Abstract:
:A monoclonal anti-Lyt-1.1 serum has been characterized in terms of its effect on various cell populations involved in cell-mediated immune responses. The monoclonal serum was compared to a conventionally prepared anti-Lyt-1.1 serum. Cytotoxic T cell precursors and effectors were found to be Lyt-1.1+. Helper T cells which participate in the induction of a cytotoxic response were also Lyt-1.1+ as were suppressor T cells which inhibit cytotoxic responses. The T cell that is required for the production of a nonspecific stimulatory factor, costimulator, and that has been shown to bear the same Ly markers as does the helper T cell, bears Lyt-1.1. Finally, the effector cell which mediates delayed-type hypersensitivity reactions to alloantigens has been shown to be Lyt-1.1+. In all of these cases treatment with the monoclonal anti-Lyt-1.1 and complement had the same effect as did treatment with a conventional anti-Lyt-1.1 and complement. The distribution of Lyt-1.1 on various cell types as determined using the monoclonal anti-Lyt-1.1 is in complete agreement with the Lyt-1.1 distribution obtained with conventional anti-Lyt-1.1 sera, and is quite different from the reactivity of an anti-Thy-1 serum as determined by strain distribution. The distribution of the Lyt-1.1 specificity on the T cells within a given strain is identical to that seen with the conventional anti-Lyt-1.1 serum and, as reported by many others, does not differ from the distribution of Thy-1 specificities.
journal_name
Transplantationjournal_title
Transplantationauthors
Shaw J,Pilarski LM,Al Adra AR,Leigh JB,Wilkins J,Hogarth PM,McKenzie IF,Paetkau Vdoi
10.1097/00007890-198101000-00013subject
Has Abstractpub_date
1981-01-01 00:00:00pages
56-60issue
1eissn
0041-1337issn
1534-6080journal_volume
31pub_type
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