The case to abandon human leukocyte antigen matching for kidney allocation: would it be wise to throw out the baby with the bathwater?

abstract：:In organ transplantation, blood borne cells and macromolecules (e.g., antibodies) of the host immune system are brought into direct contact with the endothelial cell lining of graft vessels. In this location, graft endothelial cells play several roles in allograft rejection, including the initiation of rejection respo...

journal_title：Transplantation

authors： Al-Lamki RS,Bradley JR,Pober JS

更新日期：2008-11-27 00:00:00

abstract：:In 2007, the islet community was notified that the collagenase product most commonly used for human islet isolations contained bovine neural tissue contaminants. To minimize this potential hazard, we adapted our human islet processing procedure to use a GMP-manufactured, bovine neural tissue-free collagenase blend. He...

journal_title：Transplantation

authors： Szot GL,Lee MR,Tavakol MM,Lang J,Dekovic F,Kerlan RK,Stock PG,Posselt AM

更新日期：2009-09-27 00:00:00

abstract：:Mucosal injury is an immediate event following revascularization of small intestinal grafts in the context of transplantation (SBTx). The generation of oxygen free radicals (OFR) and tissue infiltration by activated neutrophils are consequences of ischemia and reperfusion and known causative factors of tissue injury; ...

journal_title：Transplantation

authors： Cicalese L,Caraceni P,Nalesnik MA,Borle AB,Schraut WH

更新日期：1996-07-27 00:00:00

abstract：BACKGROUND:Accurate islet quantification has proven difficult to standardize in a good manufacturing practices (GMP) approved manner. METHODS:The influence of assessment variables from both manual and computer-assisted digital image analysis (DIA) methods were compared using calibrated, standardized microspheres or is...

journal_title：Transplantation

authors： Friberg AS,Brandhorst H,Buchwald P,Goto M,Ricordi C,Brandhorst D,Korsgren O

更新日期：2011-03-27 00:00:00

abstract：BACKGROUND:Transplant recipients who develop COVID-19 may be at increased risk for morbidity and mortality. Determining the status of antibodies against SARS-CoV-2 in both candidates and recipients will be important to understand the epidemiology and clinical course of COVID-19 in this population. While there are multi...

journal_title：Transplantation

authors： Bray RA,Lee JH,Brescia P,Kumar D,Nong T,Shih R,Woodle ES,Maltzman JS,Gebel HM

更新日期：2021-01-01 00:00:00

abstract：:Dendritic-shaped cells (Thy-1+DC) characterized by the surface phenotype of Thy-1+, asialo GM1+, Ia- are reported to exist exclusively in mice. However, Thy-1+ dendritic cells were observed in the skin of normal athymic nude F344, euthymic F344, and WKAH rats. Their phenotypic markers were Thy-1+, asialo GM1+, Ia-, W3...

journal_title：Transplantation

authors： Ueda A,Ito M,Ishiguro N,Miura Y,Asai J,Miura T

更新日期：1993-07-01 00:00:00

abstract：:Lethally irradiated (850 rads) DBA/2 mice which had been transplanted 10 months previously with 2 times 10-6 bone marrow cells from 3-week-old donors of the H-2-histocompatible NZB, BALB/c and DBA/2 strains were examined for manifestations of autoimmune disease. Also studied were lethally irradiated (950 rads) NZB mic...

journal_title：Transplantation

authors： Morton JI,Siegel BV,Moore RD

更新日期：1975-06-01 00:00:00

abstract：:Until 1996, living kidney donation had been neglected in Germany. To encourage potential donors and to convince them that nephrectomy is not too risky for a healthy person, the author decided to set an example with a personal nondirected donation. This donation, controversially discussed in the public domain, neverthe...

journal_title：Transplantation

authors： Hoyer J

更新日期：2003-10-27 00:00:00

abstract：BACKGROUND:The inflammation response is modulated by the elaborated chemokine-chemokine receptor system, which also plays an important role in the development of acute rejection (AR). In this study, we hypothesized that functional genetic variants of some of these modulatory proteins might influence the outcome of AR. ...

journal_title：Transplantation

authors： Simeoni E,Vassalli G,Seydoux C,Ramsay D,Noll G,von Segesser LK,Fleury S

更新日期：2005-11-15 00:00:00

abstract：:Prospective clinical trials are constructed with high levels of internal validity. Sample size and power considerations usually address primary endpoints. Primary endpoints have traditionally included events that are becoming increasingly less common and thus have led to growing use of composite endpoints and noninfer...

journal_title：Transplantation

authors： Srinivas TR,Ho B,Kang J,Kaplan B

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The short tolerable cold ischemia time and the importance of other risk factors have generally superseded the role of HLA matching in the allocation of donor hearts. Recent advances in the accuracy and time required to perform HLA typing and crossmatching, however, have led us to re-examine the United Networ...

journal_title：Transplantation

authors： Thompson JS,Thacker LR 2nd,Takemoto S

更新日期：2000-05-27 00:00:00

abstract：BACKGROUND:It is unclear to what extent cancer history affects posttransplantation mortality in solid organ transplant recipients. METHODS:We identified a Swedish population-based cohort of solid organ transplant recipients in the National Patient Register 1970 to 2008 and linked it to the Cancer and Cause-of-Death Re...

journal_title：Transplantation

authors： Brattström C,Granath F,Edgren G,Smedby KE,Wilczek HE

更新日期：2013-08-15 00:00:00

abstract：:A cluster of five cases of Legionnaires' disease in renal transplant patients is described. They were treated with erythromycin and rifampicin, and all five survived. Two of them had rejected their grafts prior to their Legionella pneumonia; two rejected their transplants after reduction of immunosuppressive therapy t...

journal_title：Transplantation

authors： Wilczek H,Kallings I,Nyström B,Hoffner S

更新日期：1987-06-01 00:00:00

abstract：:Liver transplantation for patients requiring life-support results in the lowest survival and highest costs. A ten year (1983-1993) regional experience with liver transplantation for critically ill patients was undertaken to ascertain the fate of several subgroups of patients. Of the 828 liver transplants performed at ...

journal_title：Transplantation

authors： Washburn WK,Bradley J,Cosimi AB,Freeman RB,Hull D,Jenkins RL,Lewis WD,Lorber MI,Schweizer RT,Vacanti JP,Rohrer RJ

更新日期：1996-01-27 00:00:00

abstract：:We present the youngest successful patient with combined heart-lung-liver transplantation. The patient was a 2.5-year-old child with Alagille syndrome suffering from tetralogy of Fallot with pulmonary atresia and multiple aortopulmonary collaterals and familial cholestasis. ...

journal_title：Transplantation

authors： Gandhi SK,Reyes J,Webber SA,Siewers RD,Pigula FA

更新日期：2002-06-27 00:00:00

abstract：BACKGROUND:Organ scarcity continues in solid organ transplantation, such that the availability of organs limits the number of people able to benefit from transplantation. Medical advancements in managing end-stage organ disease have led to an increasing demand for multiorgan transplant, wherein a patient with multiorga...

journal_title：Transplantation

authors： Cheng XS,Goldhaber-Fiebert J,Tan JC,Chertow GM,Kim WR,Wall AE

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:The timing of an acute rejection may have a variable impact on renal allograft survival. To determine whether the time of first acute transplant rejection (ATR) is an independent predictor of long-term allograft survival, we studied 31,600 first cadaveric renal transplants that were functional on the first t...

journal_title：Transplantation

authors： Leggat JE Jr,Ojo AO,Leichtman AB,Port FK,Wolfe RA,Turenne MN,Held PJ

更新日期：1997-05-15 00:00:00

abstract：BACKGROUND:Thromboembolism has been reported as a frequent complication after cardiac transplantation. Many risk factors for thrombosis may explain this, such as metabolic alterations and the use of cyclosporine. In the general population, two single nucleotide polymorphisms (SNPs), factor V Leiden and prothrombin G202...

journal_title：Transplantation

authors： Miriuka SG,Langman LJ,Evrovski J,Miner SE,Kozuszko S,D'Mello N,Delgado DH,Wong BY,Ross HJ,Cole DE

更新日期：2005-09-15 00:00:00

abstract：BACKGROUND:Allografts are occasionally accepted in the absence of immunosuppression. Because naturally occurring CD4(+)CD25(+) regulatory T cells (natural CD25(+) Treg cells) have been shown to inhibit allograft rejection, we investigated their influence on the outcome of allografts in nonimmunosuppressed mouse recipie...

journal_title：Transplantation

authors： Benghiat FS,Graca L,Braun MY,Detienne S,Moore F,Buonocore S,Flamand V,Waldmann H,Goldman M,Le Moine A

更新日期：2005-03-27 00:00:00

abstract：BACKGROUND:Operational tolerance is defined as long-term acceptance of a transplanted organ after complete cessation of immunosuppression (IS), but may not always protect against antigen-dependent changes in graft morphology. METHOD:IS free patients after living-donor liver transplantation (LDLT) underwent protocol bi...

journal_title：Transplantation

authors： Yoshitomi M,Koshiba T,Haga H,Li Y,Zhao X,Cheng D,Miyagawa A,Sakashita H,Tsuruyama T,Ohe H,Ueda M,Okamoto S,Egawa H,Wood K,Sakaguchi S,Manabe T,Tanaka K,Uemoto S

更新日期：2009-02-27 00:00:00

abstract：BACKGROUND:Functionally relevant polymorphisms in genes of the Th1 and Th2-inflammatory pathway influence the susceptibility to acute rejection (AR), chronic allograft nephropathy (CAN), and subclinical rejection (SR) as well as graft survival after renal transplantation. Because these findings have not been validated,...

journal_title：Transplantation

authors： Brabcova I,Petrasek J,Hribova P,Hyklova K,Bartosova K,Lacha J,Viklický O

更新日期：2007-10-27 00:00:00

abstract：:Natural anti-carbohydrate antibodies are central to hyperacute rejection in ABO-incompatible allotransplantation and in discordant xenotransplantation. ABO-incompatible rejection has been inhibited successfully using intravenous soluble carbohydrates as antibody inhibitors. The approach has been less successful previo...

journal_title：Transplantation

authors： Cairns T,Lee J,Goldberg L,Cook T,Simpson P,Spackman D,Palmer A,Taube D

更新日期：1995-12-15 00:00:00

abstract：:Research in hepatocellular gene therapy requires a consistently reproducible cell marker to detect transplanted hepatocytes. We have used a Y-specific genomic DNA probe to accomplish this goal. This technique enables the identification of transplanted male cells in recipient female tissues. Donor hepatocytes from male...

journal_title：Transplantation

authors： Eckert JW,Buerkle CJ,Major AM,Finegold MJ,Brandt ML

更新日期：1995-01-15 00:00:00

abstract：:The growing number of elderly patients with end-stage kidney disease awaiting transplantation has resulted in a corresponding rise in the number of elderly transplant recipients. In this paper, we review existing literature on age-related changes, transplant outcomes, and complications in the elderly in an attempt to ...

journal_title：Transplantation

authors： Danovitch GM,Gill J,Bunnapradist S

更新日期：2007-08-15 00:00:00

abstract：:Blocking activity of mouse pregnancy serum was investigated using a well defined one-way mixed lymphocyte culture and a cell-mediated microcytotoxicity test. Allogeneic (C57BL (H-2b) X CBA/Ca (H-2k)) and syngeneic (C57BL (H-2b) X C57BL (H-2b)) pregnancy and postpartum sera were found to stimulate rather than inhibit t...

journal_title：Transplantation

authors： Smith G

更新日期：1978-11-01 00:00:00

abstract：BACKGROUND:Donor-specific immune tolerance has been reported in isolated cases of kidney transplantation associated with bone marrow transplantation. The following is a description of a living donor liver transplantation for a hilar cholangiocarcinoma in a previous recipient of an allogeneic bone marrow transplant. ME...

journal_title：Transplantation

authors： Kadry Z,Mullhaupt B,Renner EL,Bauerfeind P,Schanz U,Pestalozzi BC,Studer G,Zinkernagel R,Clavien PA

更新日期：2003-09-27 00:00:00

abstract：BACKGROUND:To optimize the methods used for human islet isolation for transplantation, it is important to improve our understanding of the structure of the islet-exocrine interface. In this study, the composition of collagen subtypes in the interface have been characterized and quantified in human pancreas. METHODS:Hu...

journal_title：Transplantation

authors： Hughes SJ,Clark A,McShane P,Contractor HH,Gray DW,Johnson PR

更新日期：2006-02-15 00:00:00

abstract：BACKGROUND:Perioperative renal dysfunction in liver transplant recipients complicates maintenance immunosuppressive therapy, particularly in patients with hepatitis C. Calcineurin inhibitors exacerbate renal dysfunction and mammalian target-of-rapamycin inhibitors are generally avoided because of perceived perioperativ...

journal_title：Transplantation

authors： LaMattina JC,Jason MP,Hanish SI,Ottmann SE,Klassen DK,Potosky D,Hutson WR,Barth RN

更新日期：2014-01-27 00:00:00

abstract：BACKGROUND:Allogeneic bone marrow transplantation is under investigation for a range of nonmalignant indications, including tolerance induction through mixed chimerism. This strategy has so far been tested experimentally only in young recipients. Due to immunosenescence, older patients have an increase in memory T cell...

journal_title：Transplantation

authors： Hock K,Oberhuber R,Lee YL,Wrba F,Wekerle T,Tullius SG

更新日期：2013-06-27 00:00:00

abstract：BACKGROUND:The potential risk of transmission of porcine endogenous retroviruses (PERV) from xenogeneic donors into humans has been widely debated. Because we were involved in a phase I/II clinical trial using a bioartificial liver support system (BLSS), we proceeded to evaluate the biosafety of this device. MATERIALS...

journal_title：Transplantation

authors： Kuddus R,Patzer JF 2nd,Lopez R,Mazariegos GV,Meighen B,Kramer DJ,Rao AS

更新日期：2002-02-15 00:00:00