Composite tissue (limb) allografts in rats. I. Dose-dependent increase in survival with cyclosporine.

abstract：BACKGROUND:Kidney donation after cardiac death leads to vascular damage as a result of warm ischemia, affecting renovascular circulating volume. Novel ultrasound dilution techniques may be used to measure renovascular circulating volumes during hypothermic machine perfusion of donor kidneys. METHODS:Renovascular circu...

journal_title：Transplantation

authors： de Vries EE,van Smaalen TC,Boer J,Hoogland ER,Krivitski NM,Snoeijs MG,van Heurn LW

更新日期：2013-05-15 00:00:00

abstract：BACKGROUND:Since suitable recipients for hepatic allografts from donors with antibodies to hepatitis B virus (HBV) have not been determined, a review of our 7-year experience with donors positive for hepatitis B surface antibody (anti-HBs), hepatitis B core antibody (anti-HBc), or both was undertaken. METHODS:Recipien...

journal_title：Transplantation

authors： Dodson SF,Issa S,Araya V,Gayowski T,Pinna A,Eghtesad B,Iwatsuki S,Montalvo E,Rakela J,Fung JJ

更新日期：1997-12-15 00:00:00

abstract：:We have previously demonstrated that streptozotocin-induced diabetic rats have decreased guanylate cyclase (EC 4.6.1.2) activity in liver and other tissues which was returned to normal by the administration of exogenous insulin. Since successful pancreatic islet transplants have been shown to lower basal hepatic gluco...

journal_title：Transplantation

authors： Vesely DL,Selawry H,Levey GS

更新日期：1979-06-01 00:00:00

abstract：BACKGROUND:Although the value of duodenal histology as a means to diagnose acute rejection in pancreaticoduodenal allografts has been validated, it is not known how the duodenum responds to antirejection treatment in comparison with the pancreas. METHODS:Diabetic Lewis rats received a pancreaticoduodenal allograft. Cy...

journal_title：Transplantation

authors： Mark W,Hechenleitner P,Dietze O,Klima G,Schneeberger S,Steurer W,Candinas D,Margreiter R,Königsrainer A

更新日期：2002-01-27 00:00:00

abstract：BACKGROUND:Patient-level risk factors for delayed graft function (DGF) have been well described. However, the Organ Procurement and Transplantation Network definition of DGF is based on dialysis in the first week, which is subject to center-level practice patterns. It remains unclear if there are center-level differenc...

journal_title：Transplantation

authors： Orandi BJ,James NT,Hall EC,Van Arendonk KJ,Garonzik-Wang JM,Gupta N,Montgomery RA,Desai NM,Segev DL

更新日期：2015-05-01 00:00:00

abstract：:We recently reported that reconstitution of lethally irradiated B10 mouse recipients with 40 x 10(6) untreated WF rat bone marrow cells resulted in stable fully xenogeneic chimerism (WF rat----B10 mouse). In these animals, the tolerance induced for skin xenografts was highly MHC specific in that donor-specific WF rat ...

journal_title：Transplantation

authors： Zeng YJ,Ricordi C,Tzakis A,Rilo HL,Carroll PB,Starzl TE,Ildstad ST

更新日期：1992-02-01 00:00:00

abstract：:Orthotopic liver allografts from BN donors to LEW recipients are spontaneously accepted, and the recipients develop donor-specific immunological unresponsiveness. This unresponsiveness may be mediated by suppressor T cells. Immunomagnetically purified splenic T cells from LEW rats bearing BN liver grafts were shown to...

journal_title：Transplantation

authors： Gassel HJ,Hutchinson IV,Engemann R,Morris PJ

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:Preexisting IgG antibodies to donor human leukocyte antigens (HLA) are a risk factor for rapid allograft rejection. However, non-HLA antibodies, of the IgM class, also called autoreactive antibodies, are not believed to affect graft survival. The aim of this study was to determine the incidence and clinical ...

journal_title：Transplantation

authors： Smith JD,Hamour IM,Burke MM,Mahesh B,Stanford RE,Haj-Yahia S,Robinson DR,Kaul P,Yacoub MH,Banner NR,Rose ML

更新日期：2009-03-27 00:00:00

abstract：:Previous studies have demonstrated that donor antigen-specific primed-lymphocyte-test (PLT) reactivity of bronchoalveolar lavage lymphocytes is strongly associated with acute pulmonary rejection and with obliterative bronchiolitis (OB); however, a systematic analysis of PLT reactivity as being class I-or II-directed h...

journal_title：Transplantation

authors： Reinsmoen NL,Bolman RM,Savik K,Butters K,Hertz M

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Although it is generally considered that livers with moderate steatosis can be safely used in the setting of living-donor liver transplantation, the effect of the regenerative process of such a graft on postoperative liver function is incompletely understood. We assessed the morphologic and functional altera...

journal_title：Transplantation

authors： Ninomiya M,Shimada M,Terashi T,Ijichi H,Yonemura Y,Harada N,Soejima Y,Suehiro T,Maehara Y

更新日期：2004-02-15 00:00:00

abstract：BACKGROUND:One third of human lung allografts develop chronic rejection manifested as obliterative bronchiolitis. Heterotopically transplanted allogeneic murine tracheas develop obliterative airway disease (OAD) leading to a lesion resembling human obliterative bronchiolitis. The purpose of this study was to determine ...

journal_title：Transplantation

authors： Kelly KE,Hertz MI,Mueller DL

更新日期：1998-09-27 00:00:00

abstract：:Heterologous anti-immunoglobulin is a potent immunosuppressive agent that prolongs H-2- and H-3-incompatible skin graft survival. In conjunction with antithymocyte serum, anti-immunoglobulin promotes greater graft life than either antiserum used alone, without evidence of toxicity to recipient animals. Combination tre...

journal_title：Transplantation

authors： Constantian MB,Couser WG,Mannick JA

更新日期：1977-11-01 00:00:00

abstract：:Antigenic requirements for the induction of T cell-independent primary splenic IgM antibody responses (plaque-forming cell responses) to H-2Dd alloantigens were studied. Results show that some functional activity or structural property of the donor cells is required for immunogenicity, because antigens are not active ...

journal_title：Transplantation

authors： Nakashima I,Clark EA,Lake P,Kato N,Nagase F,Mizoguchi K,Isobe KI,Saito M

更新日期：1983-02-01 00:00:00

abstract：BACKGROUND:The influence of the graft composition on the clinical outcome after allogeneic peripheral blood stem cell (PBSC) transplantation is not well established. METHODS:The cellular composition of the apheretic products obtained from 63 human leukocyte antigen-identical siblings was prospectively correlated with ...

journal_title：Transplantation

authors： Iori AP,Torelli GF,De Propris MS,Milano F,Pupella S,Gozzer M,Mancini F,Milani ML,Intoppa S,Cerretti R,Lucarelli B,Valle V,Malandruccolo L,Iannella E,Arleo E,Guarini A,Foà R

更新日期：2008-02-15 00:00:00

abstract：BACKGROUND:CTLA4 immunoglobulin (Ig)G that binds to B7 effectively inhibits the signaling of CD28/CTLA4-B7 pathway and induces antigen specific T cell unresponsiveness in vitro and in vivo. Using CTLA4IgG, we examined induction of long-term graft survival and the mechanism of maintenance of tolerance in rat allogeneic ...

journal_title：Transplantation

authors： Tarumi K,Murakami M,Yagihashi A,Nakagawa I,Hirata K,Uede T

更新日期：1999-02-27 00:00:00

abstract：BACKGROUND:Ischemia-reperfusion (I/R) injury is a multifactorial phenomenon that occurs during the transplant event and frequently compromises early graft function after liver transplantation (LT). Current comprehension of molecular mechanisms and regulation processes of I/R injury lacks clarity. MicroRNA (miRNA) regul...

journal_title：Transplantation

authors： Gehrau RC,Mas VR,Dumur CI,Ladie DE,Suh JL,Luebbert S,Maluf DG

更新日期：2013-11-27 00:00:00

abstract：BACKGROUND:Cardiovascular disease remains epidemic in transplant recipients, despite aggressive treatment of cardiovascular risk factors. Thus, novel risk factors could play a role in the genesis of cardiovascular events in this population. METHODS:We evaluated the impact of early posttransplant anemia on cardiovascul...

journal_title：Transplantation

authors： Djamali A,Becker YT,Simmons WD,Johnson CA,Premasathian N,Becker BN

更新日期：2003-09-15 00:00:00

abstract：BACKGROUND:Few studies have directly compared preemptive therapy (PET) and antiviral prophylaxis (AP) for prevention of cytomegalovirus (CMV) disease in CMV seropositive (R+) orthotopic liver transplant (OLT) recipients. METHODS:We prospectively assessed CMV disease and clinical outcomes among 160 consecutive R+ OLT r...

journal_title：Transplantation

authors： Liu AW,Jutivorakool K,Fisher CE,Rakita RM,Reyes JD,Bhattacharya RB,Jerome KR,Limaye AP

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Defining the clinical relevance of donor-specific HLA-antibodies detected by single-antigen flow-beads (SAFB) is important because these assays are increasingly used for pretransplant risk assessment and organ allocation. The aims of this study were to investigate to which extent HLA-DSA detected by SAFB rep...

journal_title：Transplantation

authors： Amico P,Hönger G,Mayr M,Steiger J,Hopfer H,Schaub S

更新日期：2009-06-15 00:00:00

abstract：BACKGROUND:In Th (T helper) 1/Th2 balance in response to signals given during donor antigen presentation, induction of allograft prolongation is more often related to Th2-type than with Th1-type immunity. Here, we examined the effect of interleukin (IL)-33, a novel member of the IL-1 family, on cardiac allograft surviv...

journal_title：Transplantation

authors： Yin H,Li XY,Jin XB,Zhang BB,Gong Q,Yang H,Zheng F,Gong FL,Zhu JY

更新日期：2010-05-27 00:00:00

abstract：BACKGROUND:To date, the outcomes of transplant tourism have not been reported extensively. In addition, data about the accuracy of urine cytology for the detection and the role of the BK virus (BKV) in the carcinogenesis of urothelial carcinoma (UC) after renal transplantation are lacking. METHODS:Three hundred seven ...

journal_title：Transplantation

authors： Tsai HL,Chang JW,Wu TH,King KL,Yang LY,Chan YJ,Yang AH,Chang FP,Pan CC,Yang WC,Loong CC

更新日期：2014-07-15 00:00:00

abstract：BACKGROUND:The objective of this study was to investigate purine nucleotide metabolism in peripheral blood mononuclear cells (PBMC) of cardiac transplant recipients switched from azathioprine to mycophenolate mofetil (MMF). METHODS:Concentrations of guanosine 5'triphosphate (GTP) and adenosine 5'triphosphate (ATP), th...

journal_title：Transplantation

authors： Devyatko E,Zuckermann A,Bohdjalian A,Roedler S,Dunkler D,Grimm M,Weigel G

更新日期：2006-07-15 00:00:00

abstract：:Mice of the B10 background that are class II I-E nonexpressing demonstrate a relative resistance to neonatal induction of tolerance of class I alloantigens from I-E-expressing B10 strains. The majority of these injected mice delete donor-responsive and "I-E-reactive" (V beta 11+) cells in the immediate postinoculation...

journal_title：Transplantation

authors： Nassiri M,Viciana A,Streilein JW,Ruiz P

更新日期：1993-12-01 00:00:00

abstract：:The response to IL-2 and IL-4 of several functionally defined lymphoid cell types was assessed at the individual responding cell level in limiting dilution experiments in which exogenous IL-2 or IL-4 was used to promote cellular activation and expansion. Splenic precursors that give rise to alloreactive CTL in LDA sup...

journal_title：Transplantation

authors： Widmer MB,Voice RF,Conlon PJ,Grabstein KH

更新日期：1990-04-01 00:00:00

abstract：:In a prospective randomized double-blind placebo-controlled trial, the effect of rh-SOD, given in a dose of 200 mg intravenously during surgery to cyclosporine-treated recipients of cadaveric renal allografts, on both acute and chronic rejection events as well as patient and graft survival was investigated by analyzin...

journal_title：Transplantation

authors： Land W,Schneeberger H,Schleibner S,Illner WD,Abendroth D,Rutili G,Arfors KE,Messmer K

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Apoptosis is a well-documented pathway for islet cell death. One potential mechanism is overexpression of death-promoting Bax compared with antiapoptotic Bcl-2 in islets. METHODS:We isolated islets from 10 human pancreata and measured the expression of Bax mRNA and Bcl-2 mRNA by real-time quantitative polym...

journal_title：Transplantation

authors： Thomas D,Yang H,Boffa DJ,Ding R,Sharma VK,Lagman M,Li B,Hering B,Mohanakumar T,Lakey J,Kapur S,Hancock WW,Suthanthiran M

更新日期：2002-12-15 00:00:00

abstract：BACKGROUND:Graft arterial disease (GAD) is a major cause of late graft loss after organ transplantation. Alloimmune responses and vascular remodeling eventually cause the transplant organ to develop GAD. In this study, we aimed to limit the development of GAD by inhibiting alloimmune responses and vascular smooth muscl...

journal_title：Transplantation

authors： Zaitsu M,Yamashita K,Shibasaki S,Tsunetoshi Y,Fukai M,Ogura M,Yoshida T,Igarashi R,Kobayashi N,Umezawa K,Todo S

更新日期：2015-05-01 00:00:00

abstract：:Reports of early success with cryopreserved saphenous veins (CSV) as arterial conduits led us to develop cryopreserved iliac veins (CIV) as interposition grafts for portal vein reconstruction in living-related liver transplantation (LRLT). Despite encouraging short-term results, retrospective analysis of long-term cry...

journal_title：Transplantation

authors： Kuang AA,Renz JF,Ferrell LD,Ring EJ,Rosenthal P,Lim RC,Roberts JP,Ascher NL,Emond JC

更新日期：1996-09-27 00:00:00

abstract：BACKGROUND:Interspecies differences create important shortcomings in existing animal models used to describe in vivo events responsible for allograft rejection. Alloimmune destruction of human dermal microvessels, histologically consistent with rejection, has been demonstrated in human skin-grafted severe combined immu...

journal_title：Transplantation

authors： Lorber MI,Wilson JH,Robert ME,Schechner JS,Kirkiles N,Qian HY,Askenase PW,Tellides G,Pober JS

更新日期：1999-03-27 00:00:00

abstract：BACKGROUND:Goal tacrolimus concentrations for the prevention of rejection in sensitized renal transplant recipients are not well established. METHODS:We evaluated the association between discharge tacrolimus trough concentration and the incidence of biopsy-proven acute rejection (BPAR) in 216 moderately sensitized ren...

journal_title：Transplantation

authors： Richards KR,Hager D,Muth B,Astor BC,Kaufman D,Djamali A

更新日期：2014-05-27 00:00:00