Abstract:
:In this report we describe a modified, sensitive MLR test that appears to detect fine antigenic disparities between HLA-identical siblings confirmed as such by serology and the standard MLR test. In a group of 40 consecutive allogeneic bone marrow transplants, reactivity detected by the modified MLR test correlated with the development of rejection of matched marrow grafts and onset of acute graft vs. host disease (aGVHD). Thus, 13/15 positively reacting patient/donor pairs developed one of these complications (P < 0.001), while only 2/25 developed aGVHD in the negatively reacting group. This test may be useful for selecting the most compatible donor when several potential donors are available.
journal_name
Transplantationjournal_title
Transplantationauthors
Bishara A,Brautbar C,Nagler A,Slavin S,Leshem B,Cohen I,Kedar Esubject
Has Abstractpub_date
1994-05-27 00:00:00pages
1474-9issue
10eissn
0041-1337issn
1534-6080journal_volume
57pub_type
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