Variability in donation after cardiac death protocols: a national survey.


:As donation after cardiac death practices expand, the number of institutional policies is increasing. We contacted organ procurement organizations throughout the United States and requested protocols in hospitals in their donor service areas. Sixty-four protocols were obtained with representation from 16 different states. The terminology and recommended practices varied substantially. The methods for death determination were not specified in 28 (44%) protocols. Most adhered to a 2- to 5-min observation time between circulatory arrest and organ procurement, but 10 (16%) provided no information. This variability reveals a need to define a uniform standard in donation after cardiac death protocols and death determination practices.






Fugate JE,Stadtler M,Rabinstein AA,Wijdicks EF




Has Abstract


2011-02-27 00:00:00












  • Injury Pathways That Lead to AKI in a Mouse Kidney Transplant Model.

    abstract:BACKGROUND:Prolonged cold ischemia (CI) is a risk factor for acute kidney injury after kidney transplantation. We endeavored to determine the pathways involved in the development of tubular cell injury and death before and after transplantation. We hypothesized that ex vivo cold storage before transplant would produce ...


    pub_type: 杂志文章


    authors: Jain S,Plenter R,Nydam T,Jani A

    更新日期:2020-09-01 00:00:00

  • Defining a Willingness-to-transplant Threshold in an Era of Organ Scarcity: Simultaneous Liver-kidney Transplant as a Case Example.

    abstract:BACKGROUND:Organ scarcity continues in solid organ transplantation, such that the availability of organs limits the number of people able to benefit from transplantation. Medical advancements in managing end-stage organ disease have led to an increasing demand for multiorgan transplant, wherein a patient with multiorga...


    pub_type: 杂志文章


    authors: Cheng XS,Goldhaber-Fiebert J,Tan JC,Chertow GM,Kim WR,Wall AE

    更新日期:2020-02-01 00:00:00

  • Nitric oxide synthase activity in renal ischemia-reperfusion injury in the rat: implications for renal transplantation.

    abstract::Cadaveric kidney transplants with delayed graft function have poorer graft survival by an unknown mechanism. Nitric oxide, produced by nitric oxide synthase (NOS), has a proven role in both recovery of ischemia and promotion of rejection. We therefore wished to study the patterns of NOS activity in a model of renal is...


    pub_type: 杂志文章


    authors: Shoskes DA,Xie Y,Gonzalez-Cadavid NF

    更新日期:1997-02-27 00:00:00

  • Delayed correction of portal hypertension after portal vein conduit arterialization in liver transplantation.

    abstract::A 55-year-old woman underwent orthotopic liver transplantation for autoimmune chronic active hepatitis. Extensive portal and superior mesenteric venous thrombosis precluded standard portal venous reconstruction and necessitated use of a venous conduit from the recipient splenic vein of the donor liver. Flow through th...


    pub_type: 杂志文章


    authors: Neelamekam TK,Geoghegan JG,Curry M,Hegarty JE,Traynor O,McEntee GP

    更新日期:1997-04-15 00:00:00

  • Continuous venovenous hemofiltration with dialysis in combination with total hepatectomy and portocaval shunting. Bridge to liver transplantation.

    abstract::Children who experience acute liver failure following liver transplantation will have multiple organ failure and a high rate of mortality unless emergency retransplantation can be performed. Transplant hepatectomy with portocaval shunting has been described as a bridge to transplantation in the most severe cases, as w...


    pub_type: 杂志文章


    authors: Hammer GB,So SK,Al-Uzri A,Conley SB,Concepcion W,Cox KL,Berquist WE,Esquivel CO

    更新日期:1996-07-15 00:00:00

  • Increased infections in liver transplant recipients with recurrent hepatitis C virus hepatitis.

    abstract::Infectious complications in patients with recurrent hepatitis C virus (HCV) hepatitis after liver transplantation were prospectively assessed and compared with those of all other liver transplant recipients without HCV hepatitis operated on during the same period. Major infections occurred in 64% (14/22) of the patien...


    pub_type: 杂志文章


    authors: Singh N,Gayowski T,Wagener MM,Marino IR

    更新日期:1996-02-15 00:00:00

  • Heart transplantation in diabetic recipients.

    abstract::Preexisting diabetes mellitus (DM) has been regarded as a contraindication to heart transplantation (HT). This prejudice has been based upon concern over increased infection rates and worsening DM with the initiation of prednisone immunosuppression. To better evaluate these suppositions, we reviewed our experience wit...


    pub_type: 杂志文章


    authors: Ladowski JS,Kormos RL,Uretsky BF,Griffith BP,Armitage JM,Hardesty RL

    更新日期:1990-02-01 00:00:00

  • Effect of transplantation site and alpha L3T4 treatment on survival of rat, hamster, and rabbit islet xenografts in mice.

    abstract::Rat, hamster, and rabbit islets were transplanted into diabetic C57BL/B6 mice. The effect on islet xenograft survival of low-temperature culture of the donor islets, alpha L3T4 treatment of the recipients for seven days, and transplantation of the grafts either in the renal capsule or in the liver via the portal vein ...


    pub_type: 杂志文章


    authors: Lacy PE,Ricordi C,Finke EH

    更新日期:1989-05-01 00:00:00

  • Association between capsule diameter, adequacy of encapsulation, and survival of microencapsulated rat islet allografts.

    abstract::As a consequence of its large volume, a microencapsulated islet graft can be implanted only into the peritoneal cavity. The graft volume can be reduced by using small capsules. However, reduction of the diameter of the capsules holds a certain risk, because with smaller capsules, more islets may be found to protrude f...


    pub_type: 杂志文章


    authors: De Vos P,De Haan B,Pater J,Van Schilfgaarde R

    更新日期:1996-10-15 00:00:00

  • Activation of T lymphocytes for adhesion and cytokine expression by toxin-conjugated anti-CD3 monoclonal antibodies.

    abstract:BACKGROUND:Immunosuppressive drugs that target T cells are useful for prolonging allograft survival. The anti-CD3 immunotoxin FN18-CRM9 has been shown to effectively prolong renal allograft survival in a rhesus monkey model of transplantation. However, immunotoxin-treated monkeys showed increased levels of inflammatory...


    pub_type: 杂志文章


    authors: Hamawy MM,Tsuchida M,Manthei ER,Dong Y,Fechner JE,Knechtle JS

    更新日期:1999-09-15 00:00:00

  • Successful surgical salvage of pancreas allograft.

    abstract:BACKGROUND:Early and late complications related to the pancreas after simultaneous kidney-pancreas transplantation (SKPT) frequently result in graft loss. The authors describe a surgical rescue technique that allows salvage of the pancreatic graft when surgical complications appear after the transplant. METHODS:Of 158...


    pub_type: 杂志文章


    authors: Orsenigo E,Cristallo M,Socci C,Castoldi R,Fiorina P,Invernizzi L,Caldara R,Secchi A,Di Carlo V

    更新日期:2003-01-27 00:00:00

  • Programmed cell death.

    abstract::Programmed cell death (PCD) is currently one of the most intensively studied areas in cell biology. Substantial evidence now exists demonstrating the integral role of PCD in many fundamental immunologic processes; therefore, understanding the mechanisms of PCD may provide advances with broad implications in immunobiol...


    pub_type: 杂志文章,评审


    authors: Woodle ES,Kulkarni S

    更新日期:1998-09-27 00:00:00

  • Deficient T cell granulocyte-macrophage colony stimulating factor production in allogeneic bone marrow transplant recipients.

    abstract::The proliferation and differentiation of donor hematopoietic progenitor cells in bone marrow transplantation (BMT) recipients is influenced by hematopoietic growth factors, which could derive from either T cells or adherent stromal bone marrow cells, or both. In this study of 20 BMT recipients, we asked whether T lymp...


    pub_type: 杂志文章


    authors: Thomas S,Clark SC,Rappeport JM,Nathan DG,Emerson SG

    更新日期:1990-04-01 00:00:00

  • The role of endoscopic ultrasound for evaluating portal hypertension in children being assessed for intestinal transplantation.

    abstract::Intestinal transplant is an established treatment of irreversible intestinal failure, unless complicated by advanced intestinal failure-associated liver disease, when liver-bowel transplant may be necessary. Finding at least moderate hepatic fibrosis or gastroesophageal varices (GOV) at oesophago-gastroduodenoscopy (O...


    pub_type: 杂志文章


    authors: McKiernan PJ,Sharif K,Gupte GL

    更新日期:2008-11-27 00:00:00

  • Influence of age in renal transplant infections: cases and controls study.

    abstract::Kidney transplantation in elderly patients is a good therapeutic option, but the incidence of infections compared to younger patients must be studied. Case and control study was performed with 40 cases (patients older than 65) and 40 controls (younger than 65) receiving a kidney transplant between January 2000 and Aug...


    pub_type: 杂志文章


    authors: Trouillhet I,Benito N,Cervera C,Rivas P,Cofán F,Almela M,Angeles Marcos M,Puig de la Bellacasa J,Pumarola T,Oppenheimer F,Moreno-Camacho A

    更新日期:2005-10-15 00:00:00

  • Enhancement of rat kidney allografts using haptenated alloantigens and antihapten antibody.

    abstract::The survival of semiallogeneic or fully allogeneic rat kidney allografts was prolonged in some strain combinations with immune complexes formed with hapten-conjugated alloantigens (TNP-Ag) of donor origin and a mouse monoclonal antihapten antibody (anti-TNP). Complexes were administered i.v. at the time of operation--...


    pub_type: 杂志文章


    authors: Barber WH,Hutchinson IV,Morris PJ

    更新日期:1983-11-01 00:00:00

  • MicroRNA-155 Deficiency in Kupffer Cells Ameliorates Liver Ischemia-Reperfusion Injury in Mice.

    abstract:BACKGROUND:MicroRNA-155 (miR-155) is known to be involved in autoimmune diseases, inflammation, and transplantation. However, its role in a warm hepatic ischemia-reperfusion (IR) model has not been fully elucidated. METHODS:Partial hepatic IR was performed in wild-type and miR-155-deficient mice treated with or withou...


    pub_type: 杂志文章


    authors: Li Y,Ma D,Wang Z,Yang J

    更新日期:2017-07-01 00:00:00

  • Expression of HLA system antigens on placenta.

    abstract::The levels of HLA-A and -B antigens expressed by placenta have been assessed relative to parental and other A and B antigen types that were not shared by the foetus. A purified preparation of placenta plasma membrane was used to estimate the antigen activities. The results indicate that maternally and paternally inher...


    pub_type: 杂志文章


    authors: Goodfellow PN,Barnstable CJ,Bodmer WF,Snary D,Crumpton MJ

    更新日期:1976-12-01 00:00:00

  • Pretransplant dialysis duration and risk of death after kidney transplantation in the current era.

    abstract:BACKGROUND:Although longer pretransplant dialysis has been associated with poor kidney transplant outcome, no data about this association exist from the current era or from Europe. We studied the association of pretransplant dialysis duration on outcomes after kidney transplantation across two different time periods. ...


    pub_type: 杂志文章


    authors: Helanterä I,Salmela K,Kyllönen L,Koskinen P,Grönhagen-Riska C,Finne P

    更新日期:2014-08-27 00:00:00

  • Cardiovascular risk profile of patients with acute liver failure after liver transplantation when compared with the general population.

    abstract:BACKGROUND:As opposed to most solid-organ transplant recipients, patients with acute liver failure exhibit a pretransplant health status more comparable with the general population, and any posttransplant cardiovascular risk excess should thus be more attributable to transplantation-related factors alone. METHODS:This...


    pub_type: 杂志文章


    authors: Aberg F,Jula A,Höckerstedt K,Isoniemi H

    更新日期:2010-01-15 00:00:00

  • Membranoproliferative glomerulonephritis type I in renal transplantation patients: a single-center study of a cohort of 68 renal transplants followed up for 11 years.

    abstract:BACKGROUND:To evaluate the long-term outcome of renal transplant patients with membranoproliferative glomerulonephritis (MPGN) type I and the impact of recurrence. METHODS:The outcomes of 68 renal transplants performed between 1976 and 2009 in 63 patients with MPGN were compared with those of 136 controls matched for ...


    pub_type: 杂志文章


    authors: Moroni G,Casati C,Quaglini S,Gallelli B,Banfi G,Montagnino G,Messa P

    更新日期:2011-06-15 00:00:00

  • Neoral compared to Sandimmune is associated with a decrease in histologic severity of rejection in patients undergoing primary liver transplantation.

    abstract:BACKGROUND:In a randomized, controlled study we investigated the clinical efficacy of the microemulsion formulation of cyclosporine (Neoral) in comparison with Sandimmune (SIM) in the treatment of patients who underwent primary orthotopic liver transplantation (OLT). METHODS:In total, 33 patients were randomized in a ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Graziadei IW,Wiesner RH,Marotta PJ,Porayko MK,Dahlke LJ,Wilson SM,Steers JL,Krom RA

    更新日期:1997-09-15 00:00:00

  • Monitoring the patient off immunosuppression. Conceptual framework for a proposed tolerance assay study in liver transplant recipients.

    abstract::The mission of the recently established Immune Tolerance Network includes the development of protocols for the induction of transplant tolerance in organ allograft recipients and the development of assays that correlate with and may be predictive of the tolerant state. The state of clinical organ transplant tolerance ...


    pub_type: 杂志文章,评审


    authors: Thomson AW,Mazariegos GV,Reyes J,Donnenberg VS,Donnenberg AD,Bentlejewski C,Zahorchak AF,O'Connell PJ,Fung JJ,Jankowska-Gan E,Burlingham WJ,Heeger PS,Zeevi A

    更新日期:2001-10-27 00:00:00

  • T cells receptor beta-chain repertoires are nonrandomly selected in responses to HLA-DR1.

    abstract::T cell receptor (TCR) beta-chain usage by HLA-DR1 alloreactive T cell lines was examined to determine whether common TCR gene segments were used preferentially. We have demonstrated previously that a DR1-specific, human renal allograft-derived T cell line and replicate, anti-DR1 mixed lymphocyte reactions (MLR), estab...


    pub_type: 杂志文章


    authors: Hand SL,Alter MD,Finn OJ

    更新日期:1996-04-15 00:00:00

  • Monitoring for HHV-6 infection after renal transplantation: evaluation of risk factors for sustained viral replication.

    abstract:BACKGROUND:Human herpesvirus-6 (HHV-6) is known to reactivate after renal transplantation and has been associated with several clinical manifestations. Risk factors for sustained viral replication, however, remain unclear. METHODS:Thirty consecutive kidney transplant patients were prospectively followed for HHV-6 repl...


    pub_type: 杂志文章


    authors: Luiz CR,Machado CM,Canto CL,Christ SC,Pestana JO,Kotton CN,Camargo LF

    更新日期:2013-03-27 00:00:00

  • The contribution of adhesion molecule expression in donor kidney biopsies to early allograft dysfunction.

    abstract:BACKGROUND:Renal allograft rejection is associated with the expression of adhesion molecules on vascular endothelial and tubular epithelial cells. METHODS:To assess whether the number of cell adhesion molecules expressed in donor kidneys can predict early rejection or delayed graft function, kidney biopsies from 20 li...


    pub_type: 杂志文章


    authors: Schwarz C,Regele H,Steininger R,Hansmann C,Mayer G,Oberbauer R

    更新日期:2001-06-15 00:00:00

  • A method for early detection of graft failure in pancreas transplantation.

    abstract::Pancreatic transplantation is intended to normalize carbohydrate metabolism in insulin-dependent diabetics by restoring endogenous insulin release, and it is usually performed together with kidney transplantation in patients with end-stage renal failure. A major problem in these patients is the daily control of the gr...


    pub_type: 杂志文章


    authors: Secchi A,Pontiroli AE,Traeger J,Dubernard JM,Touraine JL,Ruitton A,Blanc N,Pozza G

    更新日期:1983-04-01 00:00:00

  • How to avoid graft thrombosis requiring graftectomy: immediate posttransplant CT angiography in pancreas transplantation.

    abstract:BACKGROUND:Graft thrombosis immediately after surgery remains a problem for successful pancreas transplantation. The present study evaluated the efficacy of computed tomography (CT) angiography for monitoring of graft patency in the immediate postoperative period. METHODS:The study involved 119 patients who underwent ...


    pub_type: 杂志文章


    authors: Kim YH,Park JB,Lee SS,Byun JH,Kim SC,Han DJ

    更新日期:2012-11-15 00:00:00

  • A prospective controlled trial of cold-storage versus machine-perfusion preservation in cadaveric renal transplantation.

    abstract::A prospective controlled study was carried out in 60 consecutive cadaver renal donors comparing cold storage to pulsatile machine-perfusion preservation. Each donor served as its own control, by allocating one of the kidneys to each of the two preservation methods. There were 51 evaluable pairs of kidneys. Recipient a...


    pub_type: 杂志文章


    authors: Merion RM,Oh HK,Port FK,Toledo-Pereyra LH,Turcotte JG

    更新日期:1990-08-01 00:00:00

  • Finding a place for public preferences in liver allocation decisions.

    abstract::Over the last decade there have been major advances in all aspects of liver transplantation with the consequence that the number of patients who could benefit from the procedure is increasing. As a result, the number of patients listed for liver transplantation is growing while the donor pool is remaining constant or ...


    pub_type: 杂志文章,评审


    authors: Neuberger J,Ubel PA

    更新日期:2000-11-27 00:00:00