A possible predictive test for graft-versus-host disease in bone marrow graft recipients: the mixed-epidermal cell-lymphocyte reaction.

abstract：BACKGROUND:Perioperative renal dysfunction in liver transplant recipients complicates maintenance immunosuppressive therapy, particularly in patients with hepatitis C. Calcineurin inhibitors exacerbate renal dysfunction and mammalian target-of-rapamycin inhibitors are generally avoided because of perceived perioperativ...

journal_title：Transplantation

authors： LaMattina JC,Jason MP,Hanish SI,Ottmann SE,Klassen DK,Potosky D,Hutson WR,Barth RN

更新日期：2014-01-27 00:00:00

abstract：BACKGROUND:In nontransplant patients with chronic hepatitis C virus (HCV), HCV genotype has been linked with a differential response to antiviral therapy, risk of steatosis and fibrosis, as well as all-cause mortality, but the role of HCV genotypes in posttransplant disease progression is less clear. METHODS:Using the...

journal_title：Transplantation

authors： Campos-Varela I,Lai JC,Verna EC,O'Leary JG,Todd Stravitz R,Forman LM,Trotter JF,Brown RS,Terrault NA,Consortium to Study Health Outcomes in HCV Liver Transplant Recipients (CRUSH-C).

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Intrahepatic bile duct strictures are a serious complication after non-heart-beating (NHB) liver transplantation. Bile salt toxicity has been identified as an important factor in the pathogenesis of bile duct injury and cholangiopathies. The role of bile salt toxicity in the development of biliary strictures...

journal_title：Transplantation

authors： Yska MJ,Buis CI,Monbaliu D,Schuurs TA,Gouw AS,Kahmann ON,Visser DS,Pirenne J,Porte RJ

更新日期：2008-06-15 00:00:00

abstract：BACKGROUND:Since the Edmonton trial in 2000, increasing numbers of transplant centers have been implementing islet transplantation programs. Some institutions have elected to associate in multicenter networks, such as the Swiss-French GRAGIL (Groupe Rhin-Rhône-Alpes-Genève pour la Transplantation d'Ilots de Langerhans)...

journal_title：Transplantation

authors： Kempf MC,Andres A,Morel P,Benhamou PY,Bayle F,Kessler L,Badet L,Thivolet C,Penfornis A,Renoult E,Brun JM,Atlan C,Renard E,Colin C,Milliat-Guittard L,Pernin N,Demuylder-Mischler S,Toso C,Bosco D,Berney T,GRAGIL gro

更新日期：2005-05-15 00:00:00

abstract：BACKGROUND:Dysregulation of the coagulation system due to inflammatory responses and cross-species molecular incompatibilities represents a major obstacle to successful xenotransplantation. We hypothesized that complement inhibition mediated by transgenic expression of human CD46 in pigs might also regulate the coagula...

journal_title：Transplantation

authors： Bongoni AK,Kiermeir D,Schnider J,Jenni H,Garimella P,Bähr A,Klymiuk N,Wolf E,Ayares D,Voegelin E,Constantinescu MA,Seebach JD,Rieben R

更新日期：2015-10-01 00:00:00

abstract：:A quantitative absorption-blocking assay was used to measure the levels of antibody in immune rabbit sera that react with the serologically defined HLA molecular complex on the cell surface. Quantitation was determined by comparing the number of xenoantibody-treated cells with the number of untreated control cells nee...

journal_title：Transplantation

authors： Wilson LA,Gallaspy GT

更新日期：1978-07-01 00:00:00

abstract：:Donor-specific transfusion effects were studied in the ACI-to-Lewis rat heterotopic heart allograft model using cyclosporine immunosuppression. Low-dose CsA for 1 week plus a single fresh or stored DST given 1 day before allografting significantly prolonged graft survival over CsA therapy alone (median survival time 2...

journal_title：Transplantation

authors： Brunson ME,Tchervenkov JI,Alexander JW

更新日期：1991-09-01 00:00:00

abstract：:Single amino acid disparities in MHC class I molecules can elicit transplantation responses. Since beta 2 microglobulin (beta 2m) is noncovalently associated with class I antigens on the cell membrane we investigated whether the single amino acid polymorphism at position 85 (Asp-->Ala) in the mouse beta 2m molecule ca...

journal_title：Transplantation

authors： Hederer RA,Chandler PR,Dyson PJ,Antoniou AN,Millrain MM,Mellor AL,Simpson E,Robinson PJ

更新日期：1996-01-27 00:00:00

abstract：:Preoperative portal venous injection of donor lymphocytes has been shown to extend allograft survival in inbred animals. However, the effect of perioperative injection in a large animal model has not been carefully studied. We examined the effect of perioperative (day 0) donor spleen cell administration in a canine ki...

journal_title：Transplantation

authors： Tsuji T,Tashiro S,Tanabe D,Sawada T,Inoue K,Kawamoto S,Kamimoto Y,Miyauchi Y

更新日期：1994-10-27 00:00:00

abstract：:Organ donation after circulatory death (DCD) has been endorsed by the World Health Organization and is practiced worldwide. This overview examines current DCD practices, identifies problems and challenges, and suggests clinical strategies for possible improvement. Although there is uniform agreement on DCD donor candi...

journal_title：Transplantation

authors： Morrissey PE,Monaco AP

更新日期：2014-02-15 00:00:00

abstract：BACKGROUND:Renal transplant recipients are at increased risk of developing skin cancer. It remains difficult to establish the actual influence of overimmunosuppression in the development of skin cancers. We investigated whether lymphocyte subset count may predict the risk of developing skin cancer in long-term renal tr...

journal_title：Transplantation

authors： Ducloux D,Carron PL,Rebibou JM,Aubin F,Fournier V,Bresson-Vautrin C,Blanc D,Humbert P,Chalopin JM

更新日期：1998-05-15 00:00:00

abstract：BACKGROUND:Translational research in a relevant preclinical model is recommended before Treg-inducing protocols can be implemented in humans. We have characterized rhesus monkey CD25 cells phenotypically and functionally. METHODS:The phenotype of CD4(+)CD25(high) cells was determined by FACS, focusing on established m...

journal_title：Transplantation

authors： Haanstra KG,van der Maas MJ,'t Hart BA,Jonker M

更新日期：2008-04-27 00:00:00

abstract：:Long-term graft survival is mainly influenced by early graft rejection and posttransplant graft function. The ability of both complement-dependent cytotoxicity cross-match (CDC) and flow cytometry cross-match (FCXM) to predict acute rejection episodes has been evaluated by cross-matching 40 patients who received cadav...

journal_title：Transplantation

authors： Utzig MJ,Blümke M,Wolff-Vorbeck G,Lang H,Kirste G

更新日期：1997-02-27 00:00:00

abstract：:Ninety-five dogs with spontaneous malignant lymphoma in chemotherapy-induced remission were treated with total-body irradiation (TBI) and bone marrow transplantation. Among 38 dogs treated with 8.4 Gy delivered at 4 cGy/min, 9 (24%) became long-term disease-free survivors. Ten of the 38 (26%) died of transplant-relate...

journal_title：Transplantation

authors： Appelbaum FR,Deeg HJ,Storb R,Self S,Graham TC,Sale GE,Weiden PL

更新日期：1985-05-01 00:00:00

abstract：BACKGROUND:To reduce the side effects of long-term immunosuppressive therapy, stable renal transplant patients were routinely converted from cyclosporine to either azathioprine or mycophenolate mofetil. Thereafter, the azathioprine and mycophenolate mofetil dose was reduced to 75% at 4 months and to 50% at 8 months aft...

journal_title：Transplantation

authors： van Besouw NM,van der Mast BJ,de Kuiper P,Smak Gregoor PJ,Vaessen LM,IJzermans JN,van Gelder T,Weimar W

更新日期：2000-07-15 00:00:00

abstract：BACKGROUND:Renal ischemia-reperfusion (I/R) injury is unavoidable in kidney transplantation and frequently influences both short- and long-term allograft survival rates. One of the major events in I/R injury is the generation of cytotoxic oxygen radicals. Recently, hydrogen gas has been reported to display antioxidant ...

journal_title：Transplantation

authors： Abe T,Li XK,Yazawa K,Hatayama N,Xie L,Sato B,Kakuta Y,Tsutahara K,Okumi M,Tsuda H,Kaimori JY,Isaka Y,Natori M,Takahara S,Nonomura N

更新日期：2012-07-15 00:00:00

abstract：BACKGROUND:A regimen consisting of antilymphocyte serum (ALS), sirolimus, and donor bone-marrow-cell (BMC) infusion induces indefinite skin allograft survival across fully mismatched mouse strain combinations. We investigated the role of chimerism in this transplantation tolerance model. MATERIALS:B10.A (H-2a) mice we...

journal_title：Transplantation

authors： Kanamoto A,Monaco AP,Maki T

更新日期：2004-09-27 00:00:00

abstract：:Since June 1979, percutaneous transluminal angioplasty (PTA) has been the procedure of choice for renal transplant artery stenosis (RTAS) at the Hospital of the University of Pennsylvania. Of 241 renal allograft recipients, 17 (7%) when studied by arteriogram because of suspected RTAS proved to have significant stenos...

journal_title：Transplantation

authors： Grossman RA,Dafoe DC,Shoenfeld RB,Ring EJ,McLean GK,Oleaga JA,Freiman DB,Naji A,Perloff LJ,Barker CF

更新日期：1982-12-01 00:00:00

abstract：BACKGROUND:Although islet xenotransplantation is a promising therapy for type 1 diabetes, its clinical application has been hampered by cellular rejection and the requirement for high levels of immunosuppression. The aim of this study was to determine the role of Foxp3 regulatory T (Treg) cells in costimulation blockad...

journal_title：Transplantation

authors： Wu J,Hu M,Qian YW,Hawthorne WJ,Burns H,Liuwantara D,Alexander SI,Yi S,O'Connell PJ

更新日期：2017-07-01 00:00:00

abstract：:BACKGROUND.: Rabbit antithymocyte globulins (rATGs) are known to convert CD4CD25FoxP3 T cells from healthy individuals to CD4CD25FoxP3 T cells. In this study, we investigated the effect of rATG on the induction of regulatory T cells (Tregs) from blood cells of patients with end-stage renal disease who are candidates f...

journal_title：Transplantation

authors： Sewgobind VD,van der Laan LJ,Kho MM,Kraaijeveld R,Korevaar SS,van Dam T,Ijzermans JN,Weimar W,Baan CC

更新日期：2010-03-27 00:00:00

abstract：BACKGROUND:Induction therapy is associated with excellent short-term kidney graft outcome. The aim of this study was to evaluate differences in the intragraft transcriptome after successful induction therapy using two rabbit antithymocyte globulins. METHODS:The expression of 376 target genes involved in tolerance, inf...

journal_title：Transplantation

authors： Urbanova M,Brabcova I,Girmanova E,Zelezny F,Viklicky O

更新日期：2012-03-27 00:00:00

abstract：:The aim of this study was to assess directly the function of isolated hepatocytes 1 year after transplantation into the spleen, using an original model of isolated rat-spleen perfusion. Three specific liver functions, albumin synthesis, indocyanine-green clearance, and antipyrine oxidation, were studied. Five x 10(6) ...

journal_title：Transplantation

authors： Panis Y,Puts JP,Ballet F,Penin E,Delelo R,Verthier N,Nordlinger B

更新日期：1990-04-01 00:00:00

abstract：:Loss of renal mass has been associated with the development of glomerular sclerosis in animals and human beings. The pathophysiology of this renal injury is unknown, but glomerular sclerosis in animals can be aggravated or accelerated following exposure to nephrotoxic antibodies, puromycin aminoglycoside or renal irra...

journal_title：Transplantation

authors： Parfrey PS,Hollomby DJ,Gilmore NJ,Knaack J,Schur PH,Guttmann RD

更新日期：1984-10-01 00:00:00

abstract：:Twenty eight consecutive combined renal and pancreatic transplantations with enteric exocrine diversion were performed between June 1984 and May 1986. The one-year actuarial patient survival and renal and pancreatic graft survival were 90%, 67%, and 69%, respectively. Nineteen pancreatic grafts and eighteen renal graf...

journal_title：Transplantation

authors： Tydén G,Brattström C,Lundgren G,Ostman J,Gunnarsson R,Groth CG

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND:The need to find a safe, effective liver support system for patients with fulminant hepatic failure (FHF) continues to be unmet. A system using immortalized human hepatocytes was originally developed in the early 1990s. A modified version of the initial extracorporeal liver-assist device (ELAD) was recently ...

journal_title：Transplantation

authors： Millis JM,Cronin DC,Johnson R,Conjeevaram H,Conlin C,Trevino S,Maguire P

更新日期：2002-12-27 00:00:00

abstract：BACKGROUND:The management of ureteral strictures in transplanted kidney is challenging. Open surgical treatment is effective but entails significant convalescence. Holmium:yttrium-aluminum-garnet (Ho:YAG) laser endoureterotomy is useful for other types of ureteral obstruction, and we aimed to assess its long-term succe...

journal_title：Transplantation

authors： Gdor Y,Gabr AH,Faerber GJ,Wolf JS Jr

更新日期：2008-05-15 00:00:00

abstract：BACKGROUND:Donation after circulatory death (DCD) provides an alternative pathway to deceased organ transplantation. Although clinical DCD lung, liver, and kidney transplantation are well established, transplantation of hearts retrieved from DCD donors has reached clinical translation only recently. Progress has been l...

journal_title：Transplantation

authors： Iyer A,Chew HC,Gao L,Villanueva J,Hicks M,Doyle A,Kumarasinghe G,Jabbour A,Jansz PC,Feneley MP,Harvey RP,Graham RM,Dhital KK,Macdonald PS

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Graft coronary arteriosclerosis (GCA) is the major limiting factor for long-term survival after heart transplantation. In this study, we investigated the effect of Multiglycosidorum tripterygii (MT) on GCA and platelet-derived growth factor A (PDGF-A) mRNA expression of transplanted hearts. METHODS:Two grou...

journal_title：Transplantation

authors： Hachida M,Zhang XL,Lu H,Hoshi H,Koyanagi H

更新日期：1998-06-15 00:00:00

abstract：BACKGROUND:The impact of major histocompatibility class I chain-related A (MICA) antibodies on renal graft outcomes is unclear. The goal of this work was to assess the impact of posttransplant MICA antibodies, assayed at 1 year, with two commercially available kits, on long-term renal graft outcomes. METHODS:We retros...

journal_title：Transplantation

authors： Lemy A,Andrien M,Lionet A,Labalette M,Noel C,Hiesse C,Delahousse M,Suberbielle-Boissel C,De Meyer M,Latinne D,Mourad M,Delsaut S,Racapé J,Wissing KM,Toungouz M,Abramowicz D

更新日期：2012-06-27 00:00:00

abstract：:The influence of continuous immunosuppression on the immune system of 2 neonates born to heart-lung transplant recipients was analyzed. T cells, T cell subpopulations, B cells and cyclosporine levels were measured in maternal and cord blood at the time of delivery. Cyclosporine, both parent compound, and metabolites w...

journal_title：Transplantation

authors： Rose ML,Dominguez M,Leaver N,Lachno R,Yacoub MH

更新日期：1989-08-01 00:00:00