Abstract:
:Graft-versus-host disease (GVHD)* is a frequent complication of allogeneic bone marrow transplantation. The potentially beneficial effect of phototherapy for treatment of cutaneous manifestations of GVHD led us to investigate retrospectively the effect of this therapy in a larger series of patients. Eleven patients with cutaneous GVHD (acute GVHD in 4 patients, chronic lichenoid GVHD in 6 patients, and chronic sclerodermatous GVHD in 1 patient) resistant to standard immunosuppressive drugs were treated with phototherapy. Skin lesions showed a complete clearing in 75% of patients with acute GVHD, and a response rate of 70% was observed in patients with chronic GVHD. No effect of phototherapy was achieved in 3 patients. Our results suggest that phototherapy is a nonaggressive treatment that may benefit patients with cutaneous GVHD, who already take high doses of immunosuppressive drugs.
journal_name
Transplantationjournal_title
Transplantationauthors
Aubin F,Brion A,Deconinck E,Plouvier E,Hervé P,Humbert P,Cahn JYdoi
10.1097/00007890-199501150-00030subject
Has Abstractpub_date
1995-01-15 00:00:00pages
151-5issue
1eissn
0041-1337issn
1534-6080journal_volume
59pub_type
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