The Meaning Behind the Scar: Anonymous Live Liver Donors' Perceptions of Their Surgical Scars.

abstract：:Monoclonal antibodies to CD3 have been shown to activate T cells in vivo and in vitro but have also been shown to render T cells anergic in vitro. In this study G4.18, a mouse IgG3 mAb, was produced that appeared to recognize CD3 by its binding to all peripheral T cells, including a population not recognized by mAb to...

journal_title：Transplantation

authors： Nicolls MR,Aversa GG,Pearce NW,Spinelli A,Berger MF,Gurley KE,Hall BM

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Chronic graft-versus-host disease (cGVHD) represents a double-edged sword. In its nonsevere form, cGVHD associates with better control of the malignant disease, thus highlighting graft-versus-leukemia effects. However, severe cGVHD leads to debilitating morbidity and increased nonrelapse mortality. The predi...

journal_title：Transplantation

authors： Giesen N,Schwarzbich MA,Dischinger K,Becker N,Hummel M,Benner A,Radujkovic A,Müller-Tidow C,Dreger P,Luft T

更新日期：2020-11-01 00:00:00

abstract：:Glucocorticoids (GC) inhibit IL-2 gene transcription by interfering with the binding of the nuclear factor activator protein-1 on the IL-2 promoter. Calcineurin, a Ca2+/calmodulin-dependent protein phosphatase, is an essential component of the T cell antigen receptor signal transduction pathway leading to IL-2 gene tr...

journal_title：Transplantation

authors： Paliogianni F,Boumpas DT

更新日期：1995-05-15 00:00:00

abstract：BACKGROUND:Bone marrow (BM) is an excellent source of mesenchymal stem cells (MSC) which can be expanded in vitro for further use. However, large volumes of BM specimens are not routinely available. We hypothesized that the normally discarded BM collection kits might be a convenient source of large numbers of MSC. MET...

journal_title：Transplantation

authors： Mageed AS,Pietryga DW,DeHeer DH,West RA

更新日期：2007-04-27 00:00:00

abstract：:A study was designed to determine if cold preservation induces an increase in lymphocyte adherence to liver sinusoids on reperfusion. Rat livers were stored at 1 degree C in University of Wisconsin solution for 45 min, 8 hr, or 30 hr, and then reperfused for 90 min at 37 degrees C in an isolated perfused rat liver app...

journal_title：Transplantation

authors： Clavien PA,Morgan GR,Sanabria JR,Petrunka C,Levy GA,Robert P,Harvey C,Strasberg SM

更新日期：1991-09-01 00:00:00

abstract：:Intestinal transplantation has become the treatment of choice for patients who are experiencing life-threatening complications of intestinal failure. Early attempts with intestinal transplantation were unsuccessful as a consequence of both technical and immunologic failures. The introduction of tacrolimus provided the...

journal_title：Transplantation

authors： Langnas AN

更新日期：2004-05-15 00:00:00

abstract：BACKGROUND:Mixed allogeneic hematopoietic chimerism has previously been reliably achieved and shown to induce tolerance to fully MHC-mismatched allografts in mice and monkeys. However, the establishment of hematopoietic chimerism has been difficult to achieve in the discordant pig-to-primate xenogeneic model. METHODS:...

journal_title：Transplantation

authors： Sablinski T,Emery DW,Monroy R,Hawley RJ,Xu Y,Gianello P,Lorf T,Kozlowski T,Bailin M,Cooper DK,Cosimi AB,Sachs DH

更新日期：1999-04-15 00:00:00

abstract：:Late deaths (after more than 1 year) after liver transplantation were analyzed in a series of 464 consecutive patients who received liver grafts between 1982 and 1993. Recipients who survived the first posttransplant year (n = 365) had actuarial 5- and 10-year survival rates of 92% and 84%, respectively. Thirty-five p...

journal_title：Transplantation

authors： Asfar S,Metrakos P,Fryer J,Verran D,Ghent C,Grant D,Bloch M,Burns P,Wall W

更新日期：1996-05-15 00:00:00

abstract：:Since major histocompatibility (MHC) antigen matching was introduced in the early 1970s as the key factor determining kidney transplant allocation, several studies, mainly arising from organ-sharing organizations in the United States and Europe, have debated this complex issue. The first fundamental concern is the int...

journal_title：Transplantation

authors： Hiesse C,Pessione F,Houssin D

更新日期：2004-02-27 00:00:00

abstract：:The lung is one of the primary targets of acute graft-versus-host disease (GVHD), which is the principal complication that occurs after allogeneic intestinal transplantation. The purpose of this study is to investigate the involvement of Fas/Fas ligand system in pulmonary injury after rat semi-allogeneic intestinal tr...

journal_title：Transplantation

authors： Hiroyasu S,Shiraishi M,Koji T,Mamadi T,Sugawa H,Tomori H,Muto Y

更新日期：1999-10-15 00:00:00

abstract：:In vitro studies have shown that calcium channel blockers (CCB) exert inhibitory effects on immunocompetent cells but conflicting results have been reported as to the translation of these effects into significant in vivo immunosuppression. In this study we evaluated the effects of the benzothiazepine-like calcium bloc...

journal_title：Transplantation

authors： Dumont L,Chen H,Daloze P,Xu D,Garceau D

更新日期：1993-07-01 00:00:00

abstract：:Although cyclosporine has high specificity for the immune system, immunosuppressive therapy with CsA is often complicated by nephrotoxicity. The main morphologic targets of CsA nephrotoxicity include the tubular epithelial and endothelial cells. These cells were investigated in vitro. CsA caused a dose- and time-depen...

journal_title：Transplantation

authors： Ryffel B,Foxwell BM,Gee A,Greiner B,Woerly G,Mihatsch MJ

更新日期：1988-08-01 00:00:00

abstract：BACKGROUND:Liver transplantation from donation after cardiac death (DCD) donors is an increasingly common approach for expansion of the donor organ supply. However, transplantation with DCD livers results in inferior graft survival. In this study, we examined donor and recipient characteristics that are associated with...

journal_title：Transplantation

authors： Lee KW,Simpkins CE,Montgomery RA,Locke JE,Segev DL,Maley WR

更新日期：2006-12-27 00:00:00

abstract：INTRODUCTION:This study examines the efficacy and toxicity of sirolimus used as primary immunosuppression in combination with reduced dose tacrolimus (calcineurin inhibitor [CI]-sparing regimen) or mycophenolate mofetil (CI-free regimen) in high-risk cadaveric renal transplantation. METHODS:Seventy subjects were treat...

journal_title：Transplantation

authors： Lo A,Egidi MF,Gaber LW,Amiri HS,Vera S,Nezakatgoo N,Gaber AO

更新日期：2004-04-27 00:00:00

abstract：BACKGROUND:Endomyocardial biopsy (EMB) remains the gold standard for acute cellular rejection (ACR) diagnosis in cardiac transplantation yet is subject to interobserver variability. A method that could avoid discordant EMB analysis would be desirable. The apoptosis rate in EMB correlates with ACR severity. Apollon inhi...

journal_title：Transplantation

authors： Aharinejad S,Andrukhova O,Gmeiner M,Thomas A,Krenn K,Zuckermann A,Grimm M

更新日期：2010-01-27 00:00:00

abstract：BACKGROUND:The objective of the study was to determine surveillance criteria for renal transplant recipients (RTRs) at highest risk for immunosuppressant therapy nonadherence. METHODS:Retrospective analyses were performed on follow-up data in the United States Renal Data System. Those who received transplants between ...

journal_title：Transplantation

authors： Chisholm MA,Kwong WJ,Spivey CA

更新日期：2007-11-15 00:00:00

abstract：:The incidence of interstitial pneumonitis (IP) was reviewed in 70 consecutive patients who received autologous marrow transplants for hematologic malignancies. All patients were treated with total-body irradiation (TBI), with or without other chemotherapeutic agents. Seven patients (10%) developed IP, 3 were due to cy...

journal_title：Transplantation

authors： Pecego R,Hill R,Appelbaum FR,Amos D,Buckner CD,Fefer A,Thomas ED

更新日期：1986-11-01 00:00:00

abstract：:Teratoma 402 AX is an embryo-like tumor cell line originally derived from the testicles of strain 129/J mice. This teratocarcinoma grows well in males and pregnant females but poorly in virgin females when given in small doses. Induction of growth of this tumor is syngeneic and allogeneic virgin females was achieved b...

journal_title：Transplantation

authors： Isa AM,Sanders BR

更新日期：1975-10-01 00:00:00

abstract：BACKGROUND:Hyperparathyroidism is reported in 10% to 66% of renal transplant recipients (RTR). The influence of persisting hyperparathyroidism on long-term clinical outcomes in RTR has not been examined in a large prospective study. METHODS:We investigated the association between baseline parathyroid hormone (PTH) lev...

journal_title：Transplantation

authors： Pihlstrøm H,Dahle DO,Mjøen G,Pilz S,März W,Abedini S,Holme I,Fellström B,Jardine AG,Holdaas H

更新日期：2015-02-01 00:00:00

abstract：:Acute murine cytomegalovirus (MCMV) infection enhances the ability of parental spleen cells to induce graft-vs.-host immunodeficiency (GVHID) in F1 hybrid mice when the two processes occur simultaneously in the recipient. The present study assessed GVHID as the ability of spleen cells to generate in vitro cytotoxic T ...

journal_title：Transplantation

authors： Via CS,Shanley JD,Weatherly BR,Lang P,Shearer GM

更新日期：1988-08-01 00:00:00

abstract：:A single posttransplant test for human leukocyte antigen (HLA) antibodies in heart and lung graft patients was examined for its predictive value for graft survival as part of the 13th and 14th international histocompatibility workshops. We included patients with HLA antibodies who were tested 6 or more months after tr...

journal_title：Transplantation

authors： Morales-Buenrostro LE,Castro R,Terasaki PI

更新日期：2008-02-15 00:00:00

abstract：BACKGROUND:Cardiac allograft vasculopathy (CAV) is a major limitation in long-term graft survival after heart transplantation (HTx). Its prediction and detection at an early stage is a challenge because an accurate, minimally invasive blood test is lacking. The aim of this study was to analyze the relationship of Tact ...

journal_title：Transplantation

authors： Roldán C,Mirabet S,Cecilia C,Brossa V,Roig E,Martín C,Gelpí C

更新日期：2015-07-01 00:00:00

abstract：:Flow cytometry (FC) is increasingly being used as a crossmatch procedure in addition to the standard complement-dependent cytotoxicity (CDC) test. In fact, FC offers a number of advantages over CDC and has the potential to become the primary crossmatch technique for cadaveric donor renal transplantation. We evaluated ...

journal_title：Transplantation

authors： Scornik JC,Brunson ME,Schaub B,Howard RJ,Pfaff WW

更新日期：1994-02-27 00:00:00

abstract：:In adult recipients of allogeneic hematopoietic cell transplants (HCT) studied at 1 year after grafting, there was a significant correlation between the counts of T cell receptor excision circle (TREC)-containing CD4 T cells (presumed recent thymic emigrants) and the counts of total T cells (r=0.65, P<0.001). Thus, th...

journal_title：Transplantation

authors： Storek J,Joseph A,Dawson MA,Douek DC,Storer B,Maloney DG

更新日期：2002-04-15 00:00:00

abstract：BACKGROUND:Targeting 2-hr postdose cyclosporine (C2) levels to 1,000 to 1,700 mg/dL during the first 6 months after renal transplantation is recommended for triple immunosuppressive regimens. This trial determines whether lower C2 levels could be targeted safely in de novo kidney transplant recipients under a quadruple...

journal_title：Transplantation

authors： Hardinger KL,Schnitzler MA,Koch MJ,Enkvetchakul D,Desai N,Jendrisak M,Lowell JA,Miller B,Shenoy S,Brennan DC

更新日期：2004-10-27 00:00:00

abstract：BACKGROUND:It has been suggested that T cells primed by processed donor major histocompatibility complex antigen (the "indirect" pathway of allorecognition) may be responsible for mediating chronic allograft rejection. The purpose of this study was to develop a clinically useful assay to study the occurrence of indirec...

journal_title：Transplantation

authors： Vella JP,Spadafora-Ferreira M,Murphy B,Alexander SI,Harmon W,Carpenter CB,Sayegh MH

更新日期：1997-09-27 00:00:00

abstract：BACKGROUND:Dendritic cells (DC) are important in the development of acute graft-versus-host disease (GVHD) after allogeneic hemopoietic cell transplantation (alloHCT). The trafficking of immature DC from blood to GVHD target organs is likely to be regulated by chemokine receptors. METHODS:We performed flow cytometry t...

journal_title：Transplantation

authors： Shahin K,Sartor M,Hart DN,Bradstock KF

更新日期：2013-10-27 00:00:00

abstract：BACKGROUND:Macroencapsulated islets can reverse hyperglycemia in diabetic animals when transplanted i.p. or into the fat pad. The s.c. space is an attractive site for such transplantation because macrocapsules can be implanted with local anesthesia and be easily removed or reloaded with fresh islets. METHODS:Immunopro...

journal_title：Transplantation

authors： Tatarkiewicz K,Hollister-Lock J,Quickel RR,Colton CK,Bonner-Weir S,Weir GC

更新日期：1999-03-15 00:00:00

abstract：BACKGROUND:Patients with long-term functioning organ allografts may have developed different mechanisms that explain the lack of graft rejection. However, it is not known how these mechanisms interplay or whether one of them predominates in such situations. METHODS:The authors analyzed the expression of T-cell surface...

journal_title：Transplantation

authors： Alvarez CM,Paris SC,Arango L,Arbelaez M,Garcia LF,RAD B201 study group.

更新日期：2004-11-27 00:00:00

abstract：:Recipients of solid organ allografts require lifelong immunosuppression in order to prevent graft rejection and to maintain graft function. In general, such immunosuppression greatly impairs the cellular immune system, as this level of the immune system is principally responsible for self and non-self recognition. The...

journal_title：Transplantation

authors： Van Thiel DH,Finkel R,Friedlander L,Gavaler JS,Wright HI,Gordon R

更新日期：1992-08-01 00:00:00