An effective immune-monitoring protocol based on gene expression profiles in the peripheral T-cell fraction reactive to graft antigens.

abstract：:The immunosuppressive activity of niridazole in unmatched kidney allografts in nephrectomized dogs was studied. The drug alone was not effective, but improved survival when used with azathioprine and prednisolone or azathioprine alone. However, niridazole was toxic in dogs in the doses used (25 or 50 mg/kg/day). ...

journal_title：Transplantation

authors： Sokucu N,Caridis DT,Moran J

更新日期：1980-04-01 00:00:00

abstract：BACKGROUND:To identify factors related with successful pregnancy in renal transplant recipients and the effect of pregnancy on long-term graft outcome. METHODS:The study group consisted of 48 women who conceived after undergoing renal transplantation (total pregnancies 74). The control group consisted of 187 nonpregna...

journal_title：Transplantation

authors： Kim HW,Seok HJ,Kim TH,Han DJ,Yang WS,Park SK

更新日期：2008-05-27 00:00:00

abstract：BACKGROUND:The current shortage of organ donors has led many centers to use marginal and nonheart-beating donors (NHBDs). Recent research has implicated the infiltration of lymphocytes as an important mediator of ischemia-reperfusion injury (IRI). FTY720 is an immunosuppressant that promotes lymphocyte sequestration in...

journal_title：Transplantation

authors： Delbridge MS,Shrestha BM,Raftery AT,El Nahas AM,Haylor JL

更新日期：2007-07-27 00:00:00

abstract：BACKGROUND:In previous studies of cynomolgus monkey lung allograft recipients, we demonstrated significant immunosuppressive efficacy but reduced tolerability after combined treatment with high doses of microemulsion cyclosporine (CsA) and SDZ RAD (40-O-(2-hydroxyethyl)-rapamycin). The current study was designed to com...

journal_title：Transplantation

authors： Hausen B,Gummert J,Berry GJ,Christians U,Serkova N,Ikonen T,Hook L,Legay F,Schuler W,Schreier MH,Morris RE

更新日期：2000-02-27 00:00:00

abstract：:Pulmonary endothelium is considered the compartment most susceptible to preservation damage. This investigation was designed to analyze the efficacy of an original, University of Parma low-potassium-albumin solution (SPAL UP) on cultured human pulmonary artery endothelial cells (HPAEC) and to compare its effects with ...

journal_title：Transplantation

authors： Spaggiari L,Rusca M,Carbognani P,Alfieri R,Urbani S,Cattelani L,Petronini P,Solli P,Borghetti AF,Bobbio P

更新日期：1996-11-15 00:00:00

abstract：:Previous studies in our laboratory demonstrated that several treatments that inhibited the ability of cells to stimulate the mixed lymphocyte reaction (MLR) also blocked the shedding of histocompatibility antigens and Ia antigens from murine spleen cells. In the present studies, one of these treatments, ultraviolet ra...

journal_title：Transplantation

authors： Pretell JO,Cone RE

更新日期：1985-02-01 00:00:00

abstract：BACKGROUND:If pancreas transplantation is a validated alternative for type 1 diabetic patients with end-stage renal disease, the management of patients who have lost their primary graft is poorly defined. This study aims at evaluating pancreas retransplantation outcome. METHODS:Between 1976 and 2008, 569 pancreas tran...

journal_title：Transplantation

authors： Buron F,Thaunat O,Demuylder-Mischler S,Badet L,Brunet M,Ber CE,Thivolet C,Martin X,Berney T,Morelon E

更新日期：2013-01-27 00:00:00

abstract：BACKGROUND:The low efficiency of islet transplantation necessitating sequential transplantations with the use of 2 to 3 donors for a recipient has been a major obstacle facing clinical islet transplantation. We determined whether adenosine has any beneficial effects on preventing early loss of transplanted islets in th...

journal_title：Transplantation

authors： Nitta T,Itoh T,Matsuoka N,Mera T,Kojima D,Nakano M,Yamashita Y,Yasunami Y

更新日期：2009-07-15 00:00:00

abstract：:The growing number of elderly patients with end-stage kidney disease awaiting transplantation has resulted in a corresponding rise in the number of elderly transplant recipients. In this paper, we review existing literature on age-related changes, transplant outcomes, and complications in the elderly in an attempt to ...

journal_title：Transplantation

authors： Danovitch GM,Gill J,Bunnapradist S

更新日期：2007-08-15 00:00:00

abstract：BACKGROUND:Angiogenesis contributes to the repair process after renal ischemia/reperfusion (I/R) injury. In the present study, we tested the role of miR-21 in the angiogenesis induced by hypoxia inducible factor (HIF)-1α through inhibiting a predicted target gene thrombospondin 1 (TSP-1). METHODS:To stabilize HIF-1α, ...

journal_title：Transplantation

authors： Xu X,Song N,Zhang X,Jiao X,Hu J,Liang M,Teng J,Ding X

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:The aging of liver transplant (LT) recipients, the weighting of the model for end-stage liver disease score, and the increased prevalence of nonalcoholic steatohepatitis has led to an increased number of older LT recipients with pre-LT chronic kidney disease (CKD). There are limited data on the impact of inc...

journal_title：Transplantation

authors： Goldberg DS,Vianna RM,Martin EF,Martin P,Arosemena Benitez LR,O'Brien CB,Bhamidimarri KR

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Ischemia-reperfusion (I/R) injury is a multifactorial phenomenon that occurs during the transplant event and frequently compromises early graft function after liver transplantation (LT). Current comprehension of molecular mechanisms and regulation processes of I/R injury lacks clarity. MicroRNA (miRNA) regul...

journal_title：Transplantation

authors： Gehrau RC,Mas VR,Dumur CI,Ladie DE,Suh JL,Luebbert S,Maluf DG

更新日期：2013-11-27 00:00:00

abstract：BACKGROUND:The influence of the graft composition on the clinical outcome after allogeneic peripheral blood stem cell (PBSC) transplantation is not well established. METHODS:The cellular composition of the apheretic products obtained from 63 human leukocyte antigen-identical siblings was prospectively correlated with ...

journal_title：Transplantation

authors： Iori AP,Torelli GF,De Propris MS,Milano F,Pupella S,Gozzer M,Mancini F,Milani ML,Intoppa S,Cerretti R,Lucarelli B,Valle V,Malandruccolo L,Iannella E,Arleo E,Guarini A,Foà R

更新日期：2008-02-15 00:00:00

abstract：BACKGROUND:Previous studies showed the feasibility of inducing transplantation tolerance to cadaveric renal allografts in patients given pretransplant total lymphoid irradiation (TLI). Microchimerism has been theorized to be an important or necessary factor in long-term graft acceptance and tolerance in humans. METHOD...

journal_title：Transplantation

authors： Strober S,Benike C,Krishnaswamy S,Engleman EG,Grumet FC

更新日期：2000-04-27 00:00:00

abstract：BACKGROUND:The deceased donor score (DDS), expanded criteria donor (ECD) definition, and resistive index (RI) were developed for pretransplant evaluation of donors. DDS and ECD are determined by a calculation of risk from donor variables, while RI is determined from flow characteristics of kidneys during machine preser...

journal_title：Transplantation

authors： Nyberg SL,Baskin-Bey ES,Kremers W,Prieto M,Henry ML,Stegall MD

更新日期：2005-10-15 00:00:00

abstract：:Active regulation or suppression of donor reactive cells is emerging as a key mechanism for inducing and maintaining unresponsiveness to donor alloantigens. Accumulating evidence suggests that a balance between immunoregulation and deletion of donor alloantigen reactive T cells can provide effective control of immune ...

journal_title：Transplantation

authors： Wood KJ,Luo S,Akl A

更新日期：2004-01-15 00:00:00

abstract：:Loss of renal mass has been associated with the development of glomerular sclerosis in animals and human beings. The pathophysiology of this renal injury is unknown, but glomerular sclerosis in animals can be aggravated or accelerated following exposure to nephrotoxic antibodies, puromycin aminoglycoside or renal irra...

journal_title：Transplantation

authors： Parfrey PS,Hollomby DJ,Gilmore NJ,Knaack J,Schur PH,Guttmann RD

更新日期：1984-10-01 00:00:00

abstract：BACKGROUND:Short-term outcomes using steroid-free immunosuppression after renal transplantation have been promising. No studies have examined the incidence of and reasons for steroid-avoidance protocol failures. METHODS:We present a single-center analysis of steroid-free immunosuppression failures among 129 pediatric ...

journal_title：Transplantation

authors： Sutherland S,Li L,Concepcion W,Salvatierra O,Sarwal MM

更新日期：2009-06-15 00:00:00

abstract：BACKGROUND:Since suitable recipients for hepatic allografts from donors with antibodies to hepatitis B virus (HBV) have not been determined, a review of our 7-year experience with donors positive for hepatitis B surface antibody (anti-HBs), hepatitis B core antibody (anti-HBc), or both was undertaken. METHODS:Recipien...

journal_title：Transplantation

authors： Dodson SF,Issa S,Araya V,Gayowski T,Pinna A,Eghtesad B,Iwatsuki S,Montalvo E,Rakela J,Fung JJ

更新日期：1997-12-15 00:00:00

abstract：:The pig has been considered unsuitable for experimental pancreatic transplantation. In order to develop a model for segmental transplantation, the vascular anatomy was studied in 41 pigs. No variation in venous drainage of the pancrease was found. In contrast, 3 variations of arterial supply were noted. In 29 of the p...

journal_title：Transplantation

authors： Shokouh-Amiri MH,Rahimi-Saber S,Andersen HO

更新日期：1989-01-01 00:00:00

abstract：:The histopathological changes and the course of graft-versus-host (GVH) disease were studied in the rat model of small-bowel transplantation using the Lewis----LBN-F1 strain combination. Allograft-induced GVH disease led to the recipients' death from enteritis, dermatitis and emaciation after 14.4 +/- 2.9 days (hetero...

journal_title：Transplantation

authors： Schraut WH,Lee KK,Dawson PJ,Hurst RD

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND:Galbeta1-4GlcNAcalpha2-6 sialyltransferase (ST6GalI) is an acute phase reactant whose release from cells can be induced by proinflammatory cytokines. Because patients with chronic renal failure have high circulating levels of proinflammatory cytokines, we hypothesized that patients on the renal transplant wa...

journal_title：Transplantation

authors： Thorne-Tjomsland G,Hosfield T,Jamieson JC,Liu B,Nickerson P,Gough JC,Rush DN,Jeffery JR,McKenna RM

更新日期：2000-03-15 00:00:00

abstract：BACKGROUND:Early enteral nutrition with solutions containing prebiotics (fiber) and probiotics (Lactobacillus) is suggested to reduce bacterial translocation and minimize the incidence of infections after liver transplantation. METHODS:In a prospective, randomized placebo-controlled trial consisting of 95 patients, we...

journal_title：Transplantation

authors： Rayes N,Seehofer D,Hansen S,Boucsein K,Müller AR,Serke S,Bengmark S,Neuhaus P

更新日期：2002-07-15 00:00:00

abstract：:Pulmonary complications are often lethal components of acute graft-vs.-host disease (GVHD). Although interstitial pneumonitis and lymphocytic bronchitis have been implicated as elements of acute GVHD, previous studies have not determined a correlation between the onset of these histopathologies or their contribution t...

journal_title：Transplantation

authors： Workman DL,Clancy J Jr

更新日期：1994-07-27 00:00:00

abstract：BACKGROUND:For certain uremic, diabetic patients, a sequential transplant of a kidney (usually from a living donor) followed by a cadaver pancreas has become an attractive option. But how long to wait after the kidney transplant before proceeding with a pancreas transplant is unclear. We studied outcomes in recipients ...

journal_title：Transplantation

authors： Humar A,Sutherland DE,Ramcharan T,Gruessner RW,Gruessner AC,Kandaswamy R

更新日期：2000-10-27 00:00:00

abstract：BACKGROUND:Selective inhibition of lymphocyte activation through abrogation of signal 3-cytokine transduction emerges as a new strategy for immunosuppression. This is the first report on the novel Janus kinase (JAK)1/3 inhibitors R507 and R545 for prevention of acute allograft rejection. METHODS:Pharmacokinetic and in...

journal_title：Transplantation

authors： Deuse T,Hua X,Taylor V,Stubbendorff M,Baluom M,Chen Y,Park G,Velden J,Streichert T,Reichenspurner H,Robbins RC,Schrepfer S

更新日期：2012-10-15 00:00:00

abstract：:The use of anti-CD3 monoclonal antibodies to treat organ allograft rejection has been complicated by (1) the morbidity associated with the initial dose, (2) the humoral response of the patients against the mAbs, and (3) the generalized immunosuppression induced by the mAbs. We investigated the potential of F(ab')2 fra...

journal_title：Transplantation

authors： Hirsch R,Bluestone JA,DeNenno L,Gress RE

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND:Recipient antidonor cytotoxic T-cell activity has been associated with graft loss and acute rejection in renal allograft recipients. The role of immunologic mechanisms in the development of chronic graft rejection is controversial. We analyzed all living related renal transplants performed at Children's Hosp...

journal_title：Transplantation

authors： Alexander SI,Younes SB,Yunis JJ,Zurakowski D,Mirza N,Dubey D,Drew MP,Harmon WE,Yunis EJ

更新日期：1997-06-27 00:00:00

abstract：:Organ donation after circulatory death (DCD) has been endorsed by the World Health Organization and is practiced worldwide. This overview examines current DCD practices, identifies problems and challenges, and suggests clinical strategies for possible improvement. Although there is uniform agreement on DCD donor candi...

journal_title：Transplantation

authors： Morrissey PE,Monaco AP

更新日期：2014-02-15 00:00:00

abstract：BACKGROUND:Historically, ex vivo physiological evaluation of cadaveric renal allografts has been limited to assessing perfusate flow (PF) during hypothermic perfusion preservation (HPP). Using a small animal model, we have previously described a method for continuous monitoring of glomerular filtration rate (GFR) durin...

journal_title：Transplantation

authors： Inman SR,Osgood RW,Plott WK,Richardson BF,Lewis RM

更新日期：1999-11-27 00:00:00