Abstract:
:Heterologous anti-immunoglobulin is a potent immunosuppressive agent that prolongs H-2- and H-3-incompatible skin graft survival. In conjunction with antithymocyte serum, anti-immunoglobulin promotes greater graft life than either antiserum used alone, without evidence of toxicity to recipient animals. Combination treatment with anti-immunoglobulin, antithymocyte serum, and donor spleen cells produces long-term allograft survival to the lifetime of the host and can result in antigen-specific immune unresponsiveness of sufficient strength to permit acceptance of a second-set graft. Anti-immunoglobulin complexes formed in treated mice appear to be localized primarily in the lymphatic reticuloendothelial system.
journal_name
Transplantationjournal_title
Transplantationauthors
Constantian MB,Couser WG,Mannick JAdoi
10.1097/00007890-197711000-00007subject
Has Abstractpub_date
1977-11-01 00:00:00pages
358-66issue
5eissn
0041-1337issn
1534-6080journal_volume
24pub_type
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