytokines, we hypothesized that patients on the renal transplant wa...

journal_title：Transplantation

authors： Thorne-Tjomsland G,Hosfield T,Jamieson JC,Liu B,Nickerson P,Gough JC,Rush DN,Jeffery JR,McKenna RM

更新日期：2000-03-15 00:00:00

abstract：BACKGROUND:It has been suggested that cytomegalovirus infection increases the risk of ischemic heart disease. Both cytomegalovirus and ischemic heart disease are common after renal transplantation, suggesting a possible causal association in this population. METHODS AND PATIENTS:We studied 1004 consecutive renal trans...

journal_title：Transplantation

authors： Hernández D,Hanson E,Kasiske MK,Danielson B,Roel J,Kasiske BL

更新日期：2001-10-27 00:00:00

abstract：BACKGROUND:Imported pancreata accumulate cold ischemia time (CIT), limiting utilization and worsening outcomes. Flow cytometric crossmatching (FXM) is a standard method to assess recipient and donor compatibility, but can prolong CIT. Single-antigen bead assays allow for detection of recipient donor-specific HLA antibo...

journal_title：Transplantation

authors： Eby BC,Redfield RR,Ellis TM,Leverson GE,Schenian AR,Odorico JS

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:The detection of acute rejection in heart transplantation remains an important feature of transplant management, especially in the early phase. Frequent surveillance with endomyocardial biopsy is necessary, even though it is an invasive procedure and carries a certain risk. Hence, noninvasive biomarkers able...

journal_title：Transplantation

authors： Crescioli C,Buonamano A,Scolletta S,Sottili M,Francalanci M,Giomarelli P,Biagioli B,Lisi G,Pradella F,Serio M,Romagnani P,Maccherini M

更新日期：2009-01-27 00:00:00

abstract：BACKGROUND:Significant disparity exists in the United Kingdom between the need for organ transplant and supply of deceased donor organs. In the recent years, efforts to increase donation has improved the rate of mainly deceased donors after circulatory death and from older donors. The rate of donation from pediatric po...

journal_title：Transplantation

authors： Dave RV,Hakeem AR,Dawrant MJ,Ecuyer CL,Lewington AJ,Attia MS,Hostert L,Finlay E,Ahmad N

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Intestinal transplantation is known to be associated with a high risk of early complications and mortality. METHODS:We analyzed prospective data of 51 primary small bowel transplantations from December 1999 to August 2009 and identified perioperative factors that impact on early mortality (≤6 months after t...

journal_title：Transplantation

authors： Dopazo C,Gupte GL,Sharif K,Perera MT,Hartley J,Muiesan P,Mayer DA,Bromley P,Bennett J,Kelly DA,van Mourik I,McKiernan P,Beath SV,Mirza DF

更新日期：2012-10-27 00:00:00

abstract：:Pretreatment of LEW rats with cyclosporin A (10 mg/kg/day orally for 14 days) plus 10(8) DA or (DA X LEW)F1 spleen lymphocytes on two occasions markedly prolonged the survival of subsequent DA renal allografts. The lymphocytotoxic antibody response was suppressed completely and renal biopsies showed a marked mononucle...

journal_title：Transplantation

authors： Homan WP,Williams KA,Millard PR,Morris PJ

更新日期：1981-06-01 00:00:00

abstract：:A sensitive micromethod for generating and assaying allogeneically induced cytotoxic human lymphocytes in vitro is described. Responding lymphocytes are cultured with mitomycin-C treated allogeneic stimulating cells in wells of replicate microtrays for both one-way mixed leukocyte culture (MLC) and cell-mediated lymph...

journal_title：Transplantation

authors： Zarling JM,McKeough M,Bach FH

更新日期：1976-06-01 00:00:00