KIR/HLA ligand incompatibility in kidney transplantation.

abstract：:BACKGROUND.: Rabbit antithymocyte globulins (rATGs) are known to convert CD4CD25FoxP3 T cells from healthy individuals to CD4CD25FoxP3 T cells. In this study, we investigated the effect of rATG on the induction of regulatory T cells (Tregs) from blood cells of patients with end-stage renal disease who are candidates f...

journal_title：Transplantation

authors： Sewgobind VD,van der Laan LJ,Kho MM,Kraaijeveld R,Korevaar SS,van Dam T,Ijzermans JN,Weimar W,Baan CC

更新日期：2010-03-27 00:00:00

abstract：:By means of double diffusion in gel reactions, "heterophile" antibodies were demonstrated in human renal transplantation sera. Of thirty-two recipients of renal allografts, 12 (37 per cent) had antibodies to extract of bovine erythrocyte stromata, and 5 (19 per cent) of 26 recipients produced antibodies to extract of ...

journal_title：Transplantation

authors： Kano K,Loza U,Gerbasi JR,Milgrom F

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:Pancreatic islets are avascular immediately after transplantation and depend on revascularization. Recently, the authors found decreased vascular density in mouse islets 1 month after implantation into nondiabetic recipients. This study investigated possible differences in revascularization between islets im...

journal_title：Transplantation

authors： Mattsson G,Jansson L,Nordin A,Carlsson PO

更新日期：2003-03-15 00:00:00

abstract：:Leflunomide is a compound recently shown to reduce T and B cell-mediated responses in a number of experimental rat, mouse, and human systems. To explore its potential as an immunosuppressant, we studied leflunomide in 128 Brown-Norway/Lewis cardiac transplants and in 48 unoperated Lewis rats. At doses ranging from 0.6...

journal_title：Transplantation

authors： Williams JW,Xiao F,Foster P,Clardy C,McChesney L,Sankary H,Chong AS

更新日期：1994-04-27 00:00:00

abstract：:Although the clinical relevance of endothelial cell-monocyte (E-M) antigens has been demonstrated in organ graft transplantation, very limited data exist describing the nature of these antigens. The current study presents biochemical characterization of three different surface antigens of endothelial cells and monocyt...

journal_title：Transplantation

authors： Wood NL,Schook LB,Studer EJ,Mohanakumar T

更新日期：1988-04-01 00:00:00

abstract：:Methods are described for preparing large amounts of horse anti-human thymocyte globulin (ATG, ATGAM; The Upjohn Company) for clinical use. These methods have been used since 1968 to provide material for clinical trials. Characteristics of 40 lots of ATG are summarized. ...

journal_title：Transplantation

authors： Wechter WJ,Nelson JW,Perper RJ,Parcells AJ,Riebe KW,Evans JS,Satoh PS,Ko H

更新日期：1979-10-01 00:00:00

abstract：BACKGROUND:Ischemia-reperfusion (I/R) injury after lung transplantation causes alveolar damage, lung edema, and acute rejection. Poly(adenosine diphosphate-ribose) polymerase (PARP) is a single-stranded DNA repair enzyme that induces apoptosis and necrosis after DNA damage caused by reactive oxygen species. We evaluate...

journal_title：Transplantation

authors： Hatachi G,Tsuchiya T,Miyazaki T,Matsumoto K,Yamasaki N,Okita N,Nanashima A,Higami Y,Nagayasu T

更新日期：2014-09-27 00:00:00

abstract：BACKGROUND:The liver is an immunologic privileged organ; liver allografts are accepted across major histocompatibility complex barriers in many species. However, hepatocyte transplants are acutely rejected, suggesting a role for liver nonparenchymal cells in regulating the immunoresponse. We have shown potent immunoreg...

journal_title：Transplantation

authors： Charles R,Chou HS,Wang L,Fung JJ,Lu L,Qian S

更新日期：2013-07-15 00:00:00

abstract：BACKGROUND:Socioeconomic variables including low income and noncompliance impact negatively upon long-term renal allograft survival, especially in African Americans. We sought to determine whether other socioeconomic variables contributed to noncompliance and allograft survival. METHODS:A detailed history of socioecon...

journal_title：Transplantation

authors： Butkus DE,Dottes AL,Meydrech EF,Barber WH

更新日期：2001-07-27 00:00:00

abstract：BACKGROUND:In Th (T helper) 1/Th2 balance in response to signals given during donor antigen presentation, induction of allograft prolongation is more often related to Th2-type than with Th1-type immunity. Here, we examined the effect of interleukin (IL)-33, a novel member of the IL-1 family, on cardiac allograft surviv...

journal_title：Transplantation

authors： Yin H,Li XY,Jin XB,Zhang BB,Gong Q,Yang H,Zheng F,Gong FL,Zhu JY

更新日期：2010-05-27 00:00:00

abstract：:Feline bone marrow cells treated with the soybean agglutinin (SBA) lectin are separated into two populations, the agglutinated SBA(+) fraction containing predominantly cells of myeloid origin and the nonagglutinated SBA(-) fraction consisting of cells primarily of the erythroid lineage. FACScan analyses revealed a cle...

journal_title：Transplantation

authors： Gengozian N,Reyes L,Pu R,Homer BL,Bova FJ,Yamamoto JK

更新日期：1997-08-15 00:00:00

abstract：:The fate of cell surface I-Ak and H-2Kk antigens shed by murine spleen cells in culture was studied by incubation of nonlabeled spleen cells or splenic T or B cells with culture fluids containing shed radiolabeled alloantigens. Approximately 30 to 40% of the shed alloantigens could be absorbed by syngeneic or allogene...

journal_title：Transplantation

authors： Emerson SG,Cone RE

更新日期：1982-01-01 00:00:00

abstract：:The study purpose was to identify risks, benefits and costs associated with an expanded donor protocol. The protocol design evaluated organs rescued using expanded donor criteria and weighed all costs associated with doing so. Costs were measured against conditions experienced with expanded and traditional criteria an...

journal_title：Transplantation

authors： Jacobbi LM,McBride VA,Etheredge EE,McDonald JC,Cooper ES,Frey D,Boudreaux JP,Gonzalez F,Van Meter C,McMillan R

更新日期：1995-12-27 00:00:00

abstract：BACKGROUND:Status 1A patients are prioritized over liver disease patients regardless of Model for End-stage Liver Disease (MELD) score. We aimed to identify groups with high waitlist mortality in Status 1A and MELD ≥40 patients to determine who would most benefit from transplantation. METHODS:Data on patients listed a...

journal_title：Transplantation

authors： Safwan M,Nwagu U,Collins K,Abouljoud M,Nagai S

更新日期：2019-10-01 00:00:00

abstract：:ABO-incompatible (ABOi) kidney transplantation has gained a renewed interest during the past years. In 2001, a protocol for ABOi kidney transplantation based on antigen-specific immunoadsorption and rituximab was introduced at our center. In this study long-term graft function using this protocol was assessed. All ABO...

journal_title：Transplantation

authors： Genberg H,Kumlien G,Wennberg L,Tydén G

更新日期：2007-12-27 00:00:00

abstract：BACKGROUND:The shortage of organs for liver transplantation has forced transplant centers to expand the donor pool by using donors traditionally labeled as marginal. One such example is liver transplantation using a donor with HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets), a disorder of late pre...

journal_title：Transplantation

authors： Briceno PJ,Ortiz JA,Manzarbeitia C,Jeon H,Munoz SJ,Rothstein KD,Araya V,Gala I,Reich DJ

更新日期：2004-01-15 00:00:00

abstract：:Stable renal transplant recipients (RTR) display high rates of atherosclerotic events (AE). Innate immunity and especially vascular inflammation play a role in the pathogenesis of atherosclerosis. It is illustrated both by an increased occurrence of postrenal transplant cardiovascular events in patients with elevated ...

journal_title：Transplantation

authors： Courivaud C,Ferrand C,Deschamps M,Tiberghien P,Chalopin JM,Duperrier A,Saas P,Ducloux D

更新日期：2006-04-27 00:00:00

abstract：BACKGROUND:Living kidney donors have donation-related out-of-pocket costs (direct costs) and/or ongoing daily expenses while losing income (indirect costs). Yet there is little information about how much of a subjective burden these constitute for the donors. METHODS:From December 2003 through December 2014, we survey...

journal_title：Transplantation

authors： Wiseman JF,Jacobs CL,Larson DB,Berglund DM,Garvey CA,Ibrahim HN,Matas AJ

更新日期：2017-09-01 00:00:00

abstract：:The effect of the tritiated thymidine (3H-TdR) suicide technique on the ability of donor cells to induce fatal graft-versus-host disease (GVHD) was studied. C57BL/6 (H-2b) spleen cells were stimulated in vitro with irradiated BALB/c (H-2d) Moloney lymphoma cells in mixed culture and 3H-TdR of high-specific activity ad...

journal_title：Transplantation

authors： Cheever MA,Einstein AB Jr,Kempf RA,Fefer A

更新日期：1977-04-01 00:00:00

abstract：BACKGROUND:We explored the efficacy of the Oxford classification for assessing native immunoglobulin A nephropathy (IgAN) in posttransplantation patients compared with the glomerular injury score and Haas classification. METHODS:A total of 125 renal allograft biopsies obtained from 114 patients diagnosed with IgAN reg...

journal_title：Transplantation

authors： Lim BJ,Joo DJ,Kim MS,Kim YS,Kim SI,Kim Y,Huh KH,Koh MJ,Jeong HJ

更新日期：2013-06-27 00:00:00

abstract：:Cross sensitization between the products of the H-2K and H-2D loci has been demonstrated by an experimental design in which recipients were sensitized with tissue bearing determinants controlled by one locus (e.g., H-2K), and then challenged with skin grafts expressing determinants controlled by the other locus (e.g.,...

journal_title：Transplantation

authors： Murphy DB,Shreffler DC

更新日期：1975-07-01 00:00:00

abstract：:Mandatory continuous monitoring of early transplant outcome with centralized oversight was introduced in 2004 for all 23 UK adult kidney transplant units. Risk-adjusted cumulative sum charts are used to assess 30-day graft and patient survival against past performance for each center, and change in transplant center p...

journal_title：Transplantation

authors： Collett D,Sibanda N,Pioli S,Bradley JA,Rudge C

更新日期：2009-10-27 00:00:00

abstract：:Shortage of organ donors limits the number of possible liver transplantations. Alternative therapies for treatment of liver failure are currently being developed: (i) extracorporeal artificial liver devices; (ii) bioartificial liver devices using hepatocytes; and (iii) hepatocyte transplantation. The objective of thes...

journal_title：Transplantation

authors： Sgroi A,Serre-Beinier V,Morel P,Bühler L

更新日期：2009-02-27 00:00:00

abstract：:The immunosuppressive potentials of mAbs to lymphocyte function-associated antigen-1 (LFA-1) and CD2 molecules were examined in murine islet transplantation. Crude digested islets from BALB/c (H-2d) mice were transplanted into the renal subcapsular space of streptozotocin-induced diabetic C57BL/6 (H-2b) mice. The rat ...

journal_title：Transplantation

authors： Gotoh M,Fukuzaki T,Monden M,Dono K,Kanai T,Yagita H,Okumura K,Mori T

更新日期：1994-01-01 00:00:00

abstract：:Data of 32,000 donors were utilized for a computer simulation to analyze the effect of selection parameters on the outcome of kidney transplants. If the HLA match grade is considered for organ allocation, the overall 1-year graft survival rate is up to 7% higher for first cadaver transplants and up to 12% higher for s...

journal_title：Transplantation

authors： Wujciak T,Opelz G

更新日期：1993-03-01 00:00:00

abstract：:The term "accommodation" was invoked to describe endothelial cell resistance to antibody-mediated rejection after ABO-incompatible kidney or experimental xenograft transplantation. Currently, there is much interest in how to achieve successful human leukocyte antigen (HLA)-incompatible allograft transplantation in HLA...

journal_title：Transplantation

authors： Rose ML,West LJ

更新日期：2012-02-15 00:00:00

abstract：:In the literature, varying terminology for living organ donation can be found. However, there seems to be a need for a new classification to avoid confusion. Therefore, we assessed existing terminology in the light of current living organ donation practices and suggest a more straightforward classification. We propose...

journal_title：Transplantation

authors： Dor FJ,Massey EK,Frunza M,Johnson R,Lennerling A,Lovén C,Mamode N,Pascalev A,Sterckx S,Van Assche K,Zuidema WC,Weimar W

更新日期：2011-05-15 00:00:00

abstract：:In an attempt to investigate the nonspecificity of the effect of administration of donor splenocytes treated with mitomycin C (MMC) 7 days before transplantation in inducing immunological unresponsiveness, the survival rates of liver, heart, small bowel, and skin allografts were compared in the RT1-incompatible ACI(RT...

journal_title：Transplantation

authors： Yamaguchi Y,Harland R,Wyble C,Mori K,Bollinger RR

更新日期：1989-02-01 00:00:00

abstract：:The stability of HLA alloantibodies was studied in 128 antibody-positive, potential kidney transplant recipients over an average period of 3 years. Antibody detection was performed using an anti-human globulin-complement-dependent cytotoxicity technique. In this study, the specificity of antibodies was categorized as ...

journal_title：Transplantation

authors： Rodey GE,Revels K,Fuller TC

更新日期：1997-03-27 00:00:00

abstract：:We have recently shown that a single intrathymic injection of synthetic 25mer peptides, representing full sequences of the hypervariable domain of RT1.BuB (4 peptides) and RT1.Du beta (4 peptides) WF class II MHC molecules, 48 hr before transplantation induces donor-specific unresponsiveness to WF rat renal allografts...

journal_title：Transplantation

authors： Sayegh MH,Perico N,Gallon L,Imberti O,Hancock WW,Remuzzi G,Carpenter CB

更新日期：1994-07-27 00:00:00