Anti-immunoglobulin as an adjunct in producing long-term antigen-specific allograft survival. Organ localization of immune complexes.

Abstract:

:Heterologous anti-immunoglobulin is a potent immunosuppressive agent that prolongs H-2- and H-3-incompatible skin graft survival. In conjunction with antithymocyte serum, anti-immunoglobulin promotes greater graft life than either antiserum used alone, without evidence of toxicity to recipient animals. Combination treatment with anti-immunoglobulin, antithymocyte serum, and donor spleen cells produces long-term allograft survival to the lifetime of the host and can result in antigen-specific immune unresponsiveness of sufficient strength to permit acceptance of a second-set graft. Anti-immunoglobulin complexes formed in treated mice appear to be localized primarily in the lymphatic reticuloendothelial system.

journal_name

Transplantation

journal_title

Transplantation

authors

Constantian MB,Couser WG,Mannick JA

doi

10.1097/00007890-197711000-00007

subject

Has Abstract

pub_date

1977-11-01 00:00:00

pages

358-66

issue

5

eissn

0041-1337

issn

1534-6080

journal_volume

24

pub_type

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