The poly(adenosine diphosphate-ribose) polymerase inhibitor PJ34 reduces pulmonary ischemia-reperfusion injury in rats.

abstract：BACKGROUND:We have previously shown that CD8 depletion or CD34 selection of peripheral blood stem cells (PBSC) reduced the incidence of acute graft-versus-host disease (GvHD) after nonmyeloablative stem-cell transplantation (NMSCT). In this study, we analyze the effect of CD8 depletion or CD34 selection of the graft on...

journal_title：Transplantation

authors： Baron F,Schaaf-Lafontaine N,Humblet-Baron S,Meuris N,Castermans E,Baudoux E,Frère P,Bours V,Fillet G,Beguin Y

更新日期：2003-12-27 00:00:00

abstract：BACKGROUND:Chronic graft-versus-host disease (cGVHD) represents a double-edged sword. In its nonsevere form, cGVHD associates with better control of the malignant disease, thus highlighting graft-versus-leukemia effects. However, severe cGVHD leads to debilitating morbidity and increased nonrelapse mortality. The predi...

journal_title：Transplantation

authors： Giesen N,Schwarzbich MA,Dischinger K,Becker N,Hummel M,Benner A,Radujkovic A,Müller-Tidow C,Dreger P,Luft T

更新日期：2020-11-01 00:00:00

abstract：:Two patients at our institution underwent single lung transplantation. The procedure and the patient's postoperative course were uncomplicated in each case. Pathological examination of each pneumonectomy specimen revealed a well-differentiated adenocarcinoma; both were less than 1 cm in size. The remainder of each lun...

journal_title：Transplantation

authors： Svendsen CA,Bengtson RB,Park SJ,Shumway SJ

更新日期：1998-10-27 00:00:00

abstract：BACKGROUND:Acute graft dysfunction caused by ischemia-reperfusion injury is recognized as a major source of morbidity and mortality following adult heart transplantation. The aim of this study was to determine whether treating the donor and recipient with cariporide, an inhibitor of the sodium-hydrogen exchanger, could...

journal_title：Transplantation

authors： Ryan JB,Hicks M,Cropper JR,Garlick SR,Kesteven SH,Wilson MK,Feneley MP,Macdonald PS

更新日期：2003-03-15 00:00:00

abstract：BACKGROUND:The impact of major histocompatibility class I chain-related A (MICA) antibodies on renal graft outcomes is unclear. The goal of this work was to assess the impact of posttransplant MICA antibodies, assayed at 1 year, with two commercially available kits, on long-term renal graft outcomes. METHODS:We retros...

journal_title：Transplantation

authors： Lemy A,Andrien M,Lionet A,Labalette M,Noel C,Hiesse C,Delahousse M,Suberbielle-Boissel C,De Meyer M,Latinne D,Mourad M,Delsaut S,Racapé J,Wissing KM,Toungouz M,Abramowicz D

更新日期：2012-06-27 00:00:00

abstract：BACKGROUND:We have previously shown successful engraftment of allogeneic hematopoietic stem cells (HSCs) when transplanted across the major histocompatibility antigen barriers if transplanted along with a preparation of facilitator cells (osteoblasts). We have investigated whether or not fully allogeneic HSCs from heal...

journal_title：Transplantation

authors： El-Badri NS,Wang BY,Steele A,Cherry,Marikar Y,Mizobe K,Good RA

更新日期：2000-09-27 00:00:00

abstract：:Eight patients with chronic myeloid leukemia relapse after allogeneic BMT were treated with IFN-alpha and buffy coat transfusions (BC) of the bone marrow donor. The antileukemic effect of this treatment was directly demonstrated in 4 patients by the disappearance of Philadelphia chromosome-positive metaphases or the l...

journal_title：Transplantation

authors： Hertenstein B,Wiesneth M,Novotny J,Bunjes D,Stefanic M,Heinze B,Hübner G,Heimpel H,Arnold R

更新日期：1993-11-01 00:00:00

abstract：:We investigated whether right lobe (RL) liver donation is associated with a higher incidence or severity of donor complications than left lobe (LL) liver and left lateral segment (LLS) liver donations. We studied 80 living donors: 35 RL liver donors and 45 LL/LLS liver donors. A modification of the Clavien classificat...

journal_title：Transplantation

authors： Salvalaggio PR,Baker TB,Koffron AJ,Fryer JP,Clark L,Superina RA,Blei AT,Abecassis MM

更新日期：2004-06-15 00:00:00

abstract：:The interactions of steroid hormones and human peripheral blood lymphocytes (PBLs) have been investigated following glass-wool column separation of PBLs and incubation in a serum-free medium in the presence of phytohemagglutinin (PHA). Addition of hydrocortisone or progesterone above physiological concentrations resul...

journal_title：Transplantation

authors： Neifeld JP,Tormey DC

更新日期：1979-05-01 00:00:00

abstract：:It has been demonstrated both in vivo and in vitro that cytomegalovirus regulates not only MHC class I but also class II antigen expression on vascular endothelial cells. The CMV-linked MHC induction is believed to be involved in acute rejection mechanisms and chronic vasculopathy after transplantation. In this study,...

journal_title：Transplantation

authors： Ustinov JA,Lahtinen TT,Bruggeman CA,Häyry PJ,Lautenschlager IT

更新日期：1994-11-15 00:00:00

abstract：BACKGROUND:The degree of fatty infiltration in hepatic grafts is known to be an important risk factor for primary graft nonfunction in cadaveric liver transplantation. However, the effect of hepatic steatosis in living-donor liver transplantation (LDLT) has not yet been well defined. In this study, we evaluated the imp...

journal_title：Transplantation

authors： Soejima Y,Shimada M,Suehiro T,Kishikawa K,Yoshizumi T,Hashimoto K,Minagawa R,Hiroshige S,Terashi T,Ninomiya M,Shiotani S,Harada N,Sugimachi K

更新日期：2003-07-27 00:00:00

abstract：:SLT presents an interesting concept to alleviate the organ shortage for children with end-stage liver disease. The procedure has, however, not gained wide acceptance. This is not only related to the complexity of the procedure, but also to the poorer results and the complications reported on the right side graft. We r...

journal_title：Transplantation

authors： Rogiers X,Malago M,Habib N,Knoefel WT,Pothmann W,Burdelski M,Meyer-Moldenhauer WH,Broelsch CE

更新日期：1995-04-27 00:00:00

abstract：BACKGROUND:Acute rejection of allografts remains a significant problem in clinical transplantation, and the fundamental mechanism underlying this rejection are as yet only poorly elucidated. Recently, DNA microarrays have come into use for the study of gene expression profiles, and we have taken advantage of this new t...

journal_title：Transplantation

authors： Saiura A,Mataki C,Murakami T,Umetani M,Wada Y,Kohro T,Aburatani H,Harihara Y,Hamakubo T,Yamaguchi T,Hasegawa G,Naito M,Makuuchi M,Kodama T

更新日期：2001-07-27 00:00:00

abstract：BACKGROUND:Spontaneous tolerance to liver allograft has been reported previously in outbred pig models, but the lack of genetic background did not allow to analyze the impact of the major histocompatibility complex (MHC) on tolerance induction. A model of semi-identical liver allograft was therefore developed in inbred...

journal_title：Transplantation

authors： Oike F,Talpe S,Otsuka M,Dehoux JP,Lerut J,Otte JB,Gianello P

更新日期：2000-06-15 00:00:00

abstract：BACKGROUND:New-onset diabetes after transplantation (NODAT) increases infectious and cardiovascular complications and reduces patient and graft survival. We assessed the incidence and the risk factors for glucose metabolism abnormalities before and after kidney transplantation using an oral glucose tolerance test (OGTT...

journal_title：Transplantation

authors： Caillard S,Eprinchard L,Perrin P,Braun L,Heibel F,Moreau F,Kessler L,Moulin B

更新日期：2011-04-15 00:00:00

abstract：:Liver transplantation (LT) is the most effective treatment for small and unresectable hepatocellular carcinomas (HCCs). With scarcity of deceased donor livers, living donor LT (LDLT) is the alternative to deceased donor LT (DDLT). Animal studies have suggested that regeneration of the partial liver graft encourages HC...

journal_title：Transplantation

authors： Chan SC

更新日期：2014-04-27 00:00:00

abstract：BACKGROUND:Avascular osteonecrosis (AVN) is a serious complication of allogeneic stem cell transplantation (SCT). Graft-versus-host disease and its treatment with steroids are the main risk factors; underlying diagnosis, age and gender are further risk factors. It has been speculated that low baseline bone mineral dens...

journal_title：Transplantation

authors： Schulte CM,Beelen DW

更新日期：2005-06-27 00:00:00

abstract：:We describe four patients who suffered asystole, myocardial infarction (in two cases) and supraventricular tachycardia at the time of high-dose methylprednisolone infusion. One patient died during infusion. We measured the effects of methylprednisolone and placebo infusion on heart rate, blood pressure, and cardiac ou...

journal_title：Transplantation

authors： Smith RS,Warren DJ

更新日期：1983-04-01 00:00:00

abstract：BACKGROUND:Living kidney donors have donation-related out-of-pocket costs (direct costs) and/or ongoing daily expenses while losing income (indirect costs). Yet there is little information about how much of a subjective burden these constitute for the donors. METHODS:From December 2003 through December 2014, we survey...

journal_title：Transplantation

authors： Wiseman JF,Jacobs CL,Larson DB,Berglund DM,Garvey CA,Ibrahim HN,Matas AJ

更新日期：2017-09-01 00:00:00

abstract：:To determine the importance of static lung inflation during storage, graft performance was evaluated at different levels of intratracheal pressure and varying ischemic intervals. Lewis rat lungs were perfused with low-potassium Euro-Collins and stored for 4 or 8 hr either in atelectasis (4 hr: group I; 8 hr: group IV,...

journal_title：Transplantation

authors： Hausen B,Ramsamooj R,Hewitt CW,Schroder F,Beuke M,Poets CF,Schafers HJ

更新日期：1996-12-27 00:00:00

abstract：:We studied major histocompatibility complex (MHC) and cytokine mRNA induction after renal injury in the absence of interferon-gamma (IFN-gamma) using IFN-gamma gene knockout (GKO) mice. The left renal pedicle of normal (wild-type) and GKO BALB/c mice was clamped for 60 minutes; cytokine and MHC mRNA expression were mo...

journal_title：Transplantation

authors： Goes N,Urmson J,Vincent D,Halloran PF

更新日期：1995-12-27 00:00:00

abstract：:Ling Zhi-8 (LZ-8) is a protein derived from the fungus Ganoderma lucidum and has immunomodulatory capacities. It was shown to be mitogenic toward mouse splenocytes in vitro and immunosuppressive in vivo by reducing antigen-induced antibody formation and by preventing completely the incidence of autoimmune diabetes in ...

journal_title：Transplantation

authors： van der Hem LG,van der Vliet JA,Bocken CF,Kino K,Hoitsma AJ,Tax WJ

更新日期：1995-09-15 00:00:00

abstract：:The possible ability of the mixed-epidermal-cell-lymphocyte reaction (MECLR) to detect alloreactivities in HLA-identical MLR negative siblings has been investigated before grafting in 30 donor-recipients pairs and their families. Results indicate that recipients' epidermal cells (EC) can induce proliferative responses...

journal_title：Transplantation

authors： Bagot M,Cordonnier C,Tilkin AF,Heslan M,Vernant JP,Dubertret L,Levy JP

更新日期：1986-03-01 00:00:00

abstract：:Renal transplantation is the preferred treatment for end-stage renal disease in children. Most transplant failures are due to allograft rejection. To date, only histopathological findings on renal biopsy can establish this diagnosis. Prior to the availability of cyclosporine, technetium-99m sulfur colloid nuclear scan...

journal_title：Transplantation

authors： Massengill SF,Pena DR,Drane WE,Fennell RS,Richard GA

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:Sensitization to human leukocyte antigens (HLA) is a significant barrier to transplantation. Currently, no proven therapy exists to improve access to transplantation for highly sensitized patients. Here, we report a novel approach using intravenous immune globulin to modulate anti-HLA antibody and improve th...

journal_title：Transplantation

authors： Jordan SC,Vo A,Bunnapradist S,Toyoda M,Peng A,Puliyanda D,Kamil E,Tyan D

更新日期：2003-08-27 00:00:00

abstract：BACKGROUND:A precise understanding of immunological mechanisms is needed to prevent transplant vasculopathy. METHODS:The developing process of transplant vasculopathy was investigated by retransplanting rat cardiac allografts and measuring the expressions of 21 different genes inside the retransplanted allografts unde...

journal_title：Transplantation

authors： Tori M,Kitagawa-Sakakida S,Li Z,Izutani H,Horiguchi K,Ito T,Matsuda H,Shirakura R

更新日期：2000-09-15 00:00:00

abstract：BACKGROUND:Plasma level of plasminogen activator inhibitor (PAI)-1 is genetically determined by a polymorphism in the promoter region, involving two alleles, 4G and 5G. Plasma PAI-1 concentrations are higher in subjects homozygous for the 4G allele than other genotypes (5G/5G and 4G/5G). Such genetic variation in fibri...

journal_title：Transplantation

authors： Chow KM,Szeto CC,Szeto CY,Poon P,Lai FM,Li PK

更新日期：2002-12-27 00:00:00

abstract：BACKGROUND:T-cell activation through T-cell receptor engagement requires co-stimulatory molecules and also adhesion molecules such as ICAM-1. Moreover ICAM-1 mediates leukocyte invasion from the blood into tissue during inflammatory processes. In animal studies using mouse monoclonal antibodies against ICAM-1 (enlimoma...

journal_title：Transplantation

authors： Salmela K,Wramner L,Ekberg H,Hauser I,Bentdal O,Lins LE,Isoniemi H,Bäckman L,Persson N,Neumayer HH,Jørgensen PF,Spieker C,Hendry B,Nicholls A,Kirste G,Hasche G

更新日期：1999-03-15 00:00:00

abstract：BACKGROUND:Imported pancreata accumulate cold ischemia time (CIT), limiting utilization and worsening outcomes. Flow cytometric crossmatching (FXM) is a standard method to assess recipient and donor compatibility, but can prolong CIT. Single-antigen bead assays allow for detection of recipient donor-specific HLA antibo...

journal_title：Transplantation

authors： Eby BC,Redfield RR,Ellis TM,Leverson GE,Schenian AR,Odorico JS

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:DBA/2J kidney allografts, but not heart allografts, are spontaneously accepted indefinitely in C57BL/6 (B6) mice, through regulatory tolerance mechanism dependent on Foxp3 cells. In contrast, B6 kidneys are rejected within a week in DBA/2J recipients. We hypothesized that the tolerogenic difference of the ki...

journal_title：Transplantation

authors： Oh NA,O'Shea T,Ndishabandi DK,Yuan Q,Hong S,Gans J,Ge J,Gibney S,Chase C,Yang C,Rosales I,Shinoda K,Drew B,Kojima L,Russell PS,Madsen JC,Colvin RB,Alessandrini A

更新日期：2020-01-01 00:00:00