Abstract:
BACKGROUND:Previous studies showed the feasibility of inducing transplantation tolerance to cadaveric renal allografts in patients given pretransplant total lymphoid irradiation (TLI). Microchimerism has been theorized to be an important or necessary factor in long-term graft acceptance and tolerance in humans. METHODS:A cadaveric renal transplant recipient given pretransplant total lymphoid irradiation and withdrawn from immunosuppressive drugs more than 12 years ago was tested for microchimerism using a sensitive nested polymerase chain reaction technique, and for anti-donor reactivity using the mixed leukocyte reaction and an ELISA screen for anti-HLA antibodies. Donor and recipient were mismatched for all HLA-A, B, and DR antigens. RESULTS:The "tolerant" recipient had good graft function, no detectable donor-type cells in the blood by polymerase chain reaction analysis, vigorous reactivity to donor stimulator cells in the mixed leukocyte reaction, and no detectable serum anti-HLA antibodies. CONCLUSIONS:Operational tolerance to HLA-A, B, and DR mismatched organ allografts can be induced prospectively in humans for at least 12 years after withdrawal of immunosuppressive drugs. The allograft can be maintained in the absence of detectable donor microchimerism and in the presence of anti-donor reactivity in the mixed leukocyte reaction, suggesting that neither chimerism nor clonal deletion or anergy of recipient T cells to alloantigens presented by donor Class II HLA molecules is required for persistence of the tolerant state using this total lymphoid irradiation protocol.
journal_name
Transplantationjournal_title
Transplantationauthors
Strober S,Benike C,Krishnaswamy S,Engleman EG,Grumet FCdoi
10.1097/00007890-200004270-00005subject
Has Abstractpub_date
2000-04-27 00:00:00pages
1549-54issue
8eissn
0041-1337issn
1534-6080journal_volume
69pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:Mycophenolic acid, the active metabolite of mycophenolate mofetil, inhibits the glycosylation of cell membrane glycoproteins. We hypothesized that impaired glycosylation of cell adhesion molecules on endothelial cells in vivo results in decreased susceptibility to inflammation or immunogenicity after allogen...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200002150-00006
更新日期:2000-02-15 00:00:00
abstract::Kidney transplantation in elderly patients is a good therapeutic option, but the incidence of infections compared to younger patients must be studied. Case and control study was performed with 40 cases (patients older than 65) and 40 controls (younger than 65) receiving a kidney transplant between January 2000 and Aug...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000173822.05877.d7
更新日期:2005-10-15 00:00:00
abstract::Heterologous anti-immunoglobulin is a potent immunosuppressive agent that prolongs H-2- and H-3-incompatible skin graft survival. In conjunction with antithymocyte serum, anti-immunoglobulin promotes greater graft life than either antiserum used alone, without evidence of toxicity to recipient animals. Combination tre...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197711000-00007
更新日期:1977-11-01 00:00:00
abstract:BACKGROUND:Systemic inflammation markers, such as neutrophil-to-lymphocyte ratio (NLR), have recently emerged as the prognostic factors for recurrence of liver tumors. METHODS:We assessed the ability of NLR and of other variables to predict the outcomes of orthotopic liver transplantation (OLT) for hepatocellular carc...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182187cf0
更新日期:2011-06-15 00:00:00
abstract:BACKGROUND:For men with significant genitourinary injury, penile transplantation is being considered as an option when reconstruction is not feasible or proves unacceptable to the injured patient. METHODS:A review of the literature was conducted to assess the current state of penile reconstruction and transplantation ...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000001352
更新日期:2017-06-01 00:00:00
abstract::We developed a new and simplified donor-specific blood transfusion (DSBT) protocol for prospective kidney transplant recipients from one-haplotype-mismatched related donors. Prospective kidney donors gave 450 ml of blood in a quad-pack unit, and the blood was stored in a blood bank. Twenty-five patients were transfuse...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198411000-00012
更新日期:1984-11-01 00:00:00
abstract:BACKGROUND:The use of lung grafts from non-heart-beating donors (NHBD) is one way of solving the donor organ shortage problem. In this experiment, we studied the effect of retrograde flush (RF) from the left atrium before harvest, inhaled nitric oxide (NO), and gabexate mesilate (FOY), a protease inhibitor, in the lung...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200005270-00008
更新日期:2000-05-27 00:00:00
abstract:BACKGROUND:Intrathymic events undergoing allograft rejection remain undefined. The present study investigated the role of tumor necrosis factor-beta on acute thymic involution in rat hepatic allograft recipients during rejection. METHODS:Apoptosis and cellular phenotypic changes in the thymus were studied after hepati...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199810150-00014
更新日期:1998-10-15 00:00:00
abstract:BACKGROUND:Transplantation enhances the risk of malignancies, due to the chronic use of antirejection medication. In the case of Kaposi's sarcoma (KS) the permissive effect of immunosuppression has been extensively studied, and cyclosporine (CsA) appears to play a key role. Here we have compared the incidence of KS in ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000173803.97398.31
更新日期:2005-09-27 00:00:00
abstract:BACKGROUND:Hyperparathyroidism is reported in 10% to 66% of renal transplant recipients (RTR). The influence of persisting hyperparathyroidism on long-term clinical outcomes in RTR has not been examined in a large prospective study. METHODS:We investigated the association between baseline parathyroid hormone (PTH) lev...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000583
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Encapsulation of islets has been widely investigated as a treatment for diabetes. The characteristics and dynamics of insulin secretion by encapsulated islets in response to glucose and other secretagogues are not well understood. METHODS:In our study, macroencapsulated syngeneic islets at 3-4 wk after tran...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200101270-00006
更新日期:2001-01-27 00:00:00
abstract::Long-term graft survival is mainly influenced by early graft rejection and posttransplant graft function. The ability of both complement-dependent cytotoxicity cross-match (CDC) and flow cytometry cross-match (FCXM) to predict acute rejection episodes has been evaluated by cross-matching 40 patients who received cadav...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199702270-00012
更新日期:1997-02-27 00:00:00
abstract::Adult male B6AF1 (H-2KIb/kDb/d) mice were given skin allografts from adult male C3H (H-2k) mice, with and without contralateral cotransplants. The cotransplants were of either adult or neonatal (less than 24 hr) C3H skin. In recipient mice treated peritransplantation with antilymphocyte serum and posttransplantation w...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199012000-00001
更新日期:1990-12-01 00:00:00
abstract:OBJECTIVES:Recent studies demonstrated that prolactin (PRL) has beneficial effects on beta cells for islet transplantation. We examined the effect of human recombinant PRL (rhPRL) supplementation to the culture media to determine its potential use in the context of clinical islet transplantation. MATERIALS AND METHODS...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181d98af1
更新日期:2010-06-15 00:00:00
abstract:BACKGROUND:Human herpesvirus-6 (HHV-6) has been implicated in bone marrow suppression, interstitial pneumonitis, and fatal meningoencephalitis in bone marrow transplant (BMT) recipients. METHODS:We describe the case of a woman with acute myeloid leukemia in second remission who developed febrile meningoencephalitis 8 ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199805270-00024
更新日期:1998-05-27 00:00:00
abstract:BACKGROUND:The aim of this study was to determine the efficacy of cariporide (a sodium-hydrogen exchanger inhibitor), BMS180448 (a pharmacologic ischemic preconditioning agent), and the combination thereof, as adjuvant therapies for extended cardiac allograft preservation. METHODS:A porcine model of donor brain death ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000079254.81264.6D
更新日期:2003-09-15 00:00:00
abstract::BK polyoma virus causes allograft dysfunction as a result of tubulo-interstitial nephritis in 2% to 5% of renal transplant recipients. The incidence of BK virus infection among renal transplant recipients in India is unknown. We used routine histologic examination, immunohistochemistry, and electron microscopy to retr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000113163.02039.30
更新日期:2004-02-15 00:00:00
abstract:BACKGROUND:Systemic inhibition of serum CD26/dipeptidylpeptidase (DPP IV) enzymatic activity abrogated acute rejection of pulmonary allografts, whereas organ-specific inhibition ameliorated ischemia/reperfusion injury in syngeneic transplants. Here, we analyze the effect of allograft-specific inhibitor preconditioning ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181b08e77
更新日期:2009-08-27 00:00:00
abstract:BACKGROUND:The spleen is considered to be an important secondary lymphoid organ where acute graft-versus-host disease (GVHD) is initiated by donor T cells that recognize host alloantigens after allogeneic bone-marrow transplantation (BMT). The influence of splenectomy on the development of GVHD prior to BMT has yet to ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200205270-00027
更新日期:2002-05-27 00:00:00
abstract:BACKGROUND:The long-term outcome of simultaneous kidney pancreas transplant recipients is not well established. METHODS:We retrospectively reviewed all patients who underwent simultaneous kidney-pancreas transplantation with bladder drainage at our center between January 1989 and December 1991. A total of 57 patients ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200002270-00015
更新日期:2000-02-27 00:00:00
abstract:BACKGROUND:Decapeptides derived from human HLA class I sequences have been shown to prolong allograft survival. The mechanism of action of these peptides has been uncertain, because they act in an MHC unrestricted manner. Recently, it was found that these peptides bind heme oxygenase 1 (HO-1). In the present study, we ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200001150-00021
更新日期:2000-01-15 00:00:00
abstract:BACKGROUND:New-onset diabetes is common after kidney transplantation, but the benefit of lifestyle intervention to improve glucose metabolism posttransplantation is unproven. METHODS:We conducted a single-center, randomized controlled trial involving 130 nondiabetic kidney transplant recipients with stable function be...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/TP.0000000000002969
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Natural antibodies (NAbs) against a terminal alpha1-3 galactosyl (alphaGal) epitope have been identified as the major human anti-pig NAbs. METHODS AND RESULTS:We used two synthetic alphaGal trisaccharides--type 6 (alphaGal6) and type 2(alphaGal2)--linked to an inert matrix to remove NAbs from human plasma i...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199801270-00005
更新日期:1998-01-27 00:00:00
abstract:BACKGROUND:This study investigated the use of deceased heart-beating donor livers offered for transplantation during a 10-year period, during which there has been an increasing disparity between organ supply and demand in the United Kingdom. METHODS:Summary data from the National Transplant Database were analyzed on a...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000268072.04260.69
更新日期:2007-07-15 00:00:00
abstract::The recipients of combined kidney-pancreas transplants (SPK) are unique because they routinely receive two allografts from the same donor. In a previous study, we found that the long-term graft survival of the two allografts was different, with better graft survival seen in the pancreas allograft. In an attempt to und...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199408270-00006
更新日期:1994-08-27 00:00:00
abstract::A comparative study of 24 hr preservation at 4 degrees C of excised rat livers with Euro-Collins and hydroxyethyl starch-free University of Wisconsin (UWm) solutions has been conducted based on the assessment of (1) the cellular energy status determined by 31P NMR spectroscopy and (2) cellular injury estimated from th...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199210000-00006
更新日期:1992-10-01 00:00:00
abstract::The reactions of a number of LEW anti-ACI allospecific rat monoclonal antibodies were examined in a series of breeding studies. Analysis of (LEW X ACI) F2 progeny demonstrated concordance of the monoclonal class I and class II specificities with results of conventional alloantisera typing. In addition, a "gene dosage"...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1983-11-01 00:00:00
abstract::The growing number of elderly patients with end-stage kidney disease awaiting transplantation has resulted in a corresponding rise in the number of elderly transplant recipients. In this paper, we review existing literature on age-related changes, transplant outcomes, and complications in the elderly in an attempt to ...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000275423.69689.dc
更新日期:2007-08-15 00:00:00
abstract::Graft and patient survival rates were analyzed in 239 consecutive first cadaver renal transplants as a function of time of administration of blood transfusion and the number of units given. There was no statistically significant difference in patient survival in comparing patients who were never transfused, patients n...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198012000-00008
更新日期:1980-12-01 00:00:00
abstract::The requirement for effective, minimally toxic immunosuppression remains a major obstacle to performing human composite tissue allotransplantation. The skin component of composite tissue (e.g., limb) allografts is especially antigenic, necessitating toxic immunosuppressant doses to prevent or reverse acute rejection. ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199402150-00020
更新日期:1994-02-01 00:00:00