Dose study of thymoglobulin during conditioning for unrelated donor allogeneic stem-cell transplantation.


BACKGROUND:Thymoglobulin given before allo-hematopoietic stem-cell transplantation (HSCT) from unrelated donors reduces acute graft-versus-host disease (GvHD), but the optimal dose is unknown. METHOD:Four different doses of Thymoglobulin were given to 162 patients with hematologic malignancies undergoing unrelated donor HSCT: 4, 6, 8, and 10 mg/kg. Stem-cell source was bone marrow in 102 cases and peripheral blood stem cells in 60. Conditioning was cyclophosphamide combined with total-body irradiation or busulfan. GvHD prophylaxis was cyclosporine and methotrexate. RESULTS:The lowest dose of Thymoglobulin significantly increased the risk for acute GvHD II or greater (odds ratio [OR] 2.67, P=0.015) and III or greater (OR 4.12, P=0.03). GvHD-associated deaths were more common in the lowest Thymoglobulin dose (6/51) compared with higher doses (2/111), P<0.01. No difference in bacteremia and cytomegalovirus reactivation was found. A trend for more infectious death (11/55 vs. 11/107, P=0.09) was found in the 10 mg/kg group compared with lower doses. Median dose of Thymoglobulin (6-8 mg/kg) was associated with lower transplant-related mortality (TRM) (hazard ratio [HR] 0.35, P=0.03) and better survival (HR 0.45, P=0.027) in multivariate analysis, whereas no effect on relapse and relapse-free survival was found. CONCLUSION:Low-dose (4 mg/kg) of Thymoglobulin increased the risk for severe acute GvHD, whereas 10 mg/kg increased the risk for infectious death. Median doses (6-8 mg/kg) of Thymoglobulin resulted in the lowest TRM and best survival.






Remberger M,Svahn BM,Mattsson J,Ringdén O


Has Abstract


2004-07-15 00:00:00














  • Fine specificity and idiotype diversity of the murine anti-HLA-A2, A28 monoclonal antibodies CR11-351 and KS1.

    abstract::The monoclonal antibodies (MoAb) CR11-351 and KS1 are secreted by hybridomas generated with splenocytes from BALB/c mice immunized with the cultured human B lymphoid cells LG-2 (HLA-A2,A2,B27,B27). The 2 monoclonal antibodies immunoprecipitated components with a superimposable 2-dimensional gel electrophoretic profile...


    pub_type: 杂志文章


    authors: Tsujisaki M,Sakaguchi K,Igarashi M,Richiardi P,Perosa F,Ferrone S

    更新日期:1988-03-01 00:00:00

  • Five-year follow-up of two siblings with aspartylglucosaminuria undergoing allogeneic stem-cell transplantation from unrelated donors.

    abstract:BACKGROUND:Aspartylglucosaminuria is a rare, inherited lysosomal disease characterized by a slowly progressive mental retardation and coarse facial and body features. With the intent to provide the deficient enzyme aspartylglucosaminidase, allogeneic stem-cell transplantation (ASCT) has been attempted. Only a few cases...


    pub_type: 杂志文章


    authors: Malm G,Månsson JE,Winiarski J,Mosskin M,Ringdén O

    更新日期:2004-08-15 00:00:00

  • Successful clinical islet isolation using a GMP-manufactured collagenase and neutral protease.

    abstract::In 2007, the islet community was notified that the collagenase product most commonly used for human islet isolations contained bovine neural tissue contaminants. To minimize this potential hazard, we adapted our human islet processing procedure to use a GMP-manufactured, bovine neural tissue-free collagenase blend. He...


    pub_type: 杂志文章,评审


    authors: Szot GL,Lee MR,Tavakol MM,Lang J,Dekovic F,Kerlan RK,Stock PG,Posselt AM

    更新日期:2009-09-27 00:00:00

  • The relationship between flow cytometer crossmatch results and subsequent rejection episodes in cadaver renal allograft recipients.

    abstract::Flow cytometry (FC) T and B cell crossmatches were done retrospectively for 38 cadaver renal transplant recipients (29 first and 9 retransplants--minimum follow-up 12 months) using both current pretransplant serum and peak-reactive sera. An increase in median fluorescence intensity (channel shift) and/or an increase i...


    pub_type: 杂志文章


    authors: Lazda VA,Pollak R,Mozes MF,Jonasson O

    更新日期:1988-03-01 00:00:00

  • Post hoc analyses: after the facts.

    abstract::Prospective clinical trials are constructed with high levels of internal validity. Sample size and power considerations usually address primary endpoints. Primary endpoints have traditionally included events that are becoming increasingly less common and thus have led to growing use of composite endpoints and noninfer...


    pub_type: 杂志文章,评审


    authors: Srinivas TR,Ho B,Kang J,Kaplan B

    更新日期:2015-01-01 00:00:00

  • Lectin-dependent cell-mediated cytotoxicity and natural killer function in rejecting and infected lung allografts.

    abstract::Differentiation between rejection and infection of lung allografts remains difficult. The effects of these two pathologic entities on the cytolytic activity of bronchoalveolar lavage (BAL) and PBL were investigated. Left lung allotransplantation was performed on 16 mongrel dogs of which 12 were available for complete ...


    pub_type: 杂志文章


    authors: Nguyen DM,Mulder DS,Shennib H

    更新日期:1993-06-01 00:00:00

  • Cardiac allograft rejection late after transplantation is a risk factor for graft coronary artery disease.

    abstract:BACKGROUND:Graft coronary artery disease (CAD) is an increasingly important problem during long-term survival after heart transplantation, but the importance of cellular rejection, in particular late after transplantation, remains undetermined. METHODS AND RESULTS:We analyzed 492 coronary angiographies (967+/-705 days...


    pub_type: 杂志文章


    authors: Brunner-La Rocca HP,Schneider J,Künzli A,Turina M,Kiowski W

    更新日期:1998-02-27 00:00:00

  • Transplantation of canine lung allografts preserved in UW solution for 24 hours.

    abstract::To evaluate the efficacy of University of Wisconsin (UW) solution for lung preservation, we performed canine lung allotransplantation with lungs preserved in UW solution. Donor lungs from eight dogs were flushed with UW solution and lungs from four dogs with Euro-Collins solution, and these were preserved for 24 hr in...


    pub_type: 杂志文章


    authors: Kawahara K,Itoyanagi N,Takahashi T,Akamine S,Kobayashi M,Tomota M

    更新日期:1993-01-01 00:00:00

  • The nonessential role of a humoral antibody response in acute rat cardiac allograft rejection. An ultrastructural tracer study in an adoptive transfer model.

    abstract::Progressive microvascular endothelial damage is a characteristic feature of fulminant acute cardiac allograft rejection in the rat. Serial ultrastructural tracer studies using i.v. administered colloidal carbon and horseradish peroxidase have been performed in an adoptive transfer model to determine the role of cellul...


    pub_type: 杂志文章


    authors: Lowry RP,Forbes RD

    更新日期:1984-02-01 00:00:00

  • Duodenal histology for monitoring treatment of acute rejection in pancreaticoduodenal allografts in rats.

    abstract:BACKGROUND:Although the value of duodenal histology as a means to diagnose acute rejection in pancreaticoduodenal allografts has been validated, it is not known how the duodenum responds to antirejection treatment in comparison with the pancreas. METHODS:Diabetic Lewis rats received a pancreaticoduodenal allograft. Cy...


    pub_type: 杂志文章


    authors: Mark W,Hechenleitner P,Dietze O,Klima G,Schneeberger S,Steurer W,Candinas D,Margreiter R,Königsrainer A

    更新日期:2002-01-27 00:00:00

  • The presence of activated donor HLA class I-reactive T lymphocytes is associated with rejection of corneal grafts.

    abstract::Although the cornea is considered to be an immunological privileged site, corneal transplantation can result in immunological rejection followed by graft failure, especially in patients with vascularized corneas. Several studies suggest a beneficial effect of matching for the HLA class I antigens on corneal graft surv...


    pub_type: 杂志文章


    authors: Roelen DL,van Beelen E,van Bree SP,van Rood JJ,Völker-Dieben HJ,Claas FH

    更新日期:1995-04-15 00:00:00

  • The vascular endothelial cell antigen system.

    abstract::Vascular endothelial cells (VEC) are clearly immunogenic and express antigens unique to vascular endothelial cells. The observation that peripheral blood monocytes also express this VEC antigen system made prospective testing feasible. Preformed antibody to the VEC/monocyte antigen system of the donor usually leads to...


    pub_type: 杂志文章


    authors: Cerilli J,Brasile L,Galouzis T,Lempert N,Clarke J

    更新日期:1985-03-01 00:00:00

  • Transplantomics: Toward Precision Medicine in Transplantation Research.

    abstract::Precision medicine is an emerging integrative approach for disease prevention, early detection, and treatment which takes into account individual variability in genetic and other molecular measurements, medical history, environmental exposures, and lifestyle. The development and availability of genomic and other molec...


    pub_type: 杂志文章,评审


    authors: Sirota M,Sarwal MM

    更新日期:2017-08-01 00:00:00

  • Ethnically diverse populations and their participation in living kidney donation programs.

    abstract:BACKGROUND:The number of living donor kidney transplantations increases steeply in Europeans, whereas the non-Europeans are dependent on deceased donor transplantations. We wondered whether a low attendance or a high decline of potential non-European donors could explain this difference. METHODS:This retrospective stu...


    pub_type: 杂志文章


    authors: Roodnat JI,van de Wetering J,Zuidema W,van Noord MA,Kal-van Gestel JA,Ijzermans JN,Weimar W

    更新日期:2010-05-27 00:00:00

  • Porcine model of auxiliary partial orthotopic liver transplantation for acute liver failure.

    abstract:BACKGROUND:Auxiliary partial orthotopic liver transplantation (APOLT) has been an effective alternative in acute liver failure (ALF), but clinically several problems remain to be resolved. Thus, we attempt to establish an APOLT model for ALF using a large animal and demonstrate the validity of our model. METHODS:In ex...


    pub_type: 杂志文章


    authors: Fukueda M,Ishizaki N,Hamada N,Kadono J,Kaieda M,Nakamura N,Komokata T,Sakata R

    更新日期:2006-11-27 00:00:00

  • Phototherapy in the treatment of cutaneous graft-versus-host disease. Our preliminary experience in resistant patients.

    abstract::Graft-versus-host disease (GVHD)* is a frequent complication of allogeneic bone marrow transplantation. The potentially beneficial effect of phototherapy for treatment of cutaneous manifestations of GVHD led us to investigate retrospectively the effect of this therapy in a larger series of patients. Eleven patients wi...


    pub_type: 杂志文章


    authors: Aubin F,Brion A,Deconinck E,Plouvier E,Hervé P,Humbert P,Cahn JY

    更新日期:1995-01-15 00:00:00

  • Cross reactivity between H-2K and H-2D products. III. Effect of H-2K-H-2D cross sensitization on skin graft survival.

    abstract::Cross sensitization between the products of the H-2K and H-2D loci has been demonstrated by an experimental design in which recipients were sensitized with tissue bearing determinants controlled by one locus (e.g., H-2K), and then challenged with skin grafts expressing determinants controlled by the other locus (e.g.,...


    pub_type: 杂志文章


    authors: Murphy DB,Shreffler DC

    更新日期:1975-07-01 00:00:00

  • 17β-Estradiol Treatment Protects Lungs Against Brain Death Effects in Female Rat Donor.

    abstract:BACKGROUND:Brain death (BD) affects the viability of lungs for transplantation. A correlation exists between high lung inflammation after BD and the decrease in female sex hormones, especially estradiol. Therefore, we investigated the effects of 17β-estradiol (E2) treatment on the lungs of female brain dead rats. METH...


    pub_type: 杂志文章


    authors: Ricardo-da-Silva FY,Armstrong R Jr,Vidal-Dos-Santos M,Correia CJ,Coutinho E Silva RDS,da Anunciação LF,Moreira LFP,Leuvenink HGD,Breithaupt-Faloppa AC

    更新日期:2020-10-07 00:00:00

  • Long-term duct-occluded segmental pancreatic autografts: absence of microvascular diabetic complications.

    abstract:BACKGROUND:Current insulin therapies for control of glucose metabolism in patients with type I diabetes mellitus prevent major metabolic consequences of insulin deficiency, but none prevents or arrests long-term complications. In experimental models of canine diabetes, retinopathy, neuropathy, and nephropathy have been...


    pub_type: 杂志文章


    authors: Hawthorne WJ,Wilson TG,Williamson P,Stewart GJ,Allen RD,Little JM,Deane SA,Ekberg H

    更新日期:1997-10-15 00:00:00

  • Clinical determinants of multiple acute rejection episodes in kidney transplant recipients.

    abstract:BACKGROUND:Recipients with multiple (more than one) acute rejection (AR) episodes have significantly lower graft survival rates than those with no AR or only one treated episode. However, fewer than 50% of recipients treated for one AR episode will have another episode. METHODS:We studied recipients with at least one ...


    pub_type: 杂志文章


    authors: Humar A,Payne WD,Sutherland DE,Matas AJ

    更新日期:2000-06-15 00:00:00

  • Trends in Lung Transplantation Practices Across the United States During the COVID-19 Pandemic.

    abstract:BACKGROUND:The purpose of this study is to examine the effects of the coronavirus disease 2019 (COVID-19) pandemic on adult lung transplants and report practice changes in the United States. METHODS:A retrospective analysis of a public dataset from the United Network for Organ Sharing was performed regarding adult lun...


    pub_type: 杂志文章


    authors: Chan EG,Chan PG,Harano T,Ryan JP,Morrell MR,Sanchez PG

    更新日期:2021-01-01 00:00:00

  • Cell transplantation of genetically altered cells on biodegradable polymer scaffolds in syngeneic rats.

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    pub_type: 杂志文章


    authors: Gilbert JC,Takada T,Stein JE,Langer R,Vacanti JP

    更新日期:1993-08-01 00:00:00

  • Combined cold storage-perfusion preservation with a new synthetic perfusate.

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    pub_type: 杂志文章


    authors: Hoffmann RM,Stratta RJ,D'Alessandro AM,Sollinger HW,Kalayoglu M,Pirsch JD,Southard JH,Belzer FO

    更新日期:1989-01-01 00:00:00

  • Role of polymorphic Fc receptor Fc gammaRIIa in cytokine release and adverse effects of murine IgG1 anti-CD3/T cell receptor antibody (WT31).

    abstract::Anti-CD3 monoclonal antibody (mAb) OKT3 is immunosuppressive, but causes severe adverse effects during the first administration ("first-dose reaction"). These adverse effects are presumably caused by cytokine release that results from T-cell activation. In vitro, T-cell activation by anti-CD3 mAb requires interaction ...


    pub_type: 杂志文章


    authors: Tax WJ,Tamboer WP,Jacobs CW,Frenken LA,Koene RA

    更新日期:1997-01-15 00:00:00

  • The protective effects of the thromboxane synthetase inhibitor Dazmegrel on nephrotoxicity in cyclosporine-treated rats.

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    pub_type: 杂志文章


    authors: Gladue RP,Newborg MF

    更新日期:1991-11-01 00:00:00

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    pub_type: 杂志文章


    authors: Benham Am,Sawyer GJ,Fabre JW

    更新日期:1996-05-27 00:00:00

  • Delayed hepatic artery thrombosis in adult orthotopic liver transplantation-a 12-year experience.

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    pub_type: 杂志文章


    authors: Bhattacharjya S,Gunson BK,Mirza DF,Mayer DA,Buckels JA,McMaster P,Neuberger JM

    更新日期:2001-06-15 00:00:00

  • Histologic findings in islets of whole pancreas allografts: lack of evidence for recurrent cell-mediated diabetes mellitus.

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    pub_type: 杂志文章


    authors: Drachenberg CB,Papadimitriou JC,Weir MR,Klassen DK,Hoehn-Saric E,Bartlett ST

    更新日期:1996-12-27 00:00:00

  • Flush solution 2, a new concept for one-to-three-day hypothermic renal storage preservation. Functional recovery after preservation in Euro-Collins, Collins' C2, hypertonic citrate, and F.2 solution.

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    pub_type: 杂志文章


    authors: Fischer JH,Knupfer P,Beyer M

    更新日期:1985-02-01 00:00:00

  • Direct induction of MHC class I, but not class II, expression on endothelial cells by cytomegalovirus infection.

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    pub_type: 杂志文章


    authors: van Dorp WT,Jonges E,Bruggeman CA,Daha MR,van Es LA,van Der Woude FJ

    更新日期:1989-09-01 00:00:00