Impact of early conversion from tacrolimus to sirolimus on chronic allograft changes in kidney recipients on rapid steroid withdrawal.

abstract：BACKGROUND:Recent insights suggest that endothelial cell (EC) activation plays a major role in renal ischemia-reperfusion (I/R) injury. Interactions between ECs and pericytes via signaling molecules, including angiopoietins, are involved in maintenance of the vascular integrity. Experimental data have shown that enhanc...

journal_title：Transplantation

authors： de Vries DK,Khairoun M,Lindeman JH,Bajema IM,de Heer E,Roest M,van Zonneveld AJ,van Kooten C,Rabelink TJ,Schaapherder AF,Reinders ME

更新日期：2013-08-15 00:00:00

abstract：:A sensitive micromethod for generating and assaying allogeneically induced cytotoxic human lymphocytes in vitro is described. Responding lymphocytes are cultured with mitomycin-C treated allogeneic stimulating cells in wells of replicate microtrays for both one-way mixed leukocyte culture (MLC) and cell-mediated lymph...

journal_title：Transplantation

authors： Zarling JM,McKeough M,Bach FH

更新日期：1976-06-01 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV) infection is common in kidney transplantation and is known to affect long-term patient and graft survival, as is time in renal-replacement therapy (RRT). The aim of this study was to investigate HCV in relation to time in RRT and its impact on outcome after transplantation. METHODS:A...

journal_title：Transplantation

authors： Bruchfeld A,Wilczek H,Elinder CG

更新日期：2004-09-15 00:00:00

abstract：:Pulmonary thrombus formation in the region of atrial anastomosis following lung transplantation has been reported by several authors. Such patients typically present immediately after surgery with significant hemodynamic compromise causing pulmonary edema and hypoxemia. We describe a patient who presented with bilater...

journal_title：Transplantation

authors： Stang MR,Hinderliter AL,Gott KK,Paradowski LJ,Aris RM

更新日期：1996-09-15 00:00:00

abstract：:Little is known of the host immune mechanisms responsible for initiation and progression of chronic rejection. We describe immunopathologic features associated with progressively deteriorating function of kidney allografts in the F344-to-Lewis rat strain combination, which differ at MHC and non-MHC loci. Initial rejec...

journal_title：Transplantation

authors： Hancock WH,Whitley WD,Tullius SG,Heemann UW,Wasowska B,Baldwin WM 3rd,Tilney NL

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:The inflammatory reaction that occurs during the 5 days after transplantation led at 3 days to the death of 70% of injected myoblasts. Use of anti-inflammatory agents appeared to be a possible way to increase myoblast survival. The application of gene transfer techniques to cell transplantation offers the po...

journal_title：Transplantation

authors： Merly F,Huard C,Asselin I,Robbins PD,Tremblay JP

更新日期：1998-03-27 00:00:00

abstract：:A role for cytomegalovirus (CMV) infection in the etiologies of acute and chronic rejection in renal allograft recipients has been suggested. We previously reported that preemptive treatment of CMV infection with ganciclovir in kidney transplant patients was safe and effective. We now present a retrospective analysis ...

journal_title：Transplantation

authors： Akposso K,Rondeau E,Haymann JP,Peraldi MN,Marlin C,Sraer JD

更新日期：1997-04-15 00:00:00

abstract：BACKGROUND:Toxicity of current immunosuppressive agents to islet grafts is one of the major obstacles to clinical islet transplantation (Tx). This study was designed to assess the efficacy of FTY720, a novel immunomodulator with a unique mechanism of action, on islet graft survival and function in streptozotocin (STZ)-...

journal_title：Transplantation

authors： Fu F,Hu S,Deleo J,Li S,Hopf C,Hoover J,Wang S,Brinkmann V,Lake P,Shi VC

更新日期：2002-05-15 00:00:00

abstract：:Arterial ketone body ratio (AKBR [acetoacetate/beta-hydroxybutyrate]) was measured in nineteen patients under medical supportive therapy for fulminant hepatic failure (FHF), in order to evaluate its predictive value relative to liver transplantation. Of the 19 patients 8 (42%) were salvaged and 11 (58%) died. Seven of...

journal_title：Transplantation

authors： Saibara T,Onishi S,Sone J,Yamamoto N,Shimahara Y,Mori K,Ozawa K,Yamamoto Y

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:Adult orthotopic liver transplantation is associated with significant use of allogenic blood products, which places considerable demands on finite resources. This could be reduced by autologous red cell salvage use, and we evaluated its cost effectiveness in this prospective study. METHODS:Intraoperative au...

journal_title：Transplantation

authors： Phillips SD,Maguire D,Deshpande R,Muiesan P,Bowles MJ,Rela M,Heaton ND

更新日期：2006-02-27 00:00:00

abstract：BACKGROUND:Two patients with end-stage renal disease secondary to multiple myelomas were treated with combined kidney and bone marrow transplantation in an effort to achieve donor-specific allotolerance through the induction of mixed lymphohematopoietic chimerism. METHODS:Two female patients (55 and 50 years of age) w...

journal_title：Transplantation

authors： Bühler LH,Spitzer TR,Sykes M,Sachs DH,Delmonico FL,Tolkoff-Rubin N,Saidman SL,Sackstein R,McAfee S,Dey B,Colby C,Cosimi AB

更新日期：2002-11-27 00:00:00

abstract：BACKGROUND:New insights into mechanisms of injury in orthotopic liver transplantation (OLT) often come from experiments in small animal models. Mice are particularly suitable because of the growing availability of gene-altered animals and specific antibodies. A validated model of OLT in mice is not available and, in pa...

journal_title：Transplantation

authors： Tian Y,Rüdiger HA,Jochum W,Clavien PA

更新日期：2002-11-15 00:00:00

abstract：:Late deaths (after more than 1 year) after liver transplantation were analyzed in a series of 464 consecutive patients who received liver grafts between 1982 and 1993. Recipients who survived the first posttransplant year (n = 365) had actuarial 5- and 10-year survival rates of 92% and 84%, respectively. Thirty-five p...

journal_title：Transplantation

authors： Asfar S,Metrakos P,Fryer J,Verran D,Ghent C,Grant D,Bloch M,Burns P,Wall W

更新日期：1996-05-15 00:00:00

abstract：BACKGROUND:Lower liver transplant success is observed when the donor is female. Intracellular acidosis during ischemia is proposed to contribute to the injury sustained by the transplanted organ and its role in livers obtained from nonheartbeating donors is unclear. Research has shown that livers of female rats develop...

journal_title：Transplantation

authors： Soric S,Belanger MP,Askin N,Wittnich C

更新日期：2007-09-27 00:00:00

abstract：:Clinical as well as experimental studies have shown a great interindividual variability in the immunosuppressive efficacy of CsA. Evaluating previous in vitro findings of a correlation between sensitivity of alloresponsiveness to CsA and the HLA-DR phenotype CsA levels were compared in kidney transplant recipients wit...

journal_title：Transplantation

authors： Zlabinger GJ,Kudlacek S,Pohanka E,Franz M,Hamilton G,Rosenmayr A,Kovarik J

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND:Chronic graft-versus-host disease (cGVHD) represents a double-edged sword. In its nonsevere form, cGVHD associates with better control of the malignant disease, thus highlighting graft-versus-leukemia effects. However, severe cGVHD leads to debilitating morbidity and increased nonrelapse mortality. The predi...

journal_title：Transplantation

authors： Giesen N,Schwarzbich MA,Dischinger K,Becker N,Hummel M,Benner A,Radujkovic A,Müller-Tidow C,Dreger P,Luft T

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Liver transplantation is a widely accepted treatment for end-stage liver disease. The aim of our study was to investigate the imbalance between T helper type 17 (Th17) and CD4(+) CD25(+) Foxp3(+) regulatory T (Treg) cells during hepatic allograft rejection in a rodent grafts model because their roles in live...

journal_title：Transplantation

authors： Zhou Y,Yang X,Zhang H,Jiang J

更新日期：2015-06-01 00:00:00

abstract：:The generation of Gal knockout (KO) pigs is likely to be an important advance in xenotransplantation. However, recent reports suggesting that expression of Gal may not be completely eliminated raise the possibility of a continuing anti-Gal immune response. The authors used a Gal-mismatched skin graft model to study ce...

journal_title：Transplantation

authors： Gock H,Murray-Segal L,Salvaris E,Cowan P,D'Apice AJ

更新日期：2004-03-15 00:00:00

abstract：BACKGROUND:Delayed graft function (DGF) is associated with acute tubular necrosis. In this setting, surviving tubular cells may proliferate and replace injured cells. CD133Pax-2cells may play a role in the regeneration of tubular damage. The aim of this study was to demonstrate the presence of these cells in human kidn...

journal_title：Transplantation

authors： Loverre A,Capobianco C,Ditonno P,Battaglia M,Grandaliano G,Schena FP

更新日期：2008-04-27 00:00:00

abstract：:This study evaluated the utility of duplex Doppler sonograms (DS) and the resistive index (RI) in the identification and differential diagnosis of various causes of renal allograft dysfunction. The efficacy of DS and RI was studied either during acute episodes of allograft dysfunction or during periodic posttransplant...

journal_title：Transplantation

authors： Meyer M,Paushter D,Steinmuller DR

更新日期：1990-12-01 00:00:00

abstract：:The complement system plays a major role in hyperacute rejection of discordant xenografts. In an immediately vascularized xenograft of a porcine organ to a primate, natural antibodies bind to the vascular endothelium of the graft, triggering activation of complement via the classical pathway. One consequence of antibo...

journal_title：Transplantation

authors： Dalmasso AP,Platt JL

更新日期：1993-11-01 00:00:00

abstract：:Successful cardiac transplantation requires suppression of rejection, and endomyocardial biopsy is generally used to quantify this and guide immunotherapy. Biopsy, however, is an invasive, costly, cardiac catheterization with repetition limited. Since rejection requires lymphocyte activation, an alternative method of ...

journal_title：Transplantation

authors： Young JB,Windsor NT,Smart FW,Kleiman NS,Weilbaecher DG,Noon GP,Nelson DL,Lawrence EC

更新日期：1991-03-01 00:00:00

abstract：:The pharmacologic modulation of the platelet-activating factor antagonist WEB 2086BS on the release of metabolites of the arachidonic acid and the cytokine TNF alpha was investigated in an ex vivo xenograft model of hyperacute rejection. Pig kidneys were perfused for 60 min in a perfusion system with oxygenated hepari...

journal_title：Transplantation

authors： Saumweber DM,Bergmann R,Gokel M,Hammer C

更新日期：1994-02-01 00:00:00

abstract：:We are participating in a multicenter trial testing the efficacy of a murine monoclonal antihuman peripheral T lymphocyte antibody (OKT3.PAN) as immunosuppressive therapy for the treatment of acute cadaveric renal allograft rejection. Although clinical data indicate that administration of this antibody clears the circ...

journal_title：Transplantation

authors： Bowen A,Edwards LC,Gailiunas P,Helderman JH

更新日期：1984-11-01 00:00:00

abstract：BACKGROUND:Increased numbers of macrophages and myofibroblasts are observed to occur in chronic renal allograft rejection (CR). The aim of this study was to examine the expression of cellular markers for the macrophage and myofibroblast in early renal transplant biopsy specimens and correlate these findings with allogr...

journal_title：Transplantation

authors： Pilmore HL,Painter DM,Bishop GA,McCaughan GW,Eris JM

更新日期：2000-06-27 00:00:00

abstract：BACKGROUND:As T-cell receptor-major histocompatibility complex (MHC) class I/self peptide interaction regulates T-cell development in the thymus, we reasoned that presentation of peptides by self dendritic cells (DC) to developing T cells in the thymus might induce acquired thymic tolerance. This hypothesis is based on...

journal_title：Transplantation

authors： Ali A,Garrovillo M,Jin MX,Hardy MA,Oluwole SF

更新日期：2000-01-27 00:00:00

abstract：BACKGROUND:The success of clinical xenotransplantation will depend on induction of xenotolerance. We have previously shown that combined xenothymus and vascularized xenoheart transplantation under the coverage of a tolerizing regimen (TR) can induce and maintain full xenotolerance. Here, induction/maintenance of xenoto...

journal_title：Transplantation

authors： Yu L,Yan Y,Li S,Rutgeerts O,Goebels J,Segers C,Lin Y,Vandeputte M,Waer M

更新日期：2005-03-15 00:00:00

abstract：OBJECTIVE:Intrahepatic infusion is the most common method of islet autotransplantation. Structural and functional changes within the liver may result from a number of factors, including embolization of the terminal branches of the portal vein, the effects of high insulin concentration on surrounding hepatocytes or resp...

journal_title：Transplantation

authors： Ong SL,Pollard C,Rees Y,Garcea G,Webb M,Illouz S,Berry DP,Dennison AR

更新日期：2008-06-27 00:00:00

abstract：BACKGROUND:The polymorphic family of killer-cell immunoglobulin-like receptors (KIRs) consists of activating and inhibitory receptors expressed by natural killer (NK) cells and effector T cells that recognize human leukocyte antigen (HLA) class I ligands. It has been suggested that KIR/HLA incompatibility exerts benefi...

journal_title：Transplantation

authors： Kunert K,Seiler M,Mashreghi MF,Klippert K,Schönemann C,Neumann K,Pratschke J,Reinke P,Volk HD,Kotsch K

更新日期：2007-12-15 00:00:00

abstract：BACKGROUND:A quantitative model of immunosuppression was previously developed based on the rejection of the allogeneic A/J murine tumor sarcoma 1 (Sa1) in immunocompetent mice. Here, the model is used to evaluate the immunologic mechanisms of graft rejection and to determine the potential of this model to detect synerg...

journal_title：Transplantation

authors： Hammond-McKibben D,Saulnier M,Zhang J,Risher N,Lake P,Weetall M

更新日期：2005-04-27 00:00:00