Abstract:
BACKGROUND:To stimulate organ donation, an organ procurement organization (OPO)-wide effort was undertaken to increase donors after cardiac death (DCD) over a 5-year period. This included commonality of protocols, pulsatile perfusion of kidneys, centralization of data and a regional allocation variance designed to minimize cold ischemia times and encourage adoption of DCD protocols at transplant centers. RESULTS:In one OPO, eight centers initiated DCD programs in 11 hospitals. A total of 52 DCD donors were procured, increasing from four in 1999 to 21 in 2003. Eleven donors had care withdrawn in the operating room, whereas 41 had care withdrawn in the ICU. In all, 91 patients received renal transplants from these 52 donors (12 kidneys discarded, one double transplant), whereas 5 patients received liver transplants. One-, two-, and three-year kidney graft survival rates were 90%, 90%, and 82%, respectively. Fifty-five percent of patients needed at least one session of hemodialysis postoperatively. Mean recipient hospital length of stay was 11.1+/-6 days. Mean creatinine levels at 3, 6, 12, and 24 months were 1.65, 1.40, 1.41, and 1.40, respectively. CONCLUSIONS:DCD donors can be an important source of donor organs and provide excellent overall outcomes. Regional cooperation and a prospectively considered allocation and distribution system are important considerations in stimulating DCD programs.
journal_name
Transplantationjournal_title
Transplantationauthors
Whiting JF,Delmonico F,Morrissey P,Basadonna G,Johnson S,Lewis WD,Rohrer R,O'Connor K,Bradley J,Lovewell TD,Lipkowitz Gdoi
10.1097/01.tp.0000179641.82031.easubject
Has Abstractpub_date
2006-05-27 00:00:00pages
1368-71issue
10eissn
0041-1337issn
1534-6080pii
00007890-200605270-00002journal_volume
81pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::BACKGROUND.: Reduced levels of serum adiponectin, an adipokine, are associated with cardiovascular and obesity-related diseases; however, relations between adiponectin and hypertension are unclear. METHODS.: This cross-sectional study examined adiponectin and ambulatory blood pressure monitoring (ABPM) in 33 pediatric...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181b9e1ec
更新日期:2009-10-27 00:00:00
abstract::Forty-three human liver allograft biopsies and normal liver were directly analyzed for inflammatory and immunoregulatory cytokine gene expression by polymerase chain reaction (PCR). IL-5 gene expression was predominantly present in biopsies from liver allografts with histopathological evidence of acute rejection. IL-2...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199202010-00035
更新日期:1992-02-01 00:00:00
abstract::Nuclear imaging is used to evaluate renal allografts demonstrating delayed function after transplantation. Interpretation of the nuclear scan in the context of clinical data, provides helpful information in the management of the transplant recipient. The better quality of images obtained with technetium-99m mercaptoac...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199711270-00023
更新日期:1997-11-27 00:00:00
abstract:BACKGROUND:Renal ischemia-reperfusion (I/R) injury is unavoidable in kidney transplantation and frequently influences both short- and long-term allograft survival rates. One of the major events in I/R injury is the generation of cytotoxic oxygen radicals. Recently, hydrogen gas has been reported to display antioxidant ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318255f8be
更新日期:2012-07-15 00:00:00
abstract::We report the observation that the major sources of variation in cadaver renal allograft survival rates are not related to the technique of donor organ preservation but are related solely to other factors including pretransplant blood transfusion of the recipient, antilymphocyte serum (ALS) treatment of the recipient,...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198112000-00008
更新日期:1981-12-01 00:00:00
abstract::A total of 159 patients received renal cadaveric grafts under 2 different allocation systems. System 1, a local variance (i.e., a point system different from that of United Network for Organ Sharing [UNOS]), and system 2, the current UNOS point system, differed in the relative emphasis on waiting time and HLA match. T...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1994-04-15 00:00:00
abstract:INTRODUCTION:Immune privilege provides a natural paradigm for potentially down-regulating allogeneic and xenogeneic inflammatory immune responses. Fas ligand has been suggested as a general underlying mechanism of immune privilege; the human Fas ligand has been shown to ligate murine Fas in vitro. METHODS:In this stud...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200003270-00010
更新日期:2000-03-27 00:00:00
abstract:BACKGROUND:Chronic allograft dysfunction (CAD) is a complex phenomenon caused by underlying kidney disease and superimposed environmental and genetic factors. We investigated the association of polymorphisms in the genes for angiotensin-converting enzyme (ACE), angiotensinogen (AGT), angiotensin II receptor type 1 (ATR...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000134972.81306.b1
更新日期:2004-09-27 00:00:00
abstract::Donor-specific transfusion effects were studied in the ACI-to-Lewis rat heterotopic heart allograft model using cyclosporine immunosuppression. Low-dose CsA for 1 week plus a single fresh or stored DST given 1 day before allografting significantly prolonged graft survival over CsA therapy alone (median survival time 2...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199109000-00032
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:One of the alternative options to simultaneous pancreas-kidney transplantation (SPKT) for type I diabetics with renal failure is sequential transplant of a living donor kidney followed by a deceased donor pancreas transplant (pancreas after living donor kidney transplant [PALK]). We retrospectively compared ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181dd3587
更新日期:2010-06-27 00:00:00
abstract:BACKGROUND:The aim of this article is to report our experience regarding the survival and the evolution of polyneuropathy of the extremities and autonomic dysfunction in 18 liver transplant patients with familial amyloidotic polyneuropathy type I after a mean follow-up of more than 2.5 years for 13 patients. METHODS:T...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199708270-00017
更新日期:1997-08-27 00:00:00
abstract::The influence of ultraviolet (UVB) irradiation on the survival of H-2 class II-disparate skin grafts was studied in congenic mouse strains. Isolated skin was UVB irradiated in vitro at a dose of 40 mJ/cm2 from both sides to remove Ia immunogenicity. Immediately after irradiation the skin was transplanted onto the flan...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198803000-00020
更新日期:1988-03-01 00:00:00
abstract:BACKGROUND:The polymorphic family of killer-cell immunoglobulin-like receptors (KIRs) consists of activating and inhibitory receptors expressed by natural killer (NK) cells and effector T cells that recognize human leukocyte antigen (HLA) class I ligands. It has been suggested that KIR/HLA incompatibility exerts benefi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000290681.41859.41
更新日期:2007-12-15 00:00:00
abstract::Adult male B6AF1 (H-2KIb/kDb/d) mice were given skin allografts from adult male C3H (H-2k) mice, with and without contralateral cotransplants. The cotransplants were of either adult or neonatal (less than 24 hr) C3H skin. In recipient mice treated peritransplantation with antilymphocyte serum and posttransplantation w...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199012000-00001
更新日期:1990-12-01 00:00:00
abstract:BACKGROUND:Two apolipoprotein L1 gene (APOL1) renal-risk variants in donors and African American (AA) recipient race are associated with worse allograft survival in deceased-donor kidney transplantation (DDKT) from AA donors. To detect other factors impacting allograft survival from deceased AA kidney donors, APOL1 ren...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000969
更新日期:2016-01-01 00:00:00
abstract::The majority of skin tumors induced in mice by ultraviolet (UV) light are rejected when implanted into normal syngeneic recipients. Subcarcinogenic levels of UV light exposure render the normally resistant mice susceptible to tumor challenge. The immunoregulatory effect of UV light appears to be additive, since the gr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197704000-00008
更新日期:1977-04-01 00:00:00
abstract:BACKGROUND:Despite early skepticism, the field of vascularized composite allotransplantation (VCA) has demonstrated feasibility. The ethics of VCA have moved past doubts about the morality of attempting such transplants to how to conduct them ethically. METHODS:Leaders of each program performing and/or evaluating VCA ...
journal_title:Transplantation
pub_type: 共识发展会议,杂志文章,评审
doi:10.1097/TP.0000000000002478
更新日期:2019-06-01 00:00:00
abstract:INTRODUCTION:This is a follow-up of a withdrawal study that we previously performed on 104 liver transplant patients in which immunosuppression was gradually withdrawn over a period of 3 years. Eighty-one patients were not able to be withdrawn (rejectors), and 23 patients were successfully weaned off immunosuppression ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182003db7
更新日期:2010-12-27 00:00:00
abstract::The applicability of laparoscopic donor nephrectomy (LDN) has not been assessed in the obese donor. We hypothesized that obesity is not a technical contraindication to LDN. From May 1998 to February 1999, 40 patients underwent LDN at the Georgetown Transplant Institute with the transperitoneal technique. Prophylaxis a...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200001150-00031
更新日期:2000-01-15 00:00:00
abstract::Using liposomes, multilamellar lipid vesicles (MLV), we have found that liposome-incorporated cyclosporine is not only less toxic but also more effective in prolonging survival of cardiac allografts in mice. Following intravenous injection of liposome-incorporated drug, cyclosporine levels in blood were shown to decre...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199111000-00002
更新日期:1991-11-01 00:00:00
abstract::The psychosocial and psychiatric impact of donating bone marrow (BM) has received little study. This mail questionnaire study of bone marrow donors whose recipient had survived more than one year post-BMT was undertaken to document the psychosocial consequences of donation on "successful" BM donors. Demographic, mood ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198604000-00014
更新日期:1986-04-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to examine the utility of the random urine protein to creatinine ratio (P/C) in evaluation and longitudinal management of proteinuria in adult renal transplant recipients with or without overt nephropathy in an outpatient clinic. METHODS:A total of 289 adult renal transplant re...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200110270-00021
更新日期:2001-10-27 00:00:00
abstract:BACKGROUND:Survival of ABO-mismatched kidneys with stable renal function despite the persistence of anti-ABO antibodies is called accommodation. The mechanism of accommodation is unclear, but may involve complement regulatory proteins such as CD59. The development of alpha-1,3-galactosyltransferase knock-out (GalT-KO) ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181a19afc
更新日期:2009-05-15 00:00:00
abstract::The benefits of cytomegalovirus (CMV) prophylaxis in preventing the direct effects of CMV infection and disease are well established; however, the impact of exposure to antiviral agents on preventing the indirect effects of CMV infection are poorly defined. This article reviews the results of current studies demonstra...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000230459.22968.26
更新日期:2006-07-27 00:00:00
abstract:BACKGROUND:The rate of acute rejection (AR) has decreased significantly, but whether this is associated with improvement in long-term graft survival is controversial. METHODS:We analyzed 1445 consecutive adult deceased donor kidney transplant recipients from 1985 to 2005, over two periods (1985-1995 vs. 1996-2005) to ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181c892dd
更新日期:2010-03-27 00:00:00
abstract::We describe a patient transfused with 200 ml of donor fresh whole blood three times at 2-week intervals. Three weeks after the last transfusion, transplantation and splenectomy were done at the same time. Splenic cells from this DST pretreated patient were fused with murine myeloma cells (X63-Ag8, 653). With DST pretr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198909000-00022
更新日期:1989-09-01 00:00:00
abstract::In the present study the functional and morphologic effects of two pulmoplegic solutions are evaluated. Single left-lung allotransplantation with ligation of the right pulmonary artery was performed in 15 piglets (13-20 kg). The lungs were preserved after donor prostaglandin E-1 treatment with single pulmonary artery ...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1990-06-01 00:00:00
abstract:BACKGROUND:We examined whether oral administration of alloantigen could induce the prolonged survival of cardiac allografts. METHODS:Hearts from CBK (H2k+Kb) transgenic or (C57BL/10xCBA)F1 (H2bxH2k) mice were transplanted into CBA (H2k) recipients pretreated orally with 1 x 10(7) donor splenocytes in the presence or a...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200011270-00021
更新日期:2000-11-27 00:00:00
abstract:BACKGROUND:The deleterious effect of steatosis on transplanted livers is mainly related to a microcirculation impairment. We investigated the effect of preservation duration on the recovery of isolated perfused rat steatotic livers and tested the effect of pentoxifylline (PTX), known to have a beneficial effect on hepa...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000071846.35825.B1
更新日期:2003-07-15 00:00:00
abstract::Hepatitis C virus (HCV) remains the leading indication for liver transplant in much of the world and has traditionally been associated with diminished posttransplant survival due to recurrent HCV-related liver disease. This field has been dramatically changed by the advent of safe and effective direct-acting antiviral...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000001688
更新日期:2017-05-01 00:00:00