Abstract:
BACKGROUND:Systemic inflammation markers, such as neutrophil-to-lymphocyte ratio (NLR), have recently emerged as the prognostic factors for recurrence of liver tumors. METHODS:We assessed the ability of NLR and of other variables to predict the outcomes of orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC). A retrospective analysis was performed in 219 patients with HCC who underwent OLT between 1997 and 2009, with a median follow-up of 40 months. RESULTS:Overall 3- and 5-year patient survival rates were 76.6% and 70.7%, respectively. Overall 3- and 5-year recurrence-free survival (RFS) rates were 83.8% and 82.1%, respectively. On univariate analysis, the factors affecting overall survival were α-fetoprotein more than 30 ng/mL (P=0.006), NLR more than or equal to 5 (P<0.0001), hepatitis C infection (P=0.043), and presence of microvascular invasion (MVI; P=0.006). Preoperative treatments (P=0.006), α-fetoprotein more than 30 ng/mL (P=0.003), NLR more than or equal to 5 (P<0.0001), exceeding Milan criteria at final histology (P=0.001), poor tumor differentiation (P=0.02), and presence of MVI (P<0.0001) predicted a lower RFS. Cox's proportional hazard model showed that only increased NLR and presence of MVI independently predicted overall survival and RFS. CONCLUSIONS:NLR is an important predictor of outcome after OLT for HCC and should be used to identify OLT candidates at high risk of recurrence.
journal_name
Transplantationjournal_title
Transplantationauthors
Bertuzzo VR,Cescon M,Ravaioli M,Grazi GL,Ercolani G,Del Gaudio M,Cucchetti A,D'Errico-Grigioni A,Golfieri R,Pinna ADdoi
10.1097/TP.0b013e3182187cf0subject
Has Abstractpub_date
2011-06-15 00:00:00pages
1279-85issue
11eissn
0041-1337issn
1534-6080pii
00007890-201106150-00021journal_volume
91pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::Leflunomide is a compound recently shown to reduce T and B cell-mediated responses in a number of experimental rat, mouse, and human systems. To explore its potential as an immunosuppressant, we studied leflunomide in 128 Brown-Norway/Lewis cardiac transplants and in 48 unoperated Lewis rats. At doses ranging from 0.6...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1994-04-27 00:00:00
abstract::The protective effect of oxygen free radical scavenger superoxide dismutase (SOD) against the warm ischemic damage that occurs in kidneys harvested from non-heart-beating donors is controversial because of its short half-life. In this model, we compared the protective effect of SOD and two longer lasting polyethylene ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199611150-00006
更新日期:1996-11-15 00:00:00
abstract::Endothelial injury plays a central role in the pathophysiologic mechanisms underlying cardiac allograft vasculopathy (CAV). Although the accelerated course of CAV and its localization to the allograft support an important role for the alloimmune response, there is considerable evidence implicating lipoprotein abnormal...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.TP.0000080981.90718.EB
更新日期:2003-09-27 00:00:00
abstract:BACKGROUND:Anemia after kidney transplantation has been associated with poor transplant outcomes. We hypothesized that intravenous (IV) iron may more rapidly correct anemia than oral (PO) iron. METHODS:One hundred four kidney transplant recipients were prospectively randomized to IV iron polymaltose (500 mg single dos...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/TP.0b013e318248375a
更新日期:2012-04-27 00:00:00
abstract::The ability of the popliteal lymph node assay (PLNA) To detect host-versus-graft activity in response to H-Y antigens was investigated in the rat by using presensitized recipients. It was shown that significant popliteal lymph node (PLN) enlargement in response to H-Y-incompatible lymphocytes from syngeneic donors cou...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198103000-00013
更新日期:1981-03-01 00:00:00
abstract:BACKGROUND:Cell-based insulin therapies can potentially improve glycemic regulation in insulin-dependent diabetic patients. Enteroendocrine cells engineered to secrete recombinant insulin have exhibited glycemic efficacy, but have been primarily studied as uncontrollable growth systems in immune incompetent mice. Furth...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000247
更新日期:2014-09-15 00:00:00
abstract:BACKGROUND:Umbilical cord blood transplantation (UCBT) is increasingly used and produces similar results to matched unrelated donor transplantation. METHODS:We performed a retrospective single-center analysis of 50 umbilical cord blood transplantations UCBTs performed from 2001 to 2010, including 37 single and 13 doub...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31826c39b2
更新日期:2012-11-27 00:00:00
abstract::The use of cyclosporine has been associated with an increased incidence of thrombosis and endothelial cell perturbation. To explore possible mechanisms involved, we examined the effects of CSA on the activation of protein C by thrombomodulin. Cultured bovine aortic endothelial cell monolayers were incubated for 24 hr ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199103000-00030
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND:Accelerated arteriosclerosis limits the survival of transplanted hearts. We hypothesized that insulin-like growth factor-I (IGF-I) is crucial in accelerating transplant arteriosclerosis. Recently, we reported that exposure to IGF-I prior to transplantation accelerates transplant arteriosclerosis in the rat a...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199804270-00003
更新日期:1998-04-27 00:00:00
abstract:BACKGROUND:A combined liver and kidney transplantation (CLKT) is advocated for selected individuals with chronic kidney disease undergoing liver transplantation (LT). The aim was to develop a risk score to identify the patients whose estimated glomerular filtration rate (eGFR) would decline during the year post-LT to a...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181d9e195
更新日期:2010-06-15 00:00:00
abstract:BACKGROUND:The clinical symptoms, histological findings, and treatments for antibody-mediated rejection (AMR), which is the leading cause of graft loss in adult ABO-incompatible liver transplantation (ABO-I-LT), have rarely been discussed. METHODS:We performed adult living donor ABO-I-LT on six patients. We used anti-...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31815e9672
更新日期:2008-01-27 00:00:00
abstract:BACKGROUND:Carbon monoxide (CO) inhalation protects organ by reducing inflammation and cell death during transplantation processes in animal model. However, using CO in clinical transplantation is difficult due to its delivery in a controlled manner. A manganese-containing CO releasing molecules (CORM)-401 has recently...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002201
更新日期:2018-07-01 00:00:00
abstract::Seventy-two dog kidneys were stored under hypothermia as described by Collins and Sacks between 24 and 72 hr and then transplanted. The immediate function of the kidneys was measured by p-aminohippuric acid and inulin clearances. Twenty-four hr proved to be the maximum safe preservation time with both methods. The imm...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197705000-00009
更新日期:1977-05-01 00:00:00
abstract::We have previously demonstrated that subclinical chronic rejection (CR) induces structural and functional alterations in enteric smooth muscle and nerves in a rat model of small intestinal transplantation. This study was designed to investigate the effect of prolonged FK506 rescue therapy on these sequelae of CR. Immu...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1995-01-27 00:00:00
abstract::In a prospective randomized double-blind placebo-controlled trial, the effect of rh-SOD, given in a dose of 200 mg intravenously during surgery to cyclosporine-treated recipients of cadaveric renal allografts, on both acute and chronic rejection events as well as patient and graft survival was investigated by analyzin...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007890-199401001-00010
更新日期:1994-01-01 00:00:00
abstract::Sera obtained before transplantation from 52 consecutive renal allograft recipients were tested for antibody-dependent cell-mediated cytotoxicity (ADCC) and for complement-dependent cytotoxic antibodies (CDC). A D locus antigen-defined lymphoblastoid cell panel (B lymphoblastoid cell panel) was used as targets for the...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1979-05-01 00:00:00
abstract:BACKGROUND:Translational research in a relevant preclinical model is recommended before Treg-inducing protocols can be implemented in humans. We have characterized rhesus monkey CD25 cells phenotypically and functionally. METHODS:The phenotype of CD4(+)CD25(high) cells was determined by FACS, focusing on established m...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31816b15b9
更新日期:2008-04-27 00:00:00
abstract:BACKGROUND:Donor organ shortage represents a major problem in lung transplantation. Donation after cardiac death could help to expand the pool of organs, but the additional period of warm ischemia after cardiac arrest aggravates primary graft dysfunction. The pulmonary endothelium of the graft constitutes an important ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318226bc6b
更新日期:2011-08-27 00:00:00
abstract:BACKGROUND:Immunosuppression in renal transplantation, although manageable in the short-term, is a major hurdle for long-term graft survival. Recently, increased frequencies of CD4CD25 regulatory T cells (Tregs) have been described as an additional mechanism that induces alloimmune tolerance. METHODS:We assessed 64 re...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000229473.95202.50
更新日期:2006-08-27 00:00:00
abstract::Transcription factors of the nuclear factor of activated T cells (NFAT) family regulate both immune activation and insulin production. Calcineurin inhibitors (CNIs) target NFAT activation. Hence, CNIs not only prevent organ transplant rejection but also contribute to the development of new-onset diabetes after transpl...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31823f7f26
更新日期:2012-02-15 00:00:00
abstract::An isolated vascularized bone marrow transplant (iVBMT) model was previously developed in the rat to specifically study the role of bone marrow and its environment in a composite tissue allotransplant. An extraperitoneal model was successfully created to avoid laparotomy and cross-clamping of the great vessels. The ex...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000061490.85273.29
更新日期:2003-05-15 00:00:00
abstract:BACKGROUND:Calcineurin inhibitor-induced renal dysfunction is a major problem in liver transplantation. Interleukin-2 receptor antagonist induction followed by delayed tacrolimus (Tac) administration may minimize the renal insult without compromising immunoprotection. METHODS:This open, randomized, multicenter trial e...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/TP.0b013e3181db8cf0
更新日期:2010-06-27 00:00:00
abstract::Gliotoxin is an immunosuppressive secondary metabolite produced by several pathogenic fungi. It has previously been shown to prevent graft-versus-host disease in transplantation of allogeneic mouse bone marrow and to reduce the immunogenicity of human fetal pancreas. We here report on the effect of gliotoxin on the pr...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1995-11-15 00:00:00
abstract:BACKGROUND:Sequential pancreatic islet transplantation via the portal vein has led to insulin independence in patients with type 1 diabetes. Complications associated with the injection of islets into the portal vein have been reported; therefore, in this study we sought to further characterize changes in portal venous ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200210150-00002
更新日期:2002-10-15 00:00:00
abstract:BACKGROUND:Fatty livers are more prone to primary nonfunction after transplantation. It is known that cell injury is strongly associated with alterations in the content and composition of membrane lipids. We assumed that plasma membrane (PM) fluidity, which is the most important property of the membrane, differed betwe...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199901270-00002
更新日期:1999-01-27 00:00:00
abstract:BACKGROUND:Anti-thymocyte globulin (ATG) is used frequently as induction therapy in renal transplant recipients. It has been standard practice that the various polyclonal anti-lymphocyte preparations be administered via central line, vascular shunt, or arteriovenous fistula to avoid thrombophlebitis. METHODS:We have s...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200005150-00038
更新日期:2000-05-15 00:00:00
abstract:BACKGROUND:Successful pancreatic islet transplantation (PIT) has resulted in several transplant centers wanting to start PIT programs. PIT remains experimental and must be performed safely for its continued use. We describe the radiographic techniques used at our center and their results. METHODS:Between January 17, 2...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000073976.26604.96
更新日期:2003-07-15 00:00:00
abstract:BACKGROUND:Centrilobular necrosis is not an uncommon finding after isolated liver transplantation. In this study, we sought to describe hepatic centrilobular necrosis in children after combined liver and small bowel transplantation (LSBT), and to assess the predictive factors, possible causes, and prognosis. METHODS:S...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200201270-00018
更新日期:2002-01-27 00:00:00
abstract:BACKGROUND:Although used for more than 20 years, optimal dosing strategies of most immunosuppressants have never been determined. Tacrolimus, one of the newer agents used in solid-organ transplantation, is gaining increasing popularity because of its ability to reverse refractory rejection in cyclosporine-treated patie...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-200210270-00014
更新日期:2002-10-27 00:00:00
abstract::Transplantation provides life-saving therapy to critically ill patients with end-stage organ failure. We found that the specialized knowledge of mental health clinicians and physicians, committed to the evaluation and management of transplant recipients, is essential for the optimal care of these patients who require ...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0b013e3181a754d4
更新日期:2009-06-27 00:00:00