Cells mediating graft rejection in the mouse. II. The Ly phenotypes of cells producing tumor allograft rejection.

Abstract:

:The particular T cell subsets involved in the rejection of tumor allografts were examined in mice using two different approaches. In the first, EL4 lymphoma cells or B16 melanoma cells were given to ATXBM-CBA/H mice which had been reconstituted with either naive or sensitized T cells selectively depleted with either Ly-1 or Ly-2 monoclonal antibodies. In mice receiving nonsensitized T cells, Ly-123 cells and to a lesser extent Ly-1 cells were involved in the rejection of both tumors: Ly-23 cells played no role in this rejection. By contrast, in mice receiving sensitized cells, rejection was mediated by Ly-1 cells and not by Ly-123 or Ly-23 cells. In a second approach, sensitized cells were mixed with the tumor cells prior to injection into mice (the Winn neutralization assay). In this case, Ly-123 cells were the prime mediators of graft rejection. We conclude that both Ly-1 and Ly-123 cells can act as mediators of graft rejection. Ly-1-sensitized cells probably act as in a delayed-type hypersensitivity (DTH) response where few lymphocytes can lead to the rejection of many cells. In addition, Ly-123 cells can act as killer T cells but large numbers and the close apposition with the target cells are required. Our results also demonstrate a requirement for Ly-123 precursor cells in nonsensitized mice, probably acting as precursors for both types of effector cell.

journal_name

Transplantation

journal_title

Transplantation

authors

Loveland BE,McKenzie IF

doi

10.1097/00007890-198202000-00013

subject

Has Abstract

pub_date

1982-02-01 00:00:00

pages

174-80

issue

2

eissn

0041-1337

issn

1534-6080

journal_volume

33

pub_type

杂志文章
  • Outcomes of kidney transplant tourism and risk factors for de novo urothelial carcinoma.

    abstract:BACKGROUND:To date, the outcomes of transplant tourism have not been reported extensively. In addition, data about the accuracy of urine cytology for the detection and the role of the BK virus (BKV) in the carcinogenesis of urothelial carcinoma (UC) after renal transplantation are lacking. METHODS:Three hundred seven ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000000023

    authors: Tsai HL,Chang JW,Wu TH,King KL,Yang LY,Chan YJ,Yang AH,Chang FP,Pan CC,Yang WC,Loong CC

    更新日期:2014-07-15 00:00:00

  • Peripheral blood mononuclear cell responses from type 1 diabetic patients and subjects at-risk for type 1 diabetes to human fetal pancreatic tissue proteins.

    abstract:BACKGROUND:Fetal pancreatic tissue has been suggested to be less immunogenic than adult islets. Thus, transplantation of human fetal pancreatic tissue as treatment for type 1 diabetes has been gaining interest. To investigate this question, we tested the peripheral blood mononuclear cell (PBMC) responses from different...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200005150-00028

    authors: Brooks-Worrell BM,Peterson KP,Peterson CM,Palmer JP,Jovanovic L

    更新日期:2000-05-15 00:00:00

  • Hyperexpression of Foxp3 and IDO during acute rejection of islet allografts.

    abstract:BACKGROUND:We investigated the hypothesis that Foxp3+ cells are an integral component of antiallograft immunity but are dominated by pathogenic effectors. METHODS:Wild-type H-2b C57BL/6 (B6) mice or B6 mice with a targeted disruption of c-Rel gene (c-Rel-/-) were used as recipients of islet grafts from allogeneic DBA/...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000263991.74052.46

    authors: Yang H,Ding R,Sharma VK,Hilaire FS,Lagman M,Li B,Thomas DA,Luo X,Song P,Stauffer C,August P,Suthanthiran M

    更新日期:2007-06-27 00:00:00

  • Activation of autoimmune B cells and chronic rejection.

    abstract::Allotransplantation into immunosuppressed individuals results in long-term survival of grafts. However, the grafts are damaged, probably at many stages before, during and after implantation. The hypothesis to be presented is that release of antigens and autoantigens from the chronically damaged graft results in breaki...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/01.tp.0000153294.38939.5f

    authors: Rose ML

    更新日期:2005-02-15 00:00:00

  • Holmium:yttrium-aluminum-garnet laser endoureterotomy for the treatment of transplant kidney ureteral strictures.

    abstract:BACKGROUND:The management of ureteral strictures in transplanted kidney is challenging. Open surgical treatment is effective but entails significant convalescence. Holmium:yttrium-aluminum-garnet (Ho:YAG) laser endoureterotomy is useful for other types of ureteral obstruction, and we aimed to assess its long-term succe...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31816c7f19

    authors: Gdor Y,Gabr AH,Faerber GJ,Wolf JS Jr

    更新日期:2008-05-15 00:00:00

  • Use of renal allografts from donors positive for hepatitis B core antibody confers minimal risk for subsequent development of clinical hepatitis B virus disease.

    abstract:BACKGROUND:The risk associated with transplantation of renal allografts from hepatitis B virus core antibody-positive (HBcAb(+)), hepatitis B virus surface antigen-negative (HBsAg(-)) donors is not well defined. METHODS:Over 4 years, we performed 45 kidney transplants from IgG HBcAb(+), IgM HBcAb(-), HBsAg(-) donors i...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199712270-00027

    authors: Madayag RM,Johnson LB,Bartlett ST,Schweitzer EJ,Constantine NT,McCarter RJ Jr,Kuo PC,Keay S,Oldach DW

    更新日期:1997-12-27 00:00:00

  • Beneficial effect of pentoxifylline on microvesicular steatotic livers submitted to a prolonged cold ischemia.

    abstract:BACKGROUND:The deleterious effect of steatosis on transplanted livers is mainly related to a microcirculation impairment. We investigated the effect of preservation duration on the recovery of isolated perfused rat steatotic livers and tested the effect of pentoxifylline (PTX), known to have a beneficial effect on hepa...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000071846.35825.B1

    authors: Arnault I,Bao YM,Sebagh M,Anjo A,Dimicoli JL,Lemoine A,Delvart V,Adam R

    更新日期:2003-07-15 00:00:00

  • CD4 Th2 cells do not functionally suppress CTL generation in neonatal tolerant mice.

    abstract::Injecting semiallogeneic CAF1 spleen into BALB/c newborn mice renders mice tolerant, and the majority of mice show prolonged survival of tolerogen-bearing A/J skin grafts. Moreover, graft survival is associated with enhanced Th2 cytokine responses and graft rejection with Th1 cytokine responses. To further delineate t...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Gao Q,Chen N,Field EH

    更新日期:1995-12-15 00:00:00

  • Antigen-specific immunosuppression induced by liver transplantation in the rat.

    abstract::We have demonstrated that DA hearts grafted into PVG rats were completely protected from rejection by simultaneous liver transplantation from the same donor. In subsequent experiments PVG animals were given DA hearts followed 5 or 6 days later by livers from the same donor strain. Instead of the expected rapid rejecti...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198409000-00004

    authors: Kamada N,Wight DG

    更新日期:1984-09-01 00:00:00

  • Carotid atherosclerosis in renal transplant recipients: relationships with cardiovascular risk factors and plasma lipoproteins.

    abstract:BACKGROUND:Renal transplant recipients have an increased incidence of cardiovascular disease, but less data exist about cerebrovascular atherosclerosis. In this study, we assessed the prevalence of carotid lesions as evaluated by B-mode ultrasonography in a group of renal transplant recipients, and we evaluated univari...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199902150-00005

    authors: Barbagallo CM,Pinto A,Gallo S,Parrinello G,Caputo F,Sparacino V,Cefalù AB,Novo S,Licata G,Notarbartolo A,Averna MR

    更新日期:1999-02-15 00:00:00

  • The Impact of Liver Graft Injury on Cancer Recurrence Posttransplantation.

    abstract::Liver transplantation is the most effective treatment for selected patients with hepatocellular carcinoma. However, cancer recurrence, posttransplantation, remains to be the critical issue that affects the long-term outcome of hepatocellular carcinoma recipients. In addition to tumor biology itself, increasing evidenc...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/TP.0000000000001844

    authors: Li CX,Man K,Lo CM

    更新日期:2017-11-01 00:00:00

  • Use of recipient's left hepatic artery for artery reconstruction in right lobe living donor liver transplantation with duct-to-duct anastomosis.

    abstract:BACKGROUND:The hepatic arteries (HAs) in a hepatic graft are usually reconstructed using the recipient's left or right HAs in living donor liver transplantation (LDLT). There have been no apparent selection criteria concerning which of the recipient's HAs should be used. This study retrospectively investigated whether ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/tp.0b013e3181ce77c4

    authors: Uchiyama H,Ikegami T,Soejima Y,Ninomiya M,Kayashima H,Taketomi A,Shirabe K,Maehara Y

    更新日期:2010-04-27 00:00:00

  • Histologic findings in islets of whole pancreas allografts: lack of evidence for recurrent cell-mediated diabetes mellitus.

    abstract::Cell-mediated cytotoxicity directed toward pancreatic islets plays a significant role in the pathogenesis of type 1 diabetes mellitus. Histologically, autoimmune insulitis appears as mononuclear infiltrates that precede actual beta cell loss. Experimental studies by Bartlett et al. on the BB rat model suggest that who...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199612270-00014

    authors: Drachenberg CB,Papadimitriou JC,Weir MR,Klassen DK,Hoehn-Saric E,Bartlett ST

    更新日期:1996-12-27 00:00:00

  • Increased interleukin-10 production without expansion of CD4+CD25+ T-regulatory cells in early stable renal transplant patients on calcineurin inhibitors.

    abstract:BACKGROUND:Increasing long-term allograft survival is the main challenge in organ transplantation, and allograft loss due to chronic rejection has been found to correlate with episodes of early acute rejection. It is important to understand the mechanisms that maintain the donor-specific hyporesponsive state. This stud...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1097/TP.0b013e3181af20fd

    authors: Mittal SK,Sharma RK,Gupta A,Naik S

    更新日期:2009-08-15 00:00:00

  • Liver procurement without in situ portal perfusion. A safe procedure for more flexible multiple organ harvesting.

    abstract::The outcome after liver transplantation when grafts were retrieved from the donor by the classical aortic and portal cooling (APC) method was compared with the outcome when exclusively aortic in situ perfusion (AC) was used. Retrospectively, 163 donor hepatectomies performed over a 20-month period were reviewed to ana...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199405150-00007

    authors: de Ville de Goyet J,Hausleithner V,Malaise J,Reding R,Lerut J,Jamart J,Barker A,Otte JB

    更新日期:1994-05-15 00:00:00

  • Porcine endothelium supports transendothelial migration of human leukocyte subpopulations: anti-porcine vascular cell adhesion molecule antibodies as species-specific blockers of transendothelial monocyte and natural killer cell migration.

    abstract:BACKGROUND:In cases where hyperacute rejection has been prevented, pig to primate organ transplantation results in a delayed rejection mediated by graft-infiltrating leukocytes. The migration of human leukocytes across porcine endothelium is poorly characterized, but may offer targets for species-specific antirejection...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200005150-00018

    authors: Hauzenberger E,Hauzenberger D,Hultenby K,Holgersson J

    更新日期:2000-05-15 00:00:00

  • Treatment and prevention of acute graft-versus-host disease with thalidomide in a rat model.

    abstract::We have investigated the immunosuppressive effects of thalidomide (Thal) in a bone marrow transplant (BMT) model for graft-versus-host disease (GVHD). Lewis rats received RT1-incompatible marrow transplants from ACI rats after total-body irradiation. Twenty-two of twenty-three rats with established severe acute GVHD w...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198605000-00018

    authors: Vogelsang GB,Hess AD,Gordon G,Santos GW

    更新日期:1986-05-01 00:00:00

  • Influence of prophylactic treatment with gamma-immunoglobulins on renal function after kidney transplantation in rhesus monkeys.

    abstract::The effect of prophylactic i.v. administration of high doses of human gamma-immunoglobulin (IgG) on kidney graft survival was investigated in rhesus monkeys treated with azathioprine and prednisolone. In nontransfused recipients not treated with IgG (controls), graft survival ranged from 9 to 22 days; if nontreated an...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198201000-00006

    authors: Borleffs JC,Marquet RL,de By-Aghai Z,Dolkart RE,Persijn GG,Balner H

    更新日期:1982-01-01 00:00:00

  • Major histocompatibility complex class I peptide-pulsed host dendritic cells induce antigen-specific acquired thymic tolerance to islet cells.

    abstract:BACKGROUND:As T-cell receptor-major histocompatibility complex (MHC) class I/self peptide interaction regulates T-cell development in the thymus, we reasoned that presentation of peptides by self dendritic cells (DC) to developing T cells in the thymus might induce acquired thymic tolerance. This hypothesis is based on...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200001270-00005

    authors: Ali A,Garrovillo M,Jin MX,Hardy MA,Oluwole SF

    更新日期:2000-01-27 00:00:00

  • Prolonged allogeneic marrow engraftment following nonmyeloablative conditioning using 100 cGy total body irradiation and pentostatin before and pharmacological immunosuppression after transplantation.

    abstract::In a canine model of dog leukocyte antigen (DLA)-identical nonmyeloablative marrow transplantation including postgrafting immunosuppression with cyclosporine (CSP) and mycophenolate mofetil (MMF), engraftment was only transient with 100 cGy total body irradiation (TBI) conditioning, indicating suboptimal pretransplant...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000181168.42461.0b

    authors: Panse JP,Storb R,Storer B,Santos EB,Wentzel C,Sandmaier BM

    更新日期:2005-11-27 00:00:00

  • Clinical and laboratory evaluation of the safety of a bioartificial liver assist device for potential transmission of porcine endogenous retrovirus.

    abstract:BACKGROUND:The potential risk of transmission of porcine endogenous retroviruses (PERV) from xenogeneic donors into humans has been widely debated. Because we were involved in a phase I/II clinical trial using a bioartificial liver support system (BLSS), we proceeded to evaluate the biosafety of this device. MATERIALS...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200202150-00017

    authors: Kuddus R,Patzer JF 2nd,Lopez R,Mazariegos GV,Meighen B,Kramer DJ,Rao AS

    更新日期:2002-02-15 00:00:00

  • Effect of everolimus introduction on cardiac allograft vasculopathy--results of a randomized, multicenter trial.

    abstract:BACKGROUND:Everolimus reduces the progression of cardiac allograft vasculopathy (CAV) in de novo heart transplant (HTx) recipients, but the influence on established CAV is unknown. METHODS:In this Nordic Certican Trial in Heart and lung Transplantation substudy, 111 maintenance HTx recipients (time post-HTx 5.8 ± 4.3 ...

    journal_title:Transplantation

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/TP.0b013e31822057f1

    authors: Arora S,Ueland T,Wennerblom B,Sigurdadottir V,Eiskjær H,Bøtker HE,Ekmehag B,Jansson K,Mortensen SA,Saunamaki K,Simonsen S,Gude E,Bendz B,Solbu D,Aukrust P,Gullestad L

    更新日期:2011-07-27 00:00:00

  • Long-term renal allograft survival: prognostic implication of the timing of acute rejection episodes.

    abstract:BACKGROUND:The timing of an acute rejection may have a variable impact on renal allograft survival. To determine whether the time of first acute transplant rejection (ATR) is an independent predictor of long-term allograft survival, we studied 31,600 first cadaveric renal transplants that were functional on the first t...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199705150-00013

    authors: Leggat JE Jr,Ojo AO,Leichtman AB,Port FK,Wolfe RA,Turenne MN,Held PJ

    更新日期:1997-05-15 00:00:00

  • Induction of antiidiotypic antibodies by blood transfusions. Characterization of T cell alloantigen-specific receptors by sera from transfused mice.

    abstract::Balb/c (H-2d) mice were transfused weekly with 0.1 ml of whole blood from C3H (H-2k) mice. One week after 3 blood transfusions (BT), the mice were bled and the sera collected and pooled. The 3BT serum was absorbed twice with C3H lymphocytes and IgG isolated by ion-exchange chromatography. Balb/c anti-C3H, Balb/c anti-...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198612000-00011

    authors: Singal DP,Ludwin D,Joseph S,Blajchman MA,Ofosu FA,Liao SK

    更新日期:1986-12-01 00:00:00

  • Antibodies to hepatitis C virus envelope proteins correlate with hepatitis C viraemia after liver transplantation.

    abstract:BACKGROUND:Liver transplant recipients for hepatitis C virus (HCV)-related cirrhosis usually remain anti-HCV-seropositive after transplantation. The aim of this study was to characterize, longitudinally, the profile of HCV-specific antibodies and cryoglobulins in liver transplant recipients with recurrent HCV infection...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199901150-00013

    authors: Gane EJ,Maertens G,Ducatteeuw A,Qian KP,Lau JY,Jones H,Davies E,Naoumov NV,Williams R

    更新日期:1999-01-15 00:00:00

  • Endothelial dysfunction and fetuin A levels before and after kidney transplantation.

    abstract:BACKGROUND:Endothelial dysfunction (ED) has a major role in the cardiovascular outcome of patients with chronic kidney disease (CKD). The aim of this study was to investigate the relation between fetuin A levels and ED in kidney transplant recipients. METHODS:Forty-two living donor kidney transplant recipients, 21 (11...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000251647.72673.c7

    authors: Caglar K,Yilmaz MI,Saglam M,Cakir E,Kilic S,Eyileten T,Sonmez A,Oguz Y,Oner K,Ors F,Vural A,Yenicesu M

    更新日期:2007-02-27 00:00:00

  • Molecular Imaging of Acute Cardiac Transplant Rejection: Animal Experiments and Prospects.

    abstract::Acute rejection (AR) remains the biggest challenge during the first year after heart transplantation despite advances in immunosuppressive therapy. The early detection and curbing of AR are crucial to the survival of transplant recipients. However, as the criterion standard for AR, endomyocardial biopsy has several li...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/TP.0000000000001780

    authors: Chen Y,Zhang L,Liu J,Zhang P,Chen X,Xie M

    更新日期:2017-09-01 00:00:00

  • Alteration in CD45RBhi/CD45RBlo T-cell ratio following CD45RB monoclonal-antibody therapy occurs by selective deletion of CD45RBhi effector cells.

    abstract::Tolerance induction by CD45RB monoclonal antibody (mAb) in murine allograft models is associated with an alteration in the CD45RBlo/CD45RBhi T-cell ratio in favor of CD45RBlo T cells, which can function as regulatory cells and promote tolerance. It has been proposed that inversion of the CD45RBhi/CD45RBlo normal T-cel...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000072373.77323.D4

    authors: Luke PP,Deng JP,O'Brien CA,Everest M,Hall AV,Chakrabarti S,O'Connell PJ,Zhong R,Jevnikar AM

    更新日期:2003-07-27 00:00:00

  • Thymectomy impairs but does not uniformly abrogate long-term acceptance of semi-identical liver allograft in inbred miniature Swine temporarily treated with FK506.

    abstract:BACKGROUND:Long-term acceptance of semi-identical orthotopic liver transplants (OLTs) in inbred swine is induced by a 12-day course of FK506. To study whether acceptance is attributable to central or peripheral immune mechanisms, the effect of complete thymectomy was determined. METHODS:Total thymectomy was performed ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000121762.47432.15

    authors: Uryuhara K,Ambiru S,Dehoux JP,Oike F,Talpe S,Gianello P

    更新日期:2004-04-27 00:00:00

  • Transplantation of segmental rat intestinal grafts including the ileocecal value and the ascending colon.

    abstract::Extrinsic denervation and lymphatic disruption impair nutrient absorption after small bowel transplantation. The present study was undertaken to determine whether adding the ileocecal valve with or without the ascending colon would improve the function of a segmental intestinal graft. Five groups of Lewis rats (n = 10...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Black RT,Hashimoto T,Zhong RZ,Behme RJ,Garcia BM,Duff JH,Grant DR

    更新日期:1994-04-15 00:00:00