Blood pressure and renal function after kidney donation from hypertensive living donors.

Abstract:

BACKGROUND:Rising numbers of patients reaching end-stage kidney disease intensify the demand for expansion of the living-kidney-donor pool. On the basis of low risk in white donors with essential hypertension, our transplant center undertook a structured program of accepting hypertensive donors if kidney function and urine protein were normal. This study reports outcomes of hypertensive donors 1 year after kidney donation. METHODS:We studied detailed measurements of blood pressure (oscillometric, hypertensive therapy nurse [RN], and ambulatory blood pressure monitoring [ABPM]), clinical, and renal characteristics (iothalamate glomerular filtration rate [GFR], urine protein, and microalbumin) in 148 living kidney donors before and 6 to 12 months after nephrectomy. Twenty-four were hypertensive (awake ABPM>135/85 mm Hg and clinic/RN BP>140/90 mm Hg) before donation. RESULTS:After 282 days, normotensive donors had no change in awake ABPM pressure (pre 121 +/- 1/75 +/- 2 vs. post 120 +/- 1/ 5 +/- 1 mm Hg), whereas BP in hypertensive donors fell with both nonpharmacologic and drug therapy (pre 142 +/- 3/85 +/- 2 to post 132 +/- 2/80 +/- 1 mm Hg, P<.01). Hypertensive donors were older (53.4 vs. 41.4 years, P<.001) and had lower GFR after kidney donation (61 +/- 2 vs. 68 +/- 1 mL/min/1.73m, P<.01). After correction for age, no independent BP effect was evident for predicting GFR either before or after nephrectomy. Urine protein and microalbumin did not change in either group after donor nephrectomy. CONCLUSIONS:Our results indicate that white subjects with moderate, essential hypertension and normal kidney function have no adverse effects regarding blood pressure, GFR, or urinary protein excretion during the first year after living kidney donation. Although further studies are essential to confirm long-term safety, these data suggest that selected hypertensive patients may be accepted for living kidney donation.

journal_name

Transplantation

journal_title

Transplantation

authors

Textor SC,Taler SJ,Driscoll N,Larson TS,Gloor J,Griffin M,Cosio F,Schwab T,Prieto M,Nyberg S,Ishitani M,Stegall M

doi

10.1097/01.tp.0000128168.97735.b3

subject

Has Abstract

pub_date

2004-07-27 00:00:00

pages

276-82

issue

2

eissn

0041-1337

issn

1534-6080

pii

00007890-200407270-00019

journal_volume

78

pub_type

杂志文章
  • Popliteal lymph node assay as a method of investigating H-Y antigen in the rat.

    abstract::The ability of the popliteal lymph node assay (PLNA) To detect host-versus-graft activity in response to H-Y antigens was investigated in the rat by using presensitized recipients. It was shown that significant popliteal lymph node (PLN) enlargement in response to H-Y-incompatible lymphocytes from syngeneic donors cou...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198103000-00013

    authors: Markwick JR,Pegrum GD

    更新日期:1981-03-01 00:00:00

  • Long-term Persistence of Innate Lymphoid Cells in the Gut After Intestinal Transplantation.

    abstract:BACKGROUND:Little is known about innate lymphoid cell (ILC) populations in the human gut, and the turnover of these cells and their subsets after transplantation has not been described. METHODS:Intestinal samples were taken from 4 isolated intestine and 3 multivisceral transplant recipients at the time of any operativ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000001593

    authors: Weiner J,Zuber J,Shonts B,Yang S,Fu J,Martinez M,Farber DL,Kato T,Sykes M

    更新日期:2017-10-01 00:00:00

  • Clinical benefit of neoral dose monitoring with cyclosporine 2-hr post-dose levels compared with trough levels in stable heart transplant patients.

    abstract:BACKGROUND:Based on the excellent correlation between cyclosporine A 2-hr postdose blood levels (C2) and the area under the concentration versus time curve, we evaluated the clinical benefit of Neoral dose monitoring with C2 compared trough levels (C0) in stable heart transplant patients. METHODS:We studied 114 stable...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199912270-00003

    authors: Cantarovich M,Elstein E,de Varennes B,Barkun JS

    更新日期:1999-12-27 00:00:00

  • Variations of the lymphocytotoxicity test. An evaluation of sensitivity and specificity.

    abstract::Multiple variations of the basic lymphocytotoxicity test have been reported to increase test sensitivity. Although these modifications are used routinely in crossmatch tests, as required by federal regulation, there has been no methodical assessment of the relative sensitivities and specificities of these techniques w...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199509000-00016

    authors: Zachary AA,Klingman L,Thorne N,Smerglia AR,Teresi GA

    更新日期:1995-09-15 00:00:00

  • Short-term combination of mycophenolate mofetil with cyclosporine as a therapeutic option for renal transplant recipients: A prospective, multicenter, randomized study.

    abstract:BACKGROUND:Mycophenolate mofetil (MMF), compared to azathioprine (AZA), reduces acute rejection and treatment failure in cyclosporine (CsA) and steroid regimens, but its effect on graft survival is unproven from prospective studies and prolonged use is costly. This study evaluated the efficacy and tolerability of repla...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/00007890-200208270-00013

    authors: Sadek S,Medina J,Arias M,Sennesael J,Squifflet JP,Vogt B,Neo Int-05 Study group.

    更新日期:2002-08-27 00:00:00

  • Sensitization with xenogeneic tissues alters the heavy chain repertoire of human anti-Galalpha1-3Gal antibodies.

    abstract:BACKGROUND:Antigen sensitization alters the use of genes encoding the variable and constant regions of immunoglobulin, changing avidity, and function. Alterations in variable region genes induced by carbohydrate antigens have been studied extensively in animals but are incompletely characterized in humans. We asked how...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000162976.07023.6d

    authors: Yu PB,Parker W,Nayak JV,Platt JL

    更新日期:2005-07-15 00:00:00

  • 31P nuclear magnetic resonance spectroscopic evaluation of liver preservation solutions.

    abstract::The individual effects of verapamil and 2 antioxidants on perfused rat liver nucleoside triphosphate (NTP) recovery following cold storage in University of Wisconsin (UW) solution was assessed using 31P nuclear magnetic resonance spectroscopy. The pharmacological agents were added to UW solution and were present only ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Bowers JL,Neymark E,Cook CU,Clouse ME

    更新日期:1994-06-15 00:00:00

  • Logistics and transplant coordination activity in the GRAGIL Swiss-French multicenter network of islet transplantation.

    abstract:BACKGROUND:Since the Edmonton trial in 2000, increasing numbers of transplant centers have been implementing islet transplantation programs. Some institutions have elected to associate in multicenter networks, such as the Swiss-French GRAGIL (Groupe Rhin-Rhône-Alpes-Genève pour la Transplantation d'Ilots de Langerhans)...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000161224.67535.41

    authors: Kempf MC,Andres A,Morel P,Benhamou PY,Bayle F,Kessler L,Badet L,Thivolet C,Penfornis A,Renoult E,Brun JM,Atlan C,Renard E,Colin C,Milliat-Guittard L,Pernin N,Demuylder-Mischler S,Toso C,Bosco D,Berney T,GRAGIL gro

    更新日期:2005-05-15 00:00:00

  • Effect of core pancreas temperature during cadaveric procurement on human islet isolation and functional viability.

    abstract:BACKGROUND:Success of human pancreatic islet isolation depends largely on the techniques used during pancreas procurement and the quality of the gland. Warm ischemia of the pancreas of any duration during organ procurement may be detrimental to subsequent islet yield and functional viability of the islets. The aim of t...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200204150-00016

    authors: Lakey JR,Kneteman NM,Rajotte RV,Wu DC,Bigam D,Shapiro AM

    更新日期:2002-04-15 00:00:00

  • Manufacture of antithymocyte globulin (ATGAM) for clinical trials.

    abstract::Methods are described for preparing large amounts of horse anti-human thymocyte globulin (ATG, ATGAM; The Upjohn Company) for clinical use. These methods have been used since 1968 to provide material for clinical trials. Characteristics of 40 lots of ATG are summarized. ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-197910000-00007

    authors: Wechter WJ,Nelson JW,Perper RJ,Parcells AJ,Riebe KW,Evans JS,Satoh PS,Ko H

    更新日期:1979-10-01 00:00:00

  • Major histocompatibility complex control of NK-related allogeneic lymphocyte cytotoxicity in rats. The contributions of strong and medial transplantation antigens.

    abstract::Allogeneic lymphocyte cytotoxicity (ALC) describes the elimination of allogeneic lymphocytes in vivo by an NK-related activity. There is evidence that ALC is demonstrable between donor and recipient when these are incompatible at MHC gene loci alone. Since ALC is a property of T cell-deficient nude rats, the role of t...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198811000-00025

    authors: Ager A,Fajumi J,Sparshott SM,Ford WL,Butcher GW

    更新日期:1988-11-01 00:00:00

  • Recall response to cytomegalovirus in allograft recipients: mobilization of CD57+, CD28+ cells before expansion of CD57+, CD28- cells within the CD8+ T lymphocyte compartment.

    abstract:BACKGROUND:Strong correlations have been described between persistently elevated proportions of CD57+ (CD28-) CD8+high T lymphocytes and cytomegalovirus (CMV) infection, in healthy individuals as well as in transplant patients. We investigated whether secondary exposure to CMV triggers recall responses within the CD8 T...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199703150-00014

    authors: Hazzan M,Labalette M,Noel C,Lelievre G,Dessaint JP

    更新日期:1997-03-15 00:00:00

  • Toxicity of rapamycin--a comparative and combination study with cyclosporine at immunotherapeutic dosage in the rat.

    abstract::Sprague-Dawley rats were treated for 14 days with rapamycin (RAP; 1.5 mg/kg/day i.p.), cyclosporine (15 mg/kg/day by gavage), both drugs in combination, or appropriate drug vehicles. Hematological parameters and biochemical indices of renal and hepatic function were determined throughout the experimental period, at th...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199108000-00004

    authors: Whiting PH,Woo J,Adam BJ,Hasan NU,Davidson RJ,Thomson AW

    更新日期:1991-08-01 00:00:00

  • Does liver ischemic preconditioning in brain death donors induce kidney preconditioning? A retrospective analysis.

    abstract:BACKGROUND:It is unclear whether ischemic preconditioning (IPC) of solid organs induces remote IPC (RIPC) in donors after brain death (DBD). METHODS:Outcomes in kidney recipients from 163 DBD in two randomized trials of liver IPC (5 min=62 and 10 min=101) were obtained retrospectively from the Scientific Registry of T...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000436926.30897.56

    authors: Desai KK,Mora-Esteves C,Holland BK,Dikdan G,Fisher A,Wilson DJ,Koneru B

    更新日期:2014-02-15 00:00:00

  • The use of marginal heart beating donor livers for transplantation in the United kingdom.

    abstract:BACKGROUND:This study investigated the use of deceased heart-beating donor livers offered for transplantation during a 10-year period, during which there has been an increasing disparity between organ supply and demand in the United Kingdom. METHODS:Summary data from the National Transplant Database were analyzed on a...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000268072.04260.69

    authors: Devey LR,Friend PJ,Forsythe JL,Mumford LL,Wigmore SJ

    更新日期:2007-07-15 00:00:00

  • The effects of pretransplant cyclosporine therapy on rats grafted with twelve-hour cold-stored livers--with special reference to reperfusion injury.

    abstract::The effect of pretreatment with cyclosporine on liver preservation was studied using a rat liver transplant model. In a preliminary 1-week survival study, 59 liver transplants were performed. In group A, neither donors nor recipients were treated. In group B, the recipients were pretreated by a 3-day course of CsA (10...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199110000-00007

    authors: Goto S,Kim YI,Shimada T,Kawano K,Kobayashi M

    更新日期:1991-10-01 00:00:00

  • High prevalence of thromoembolic complications in heart transplant recipients. Which preventive strategy.?

    abstract::Consecutive patients transplanted between January 1984 and December 1988 were followed until August 1992 to detect fatal and nonfatal thromboembolic complications, including sudden death, acute and chronic myocardial infarction, pulmonary and peripheral embolisms, stroke, and thrombophlebitis. The probability of devel...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199603150-00015

    authors: Forrat R,Ferrera R,Boissonnat P,Adeleine P,Dureau G,Ninet J,De Lorgeril M

    更新日期:1996-03-15 00:00:00

  • Soluble CD30 as a predictor of kidney graft outcome.

    abstract:BACKGROUND:In the present study, we investigated whether the soluble form of CD30 (sCD30), a marker for T helper 2-type cytokine-producing T cells, is increased in sera of potential kidney graft recipients. We also investigated whether the pretransplantation serum sCD30 content is related to kidney graft survival. MET...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200201150-00002

    authors: Pelzl S,Opelz G,Wiesel M,Schnülle P,Schönemann C,Döhler B,Süsal C

    更新日期:2002-01-15 00:00:00

  • Utilization of Donor Kidneys With Acute Kidney Injury in Pediatric Kidney Transplant Recipients.

    abstract:BACKGROUND:An elevated terminal creatinine is frequently used as a reason for organ refusal in pediatric kidney transplantation. There is increasing evidence that adults who receive kidneys from donors with moderate to severe acute kidney injury (AKI) have similar outcomes to recipients who receive kidneys from donors ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000002827

    authors: Solomon S,Hayde N

    更新日期:2020-03-01 00:00:00

  • Effect of granulocyte-macrophage colony-stimulating factor on the induction of unresponsiveness by lymphoid cells.

    abstract::Skin grafts can be significantly prolonged in ALS-treated mice by the injection of 25 x 10(6) donor bone marrow cells or 50 x 10(6) spleen cells. Lymph node cells and thymocytes are only minimally effective in prolonging grafts. The effect of a hematopoietic growth factor, granulocyte-macrophage colony stimulating fac...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199101000-00035

    authors: Monaco AP,Wood ML,Gottschalk R,Seiler FR

    更新日期:1991-01-01 00:00:00

  • T cells receptor beta-chain repertoires are nonrandomly selected in responses to HLA-DR1.

    abstract::T cell receptor (TCR) beta-chain usage by HLA-DR1 alloreactive T cell lines was examined to determine whether common TCR gene segments were used preferentially. We have demonstrated previously that a DR1-specific, human renal allograft-derived T cell line and replicate, anti-DR1 mixed lymphocyte reactions (MLR), estab...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199604150-00017

    authors: Hand SL,Alter MD,Finn OJ

    更新日期:1996-04-15 00:00:00

  • Late recurrent urinary tract infections may produce renal allograft scarring even in the absence of symptoms or vesicoureteric reflux.

    abstract:BACKGROUND:The significance of late urinary tract infections (UTIs) after renal transplantation and their association with scarring and graft dysfunction remains controversial. We sought to define the prevalence of renal scarring in allograft recipients with a history of late recurrent UTIs, to determine whether the pr...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000275377.09660.fa

    authors: Dupont PJ,Psimenou E,Lord R,Buscombe JR,Hilson AJ,Sweny P

    更新日期:2007-08-15 00:00:00

  • Apoptosis and the expression of Fas and Fas ligand (FasL) antigen in rejection and reinfection in liver allograft specimens.

    abstract:BACKGROUND AND METHODS:To investigate the frequency of apoptosis and the expression of Fas/Fas ligand (FasL) in liver allografts, we examined 97 biopsy specimens from 62 patients after orthotopic liver transplantation. The results of the biopsies were as follows: acute allograft rejection (n=32); hepatitis C virus (HCV...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199904150-00027

    authors: Tannapfel A,Kohlhaw K,Ebelt J,Hauss J,Liebert U,Berr F,Wittekind C

    更新日期:1999-04-15 00:00:00

  • The risks, benefits, and costs of expanding donor criteria. A collaborative prospective three-year study.

    abstract::The study purpose was to identify risks, benefits and costs associated with an expanded donor protocol. The protocol design evaluated organs rescued using expanded donor criteria and weighed all costs associated with doing so. Costs were measured against conditions experienced with expanded and traditional criteria an...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199560120-00021

    authors: Jacobbi LM,McBride VA,Etheredge EE,McDonald JC,Cooper ES,Frey D,Boudreaux JP,Gonzalez F,Van Meter C,McMillan R

    更新日期:1995-12-27 00:00:00

  • Innominate artery interposition graft simplifies the portal venous drainage method of pancreas transplantation.

    abstract::Pancreas transplantation utilizing portal venous and enteric exocrine drainage has potential benefits over the standard systemic venous and bladder exocrine drainage method. Unfortunately, technical difficulties are often experienced with the arterial anastomosis after the portal venous anastomosis is completed. We ha...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199907270-00029

    authors: Bigam DL,Hemming AW,Sanabria JR,Cattral MS

    更新日期:1999-07-27 00:00:00

  • The impact of donor age on living donor liver transplantation.

    abstract:BACKGROUND:The impact of the age of the donor on the outcome of living related liver transplantation is yet to be clarified. METHODS:During October 14, 1996 and December 20, 1999, 34 living related liver transplantations were performed. Of these, 26 cases were performed using the extended left lobe graft, which were c...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200012270-00007

    authors: Ikegami T,Nishizaki T,Yanaga K,Shimada M,Kishikawa K,Nomoto K,Uchiyama H,Sugimachi K

    更新日期:2000-12-27 00:00:00

  • Attenuation of ischemia-reperfusion injury of the liver in dogs by cyclosporine. A comparative study with allopurinol and methylprednisolone.

    abstract::The effects of pretreatment with cyclosporine, allopurinol, or methylprednisolone on ischemia-reperfusion injury of the liver were investigated. A total of 32 adult mongrel dogs that received one of the pretreatments were divided into four groups and were subjected to 90 min liver ischemia. Serum activities of asparta...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199107000-00005

    authors: Yamanoi A,Nagasue N,Kohno H,Chang YC,Hayashi T,Nakamura T

    更新日期:1991-07-01 00:00:00

  • Evolution and etiology of cardiovascular diseases in renal transplant recipients.

    abstract::The mortality rates for CVDs in transplant recipients are greater than those in the general population (13). CVDs are a major cause of both patient and graft loss in renal transplant recipients, and improving cardiovascular health may help to extend both patient and graft survival. A complication of chronic renal fail...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:

    authors: Wheeler DC,Steiger J

    更新日期:2000-12-15 00:00:00

  • Resolution and relapse of osteopetrosis in mice transplanted with myeloid tissue of variable histocompatibility.

    abstract::Osteopetrotic microphthalmic mice (mi/mi) were treated by injections of suspensions of myeloid tissue, newborns i.p., and weanlings i.v. Donated syngeneic material effected permanent cure of oteopetrosis provided that the dose was large enough (10(8) cells of bone marrow). H-2-compatible allogeneic bone marrow was ini...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-197910000-00004

    authors: Nisbet NW,Menage J,Loutit JF

    更新日期:1979-10-01 00:00:00

  • Rituximab, IVIG, and plasma exchange without graft local infusion treatment: a new protocol in ABO incompatible living donor liver transplantation.

    abstract:BACKGROUND:Although graft local infusion (GLI) treatment via the portal vein or the hepatic artery has been the pivotal strategy in ABO incompatible (ABOi) living donor liver transplantation (LDLT) in Japan, the procedure is associated with a high rate of catheter-associated complications. METHODS:A new ABOi-LDLT prot...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3181adcae6

    authors: Ikegami T,Taketomi A,Soejima Y,Yoshizumi T,Uchiyama H,Harada N,Iguchi T,Hashimoto N,Maehara Y

    更新日期:2009-08-15 00:00:00