Immunological Determinants of Liver Transplant Outcomes Uncovered by the Rat Model.

Abstract:

:For many individuals suffering from end-stage liver disease (ESLD), the only treatment option is liver transplantation. However, liver transplant rejection is observed in 24-80% of transplant patients and lifelong drug regimens that follow the transplant procedure lead to serious side effects. Furthermore, the pool of donor livers available for transplantation is far less than the demand. Well-characterized and physiologically relevant models of liver transplantation are crucial to a deeper understanding of the cellular processes governing the outcomes of liver transplantation and serve as platform for testing new therapeutic strategies to enhance graft acceptance. Such a model has been found in the rat transplant model which has an advantageous size for surgical procedure, similar post-operative immunological progression and high genome match to the human liver. From rat liver transplant studies published in the last 5 years, it is clear that the rat model serves as a strong platform to elucidate transplant immunological mechanisms. Using the model, we have begun to uncover potential players and possible therapeutic targets to restore liver tolerance and preserve host immunocompetence. Here, we present an overview of recent literature for rat liver transplant models, with an aim to highlight the value of the models and to provide future perspectives on how these models could be further characterized to enhance the overall value of rat models to the field of liver transplantation.

journal_name

Transplantation

journal_title

Transplantation

authors

Wang X,MacParland SA,Perciani CT

doi

10.1097/TP.0000000000003598

subject

Has Abstract

pub_date

2021-01-06 00:00:00

eissn

0041-1337

issn

1534-6080

pii

00007890-900000000-95439

journal_volume

Publish Ahead of Print

pub_type

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