Abstract:
BACKGROUND:In the present study, we investigated whether the soluble form of CD30 (sCD30), a marker for T helper 2-type cytokine-producing T cells, is increased in sera of potential kidney graft recipients. We also investigated whether the pretransplantation serum sCD30 content is related to kidney graft survival. METHODS:Pretransplantation sera of 844 cadaver kidney recipients from three transplant centers in Germany were tested for serum sCD30 content using a commercially available ELISA kit. RESULTS:Kidney graft recipients showed a significantly higher serum sCD30 content than healthy controls (P<0.0001). High sCD30 serum content was associated with graft rejection. The 2-year graft survival rate in recipients with a high pretransplantation serum sCD30 was 68+/-6%, significantly lower than the 86+/-1% rate in recipients with a low sCD30 (P<0.0001). Importantly, high sCD30 was indicative of an increased risk of graft loss even in recipients without lymphocytotoxic alloantibodies. CONCLUSION:These data show that an elevated pretransplantation serum sCD30 reflects an immune state that is detrimental for kidney graft survival.
journal_name
Transplantationjournal_title
Transplantationauthors
Pelzl S,Opelz G,Wiesel M,Schnülle P,Schönemann C,Döhler B,Süsal Cdoi
10.1097/00007890-200201150-00002subject
Has Abstractpub_date
2002-01-15 00:00:00pages
3-6issue
1eissn
0041-1337issn
1534-6080journal_volume
73pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::We are reporting the first known case of sequential combined living donor liver/small bowel transplantation (LDL/SBT). A 2-year-old boy born with gastroschisis and intestinal malrotation lost his entire small bowel and colon shortly after birth. He underwent a living donor small bowel transplant at 1 year of age that ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000157280.75015.14
更新日期:2005-05-27 00:00:00
abstract::Imaging methods such as nuclear medicine (including positron emission tomography), magnetic resonance imaging, ultrasound, and optical imaging can be used to provide information about the expression of genes, and the location of molecules and cells in intact animals or patients. In the setting of transplantation, this...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000235530.80305.d2
更新日期:2006-11-15 00:00:00
abstract::The science of composite tissue allotransplantation (CTA) is rooted in progressive thinking by surgeons, fueled by innovative solutions, and aided by understanding the immunology of tolerance and rejection. These three factors have allowed CTA to progress from science fiction to science fact. Research using preclinica...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0b013e318184ca6a
更新日期:2008-09-15 00:00:00
abstract::Donor-specific blood transfusion (DSBT) in animals and humans can either promote subsequent renal graft survival or lead to sensitization and graft rejection. Using a rat renal allograft model, we have examined whether the effects of DSBT on renal allograft outcome and IgG alloantibody responses are linked to the host...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199309000-00033
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:Accurate islet quantification has proven difficult to standardize in a good manufacturing practices (GMP) approved manner. METHODS:The influence of assessment variables from both manual and computer-assisted digital image analysis (DIA) methods were compared using calibrated, standardized microspheres or is...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31820ae48e
更新日期:2011-03-27 00:00:00
abstract::The growing number of elderly patients with end-stage kidney disease awaiting transplantation has resulted in a corresponding rise in the number of elderly transplant recipients. In this paper, we review existing literature on age-related changes, transplant outcomes, and complications in the elderly in an attempt to ...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000275423.69689.dc
更新日期:2007-08-15 00:00:00
abstract::The value of percutaneous core needle biopsy in the immunohistological evaluation of renal allograft dysfunction was studied in 72 consecutive biopsies performed in 42 patients. The phenotypes of infiltrating cells mediating graft destruction were identified with monoclonal antibodies and immunoperoxidase staining tec...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198701000-00022
更新日期:1987-01-01 00:00:00
abstract::Considerable variations in the suppression of graft-versus-host disease with monoclonal anti-Thy-1 antibodies were found to relate to substantial differences noted in the expression of mouse Thy-1 marker on lymph node and spleen cells of Thy-1.1 (AKR/J, C57BL/6.Thy-1.1) and Thy 1.2 (AKR/Cu, C57BL/6) mice. Thy-1.1 mice...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1990-04-01 00:00:00
abstract:BACKGROUND:We assess whether remote ischemic preconditioning (rIPC) of the recipient can modify ischemia-reperfusion (IR) injury in the donor heart following orthotopic heart transplantation from brain dead donors and to examine potential mechanisms of protection. METHODS:Sixteen pigs weighing from 26 to 34.2 (mean 29...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000159137.76400.5d
更新日期:2005-06-27 00:00:00
abstract:BACKGROUND:Connective tissue growth factor (CTGF) is a key mediator of tissue fibrogenesis in kidney disease. Its involvement in renal allograft fibrosis was recently demonstrated in a mouse model. METHODS:We prospectively studied the association between urinary CTGF (CTGFu) levels and renal allograft fibrosis during ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31829b07e1
更新日期:2013-09-15 00:00:00
abstract::First cadaver, unrelated kidney graft survival at one year from 50 Eurotransplant centers was analyzed and found to show marked changes in survival rates over the 20-year period from 1967 to 1986 inclusive. Full information on HLA-A, -B, and -DR matching and use of cyclosporine therapy was only available for the perio...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198811000-00012
更新日期:1988-11-01 00:00:00
abstract:BACKGROUND:The aim of this study was to determine the efficacy of cariporide (a sodium-hydrogen exchanger inhibitor), BMS180448 (a pharmacologic ischemic preconditioning agent), and the combination thereof, as adjuvant therapies for extended cardiac allograft preservation. METHODS:A porcine model of donor brain death ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000079254.81264.6D
更新日期:2003-09-15 00:00:00
abstract::Seventy-two dog kidneys were stored under hypothermia as described by Collins and Sacks between 24 and 72 hr and then transplanted. The immediate function of the kidneys was measured by p-aminohippuric acid and inulin clearances. Twenty-four hr proved to be the maximum safe preservation time with both methods. The imm...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197705000-00009
更新日期:1977-05-01 00:00:00
abstract::Pulmonary endothelium is considered the compartment most susceptible to preservation damage. This investigation was designed to analyze the efficacy of an original, University of Parma low-potassium-albumin solution (SPAL UP) on cultured human pulmonary artery endothelial cells (HPAEC) and to compare its effects with ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199611150-00036
更新日期:1996-11-15 00:00:00
abstract::Various autoantibodies were screened in 53 long-term survivors after allogeneic bone marrow transplantation. Among them, 40 displayed chronic graft-versus-host disease, with clinical features reminiscent of collagen diseases, especially scleroderma, Sjögren's syndrome, and autoimmune hepatitis. Antinuclear, anti-smoot...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198808000-00010
更新日期:1988-08-01 00:00:00
abstract:BACKGROUND & AIMS:Direct-acting antiviral (DAA) therapy made possible the novel practice of utilizing HCV-viremic (HCV-RNA-positive) donors into HCV-negative recipients in the United States. Although initial reports of outcomes have been satisfactory, higher-quality longer-term outcomes remain to be elucidated. METHOD...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003382
更新日期:2020-06-29 00:00:00
abstract:BACKGROUND:Tacrolimus (Tac) and mycophenolate mofetil (MMF) are newly approved immunosuppressive agents. However, the safety and efficacy of the combination of MMF and Tac in primary liver transplantation has not been determined. METHODS:An Institutional Review Board-approved, open-label prospective randomized protoco...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007890-199811270-00024
更新日期:1998-11-27 00:00:00
abstract:BACKGROUND:Primary hyperoxaluria type-1 (PH1) is an autosomal recessive disease characterized by excessive oxalate production by hepatocytes caused by the deficiency of peroxisomal alanine-glyoxylate aminotransferase (AGT) activity. Persistent hyperoxaluria causes nephrocalcinosis and urolithiasis, leading to renal fai...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31816de49e
更新日期:2008-05-15 00:00:00
abstract::The effect of the spleen cells and thymus cells from Corynebacterium liquefaciens-treated (C57BL/6 x BALB/c)F1 hybrid mice on graft-versus-host (GVH) reaction, initiated in the parental to newborn F1 hybrid strain combination, was studied by using Simonsen's spleen assay. The combined inocula of 5 x 10(6) normal BALB/...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198001000-00009
更新日期:1980-01-01 00:00:00
abstract::After small bowel transplantation, not only rejection but also graft-versus-host reaction (GVHR) may occur. Donor T lymphocytes, transferred together with the graft, are a prerequisite for the development of GVHR. So far, however, little is known about the effector mechanisms in acute GVHR. It can be assumed that not ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199608150-00007
更新日期:1996-08-15 00:00:00
abstract::Rapamycin prolongs allograft survival and induces donor-specific tolerance in some small animal transplant models. Large animal studies, however, are limited. We studied rapamycin in a porcine renal allograft model. Donor-recipient combinations were chosen based on high response in pretransplant MLCs. Allografts were ...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1993-08-01 00:00:00
abstract::A murine monoclonal antihuman T cell antibody is described that is pan-T in that it reacts with all T cells, including those from thymus, but not with B cells or other cells, except for a small subpopulation of null cells. Biochemical analysis demonstrated that the antigen detected is a glycoprotein, Mr 50,000 daltons...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198309000-00013
更新日期:1983-09-01 00:00:00
abstract::Recipient dogs were conditioned with 9.2 Gy of total-body irradiation followed by the infusion of bone marrow and peripheral blood leukocytes from a DLA-haploidentical littermate (N = 10) or a completely allogeneic unrelated donor (n = 9). Graft-vs.-host disease (GVHD) prophylaxis consisted of methotrexate (MTX) and c...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198711000-00006
更新日期:1987-11-01 00:00:00
abstract:OBJECTIVE:We compared the enzyme release from preserved and ex vivo reperfused livers after acute injury or inflammatory stimulus with organ function. METHODS:Acute injury was induced by carbon tetrachloride and inflammation was induced by turpentine oil treatments. Livers were exsanguinated and preserved for 8 or 24 ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200210270-00004
更新日期:2002-10-27 00:00:00
abstract::Neither the presence nor the specific role of secretory cytokines in in vivo allograft rejection has been extensively studied. We quantitated the levels of colony-stimulating factors, tumor necrosis factor, and interleukin 1 within the rejecting allograft. BALB/c (H-2d) mice were implanted with polyurethane sponges co...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199009000-00020
更新日期:1990-09-01 00:00:00
abstract:BACKGROUND:Scarring can greatly impact quality of life for individuals (ie, causing depression posttraumatic stress disorder, body image issues). Those who wish to be anonymous live liver donors are warned of the potential negative psychological impacts associated with the large scar left from liver donation surgery. G...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003333
更新日期:2020-05-25 00:00:00
abstract::Reports of early success with cryopreserved saphenous veins (CSV) as arterial conduits led us to develop cryopreserved iliac veins (CIV) as interposition grafts for portal vein reconstruction in living-related liver transplantation (LRLT). Despite encouraging short-term results, retrospective analysis of long-term cry...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/00007890-199609270-00007
更新日期:1996-09-27 00:00:00
abstract::A comparative study of 24 hr preservation at 4 degrees C of excised rat livers with Euro-Collins and hydroxyethyl starch-free University of Wisconsin (UWm) solutions has been conducted based on the assessment of (1) the cellular energy status determined by 31P NMR spectroscopy and (2) cellular injury estimated from th...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199210000-00006
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND:Leflunomide is a novel immunosuppressive agent with promising activity for xenotransplantation. It is not clear yet which mechanisms of action of leflunomide are responsible for that. METHODS:In a hamster-to-C57BL/6 nude mouse heart transplantation model, a 2-week course of leflunomide was used after transp...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000147464.63188.4b
更新日期:2005-01-27 00:00:00
abstract:BACKGROUND:The management of small bowel transplantation is unique because signs of rejection can be obtained visually by endoscopy. The aim of this study was to evaluate the accuracy of endoscopic appearance in assessing histologic evidence of acute cellular rejection (ACR). METHODS:Endoscopies were performed in 66 a...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31825f4410
更新日期:2012-10-15 00:00:00