Abstract:
:In adult recipients of allogeneic hematopoietic cell transplants (HCT) studied at 1 year after grafting, there was a significant correlation between the counts of T cell receptor excision circle (TREC)-containing CD4 T cells (presumed recent thymic emigrants) and the counts of total T cells (r=0.65, P<0.001). Thus, the reconstitution of CD4 T cell pool depends on T cell generation from hematopoietic stem cells (T-lymphopoiesis). We evaluated factors that could affect T-lymphopoiesis. Low TREC-containing CD4 T cell counts were associated with older patient age (r=-0.41, P=0.01) but not with donor age, graft type (marrow vs. blood stem cells), CD34 cell dose, conditioning (with vs. without irradiation), acute graft-versus-host disease (aGVHD), or chronic graft-versus-host disease (cGVHD) in multivariate analysis. We conclude that patient age is the primary determinant of CD4 T-lymphopoiesis after allogeneic HCT.
journal_name
Transplantationjournal_title
Transplantationauthors
Storek J,Joseph A,Dawson MA,Douek DC,Storer B,Maloney DGdoi
10.1097/00007890-200204150-00026subject
Has Abstractpub_date
2002-04-15 00:00:00pages
1154-8issue
7eissn
0041-1337issn
1534-6080journal_volume
73pub_type
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