Impact of cytochrome p450 3A5 genetic polymorphism on tacrolimus doses and concentration-to-dose ratio in renal transplant recipients.

abstract：BACKGROUND:A 35-year period of clinical development resulted in orthotopic liver transplantation (OLT) becoming a standardized surgical procedure. Despite this progress, the rate of technical complications is still high. Although the main problem in most analyses is vascular or bile duct failure, we observed a remarkab...

journal_title：Transplantation

authors： Soliman T,Langer F,Puhalla H,Pokorny H,Grunberger T,Berlakovich GA,Langle F,Muhlbacher F,Steininger R

更新日期：2000-05-27 00:00:00

abstract：BACKGROUND:Donor pigs transgenic for human decay-accelerating factor (hDAF) were used in a xenogeneic ex vivo liver perfusion model to study the effect of this modification on the development of hyperacute rejection. METHODS:Three transgenic pigs were hepatectomized after hypothermic portal and transaortal gravity per...

journal_title：Transplantation

authors： Pascher A,Poehlein C,Storck M,Prestel R,Mueller-Hoecker J,White DJ,Abendroth D,Hammer C

更新日期：1997-08-15 00:00:00

abstract：:Most patients with secondary hypertension due to renal disease or on maintenance hemodialysis have lost the physiologic fall of blood pressure during sleep. To test the notion that kidney transplantation normalizes the blood pressure profile, we monitored ambulatory blood pressure over 24 hr in 45 patients (29 males a...

journal_title：Transplantation

authors： Gatzka CD,Schobel HP,Klingbeil AU,Neumayer HH,Schmieder RE

更新日期：1995-05-15 00:00:00

abstract：BACKGROUND:We have previously shown that an immunomodulatory enzyme, indoleamine 2,3-dioxygenase (IDO) in dermal fibroblasts generates a tryptophan-deficient environment that selectively inhibits proliferation and induces apoptosis of bystander CD4+ and CD8+ T cells, but not pancreatic islets. Because these immune cell...

journal_title：Transplantation

authors： Hosseini-Tabatabaei A,Jalili RB,Khosravi-Maharlooei M,Hartwell R,Kilani RT,Zhang Y,Ghahary A

更新日期：2015-07-01 00:00:00

abstract：:The fungal metabolite FK506 was discovered because it shared an important property, the ability to inhibit production of IL-2, with another well-known immunosuppressive fungal metabolite, CsA. FK506 has, since its isolation, also been shown to share other immunosuppressive effects with CsA. This study was performed to...

journal_title：Transplantation

authors： Johansson A,Möller E

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:The aim of this study was to analyze humoral xenoreactivity of various Old World primate species sera against pig islets and the effects of these sera on pig islet viability and function after culture. METHODS:Freshly isolated or cultured adult pig islets were analyzed by immunohistology or by cytofluorimet...

journal_title：Transplantation

authors： Mirenda V,Le Mauff B,Boeffard F,Cassard A,Jugeau N,Soulillou JP,Anegon I

更新日期：1998-12-15 00:00:00

abstract：:Transplantation tolerance can be induced in the adult mouse by the selective manipulation of the CD4+ T cell subset. C3H/He recipients with prolonged survival (> 120 days) of C57BL/10 cardiac allografts induced by treatment, at the time of transplantation, with the anti-CD4 mAb, YTS 191.1, were skin grafted simultaneo...

journal_title：Transplantation

authors： Pearson TC,Darby CR,Bushell AR,West LJ,Morris PJ,Wood KJ

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:Black American heart transplant recipients receiving cyclosporine-based primary immunoprophylaxis suffer higher rates of allograft rejection with hemodynamic compromise, infections, and posttransplant coronary artery disease. We examined the hypothesis that a combination of tacrolimus and mycophenolate mofet...

journal_title：Transplantation

authors： Mehra MR,Uber PA,Scott RL,Park MH

更新日期：2002-12-15 00:00:00

abstract：:The purpose of this study was to investigate the effect of prostaglandin E1 on rabbit heart preservation. The hearts were arrested with cardioplegia (CP) solution, followed by intracoronary infusion of Euro-Collins (E-C) solution. They were immersed in E-C solution at 4 degrees C for 9 hr, flushed with terminal warm C...

journal_title：Transplantation

authors： Ueno T,Horita K,Okazaki Y,Itoh T,Natsuaki M

更新日期：1992-09-01 00:00:00

abstract：:For many individuals suffering from end-stage liver disease (ESLD), the only treatment option is liver transplantation. However, liver transplant rejection is observed in 24-80% of transplant patients and lifelong drug regimens that follow the transplant procedure lead to serious side effects. Furthermore, the pool of...

journal_title：Transplantation

authors： Wang X,MacParland SA,Perciani CT

更新日期：2021-01-06 00:00:00

abstract：:Fine-needle aspiration biopsies were used for clinical monitoring of liver allografts; 21 patients with an inflammatory episode of acute rejection (12.0 +/- 3.3 CIU at the peak) were studied; all episodes were reversible. The inflammatory infiltrate consisted mainly of lymphoid cells, including lymphoid blasts, with i...

journal_title：Transplantation

authors： Lautenschlager I,Höckerstedt K,Salmela K,Isoniemi H,Holmberg C,Jalanko H,Häyry P

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:A regimen consisting of antilymphocyte serum (ALS), sirolimus, and donor bone-marrow-cell (BMC) infusion induces indefinite skin allograft survival across fully mismatched mouse strain combinations. We investigated the role of chimerism in this transplantation tolerance model. MATERIALS:B10.A (H-2a) mice we...

journal_title：Transplantation

authors： Kanamoto A,Monaco AP,Maki T

更新日期：2004-09-27 00:00:00

abstract：BACKGROUND:In patients with acute liver failure (ALF) of unknown cause, viral infections are believed to be involved. This study investigates the involvement of human herpesvirus-6 (HHV-6). METHODS:Thirty-two patients with ALF who underwent transplantations during a 6-year period were studied for viruses in biopsies f...

journal_title：Transplantation

authors： Härmä M,Höckerstedt K,Lautenschlager I

更新日期：2003-08-15 00:00:00

abstract：:Incompatibility for DBA/2 (D2) minor histocompatibility antigens (MiHA) alone leads to a severe lethal graft-versus-host reaction (GVHR) in irradiated (D2 X B10.D2)F1 mice receiving a bone-marrow-plus-spleen-cell graft from B10.D2 donors. This mortality is abrogated when the donors are preimmunized simultaneously agai...

journal_title：Transplantation

authors： Pritchard LL,Halle-Pannenko O

更新日期：1983-09-01 00:00:00

abstract：BACKGROUND:Vascular complications remain an important cause of postoperative morbidity in liver transplant patients. Herein, we present an unusual case of nonanastomotic inferior vena cava (IVC) stenosis in a patient with a "piggyback" caval anastomosis. METHODS:A 59-year-old woman underwent liver transplantation usin...

journal_title：Transplantation

authors： Orons PD,Hari AK,Zajko AB,Marsh JW

更新日期：1997-11-15 00:00:00

abstract：BACKGROUND:Both laboratory and clinical studies have shown that dietary lipids may affect immunologic responses. This study was conducted to compare different classes of long-chain unsaturated fatty acids for their effect on allograft survival in animals receiving a donor-specific transfusion and a short course of low-...

journal_title：Transplantation

authors： Alexander JW,Valente JF,Greenberg NA,Custer DA,Ogle CK,Gibson SW,Babcock GF

更新日期：1998-05-27 00:00:00

abstract：:Adhesion of leukocytes to vascular endothelium is a necessary step leading to the migration of cells into underlying tissues. Vascular adhesion molecules regulate this process and may play an important role in graft rejection. Immunocytochemical studies have been used to investigate the expression of vascular adhesion...

journal_title：Transplantation

authors： Taylor PM,Rose ML,Yacoub MH,Pigott R

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:Renal allograft rejection is associated with the expression of adhesion molecules on vascular endothelial and tubular epithelial cells. METHODS:To assess whether the number of cell adhesion molecules expressed in donor kidneys can predict early rejection or delayed graft function, kidney biopsies from 20 li...

journal_title：Transplantation

authors： Schwarz C,Regele H,Steininger R,Hansmann C,Mayer G,Oberbauer R

更新日期：2001-06-15 00:00:00

abstract：:A comparative study of 24 hr preservation at 4 degrees C of excised rat livers with Euro-Collins and hydroxyethyl starch-free University of Wisconsin (UWm) solutions has been conducted based on the assessment of (1) the cellular energy status determined by 31P NMR spectroscopy and (2) cellular injury estimated from th...

journal_title：Transplantation

authors： Gulian JM,Dalmasso C,Desmoulin F,Scheiner C,Cozzone PJ

更新日期：1992-10-01 00:00:00

abstract：:Blood transfusions are common in patients with end-stage liver disease (ESLD), and their effects on sensitization, rejection, and liver graft survival are not well known. These effects were examined in 121 recipients of primary liver grafts, surviving > or = 30 days. Ninety-six (79%) patients received transfusions bef...

journal_title：Transplantation

authors： Koneru B,Harrison D,Rizwan M,Holland BK,Ippolito T,Holman MJ,Leevy CB

更新日期：1997-06-15 00:00:00

abstract：BACKGROUND:It has been suggested that T cells primed by processed donor major histocompatibility complex antigen (the "indirect" pathway of allorecognition) may be responsible for mediating chronic allograft rejection. The purpose of this study was to develop a clinically useful assay to study the occurrence of indirec...

journal_title：Transplantation

authors： Vella JP,Spadafora-Ferreira M,Murphy B,Alexander SI,Harmon W,Carpenter CB,Sayegh MH

更新日期：1997-09-27 00:00:00

abstract：:Eight patients with chronic myeloid leukemia relapse after allogeneic BMT were treated with IFN-alpha and buffy coat transfusions (BC) of the bone marrow donor. The antileukemic effect of this treatment was directly demonstrated in 4 patients by the disappearance of Philadelphia chromosome-positive metaphases or the l...

journal_title：Transplantation

authors： Hertenstein B,Wiesneth M,Novotny J,Bunjes D,Stefanic M,Heinze B,Hübner G,Heimpel H,Arnold R

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:The use of calcineurin inhibitors is associated with chronic nephrotoxicity and lower glomerular filtration rate (GFR). As a result, one strategy of transplant immunosuppression is calcineurin inhibitor elimination. METHODS:The aim of this study was to determine the outcome of a prospective randomized trial...

journal_title：Transplantation

authors： Heilman RL,Younan K,Wadei HM,Mai ML,Reddy KS,Chakkera HA,Gonwa TA

更新日期：2011-10-15 00:00:00

abstract：BACKGROUND:Bone marrow transplantation (BMT) for class 3 patients with thalassemia is challenging due to high rates of graft rejection and transplant-related mortality. Since the first studies of BMT in the late 1980s, a number of conditioning regimens have been designed to improve outcomes, but with suboptimal results...

journal_title：Transplantation

authors： Gaziev J,Isgrò A,Sodani P,Marziali M,Paciaroni K,Gallucci C,De Angelis G,Andreani M,Testi M,Alfieri C,Ribersani M,Galluccio T,Battarra MR,Morrone A,Lucarelli G

更新日期：2016-04-01 00:00:00

abstract：:DA rats treated with cyclosporine for 2 weeks after being grafted with an RT1-incompatible PVG heart graft did not reject the graft and developed a state of specific unresponsiveness to graft antigens. The cellular mechanisms maintaining this state of unresponsiveness were studied by testing the capacity of lymphocyte...

journal_title：Transplantation

authors： Hall BM,Jelbart ME,Dorsch SE

更新日期：1984-06-01 00:00:00

abstract：BACKGROUND:Pneumocystis jirovecii pneumonia (PJP) is an important infection-related complication, whose mode of transmission remains uncertain. METHODS:We investigated a nosocomial cluster of 14 PJP cases (11 confirmed and 3 probable) in kidney transplant recipients using epidemiological and genotyping methods. RESUL...

journal_title：Transplantation

authors： Phipps LM,Chen SC,Kable K,Halliday CL,Firacative C,Meyer W,Wong G,Nankivell BJ

更新日期：2011-12-27 00:00:00

abstract：:Rabbit antisera to rat thoracic duct lymphocytes were examined by absorption analysis with quantitative radioimmunoassays to determine the tissue distribution of the antigens recognised and the amount of antibody against different specificities. Seven of eight sera were remarkably specific for leucocytes and one serum...

journal_title：Transplantation

authors： Fabre JW,Williams AF

更新日期：1977-04-01 00:00:00

abstract：BACKGROUND:In a recent trial, targeted mild hypothermia in brain-dead organ donors significantly reduced the incidence of delayed graft function after kidney transplantation. This trial was stopped early for efficacy. Here, we report long-term graft survival for all organs along with donor critical care end points. ME...

journal_title：Transplantation

authors： Malinoski D,Patel MS,Axelrod DA,Broglio K,Lewis RJ,Groat T,Niemann CU

更新日期：2019-11-01 00:00:00

abstract：:Programmed cell death (PCD) is currently one of the most intensively studied areas in cell biology. Substantial evidence now exists demonstrating the integral role of PCD in many fundamental immunologic processes; therefore, understanding the mechanisms of PCD may provide advances with broad implications in immunobiol...

journal_title：Transplantation

authors： Woodle ES,Kulkarni S

更新日期：1998-09-27 00:00:00

abstract：:We recently reported that reconstitution of lethally irradiated B10 mouse recipients with 40 x 10(6) untreated WF rat bone marrow cells resulted in stable fully xenogeneic chimerism (WF rat----B10 mouse). In these animals, the tolerance induced for skin xenografts was highly MHC specific in that donor-specific WF rat ...

journal_title：Transplantation

authors： Zeng YJ,Ricordi C,Tzakis A,Rilo HL,Carroll PB,Starzl TE,Ildstad ST

更新日期：1992-02-01 00:00:00