Abstract:
BACKGROUND:We previously showed that bortezomib (BTZ) partially depletes plasma cells, yet has limited efficacy for desensitization in kidney transplant candidates when up to 16 doses is given. METHODS:This study aimed to determine the safety and efficacy of 32 doses of BTZ (1.3 mg/m of body surface area) in 10 highly sensitized kidney transplant candidates with alloantibodies against their intended living donor. RESULTS:Dose reduction was needed in 2 patients and 2 others completely discontinued therapy for adverse events. Anti-HLA antibodies mean fluorescence intensity (MFI) values were stable prior to BTZ (P = 0.96) but decreased after therapy (mean decrease of 1916 [SE, 425] MFI, P < 0.01). No patient developed a negative crossmatch against their original intended donor, and the calculated panel-reactive antibodies based on MFI of 2000, 4000, and 8000 was unchanged in all patients. CONCLUSIONS:These data suggest that 32 doses of BTZ monotherapy was not well tolerated and resulted in only a modest reduction in anti-HLA antibodies.
journal_name
Transplantationjournal_title
Transplantationauthors
Moreno Gonzales MA,Gandhi MJ,Schinstock CA,Moore NA,Smith BH,Braaten NY,Stegall MDdoi
10.1097/TP.0000000000001330subject
Has Abstractpub_date
2017-06-01 00:00:00pages
1222-1227issue
6eissn
0041-1337issn
1534-6080journal_volume
101pub_type
临床试验,杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:Infectious complications occur in approximately 50% of cadaveric liver transplant (CDLT) recipients. Living-donor liver transplantation (LDLT) is an established alternative to shorten the waiting time. Currently, the incidence of pulmonary infections after LDLT and the microbiologic causes are unknown. In th...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31816f61a6
更新日期:2008-06-15 00:00:00
abstract::In liver allograft rejection, interlobular bile ducts are thought to be the main target of rejection. In contrast, in other organ allografts the capillary bed of the graft appears to be the primary target. To determine whether portal tract microvasculature is destroyed in liver allografts during rejection, we have ide...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199307000-00012
更新日期:1993-07-01 00:00:00
abstract::Hemorrhagic cystitis (HC) is a major cause of morbidity after BMT; we have analyzed its incidence, risk factors, and complications in 977 patients undergoing BMT between 1974 and 1988. Despite vigorous hydration and frequent voiding in all patients receiving cyclophosphamide, 135/977 (15% by Kaplan-Meier projection) d...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199310000-00020
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND:Bone marrow transplantation (BMT) for class 3 patients with thalassemia is challenging due to high rates of graft rejection and transplant-related mortality. Since the first studies of BMT in the late 1980s, a number of conditioning regimens have been designed to improve outcomes, but with suboptimal results...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000928
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Suppressive dendritic cells (DCs) are a promising tool for tolerance induction in transplantation. A human DCs subpopulation, which constitutively expresses indoleamine-2,3-dioxygenase (IDO), a molecule shown to prevent the rejection of fetus during pregnancy, has recently been described. This subset, charac...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000251646.09702.ec
更新日期:2007-02-27 00:00:00
abstract:BACKGROUND:Immunosuppression in renal transplantation, although manageable in the short-term, is a major hurdle for long-term graft survival. Recently, increased frequencies of CD4CD25 regulatory T cells (Tregs) have been described as an additional mechanism that induces alloimmune tolerance. METHODS:We assessed 64 re...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000229473.95202.50
更新日期:2006-08-27 00:00:00
abstract:BACKGROUND:We previously reported the novel activity of alloprimed CD8 T cells that suppress posttransplant alloantibody production. The purpose of the study is to investigate the expression and role of CXCR5 on antibody-suppressor CD8 T-cell function. METHODS:C57BL/6 mice were transplanted with FVB/N hepatocytes. All...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002683
更新日期:2019-09-01 00:00:00
abstract::Mice given a pretransplant i.v. infusion of spleen cells from donors incompatible with the recipients with respect to individual minor H antigens exhibit a delayed rejection of skin grafts from these incompatible donors. Attempts were made to detect suppressor T cells, possibly induced by the i.v. infusion of donor ce...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199001000-00034
更新日期:1990-01-01 00:00:00
abstract::The effect of cyclosporin A was tested in a heterotopic cardiac xenograft model, in which hamster hearts were implanted into LEW rats. Despite the presence of low titers of rat anti-hamster lymphocytotoxic antibodies immediate rejection of the hamster hearts did not occur, suggesting that this model represented a xeno...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198103000-00004
更新日期:1981-03-01 00:00:00
abstract:BACKGROUND:After the discontinuation of the manufacturing Liberase HI because of a small potential for prion disease transmission, Roche Diagnostics (Indianapolis, IN) developed a new enzyme product (Liberase MTF [mammalian tissue free]), which is similar to Liberase HI with the exception that no mammalian tissue is us...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181e117ce
更新日期:2010-08-15 00:00:00
abstract:BACKGROUND:Although islet xenotransplantation is a promising therapy for type 1 diabetes, its clinical application has been hampered by cellular rejection and the requirement for high levels of immunosuppression. The aim of this study was to determine the role of Foxp3 regulatory T (Treg) cells in costimulation blockad...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001482
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Extensive third degree burn wounds can be permanently covered by the transplantation of autologous cultured keratinocytes. Many modifications to Green and colleagues' original technique have been suggested, including the use of a fibrin matrix. However, the properties of the cultured cells must be assessed u...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200012150-00009
更新日期:2000-12-15 00:00:00
abstract::Endothelial cells, one of several in vivo host cells for cytomegalovirus (CMV), participate in solid organ allograft rejection in part through the expression of leukocyte adhesion molecules. The hypothesis that CMV infection alters the constitutive and induced expression of ELAM-1, ICAM-1, and VCAM-1 on infected human...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1994-12-27 00:00:00
abstract::It was the objective of these experiments to study the time-related changes in the responsiveness of the cellular elements of the immune system following contact with single non-H-2 or multiple H-2 histocompatibility antigens. The reactivity of spleen cells from mice that received injections of spleen cells bearing H-...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198802000-00047
更新日期:1988-02-01 00:00:00
abstract:BACKGROUND:Most transplant centers in the United States, including our own, use creatinine clearance (Ccr) to estimate glomerular filtration rate (GFR) in potential living kidney donors. The purpose of this study was to evaluate our experience with estimation of donor GFR by Ccr and to explore other potential strategie...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200101270-00016
更新日期:2001-01-27 00:00:00
abstract::Cytomegalovirus remains a significant source of morbidity and mortality in immunocompromised hosts. The increased sensitivity of molecular diagnostic techniques (PCR, antigenemia) has resulted in our ability to detect viral replication earlier in the posttransplant period, before the onset of symptoms. With the advent...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199701270-00017
更新日期:1997-01-27 00:00:00
abstract:BACKGROUND:The emergence of a ganciclovir (GCV)-resistant human cytomegalovirus (HCMV) strain in a heart transplant recipient (HTR) coinfected by multiple HCMV strains was investigated. METHODS:A HTR with primary HCMV infection was treated with three induction courses of intravenous GCV followed by a 2-month maintenan...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199808150-00008
更新日期:1998-08-15 00:00:00
abstract::Sprague-Dawley rats were treated for 14 days with rapamycin (RAP; 1.5 mg/kg/day i.p.), cyclosporine (15 mg/kg/day by gavage), both drugs in combination, or appropriate drug vehicles. Hematological parameters and biochemical indices of renal and hepatic function were determined throughout the experimental period, at th...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199108000-00004
更新日期:1991-08-01 00:00:00
abstract::Cytomegalovirus disease is an important cause of morbidity following liver transplantation. To date there has not been an effective prophylaxis for CMV disease after liver transplantation. One hundred forty-three patients were randomized to receive either high dose oral acyclovir (800 mg 4 times a day) alone for 3 mon...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007890-199410150-00005
更新日期:1994-10-15 00:00:00
abstract:BACKGROUND:Operational tolerance is defined as long-term acceptance of a transplanted organ after complete cessation of immunosuppression (IS), but may not always protect against antigen-dependent changes in graft morphology. METHOD:IS free patients after living-donor liver transplantation (LDLT) underwent protocol bi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318195a7cb
更新日期:2009-02-27 00:00:00
abstract:BACKGROUND:Many reports of successful early withdrawal of regular maintenance steroids in transplant recipients have appeared in recent years. The question now arises whether, in the current age of powerful nonsteroidal immunosuppressants such as Neoral and Tacrolimus, routine administration of steroids posttransplant ...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007890-199910270-00021
更新日期:1999-10-27 00:00:00
abstract:BACKGROUND:In the acute rejection of allografts, the interaction between Fas (CD95) and its ligand (FasL; CD95L) has been shown to be involved in mediating apoptotic cell death. The role, however, of these molecules in the pathogenesis of transplant vascular sclerosis is as yet undetermined. The present study was there...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199905270-00001
更新日期:1999-05-27 00:00:00
abstract:BACKGROUND:This study aimed at investigating the efficacy of the novel immunosuppressant FK778 to prevent the development and progression of chronic allograft vasculopathy (CAV). METHODS:Orthotopic aortic transplantations were performed in the PVG-to-ACI rat model and followed over the course of 120 days. Immunosuppre...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181673608
更新日期:2008-03-27 00:00:00
abstract::Suppressor cell activity in the spleen of 4-5-day-old mice is high and can be assayed in mixed lymphocyte cultures. The suppressor cells inhibit the proliferation of adult mouse spleen cells responding in vitro to an allogeneic stimulus. This suppressor cell activity can be increased by injecting the mice, on the day ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198409000-00010
更新日期:1984-09-01 00:00:00
abstract:BACKGROUND:Geographic variation in kidney transplantation rates in the United States has been described previously but remains unexplained by age, race, sex, or socioeconomic status differences. Geographic variations in the concentration of poverty appear to impact end-stage renal disease care and potentially access to...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000125
更新日期:2014-09-27 00:00:00
abstract:BACKGROUND:Deoxyspergualin (DSG), a potent immunosuppressive drug, has been clinically used as a rescue therapy for acute graft rejection. However, DSG has severe adverse effects that limits its use. Here, we examined the optimized therapeutic protocol for DSG using chronopharmacological profiles of it. METHODS:First,...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199905150-00012
更新日期:1999-05-15 00:00:00
abstract:BACKGROUND:In transplantation, novel methods are required to augment the supply of donor organs. We report the first domino liver transplant in which a patient with familial amyloid polyneuropathy (FAP) received an orthotopic split liver graft, and her explanted liver was donated to another patient. Three successful li...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199806150-00016
更新日期:1998-06-15 00:00:00
abstract::Invasive aspergillosis and mucormycosis are life-threatening infections in solid organ and hematopoietic cell transplant recipients. Despite medical advancements in the care of these patients and the availability of new mold-active drugs, the outcomes remain suboptimal. Therefore, there has been increased interest in ...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000002353
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Although the value of duodenal histology as a means to diagnose acute rejection in pancreaticoduodenal allografts has been validated, it is not known how the duodenum responds to antirejection treatment in comparison with the pancreas. METHODS:Diabetic Lewis rats received a pancreaticoduodenal allograft. Cy...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200201270-00008
更新日期:2002-01-27 00:00:00
abstract::Acute antibody-mediated rejection (AAR) of mouse skin allografts was studied in nine donor-recipient combinations with increasing histoincompatibility ranging from an H-Y to a complete H-2 plus on-H-2 disparity. AAR was induced by the injection of specific alloantiserum along with a heterologous complement on day 7 af...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197709000-00002
更新日期:1977-09-01 00:00:00