Abstract:
BACKGROUND:Anti-thymocyte globulin (ATG) is used frequently as induction therapy in renal transplant recipients. It has been standard practice that the various polyclonal anti-lymphocyte preparations be administered via central line, vascular shunt, or arteriovenous fistula to avoid thrombophlebitis. METHODS:We have safely administered equine ATG (Atgam) via peripheral veins since 1978. We now retrospectively review recent experience with 83 patients transplanted between 1993 and 1998 who received Atgam induction via peripheral vein. Heparin 1000 U and Solucortef 20 mg were added to the infusion. Acetaminophen and diphenhydramine were given before infusion. RESULTS:Only two of 83 patients developed mild edema/erythema at or around the i.v. site. These reactions responded promptly to local management with warm soaks. No phlebitis or symptomatic venous thrombosis occurred in any patients. CONCLUSIONS:Equine ATG can be safely administered via peripheral vein infusion. Its use does not require continued hospitalization or placement of a central line. Peripheral vein infusion is safe, convenient, and economical.
journal_name
Transplantationjournal_title
Transplantationauthors
Rahman GF,Hardy MA,Cohen DJdoi
10.1097/00007890-200005150-00038subject
Has Abstractpub_date
2000-05-15 00:00:00pages
1958-60issue
9eissn
0041-1337issn
1534-6080journal_volume
69pub_type
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