Abstract:
:We studied the role of interleukin (IL)-8 during engraftment after hematopoietic stem cell transplantation. In 40 consecutive patients undergoing either allogeneic marrow (n=32) or autologous peripheral blood stem cell transplantation (n=8), IL-8 plasma levels were serially determined. Median IL-8 concentrations peaked during the neutropenic phase and, subsequently, subsided to pretransplant levels in patients achieving engraftment. In all patients, we observed an inverse correlation of IL-8 with leukocytes (P<0.0001) and a direct correlation of IL-8 with the extent of neutropenia (P<0.0001). Four patients who developed graft failure showed sustained median IL-8 concentrations of >300 pg/mL together with persistent neutropenia. This marked elevation of IL-8 was statistically significant as early as day 11 after transplantation, at a time when no other evidence alluded to imminent graft failure. Our data suggest that IL-8 may play an important role during engraftment after hematopoietic stem cell transplantation.
journal_name
Transplantationjournal_title
Transplantationauthors
Schwabe M,Hartert AM,Bertz H,Finke Jdoi
10.1097/01.tp.0000135564.82707.f0subject
Has Abstractpub_date
2004-10-15 00:00:00pages
1086-8issue
7eissn
0041-1337issn
1534-6080pii
00007890-200410150-00023journal_volume
78pub_type
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