Kidney transplantation and the intensity of poverty in the contiguous United States.

abstract：:We investigated the preventive effect of the immunosuppressive agent FK506 on autoimmune insulitis in nonobese diabetic mice. The mice were given FK506 in a dose of 1.0 mg/kg, every other day, from age 2 to 12, 2 to 6, and 4 to 12 weeks, respectively; after which, the incidence of insulitis and overt diabetes was moni...

journal_title：Transplantation

authors： Kai N,Motojima K,Tsunoda T,Kanematsu T

更新日期：1993-04-01 00:00:00

abstract：:We have tested the predictive model for risk of sensitization by donor-specific transfusions developed at the University of California, San Francisco for its applicability to the DST experience at UW/Madison. Patient sample sizes between the two groups were similar (n = 249 for UW/Madison, n = 261 for UCSF) and the tw...

journal_title：Transplantation

authors： Burlingham WJ,Stratta R,Mason B,Lorentzen D,Feyzi J,Sollinger HW,Belzer FO

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Humanized Fc receptor (FcR)-nonbinding antibodies against CD3 are promising immunosuppressive agents that may overcome both the neutralizing response to and the cytokine release syndrome seen with conventional monoclonal antibodies against CD3. In addition, evidence from several murine models suggests that t...

journal_title：Transplantation

authors： Chau LA,Tso JY,Melrose J,Madrenas J

更新日期：2001-04-15 00:00:00

abstract：BACKGROUND:Decapeptides derived from human HLA class I sequences have been shown to prolong allograft survival. The mechanism of action of these peptides has been uncertain, because they act in an MHC unrestricted manner. Recently, it was found that these peptides bind heme oxygenase 1 (HO-1). In the present study, we ...

journal_title：Transplantation

authors： DeBruyne LA,Magee JC,Buelow R,Bromberg JS

更新日期：2000-01-15 00:00:00

abstract：:Progressive microvascular endothelial damage is a characteristic feature of fulminant acute cardiac allograft rejection in the rat. Serial ultrastructural tracer studies using i.v. administered colloidal carbon and horseradish peroxidase have been performed in an adoptive transfer model to determine the role of cellul...

journal_title：Transplantation

authors： Lowry RP,Forbes RD

更新日期：1984-02-01 00:00:00

abstract：BACKGROUND:Renal dysfunction early after kidney transplantation has multiple causes including ischemia-reperfusion (I/R) injury and drug-induced nephrotoxicity. This study assesses the acute nephrotoxicity of tacrolimus (Tac) and sirolimus (Sir) in a rat renal isograft model. METHODS:Lewis renal isografts and uninephr...

journal_title：Transplantation

authors： Ninova D,Covarrubias M,Rea DJ,Park WD,Grande JP,Stegall MD

更新日期：2004-08-15 00:00:00

abstract：:Increased susceptibility to bacterial infection is a recognized side-effect of sirolimus treatment after transplantation, which could be caused by inhibition of neutrophil activation. Blood from 24 healthy subjects was equilibrated with 0 to 50 ng/mL sirolimus or 60 microg/mL propofol. Blood was also collected from 23...

journal_title：Transplantation

authors： Gee I,Trull AK,Charman SC,Alexander GJ

更新日期：2003-12-27 00:00:00

abstract：BACKGROUND:Immunomodulatory protocols including intravenous immunoglobulin/rituximab (IVIG/R) are employed to decrease anti-human leukocyte antigen (HLA) antibody levels for patients broadly sensitized to HLA and increase chances for transplantation with a compatible deceased donor (DD). The aim of our study was to ide...

journal_title：Transplantation

authors： Lai CH,Cao K,Ong G,Naim M,Wang Q,Mirocha J,Vo A,Jordan SC,Reinsmoen NL

更新日期：2011-07-15 00:00:00

abstract：METHODS:Two hundred twenty-three recipients of first cadaveric kidney allografts were randomized to receive tacrolimus (TAC) + mycophenolate mofetil (MMF), TAC + azathioprine (AZA), or cyclosporine (Neoral; CsA) + MMF. All regimens contained corticosteroids, and antibody induction was used only in patients who experien...

journal_title：Transplantation

authors： Gonwa T,Johnson C,Ahsan N,Alfrey EJ,Halloran P,Stegall M,Hardy M,Metzger R,Shield C 3rd,Rocher L,Scandling J,Sorensen J,Mulloy L,Light J,Corwin C,Danovitch G,Wachs M,VanVeldhuisen P,Leonhardt M,Fitzsimmons WE

更新日期：2003-06-27 00:00:00

abstract：:In this report we describe a modified, sensitive MLR test that appears to detect fine antigenic disparities between HLA-identical siblings confirmed as such by serology and the standard MLR test. In a group of 40 consecutive allogeneic bone marrow transplants, reactivity detected by the modified MLR test correlated wi...

journal_title：Transplantation

authors： Bishara A,Brautbar C,Nagler A,Slavin S,Leshem B,Cohen I,Kedar E

更新日期：1994-05-27 00:00:00

abstract：:Recent reports document the efficacy of transjugular intrahepatic portocaval shunts (TIPS) for the prevention of portal hypertensive bleeding and have advocated its use as a bridge to liver transplantation. There are no reports, however, analyzing liver transplant results for patients with indwelling TIPS. We reviewed...

journal_title：Transplantation

authors： Freeman RB Jr,FitzMaurice SE,Greenfield AE,Halin N,Haug CE,Rohrer RJ

更新日期：1994-08-15 00:00:00

abstract：BACKGROUND:When a deceased-donor kidney is offered to a waitlisted candidate, the decision to accept or decline the organ relies primarily upon a practitioner's experience and intuition. Such decisions must achieve a delicate balance between estimating the immediate benefit of transplantation and the potential for futu...

journal_title：Transplantation

authors： Bertsimas D,Kung J,Trichakis N,Wojciechowski D,Vagefi PA

更新日期：2017-12-01 00:00:00

abstract：:Histoincompatibility was analyzed to describe as precisely as possible the sequence of gross morphological events taking place during allograft rejection among closely related conspecifics from a natural population of the bisexual lizard Cnemidophorus tigris. Two types of rejection were noted, depending on whether the...

journal_title：Transplantation

authors： Cuellar O,Smart C

更新日期：1977-08-01 00:00:00

abstract：:Despite previous attempts there is currently no suitable animal model available for xenogeneic graft versus host disease (XGVHD) mediated via human immunocompetent cells. Recently, we have developed an efficient protocol to engraft SCID mice with human peripheral blood lymphocytes (Hu-PBLs). The engraftment efficiency...

journal_title：Transplantation

authors： Sandhu JS,Gorczynski R,Shpitz B,Gallinger S,Nguyen HP,Hozumi N

更新日期：1995-07-27 00:00:00

abstract：BACKGROUND:In clinical transplantation, "passenger" dendritic cells (DCs) in the allograft have been thought to induce allograft rejection. However, the presence of DCs in the normal human kidney is controversial. Most reports have relied on the examination of MHC class I and II antigen expression in combination with D...

journal_title：Transplantation

authors： Sonderbye L,Meehan S,Palsson R,Ahsan N,Ladefoged J,Langhoff E

更新日期：1998-04-15 00:00:00

abstract：:Patients with renal transplants that survive the first year often ask about the chance of long-term function. We studied 1850 patients with primary transplants from June 7, 1963 to September 1, 1988 who had graft survival of greater than 1 year. Patients were grouped by donor type, diabetic status, and whether or not ...

journal_title：Transplantation

authors： Fischel RJ,Payne WD,Gillingham KJ,Dunn DL,Sutherland DE,Matas AJ,Najarian JS

更新日期：1991-01-01 00:00:00

abstract：:Fifty seven recipients of renal allografts initially treated with CsA and low-dose prednisone were switched to azathioprine and low-dose steroids. Ten had prolonged (greater than 28 days) allograft nonfunction after transplantation (group 1), 8 had ongoing, poorly controlled rejection (group 2), and 39 had stable func...

journal_title：Transplantation

authors： Rocher LL,Milford EL,Kirkman RL,Carpenter CB,Strom TB,Tilney NL

更新日期：1984-12-01 00:00:00

abstract：OBJECTIVE:Exact knowledge of biliary anatomy is essential in living donor liver transplantation. The purpose of this study was to evaluate the accuracy of pretransplant magnetic resonance cholangiography (MRC) in depicting the biliary anatomy in comparison with intraoperative cholangiography (IOC). MATERIALS AND METHO...

journal_title：Transplantation

authors： Hsu HW,Tsang LL,Yap A,Huang TL,Chen TY,Lin TS,Concejero AM,Ou SY,Yu CY,Chen CL,Cheng YF

更新日期：2011-07-15 00:00:00

abstract：:Anti-CD3 mAbs are potent inhibitors of T cell function; however, administration of mitogenic mAb can cause significant morbidity secondary to T cell activation and cytokine release. Nonmitogenic anti-CD3 mAb is immunosuppressive in mice without inducing detectable morbidity, and may thus be preferable for in vivo T ce...

journal_title：Transplantation

authors： Sawchuk SS,Gates R,Hirsch R

更新日期：1995-12-15 00:00:00

abstract：BACKGROUND:Urothelial carcinoma (UC) is a common complication after renal replacement therapy (RRT) among Chinese end-stage renal disease (ESRD) patients. It is unclear whether there are any differences in the clinicopathologic characteristics of UC between renal transplantation (RT) and dialysis patients; such differe...

journal_title：Transplantation

authors： Zhang B,Shen C,Han WK,Yu W

更新日期：2014-09-15 00:00:00

abstract：:Since calcium channel blocking agents and CsA exert an antiproliferative effect upon T cell mitogenesis, we have compared and characterized their immunosuppressive properties at the level of gene activation. Verapamil (greater than or equal to 30 microM), which blocks T cell mitogenesis and a rise in cytosolic calcium...

journal_title：Transplantation

authors： Walz G,Zanker B,Wieder K,Hadro E,Moscovitch-Lopatin M,Smith BR,Strom TB

更新日期：1989-02-01 00:00:00

abstract：:We developed a multiplex, quantitative, real-time, polymerase chain reaction assay for cytomegalovirus (CMV) and used it to measure the CMV viral load in weekly blood specimens from 43 lung transplant recipients. The median viral load in blood samples immediately preceding bronchoscopy was 1150 copies/microg human DNA...

journal_title：Transplantation

authors： Sanchez JL,Kruger RM,Paranjothi S,Trulock EP,Lynch JP,Hicks C,Shannon WD,Storch GA

更新日期：2001-08-27 00:00:00

abstract：BACKGROUND:Circulating transthyretin (TTR) is derived from the liver, and orthotopic liver transplantation (OLT) is widely performed for variant TTR-associated familial amyloid polyneuropathy (FAP). The effect of OLT on FAP-related cardiac amyloid is of particular interest because wild-type TTR can itself be deposited ...

journal_title：Transplantation

authors： Stangou AJ,Hawkins PN,Heaton ND,Rela M,Monaghan M,Nihoyannopoulos P,O'Grady J,Pepys MB,Williams R

更新日期：1998-07-27 00:00:00

abstract：:Cytomegalovirus remains a significant source of morbidity and mortality in immunocompromised hosts. The increased sensitivity of molecular diagnostic techniques (PCR, antigenemia) has resulted in our ability to detect viral replication earlier in the posttransplant period, before the onset of symptoms. With the advent...

journal_title：Transplantation

authors： Abecassis MM,Koffron AJ,Kaplan B,Buckingham M,Muldoon JP,Cribbins AJ,Kaufman DB,Fryer JP,Stuart J,Stuart FP

更新日期：1997-01-27 00:00:00

abstract：BACKGROUND:The strategy of evaluating every donation opportunity warrants an investigation into the financial feasibility of this practice. The purpose of this investigation is to measure resource utilization required for procurement of transplantable organs in an organ procurement organization (OPO). METHODS:Donors w...

journal_title：Transplantation

authors： DuBay DA,Redden DT,Bryant MK,Dorn DP,Fouad MN,Gray SH,White JA,Locke JE,Meeks CB,Taylor GC,Kilgore ML,Eckhoff DE

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:A successful kidney transplant from a living-related donor (LRD) remains the most effective renal replacement therapy for children with end-stage renal failure. The use of LRD kidneys results in decreased time on dialysis, increased graft survival, and better function compared with kidneys transplanted from ...

journal_title：Transplantation

authors： Ishitani M,Isaacs R,Norwood V,Nock S,Lobo P

更新日期：2000-07-27 00:00:00

abstract：:Solid organ and allogeneic hematopoietic cell transplantation have become standard therapeutic interventions that save patient lives and improve quality of life. Our enhanced understanding of transplantation immunobiology has refined clinical management and improved outcomes. However, organ rejection and graft-versus-...

journal_title：Transplantation

authors： Radojcic V,Maillard I

更新日期：2016-12-01 00:00:00

abstract：:Several approaches have been attempted to manage renal allograft dysfunction in cyclosporine-prednisone (CsA-Pred)-treated patients. Conversion to conventional therapy and perioperative triple drug have been associated with high rates of acute rejection episodes, infections, or neoplasms. We report our experience in d...

journal_title：Transplantation

authors： Pascual J,Marcén R,Orofino L,Quereda C,Mampaso F,Liaño F,Ortuño J

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND:Human herpesvirus-6 (HHV-6) is known to reactivate after renal transplantation and has been associated with several clinical manifestations. Risk factors for sustained viral replication, however, remain unclear. METHODS:Thirty consecutive kidney transplant patients were prospectively followed for HHV-6 repl...

journal_title：Transplantation

authors： Luiz CR,Machado CM,Canto CL,Christ SC,Pestana JO,Kotton CN,Camargo LF

更新日期：2013-03-27 00:00:00

abstract：BACKGROUND:In 2000, the United Network for Organ Sharing/Organ Procurement and Transplantation Network Registry reported 540 recovered kidneys were discarded because of biopsy results, and 210 were discarded because of poor organ function. We compared the percentage of glomerulosclerosis (GS) and creatinine clearance (...

journal_title：Transplantation

authors： Edwards EB,Posner MP,Maluf DG,Kauffman HM

更新日期：2004-05-15 00:00:00