Abstract:
BACKGROUND:Immunosuppression in renal transplantation, although manageable in the short-term, is a major hurdle for long-term graft survival. Recently, increased frequencies of CD4CD25 regulatory T cells (Tregs) have been described as an additional mechanism that induces alloimmune tolerance. METHODS:We assessed 64 renal transplant recipients with stable renal function for at least one year. Patients were divided into two groups according to the immunosuppression they were receiving at the moment of the study: one consisted of patients receiving rapamycin (Rapa) but not calcineurin inhibitors (CNI), and the other group received CNI but not Rapa. The Rapa group was further divided into three subgroups according to their previous experience with CNI: CNI-free, CNI withdrawal, and CNI conversion. Frequencies of blood Tregs were studied by flow cytometry after staining with monoclonal antibodies specific for different markers of Tregs. RESULTS:Frequencies of CD4 T cells with regulatory phenotype and function were significantly decreased in peripheral blood of renal transplant patients receiving CNI compared with those receiving Rapa. This effect was independent of an early exposure to CNI because the CNI-free patients in the Rapa group showed similar frequencies of Tregs to the CNI withdrawal and CNI conversion groups. CONCLUSIONS:CNI, but not Rapa, induce a decrease of circulating Tregs in stable renal transplant recipients. Thus, Rapa might be further explored in strategies using preservation of Tregs for transplant tolerance. Furthermore, quantification of blood Tregs may be a suitable tool to identify renal transplant recipients who may be candidates for reduced immunosuppression.
journal_name
Transplantationjournal_title
Transplantationauthors
Segundo DS,Ruiz JC,Izquierdo M,Fernández-Fresnedo G,Gómez-Alamillo C,Merino R,Benito MJ,Cacho E,Rodrigo E,Palomar R,López-Hoyos M,Arias Mdoi
10.1097/01.tp.0000229473.95202.50subject
Has Abstractpub_date
2006-08-27 00:00:00pages
550-7issue
4eissn
0041-1337issn
1534-6080pii
00007890-200608270-00016journal_volume
82pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::Solid organ and allogeneic hematopoietic cell transplantation have become standard therapeutic interventions that save patient lives and improve quality of life. Our enhanced understanding of transplantation immunobiology has refined clinical management and improved outcomes. However, organ rejection and graft-versus-...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000001468
更新日期:2016-12-01 00:00:00
abstract::Subsets of T cells have been identified by the expression of different isoforms of CD45. Some T cells expressing CD45RA (gp220) have been characterized as "naive" in their response to antigens including alloantigens, whereas T cells expressing CD45RO (gp180) have been characterized as "memory" T cells. To examine the ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199503150-00015
更新日期:1995-03-15 00:00:00
abstract:BACKGROUND:In the hamster to rat xenogeneic combination, antibodies, T cells, and natural killer (NK) cells have all been implicated in the process of rejection. 3.2.3 is a mouse IgG1kappa monoclonal antibody (mAb) directed against NKR-P1A on rat NK cells. The purpose of this study was to evaluate the effect of this mA...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199803150-00021
更新日期:1998-03-15 00:00:00
abstract::The presence of major histocompatibility complex (MHC)-encoded antigens (RT1) on endothelium of rat kidneys was investigated using hyperimmune allogeneic rat sera (HIS) in an indirect immunofluorescence technique with kidney sections. Endothelial antigens detected with anti-MHC sera segregated in an F2 generation with...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198209000-00002
更新日期:1982-09-01 00:00:00
abstract::Patients with short-gut syndrome may develop total parenteral nutrition-associated liver disease, which may preclude them from isolated intestinal transplantation and require combined liver and intestinal transplantation. Traditionally, these multiorgan transplantations are performed using en bloc liver and intestinal...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000045711.68765.84
更新日期:2003-02-27 00:00:00
abstract:BACKGROUND:Although the clinical features of early hepatic artery thrombosis (HAT) are well defined, the features of delayed (more than 4 weeks after transplantation) hepatic artery thrombosis are less clearly defined. The aim of our study was to identify risk factors, clinical presentation, and outcome of management o...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200106150-00018
更新日期:2001-06-15 00:00:00
abstract::Rat, hamster, and rabbit islets were transplanted into diabetic C57BL/B6 mice. The effect on islet xenograft survival of low-temperature culture of the donor islets, alpha L3T4 treatment of the recipients for seven days, and transplantation of the grafts either in the renal capsule or in the liver via the portal vein ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198905000-00002
更新日期:1989-05-01 00:00:00
abstract:BACKGROUND:Osteoporosis is a well-documented complication of organ transplantation. Bisphosphonates have been shown to be effective in preventing corticosteroid-induced osteoporosis in renal transplant recipients, but data are lacking for treatment of established osteoporosis. This study reports our clinical experience...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200103150-00017
更新日期:2001-03-15 00:00:00
abstract:BACKGROUND:Remote ischemic preconditioning (RIPC) protects against liver ischemia reperfusion (IR) injury. An essential circulating mediator of this protection is nitric oxide (NO) induced by lower limb RIPC. One of the mechanisms through which NO generally acts is the soluble guanylyl cyclase-cyclic GMP (sGC-cGMP) pat...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31824cd59d
更新日期:2012-05-15 00:00:00
abstract::Hepatocyte transplantation is an investigational alternative to orthotopic liver transplantation to treat liver based inborn errors of metabolism. We report successful hepatocyte transplantation in a 4-year-old girl with infantile Refsum disease. Hepatocytes were isolated from the left liver segment of two male donors...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000077420.81365.53
更新日期:2003-08-27 00:00:00
abstract:BACKGROUND:Reconstitution of hematopoiesis after hematopoietic stem cell transplantation (HSCT) occurs through a reservoir of donor CD34+ HSC. CD34+/VEGFR-2+ is a primitive, quiescent subpopulation of HSC known to generate hematopoietic or endothelial progeny in vitro and in vivo. We hypothesized that donor-specific an...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181820333
更新日期:2008-09-15 00:00:00
abstract::Gastrointestinal infection due to cytomegalovirus occurs frequently in liver transplant recipients. Upper gastrointestinal cytomegalovirus infection is associated with subjective complaints of nausea, a sense of abdominal fullness, and occasionally emesis and/or dysphagia. In order to determine whether these symptoms ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199207000-00012
更新日期:1992-07-01 00:00:00
abstract::An increased frequency of kidney rejection has been reported in diabetic patients who have simultaneous pancreas and kidney transplantation compared with patients who have a kidney transplant alone. Kidney graft outcome is similar in the two groups. The mechanism for increased kidney graft rejection with a simultaneou...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199304000-00015
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:Infectious complications still represent a major cause of morbidity and mortality in patients with organ transplantation. In particular, small bowel or multivisceral transplantation is complicated to a greater extent than other grafts as a consequence of infectious complications including sepsis. METHODS:Th...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000185622.91708.57
更新日期:2005-12-27 00:00:00
abstract::Allotransplantation into immunosuppressed individuals results in long-term survival of grafts. However, the grafts are damaged, probably at many stages before, during and after implantation. The hypothesis to be presented is that release of antigens and autoantigens from the chronically damaged graft results in breaki...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000153294.38939.5f
更新日期:2005-02-15 00:00:00
abstract::We have recently demonstrated that three synthetic peptides corresponding to the donor class I RT1.Aa molecule induce long-term survival of cardiac allografts in the PVG.R8-to-PVG.1U rat strain combination (disparate for one isolated class I, RT1.A, molecule) when presented to the recipient immune system in the thymus...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199712270-00007
更新日期:1997-12-27 00:00:00
abstract::The association of renal vein thrombosis and membranous glomerulopathy in native kidneys has been well documented. However, this association has only occasionally been described following renal transplantation. A review of 693 renal transplant recipients revealed 77 (11%) in whom persistent, heavy proteinuria (greater...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1984-12-01 00:00:00
abstract::Serologic evidence of resolved hepatitis B virus (HBV) infection (HBV surface antigen negative, anti-HBV core antibody [HBc] positive) in a liver donor can be regarded as an occult infection with episomal HBV in the liver. The purpose of this study was to evaluate the safety of anti-HBc-positive living donors. Between...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000047030.38665.0D
更新日期:2003-02-15 00:00:00
abstract:BACKGROUND:Blood group-incompatible transplantation is one strategy used when a potential recipient does not have a compatible living donor. Current practice includes desensitization strategies to reduce antibody titers. However, when antibodies are low, in cardiac transplantation in neonates for example, no desensitiz...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31825b7608
更新日期:2012-08-27 00:00:00
abstract:BACKGROUND:Thymoglobulin given before allo-hematopoietic stem-cell transplantation (HSCT) from unrelated donors reduces acute graft-versus-host disease (GvHD), but the optimal dose is unknown. METHOD:Four different doses of Thymoglobulin were given to 162 patients with hematologic malignancies undergoing unrelated don...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:2004-07-15 00:00:00
abstract::Orthotopic liver allografts from BN donors to LEW recipients are spontaneously accepted, and the recipients develop donor-specific immunological unresponsiveness. This unresponsiveness may be mediated by suppressor T cells. Immunomagnetically purified splenic T cells from LEW rats bearing BN liver grafts were shown to...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199212000-00019
更新日期:1992-12-01 00:00:00
abstract:BACKGROUND:Murine umbilical cord blood cells (UCBCs) were studied for their ability to reconstitute the hematopoietic system. METHODS:On average, 150 microL of cord blood per fetus containing 1.2 to 2 x 10(4) nucleated cells were collected from day 18.5 fetal umbilical cord, and 3 to 6 x 10(3) cells per fetus were obt...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000065295.99190.03
更新日期:2003-06-15 00:00:00
abstract:BACKGROUND:Subclinical T cell-mediated rejection (subTCMR) is commonly found after liver transplantation and has a good short-term prognosis, even when it is left untreated. Donor-specific antibodies (DSA) are putatively associated with a worse prognosis for recipient and graft after liver transplantation. METHODS:To ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003034
更新日期:2020-03-01 00:00:00
abstract::A comparative study of 24 hr preservation at 4 degrees C of excised rat livers with Euro-Collins and hydroxyethyl starch-free University of Wisconsin (UWm) solutions has been conducted based on the assessment of (1) the cellular energy status determined by 31P NMR spectroscopy and (2) cellular injury estimated from th...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199210000-00006
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND:Apoptosis is a well-documented pathway for islet cell death. One potential mechanism is overexpression of death-promoting Bax compared with antiapoptotic Bcl-2 in islets. METHODS:We isolated islets from 10 human pancreata and measured the expression of Bax mRNA and Bcl-2 mRNA by real-time quantitative polym...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200212150-00003
更新日期:2002-12-15 00:00:00
abstract:BACKGROUND:When a deceased-donor kidney is offered to a waitlisted candidate, the decision to accept or decline the organ relies primarily upon a practitioner's experience and intuition. Such decisions must achieve a delicate balance between estimating the immediate benefit of transplantation and the potential for futu...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001824
更新日期:2017-12-01 00:00:00
abstract::The levels of HLA-A and -B antigens expressed by placenta have been assessed relative to parental and other A and B antigen types that were not shared by the foetus. A purified preparation of placenta plasma membrane was used to estimate the antigen activities. The results indicate that maternally and paternally inher...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197612000-00009
更新日期:1976-12-01 00:00:00
abstract::Sera from 56 recipients of liver or heart transplants were investigated for monoclonal immunoglobulins (mIg) by immunofixation electrophoresis (IFE) at different times during 4 years after transplantation. Transient, changing, or stable mIgs were found in 18 patients. A significantly increased mIg incidence was observ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198809000-00011
更新日期:1988-09-01 00:00:00
abstract::We developed a new and simplified donor-specific blood transfusion (DSBT) protocol for prospective kidney transplant recipients from one-haplotype-mismatched related donors. Prospective kidney donors gave 450 ml of blood in a quad-pack unit, and the blood was stored in a blood bank. Twenty-five patients were transfuse...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198411000-00012
更新日期:1984-11-01 00:00:00
abstract:BACKGROUND:Preemptive kidney transplantation (prior to the institution of dialysis) avoids the morbidity and mortality of dialysis; however, detailed studies of high-risk patients are lacking. The aim of the current study was to compare recent outcomes of preemptive (P) versus nonpreemptive (NP) living donor kidney tra...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000250555.46539.65
更新日期:2007-01-27 00:00:00